Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0346 | 0.0346 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0346 | 0.0346 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0346 | 0.0346 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.4956 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0346 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0346 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0346 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.4956 | 0.4956 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0346 | 1 |
Mycobacterium leprae | PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0346 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0346 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.0346 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Mycobacterium leprae | Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0346 | 0.0346 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.4956 | 0.4956 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0346 | 0.0346 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0346 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.