TDR Targets

Basic information

Technical information

TDR Targets ID: 1435077
Name: 2-(2,4-dichlorophenyl)-N-(2-methyl-2-morpholi n-4-ylpropyl)acetamide
MW: 345.264 | Formula: C16H22Cl2N2O2
H donors: 1 H acceptors: 1 LogP: 2.67 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1ccc(cc1Cl)Cl)NCC(N1CCOCC1)(C)C
InChi: 1S/C16H22Cl2N2O2/c1-16(2,20-5-7-22-8-6-20)11-19-15(21)9-12-3-4-13(17)10-14(12)18/h3-4,10H,5-9,11H2,1-2H3,(H,19,21)
InChiKey: BROHCHAICGXAJZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2,4-dichlorophenyl)-N-(2-methyl-2-morpholino-propyl)acetamide
2-(2,4-dichlorophenyl)-N-(2-methyl-2-morpholinopropyl)acetamide
2-(2,4-dichlorophenyl)-N-(2-methyl-2-morpholin-4-yl-propyl)ethanamide
T5381102

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0004	0.0004
Echinococcus multilocularis	notch	0.0745	0.2057	0.2054
Brugia malayi	notch-like transmembrane receptor	0.0745	0.2057	0.2054
Brugia malayi	Delta serrate ligand family protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	animal heme peroxidase	0.3487	1	1
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Schistosoma mansoni	notch	0.0745	0.2057	0.2054
Brugia malayi	Animal haem peroxidase family protein	0.3487	1	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.3487	1	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0745	0.2057	0.2054
Echinococcus multilocularis	slit 2 protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0113	0.0228	0.0224
Schistosoma mansoni	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	animal heme peroxidase	0.3487	1	1
Echinococcus granulosus	notch	0.0745	0.2057	0.2057
Schistosoma mansoni	septate junction protein	0.0745	0.2057	0.2054
Schistosoma mansoni	hypothetical protein	0.0745	0.2057	0.2054
Echinococcus granulosus	fibropellin Ia	0.0745	0.2057	0.2057
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.0728	0.5
Echinococcus granulosus	slit 2 protein	0.0745	0.2057	0.2057
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0077	0.0124	0.0121
Brugia malayi	EGF-like domain containing protein	0.0745	0.2057	0.2054
Schistosoma mansoni	peroxidasin	0.3487	1	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0745	0.2057	0.2054
Schistosoma mansoni	hypothetical protein	0.0745	0.2057	0.2054
Schistosoma mansoni	laminin gamma-3 chain	0.0745	0.2057	0.2054
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0004	0.0001
Brugia malayi	Cadherin domain containing protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0228	0.0224
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0745	0.2057	0.2054
Echinococcus granulosus	neurogenic locus notch protein 4	0.0745	0.2057	0.2057
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Onchocerca volvulus		0.0745	0.2057	0.2053
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0059	0.0056
Brugia malayi	Animal haem peroxidase family protein	0.3487	1	1
Brugia malayi	Animal haem peroxidase family protein	0.3487	1	1
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Brugia malayi	EGF-like domain containing protein	0.0745	0.2057	0.2054
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Echinococcus multilocularis	neurogenic locus protein delta	0.0745	0.2057	0.2054
Echinococcus multilocularis	neurogenic locus notch protein	0.0745	0.2057	0.2054
Schistosoma mansoni	hypothetical protein	0.0745	0.2057	0.2054
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0036	0.0003	0.0003
Brugia malayi	Blistered cuticle protein 3	0.3487	1	1
Schistosoma mansoni	notch	0.0745	0.2057	0.2054
Schistosoma mansoni	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Echinococcus multilocularis	protein jagged 1	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Plasmodium vivax	SET domain protein, putative	0.0036	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0059	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Echinococcus granulosus	protein jagged 2	0.0745	0.2057	0.2057
Onchocerca volvulus		0.0745	0.2057	0.2053
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Schistosoma mansoni	notch	0.0745	0.2057	0.2054
Onchocerca volvulus	Dual oxidase homolog	0.3487	1	1
Echinococcus multilocularis	protein jagged 2	0.0745	0.2057	0.2054
Onchocerca volvulus		0.0286	0.0728	0.0724
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0004	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0059	0.0056
Brugia malayi	EGF-like domain containing protein	0.0745	0.2057	0.2054
Brugia malayi	Pre-SET motif family protein	0.0036	0.0004	0.0001
Onchocerca volvulus	Peroxidasin homolog	0.3487	1	1
Echinococcus granulosus	neural cadherin	0.0745	0.2057	0.2057
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Echinococcus granulosus	neurogenic locus notch protein	0.0745	0.2057	0.2057
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Echinococcus granulosus	neurogenic locus notch protein	0.0745	0.2057	0.2057
