Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 25B | Starlite/ChEMBL | References |
Homo sapiens | cell division cycle 25C | Starlite/ChEMBL | References |
Homo sapiens | cell division cycle 25A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0451 | 0.0554 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0205 | 0.0611 | 0.0611 |
Trichomonas vaginalis | cdc25c, putative | 0.0205 | 0.0611 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0205 | 0.0611 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0154 | 0.0098 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0098 | 0.012 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0962 | 0.8142 | 1 |
Onchocerca volvulus | 0.0205 | 0.0611 | 0.059 | |
Brugia malayi | Kringle domain containing protein | 0.0154 | 0.0098 | 0.012 |
Trichomonas vaginalis | cdc25b, putative | 0.0205 | 0.0611 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0154 | 0.0098 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0154 | 0.0098 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0205 | 0.0611 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1026 | 0.8783 | 1 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0205 | 0.0611 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0154 | 0.0098 | 0.012 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1148 | 1 | 1 |
Onchocerca volvulus | 0.0205 | 0.0611 | 0.059 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0154 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0611 | 0.075 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0154 | 0.0098 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0154 | 0.0098 | 0.0098 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0205 | 0.0611 | 0.0611 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0154 | 0.0098 | 0.0104 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0205 | 0.0611 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0904 | 0.7569 | 0.9297 |
Brugia malayi | nuclear hormone receptor | 0.0962 | 0.8142 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0611 | 0.075 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1084 | 0.9359 | 1 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0205 | 0.0611 | 0.075 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0205 | 0.0611 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0205 | 0.0611 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0205 | 0.0611 | 0.5 |
Onchocerca volvulus | 0.0205 | 0.0611 | 0.059 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0205 | 0.0611 | 0.5 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0205 | 0.0611 | 0.075 |
Toxoplasma gondii | kringle domain-containing protein | 0.0154 | 0.0098 | 0.5 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0205 | 0.0611 | 0.0652 |
Onchocerca volvulus | 0.0205 | 0.0611 | 0.059 | |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0451 | 0.0554 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0205 | 0.0611 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.2 uM | Eight point inhibitory concentration against Cell division cycle 25A was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 4.2 uM | Eight point inhibitory concentration against Cell division cycle 25B was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 4.2 uM | Eight point inhibitory concentration against Cell division cycle 25A was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 4.2 uM | Eight point inhibitory concentration against Cell division cycle 25B was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 6.9 uM | Eight point inhibitory concentration against Cell division cycle 25 degree C was determined | ChEMBL. | 12801222 |
IC50 (binding) | = 6.9 uM | Eight point inhibitory concentration against Cell division cycle 25 degree C was determined | ChEMBL. | 12801222 |
Inhibition (binding) | = 85 % | Percent inhibition of cell division cycle 25 degree C at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 85 % | Percent inhibition of cell division cycle 25 degree C at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 97 % | Percent inhibition of cell division cycle 25B at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 97 % | Percent inhibition of cell division cycle 25B at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 98 % | Percent inhibition of cell division cycle 25A at 50 microM. | ChEMBL. | 12801222 |
Inhibition (binding) | = 98 % | Percent inhibition of cell division cycle 25A at 50 microM. | ChEMBL. | 12801222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.