Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0314 | 0.2557 | 0.2557 |
Echinococcus granulosus | nervana 2 | 0.0601 | 0.5913 | 0.8681 |
Echinococcus multilocularis | nervana 2 | 0.0601 | 0.5913 | 0.8681 |
Trichomonas vaginalis | AGC family protein kinase | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0314 | 0.2557 | 0.2557 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0601 | 0.5913 | 0.8681 |
Entamoeba histolytica | protein kinase, putative | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0915 | 0.9569 | 0.9569 |
Brugia malayi | Protein kinase domain containing protein | 0.0314 | 0.2557 | 0.2557 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0645 | 0.6423 | 0.5194 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0645 | 0.6423 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0601 | 0.5913 | 0.8681 |
Trichomonas vaginalis | AGC family protein kinase | 0.0314 | 0.2557 | 0.0105 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0314 | 0.2557 | 0.2557 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0952 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0094 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0952 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0952 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0952 | 1 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.0645 | 0.6423 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0952 | 1 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0645 | 0.6423 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0247 | 0.1776 | 0.1776 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0601 | 0.5913 | 0.8681 |
Echinococcus multilocularis | nervana 2 | 0.0601 | 0.5913 | 0.8681 |
Echinococcus granulosus | nervana 2 | 0.0601 | 0.5913 | 0.8681 |
Brugia malayi | Protein kinase domain containing protein | 0.0314 | 0.2557 | 0.2557 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0645 | 0.6423 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0952 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.035 | 0.2988 | 0.0678 |
Trichomonas vaginalis | AGC family protein kinase | 0.0952 | 1 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0608 | 0.5992 | 0.8885 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0608 | 0.5992 | 0.8885 |
Brugia malayi | Hr1 repeat family protein | 0.0314 | 0.2557 | 0.2557 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0645 | 0.6423 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0608 | 0.5992 | 0.5 |
Giardia lamblia | Kinase, AGC PKA | 0.0608 | 0.5992 | 0.5 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0915 | 0.9569 | 0.9569 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0608 | 0.5992 | 0.9329 |
Trichomonas vaginalis | AGC family protein kinase | 0.0314 | 0.2557 | 0.0105 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0314 | 0.2557 | 0.2557 |
Brugia malayi | Cytochrome P450 family protein | 0.0247 | 0.1776 | 0.1776 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0645 | 0.6423 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.2557 | 0.2557 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0601 | 0.5913 | 0.8681 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0608 | 0.5992 | 0.5 |
Entamoeba histolytica | protein kinase 2, putative | 0.0608 | 0.5992 | 0.4615 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0645 | 0.6423 | 0.5194 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0314 | 0.2557 | 0.2557 |
Brugia malayi | protein kinase C II. | 0.0314 | 0.2557 | 0.2557 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0314 | 0.2557 | 0.2557 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0608 | 0.5992 | 0.8885 |
Toxoplasma gondii | AGC kinase | 0.0915 | 0.9569 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0314 | 0.2557 | 0.0105 |
Entamoeba histolytica | protein kinase, putative | 0.0915 | 0.9569 | 0.9421 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.