Loa Loa (eye worm)	animal heme peroxidase	0.3487	1	1
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Onchocerca volvulus	Putative cubilin	0.0745	0.2057	0.2053
Brugia malayi	Calcium binding EGF domain containing protein	0.0745	0.2057	0.2054
Schistosoma mansoni	notch	0.0745	0.2057	0.2054
Schistosoma mansoni	notch	0.0745	0.2057	0.2054
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.0627	0.0624
Schistosoma mansoni	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	Notch2	0.0745	0.2057	0.2054
Schistosoma mansoni	slit	0.0745	0.2057	0.2054
Echinococcus granulosus	delta-like protein 1	0.0745	0.2057	0.2057
Onchocerca volvulus	Peroxidasin homolog	0.3487	1	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0004	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0113	0.0228	0.0224
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Echinococcus granulosus	GPCR family 2	0.0036	0.0003	0.0003
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Schistosoma mansoni	hypothetical protein	0.0745	0.2057	0.2054
Echinococcus granulosus	protein jagged 2	0.0745	0.2057	0.2057
Onchocerca volvulus	Chorion peroxidase homolog	0.3487	1	1
Echinococcus granulosus	neurogenic locus protein delta	0.0745	0.2057	0.2057
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0004	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Onchocerca volvulus		0.3487	1	1
Echinococcus multilocularis	fibropellin Ia	0.0745	0.2057	0.2054
Brugia malayi	EGF-like domain containing protein	0.0745	0.2057	0.2054
Brugia malayi	Animal haem peroxidase family protein	0.3487	1	1
Brugia malayi	Pre-SET motif family protein	0.0251	0.0627	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Brugia malayi	Calcium binding EGF domain containing protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Brugia malayi	Muscle positioning protein 4	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0004	0.0001
Onchocerca volvulus	Peroxidase homolog	0.3487	1	1
Schistosoma mansoni	hypothetical protein	0.0077	0.0124	0.0121
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0059	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0745	0.2057	0.2054
Brugia malayi	EGF-like domain containing protein	0.0745	0.2057	0.2054
Giardia lamblia	High cysteine protein	0.0745	0.2057	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0004	0.0001
Brugia malayi	Peroxidasin	0.3487	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.3487	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0059	0.0059
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0004	0.0001
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Onchocerca volvulus		0.0745	0.2057	0.2053
Schistosoma mansoni	peroxidasin	0.3487	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0059	0.0056
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0059	0.0056
Loa Loa (eye worm)	hypothetical protein	0.3487	1	1
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0036	0.0003	0.0003
Echinococcus multilocularis	neural cadherin	0.0745	0.2057	0.2054
Onchocerca volvulus	Peroxidase homolog	0.3487	1	1
Echinococcus multilocularis	peroxidasin	0.3487	1	1
Brugia malayi	GCC2 and GCC3 family protein	0.0745	0.2057	0.2054
Onchocerca volvulus		0.3487	1	1
Loa Loa (eye worm)	notch protein	0.0745	0.2057	0.2054
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0113	0.0228	0.0224
Brugia malayi	EGF-like domain containing protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0745	0.2057	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0124	0.0121
Echinococcus granulosus	peroxidasin	0.3487	1	1
Schistosoma mansoni	cell polarity protein	0.0745	0.2057	0.2054
Onchocerca volvulus		0.3487	1	1
Toxoplasma gondii	EGF family domain-containing protein	0.0745	0.2057	1
Schistosoma mansoni	notch	0.0745	0.2057	0.2054
Echinococcus multilocularis	neurogenic locus notch protein	0.0745	0.2057	0.2054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0059	0.0056
Onchocerca volvulus	Neurogenic locus notch homolog	0.0745	0.2057	0.2053
Onchocerca volvulus		0.0745	0.2057	0.2053
Onchocerca volvulus		0.0745	0.2057	0.2053
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0745	0.2057	0.2053
Echinococcus granulosus	protein jagged 1	0.0745	0.2057	0.2057
Echinococcus granulosus	protein jagged 1	0.0745	0.2057	0.2057
Onchocerca volvulus	Slit protein homolog	0.0745	0.2057	0.2053
Brugia malayi	EGF-like domain containing protein	0.0745	0.2057	0.2054
Echinococcus multilocularis	protein jagged 1	0.0745	0.2057	0.2054
Brugia malayi	Cadherin domain containing protein	0.0745	0.2057	0.2054
Brugia malayi	Animal haem peroxidase family protein	0.3487	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.2818 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1579144

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1435077