Detailed information for compound 1435744

Basic information

Technical information
  • TDR Targets ID: 1435744
  • Name: N-(4-hydroxyphenyl)cyclohex-3-ene-1-carboxami de
  • MW: 217.264 | Formula: C13H15NO2
  • H donors: 2 H acceptors: 2 LogP: 2.22 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCC=CC1)Nc1ccc(cc1)O
  • InChi: 1S/C13H15NO2/c15-12-8-6-11(7-9-12)14-13(16)10-4-2-1-3-5-10/h1-2,6-10,15H,3-5H2,(H,14,16)
  • InChiKey: CYGUEFBLPFEAOS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-hydroxyphenyl)-1-cyclohex-3-enecarboxamide
  • BAS 01819225
  • Cyclohex-3-enecarboxylic acid (4-hydroxy-phenyl)-amide
  • MLS000111651
  • Oprea1_054212
  • SMR000107573
  • Oprea1_641689

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Simian virus 40 Large T antigen Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens SUMO/sentrin specific peptidase family member 8 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens estrogen receptor 2 (ER beta) Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi DnaJ domain containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132364 All targets in OG5_132364
Echinococcus granulosus sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_132364 All targets in OG5_132364
Trichomonas vaginalis Sentrin-specific protease, putative Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) DnaJ domain-containing protein Get druggable targets OG5_132364 All targets in OG5_132364
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis dnaJ subfamily C 6 Get druggable targets OG5_132364 All targets in OG5_132364
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K09536 DnaJ homolog, subfamily C, member 16, putative Get druggable targets OG5_132364 All targets in OG5_132364
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) Ulp1 protease Get druggable targets OG5_129942 All targets in OG5_129942
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis protein kinase inhibitor, putative Get druggable targets OG5_132364 All targets in OG5_132364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_129942 All targets in OG5_129942
Neospora caninum hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma japonicum ko:K08597 sentrin-specific protease 8, putative Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Plasmodium falciparum sentrin-specific protease 1 SUMO/sentrin specific peptidase family member 8 212 aa 197 aa 23.4 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.008 0.157 0.1566
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0011 0.007 0.1056
Loa Loa (eye worm) hypothetical protein 0.0148 0.3046 0.3043
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0022 0.0018
Mycobacterium ulcerans beta-lactamase 0.0037 0.0633 0.0839
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.047 0.0466
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.059 0.931
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0162 0.0211
Loa Loa (eye worm) DnaJ domain-containing protein 0.0074 0.1434 0.1431
Brugia malayi PHD-finger family protein 0.0012 0.0073 0.0124
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0363 0.2384
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.033 0.7009 0.7008
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.007 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0066
Schistosoma mansoni coup transcription factor 0.0009 0.0022 0.0018
Echinococcus multilocularis lipoxygenase domain containing protein 0.0068 0.13 0.1297
Toxoplasma gondii aminopeptidase N protein 0.0025 0.0363 0.5714
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0363 0.2384
Brugia malayi jmjC domain containing protein 0.0115 0.2335 0.416
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0467 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0022 0.0033
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.0658 0.0654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0495 0.0491
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7512 1
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0994 0.099
Echinococcus granulosus sentrin specific protease 7 0.0016 0.0162 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0022 0.0033
Schistosoma mansoni biogenic amine (5HT) receptor 0.0254 0.5364 0.5362
Echinococcus granulosus Polycystic kidney disease protein 0.0068 0.13 0.1297
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0162 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0022 0.0033
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.0162 0.0158
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.3579 1
Schistosoma mansoni ets 0.0013 0.0099 0.0095
Loa Loa (eye worm) Ulp1 protease 0.008 0.157 0.1566
Echinococcus multilocularis aminopeptidase N 0.0025 0.0363 0.036
Schistosoma mansoni hypothetical protein 0.0012 0.0073 0.007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0254 0.5364 0.5362
Schistosoma mansoni jumonji domain containing protein 0.0011 0.007 0.0066
Schistosoma mansoni hypothetical protein 0.0013 0.0099 0.0095
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0363 0.0484
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0015 0.0159 0.0155
Brugia malayi TATA binding protein associated factor 0.0025 0.0363 0.0642
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0099 0.0095
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0363 0.036
Plasmodium falciparum sentrin-specific protease 1 0.0016 0.0162 0.0747
