Detailed information for compound 1435604

Basic information

Technical information
  • TDR Targets ID: 1435604
  • Name: [4-(phenylmethyl)piperazin-1-yl]-(4,5,6,7-tet rahydro-1,2-benzoxazol-3-yl)methanone
  • MW: 325.405 | Formula: C19H23N3O2
  • H donors: 0 H acceptors: 2 LogP: 2.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1noc2c1CCCC2)N1CCN(CC1)Cc1ccccc1
  • InChi: 1S/C19H23N3O2/c23-19(18-16-8-4-5-9-17(16)24-20-18)22-12-10-21(11-13-22)14-15-6-2-1-3-7-15/h1-3,6-7H,4-5,8-14H2
  • InChiKey: WVNLXKSZLUBBTL-UHFFFAOYSA-N  

Network

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Synonyms

  • [4-(phenylmethyl)-1-piperazinyl]-(4,5,6,7-tetrahydro-1,2-benzoxazol-3-yl)methanone
  • [4-(benzyl)piperazin-1-yl]-(4,5,6,7-tetrahydroindoxazen-3-yl)methanone
  • 3-[(4-benzylpiperazin-1-yl)carbonyl]-4,5,6,7-tetrahydro-1,2-benzisoxazole
  • MLS000087358
  • SMR000023581
  • EU-0057205

