Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0730198 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0730198 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0730198 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0730198 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0730198 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0730198 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0730198 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0730198 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00883118 | 0.111699 | 0.110137 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0730198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245986 | 0.329903 | 0.328725 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0730198 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0730198 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0730198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246978 | 0.331275 | 0.330099 |
Brugia malayi | MAP kinase sur-1 | 0.0730198 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.00893036 | 0.113071 | 0.113071 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0730198 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0246978 | 0.331275 | 0.330099 |
Plasmodium falciparum | protein kinase, putative | 0.000759843 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0730198 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0730198 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0730198 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0730198 | 1 | 1 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0246978 | 0.331275 | 0.331275 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0730198 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.000759843 | 0 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0730198 | 1 | 1 |
Echinococcus multilocularis | transfer RNA-Thr | 0.0246978 | 0.331275 | 0.331275 |
Echinococcus multilocularis | protein KINase family member (kin 25) | 0.00893036 | 0.113071 | 0.113071 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.0246978 | 0.331275 | 0.331275 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0730198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00883118 | 0.111699 | 0.110137 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.0246978 | 0.331275 | 0.331275 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.00893036 | 0.113071 | 0.113071 |
Loa Loa (eye worm) | hypothetical protein | 0.00893036 | 0.113071 | 0.111512 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.21 uM | In vitro antimalarial activity against Plasmodium falciparum using a chloroquine sensitive FCR-3 strain | ChEMBL. | 10411480 |
EC50 (functional) | = 0.21 uM | In vitro antimalarial activity against Plasmodium falciparum using a chloroquine sensitive FCR-3 strain | ChEMBL. | 10411480 |
EC50 (functional) | = 10 uM | In vitro cytotoxicity in mouse mammary tumor FM3A cells | ChEMBL. | 10411480 |
EC50 (functional) | = 10 uM | In vitro cytotoxicity in mouse mammary tumor FM3A cells | ChEMBL. | 10411480 |
Growth inhibition (functional) | = 0 % | In vivo antimalarial activity of the compound against Plasmodium berghei ( NK 65 strain ) in mice at 20 mg/kg/day | ChEMBL. | 10411480 |
Growth inhibition (functional) | = 0 % | In vivo antimalarial activity of the compound against Plasmodium berghei ( NK 65 strain ) in mice at 20 mg/kg/day | ChEMBL. | 10411480 |
Growth inhibition (functional) | = 15 % | In vivo antimalarial activity of the compound against Plasmodium berghei ( NK 65 strain ) in mice at 50 mg/kg/day | ChEMBL. | 10411480 |
Growth inhibition (functional) | = 15 % | In vivo antimalarial activity of the compound against Plasmodium berghei ( NK 65 strain ) in mice at 50 mg/kg/day | ChEMBL. | 10411480 |
Selectivity (functional) | = 48 | Selectivity of the compound tested against EC50 value of FM3A /EC50 value of P. falciparum | ChEMBL. | 10411480 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 10411480 | |
Mus musculus | ChEMBL23 | 10411480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.