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0022 0.0018
Onchocerca volvulus 0.0037 0.0633 0.1189
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0022 0.0018
Onchocerca volvulus 0.0031 0.0495 0.092
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0018
Echinococcus multilocularis protein C ets 2 0.0013 0.0099 0.0095
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7512 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.0095
Echinococcus granulosus lipoxygenase domain containing protein 0.0068 0.13 0.1297
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0098 0.0094
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0633 0.063
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0633 0.063
Schistosoma mansoni hypothetical protein 0.0035 0.059 0.0586
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0016 0.0162 0.1632
Loa Loa (eye worm) hypothetical protein 0.0037 0.0633 0.063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0022 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0022 0.0018
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.059 0.0586
Brugia malayi protein kinase C II. 0.0015 0.0159 0.0276
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.0162 0.0158
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Schistosoma mansoni phd/f-box containing protein 0.0011 0.007 0.0066
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Echinococcus multilocularis sentrin specific protease 8 0.008 0.157 0.1566
Plasmodium falciparum LCCL domain-containing protein 0.0068 0.13 1
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.007 0.0066
Brugia malayi jmjC domain containing protein 0.0011 0.007 0.0119
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.008 0.157 0.209
Echinococcus multilocularis ankyrin repeat protein 0.0163 0.337 0.3367
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Onchocerca volvulus Huntingtin homolog 0.0148 0.3046 0.5885
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7512 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0162 0.0216
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0022 0.0018
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0162 0.0283
Brugia malayi Protein kinase c protein 2 0.0046 0.0817 0.1451
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0022 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0022 0.0018
Schistosoma mansoni hypothetical protein 0.0074 0.1434 0.1431
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0016 0.0162 0.0216
Echinococcus multilocularis muscleblind protein 1 0.0146 0.3013 0.301
Brugia malayi beta-lactamase 0.0037 0.0633 0.1123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0022 0.0018
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2335 0.2332
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.0658 0.0654
Loa Loa (eye worm) doublecortin family protein 0.0068 0.13 0.1297
Loa Loa (eye worm) hypothetical protein 0.0025 0.0363 0.036
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0099 0.0095
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.089 0.0887
Brugia malayi jmjC domain containing protein 0.0011 0.007 0.0119
Schistosoma mansoni rab6-interacting 0.0068 0.13 0.1297
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0363 0.0642
Echinococcus multilocularis sentrin specific protease 1 0.0016 0.0162 0.0158
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0018
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.007 0.0066
Echinococcus granulosus lipoxygenase domain containing protein 0.0068 0.13 0.1297
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1026 0.1023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0022 0.0033
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0633 0.3754
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0162 0.0283
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0099 0.0095
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0363 0.036
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.5 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0495 0.0491
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0073 0.0025
Plasmodium falciparum phd finger protein, putative 0.0035 0.059 0.4224
Echinococcus multilocularis ets variant gene 4 0.0013 0.0099 0.0095
Brugia malayi Doublecortin family protein 0.0068 0.13 0.2313
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0363 0.5208
Brugia malayi AF-10 protein 0.0012 0.0073 0.0124
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0254 0.5364 0.5362
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0495 0.0491
Schistosoma mansoni rab6-interacting 0.0068 0.13 0.1297
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0363 0.1955
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0073 0.1106
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0022 0.0018
Brugia malayi Muscleblind-like protein 0.0146 0.3013 0.537
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.0363 0.036
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0633 0.0843
Loa Loa (eye worm) hypothetical protein 0.0012 0.0073 0.007
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0162 0.0216
Loa Loa (eye worm) hypothetical protein 0.0016 0.0162 0.0158
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0162 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0633 0.3754