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0305 0.4366 0.3546
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0419 0.0169
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.01 0.127 0.127
Echinococcus granulosus proteasome subunit alpha type 6 0.01 0.127 0.127
Echinococcus multilocularis lamin dm0 0.0033 0.0254 0.0254
Plasmodium vivax proteasome subunit beta type-1, putative 0.0149 0.2018 0.1669
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.01 0.127 0.0889
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.01 0.127 0.0889
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.01 0.127 0.1043
Plasmodium vivax proteasome subunit alpha type-1, putative 0.01 0.127 0.0889
Toxoplasma gondii proteasome beta subunit 0.01 0.127 0.0889
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.01 0.127 0.1043
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.01 0.127 0.0889
Loa Loa (eye worm) proteasome subunit alpha type 3 0.01 0.127 0.127
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.01 0.127 0.0889
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.01 0.127 0.1043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.0419
Echinococcus granulosus Proteasome subunit alpha beta 0.01 0.127 0.127
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.01 0.127 0.0889
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.01 0.127 0.0889
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0596 0.0351
Echinococcus multilocularis proteasome subunit alpha type 2 0.01 0.127 0.127
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.01 0.127 0.0889
Plasmodium vivax proteasome subunit alpha type-4, putative 0.01 0.127 0.0889
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.01 0.127 0.127
Brugia malayi proteasome subunit alpha type 2 0.01 0.127 0.1248
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.01 0.127 0.1043
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0026 0.0026
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.01 0.127 0.0889
Leishmania major proteasome alpha 2 subunit, putative 0.01 0.127 0.0889
Trypanosoma brucei proteasome beta 6 subunit 0.0149 0.2018 0.1669
Plasmodium vivax proteasome subunit alpha type-6, putative 0.01 0.127 0.0889
Trypanosoma brucei proteasome beta 3 subunit, putative 0.01 0.127 0.0889
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.01 0.127 0.0889
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.01 0.127 0.0889
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0305 0.4366 0.4219
Loa Loa (eye worm) proteasome subunit alpha type 1 0.01 0.127 0.127
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0679 1 1
Leishmania major proteasome alpha 3 subunit, putative 0.01 0.127 0.0889
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.01 0.127 0.0889
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.01 0.127 0.0889
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.0419
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0149 0.2018 0.1669
Echinococcus granulosus Proteasome subunit alpha type 7 0.01 0.127 0.127
Echinococcus multilocularis subfamily T1A non peptidase ue 0.01 0.127 0.127
Echinococcus multilocularis lamin 0.0033 0.0254 0.0254
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0149 0.2018 0.1669
Onchocerca volvulus 0.0043 0.0419 0.162
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.01 0.127 0.1043
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.01 0.127 0.0889
Echinococcus multilocularis Proteasome subunit alpha type 7 0.01 0.127 0.127
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.01 0.127 0.1043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.0419
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.01 0.127 0.127
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0679 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0596 0.0572
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0679 1 1
Giardia lamblia Proteasome subunit beta type 1 0.0149 0.2018 0.0856
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.01 0.127 0.0889
Plasmodium vivax proteasome subunit beta type-5, putative 0.0679 1 1
Plasmodium vivax proteasome subunit alpha type-2, putative 0.01 0.127 0.0889
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.01 0.127 0.0889
Echinococcus multilocularis Proteasome subunit alpha type 7 0.01 0.127 0.127
Echinococcus multilocularis musashi 0.0033 0.0254 0.0254
Giardia lamblia Proteasome subunit beta type 2 0.0305 0.4366 0.3546
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.01 0.127 0.0889
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.01 0.127 0.0889
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.01 0.127 0.1043
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0679 1 1
Toxoplasma gondii proteasome subunit 0.01 0.127 0.0889
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.01 0.127 0.1043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0596 0.0596
Loa Loa (eye worm) proteasome subunit beta type 1 0.0149 0.2018 0.2018
Echinococcus granulosus proteasome subunit beta type 6 0.01 0.127 0.127
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0305 0.4366 0.4119
Plasmodium vivax proteasome subunit beta type-2, putative 0.0305 0.4366 0.4119
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0419 0.0419
Leishmania major proteasome alpha 1 subunit, putative 0.01 0.127 0.0889
Onchocerca volvulus 0.006 0.0664 0.4031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0596 0.0351
Mycobacterium ulcerans proteasome PrcA 0.01 0.127 0.0889
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0149 0.2018 0.0856
Trypanosoma brucei proteasome alpha 7 subunit 0.01 0.127 0.0889
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0596 0.0351
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0149 0.2018 0.1669
Onchocerca volvulus 0.0043 0.0419 0.162
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.01 0.127 0.0889
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0679 1 1
Toxoplasma gondii peptidase, T1 family protein 0.01 0.127 0.0889
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.01 0.127 0.0889
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.01 0.127 0.0889
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.01 0.127 0.0889
Echinococcus granulosus intermediate filament protein 0.0033 0.0254 0.0254
Brugia malayi Proteasome subunit alpha type 1 0.01 0.127 0.1248
Brugia malayi proteasome subunit beta type 1 0.0149 0.2018 0.1997
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.01 0.127 0.1043
Trypanosoma brucei proteasome beta-1 subunit, putative 0.01 0.127 0.0889
Echinococcus granulosus subfamily T1A non peptidase ue 0.01 0.127 0.127
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.01 0.127 0.127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0596 0.0596
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.01 0.127 0.0889
Toxoplasma gondii proteasome subunit beta type, putative 0.0679 1 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0254 0.0254
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0305 0.4366 0.4219
Leishmania major proteasome beta 5 subunit, putative 0.0679 1 1
Echinococcus multilocularis proteasome subunit beta type 7 0.01 0.127 0.127
Leishmania major proteasome beta 7 subunit, putative 0.01 0.127 0.0889
Plasmodium vivax proteasome subunit beta type-3, putative 0.01 0.127 0.0889
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.01 0.127 0.127
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0149 0.2018 0.0856
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.01 0.127 0.0889
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0664 0.042
Echinococcus granulosus proteasome prosome macropain 0.0679 1 1
Echinococcus granulosus proteasome subunit beta type 7 0.01 0.127 0.127
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0419 0.0394
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.01 0.127 0.0889
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0254 0.0229
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.01 0.127 0.0889
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.01 0.127 0.5
Brugia malayi Proteasome subunit alpha type 7-1 0.01 0.127 0.1248
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.01 0.127 0.0889
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0149 0.2018 0.1669
Brugia malayi beta-lactamase family protein 0.0043 0.0419 0.0394
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.01 0.127 0.0889
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3953 0.3688
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.0419
Echinococcus granulosus tumor protein p63 0.0408 0.5917 0.5917
Echinococcus granulosus lamin dm0 0.0033 0.0254 0.0254
Brugia malayi Proteasome A-type and B-type family protein 0.01 0.127 0.1248
Echinococcus multilocularis Proteasome, subunit alpha beta 0.01 0.127 0.127
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.01 0.127 0.0889
Plasmodium falciparum proteasome subunit beta type-5 0.0679 1 1
Brugia malayi proteasome subunit alpha type 3 0.01 0.127 0.1248
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0305 0.4366 0.4119
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0305 0.4366 0.3546
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.01 0.127 0.0889
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.01 0.127 0.0889
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0149 0.2018 0.2018
Toxoplasma gondii heat shock protein hslv, putative 0.01 0.127 0.0889
Onchocerca volvulus 0.0043 0.0419 0.162
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.01 0.127 0.0889
Echinococcus multilocularis proteasome subunit alpha type 6 0.01 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.0033 0.0254 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0596 0.0596
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.01 0.127 0.0889
Trypanosoma brucei proteasome beta 2 subunit, putative 0.01 0.127 0.0889
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.01 0.127 0.0889
Brugia malayi proteasome subunit beta type 3 0.01 0.127 0.1248
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.0419
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.01 0.127 0.0889
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.01 0.127 0.1043
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.01 0.127 0.1043
Loa Loa (eye worm) hypothetical protein 0.006 0.0664 0.0664
Onchocerca volvulus Notchless protein homolog 0.01 0.127 1
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.01 0.127 0.0889
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.01 0.127 0.0889
Brugia malayi intermediate filament protein 0.0033 0.0254 0.0229
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.01 0.127 0.0889
Brugia malayi proteasome subunit beta type 2 0.0305 0.4366 0.4351
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.01 0.127 0.0889
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.01 0.127 0.0889
Loa Loa (eye worm) hypothetical protein 0.0043 0.0419 0.0419
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.01 0.127 0.0889
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0419 0.0419
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.01 0.127 0.0889
Loa Loa (eye worm) proteasome subunit alpha type 6 0.01 0.127 0.127
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0305 0.4366 0.4366
Plasmodium vivax proteasome subunit beta type-4, putative 0.01 0.127 0.0889
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.01 0.127 0.127
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0679 1 1
Leishmania major proteasome beta-1 subunit, putative 0.01 0.127 0.0889
Toxoplasma gondii proteasome subunit alpha type, putative 0.01 0.127 0.0889
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.01 0.127 0.0889
Leishmania major proteasome beta 3 subunit, putative 0.01 0.127 0.0889
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0149 0.2018 0.2018
Toxoplasma gondii proteasome subunit alpha1, putative 0.01 0.127 0.0889
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.01 0.127 0.1043
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0679 1 1
Brugia malayi proteasome subunit alpha type 6 0.01 0.127 0.1248
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.01 0.127 0.0889
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.01 0.127 0.1043
Plasmodium vivax proteasome subunit alpha type-5, putative 0.01 0.127 0.0889
Trypanosoma brucei proteasome beta 7 subunit 0.01 0.127 0.0889
Leishmania major proteasome beta 2 subunit, putative 0.01 0.127 0.0889
Echinococcus granulosus lamin 0.0033 0.0254 0.0254
Loa Loa (eye worm) proteasome subunit beta type 3 0.01 0.127 0.127
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.01 0.127 0.0889
Echinococcus granulosus proteasome subunit beta t family 0.01 0.127 0.127
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0596 0.0596
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.01 0.127 0.127
Loa Loa (eye worm) beta-lactamase 0.0043 0.0419 0.0419
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.01 0.127 0.0889
Brugia malayi 20S proteasome alpha5 subunit 0.01 0.127 0.1248
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0419 0.0419
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0305 0.4366 0.4119
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0679 1 1
Echinococcus multilocularis tumor protein p63 0.0408 0.5917 0.5917
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0149 0.2018 0.1669
Leishmania major proteasome beta 2 subunit, putative 0.0305 0.4366 0.4119
Mycobacterium ulcerans proteasome PrcB 0.0679 1 1
Leishmania major proteasome alpha 1 subunit, putative 0.01 0.127 0.0889
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.01 0.127 0.0889
Plasmodium vivax proteasome subunit beta type-7, putative 0.01 0.127 0.0889
Leishmania major proteasome alpha 7 subunit, putative 0.01 0.127 0.0889
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.01 0.127 0.0889
Leishmania major proteasome alpha 7 subunit, putative 0.01 0.127 0.0889
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.01 0.127 0.0889
Trypanosoma cruzi 20S proteasome subunit 0.0305 0.4366 0.4119
Echinococcus granulosus 20S proteasome subunit alpha 6 0.01 0.127 0.127
Echinococcus multilocularis Proteasome subunit alpha type 7 0.01 0.127 0.127
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.01 0.127 0.127
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.01 0.127 0.127
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.01 0.127 0.0889
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.01 0.127 0.0889
Loa Loa (eye worm) proteasome subunit alpha type 2 0.01 0.127 0.127
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.01 0.127 0.127
Loa Loa (eye worm) PAS-3 protein 0.01 0.127 0.127
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0305 0.4366 0.4366
Brugia malayi proteasome subunit alpha type 4 0.01 0.127 0.1248
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.01 0.127 0.0889
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.01 0.127 0.0889
Brugia malayi Proteasome A-type and B-type family protein 0.01 0.127 0.1248
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0305 0.4366 0.4119
Echinococcus multilocularis proteasome (prosome, macropain) 0.0679 1 1
Echinococcus multilocularis proteasome subunit beta type 6 0.01 0.127 0.127
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.01 0.127 0.0889
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0419 0.0169
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.01 0.127 0.1043
Plasmodium vivax proteasome subunit alpha type-3, putative 0.01 0.127 0.0889
Brugia malayi Proteasome A-type and B-type family protein 0.01 0.127 0.1248
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0305 0.4366 0.4119
Loa Loa (eye worm) proteasome subunit beta type 2 0.0305 0.4366 0.4366
Brugia malayi beta-lactamase family protein 0.0043 0.0419 0.0394
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.01 0.127 0.0889
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0149 0.2018 0.1809
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0596 0.0596
Echinococcus granulosus proteasome subunit alpha type 2 0.01 0.127 0.127
Plasmodium vivax proteasome subunit alpha type-7, putative 0.01 0.127 0.0889
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.01 0.127 0.127
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.01 0.127 0.1043
Brugia malayi beta-lactamase 0.0043 0.0419 0.0394
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0679 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0245 0.0245
Brugia malayi proteasome subunit alpha type 1 0.01 0.127 0.1248
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.01 0.127 0.0889
Plasmodium vivax proteasome subunit beta type-6, putative 0.01 0.127 0.0889
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0679 1 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.01 0.127 0.0889

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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