Echinococcus granulosus arachidonate 5 lipoxygenase 0.033 0.7009 0.7008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0022 0.0018
Echinococcus multilocularis transient receptor potential cation channel 0.0166 0.3447 0.3445
Onchocerca volvulus 0.0025 0.0363 0.0664
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0162 0.0211
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0633 0.0843
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.008 0.157 0.209
Brugia malayi steroid hormone receptor 0.0009 0.0022 0.0033
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0011 0.007 0.1056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2335 0.2332
Schistosoma mansoni hypothetical protein 0.0068 0.13 0.1297
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0012 0.0073 0.1106
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0162 0.0216
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0025 0.0363 0.036
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0022 0.0018
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.7512 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0495 0.0491
Echinococcus granulosus ankyrin repeat protein 0.0163 0.337 0.3367
Loa Loa (eye worm) hypothetical protein 0.0037 0.0633 0.063
Schistosoma mansoni lipoxygenase 0.033 0.7009 0.7008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7512 1
Brugia malayi hypothetical protein 0.0025 0.0363 0.0642
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0018
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0751 0.0748
Mycobacterium ulcerans hypothetical protein 0.0037 0.0633 0.0839
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1819 0.1815
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0495 0.7799
Loa Loa (eye worm) hypothetical protein 0.0037 0.0633 0.063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1026 0.1023
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0099 0.0095
Schistosoma mansoni protein phosphatase 2C 0.0011 0.007 0.0066
Onchocerca volvulus 0.0025 0.0363 0.0664
Brugia malayi jmjC domain containing protein 0.0011 0.007 0.0119
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.0363 0.5714
Brugia malayi Ets-domain containing protein 0.0087 0.1728 0.3077
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0751 0.0748
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0022 0.0018
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0363 0.5714
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.007 0.0066
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.0658 0.0654
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Echinococcus multilocularis RUN 0.0068 0.13 0.1297
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.0162 0.2516
Schistosoma mansoni ets-related 0.0013 0.0099 0.0095
Echinococcus multilocularis lipoxygenase domain containing protein 0.0068 0.13 0.1297
Echinococcus multilocularis protein kinase c iota type 0.0014 0.0132 0.0128
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.008 0.157 0.2086
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0016 0.0162 0.0158
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0073 0.1106
Schistosoma mansoni hypothetical protein 0.0013 0.0099 0.0095
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0099 0.0095
Brugia malayi nuclear receptor NHR-88 0.0009 0.0022 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0022 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1026 0.1023
Onchocerca volvulus 0.0025 0.0363 0.0664
Loa Loa (eye worm) hypothetical protein 0.0148 0.3046 0.3043
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.0994 0.099
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0073 0.1106
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0011 0.007 0.1056
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0025 0.0363 0.036
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.3579 1
Echinococcus granulosus jumonji domain containing protein 0.0049 0.089 0.0887
Echinococcus multilocularis protein kinase c epsilon type 0.0015 0.0159 0.0155
Brugia malayi transcription factor E74 isoform 0.0013 0.0099 0.017
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0363 0.0642
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.3579 0.6745
Brugia malayi PHD-finger family protein 0.0035 0.059 0.1046
Trichomonas vaginalis esterase, putative 0.0037 0.0633 0.0843
Schistosoma mansoni elf1 0.0013 0.0099 0.0095
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0016 0.0162 0.5
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Brugia malayi Bromodomain containing protein 0.0035 0.059 0.1046
Loa Loa (eye worm) hypothetical protein 0.0068 0.13 0.1297
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7512 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0658 0.0654
Echinococcus granulosus phd:f box containing protein 0.0011 0.007 0.0066
Onchocerca volvulus 0.0037 0.0633 0.1189
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.007 0.0066
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0016 0.0162 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0022 0.0033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0022 0.0018
Plasmodium vivax multidomain scavenger receptor, putative 0.0068 0.13 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0633 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0025 0.0363 0.036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0022 0.0018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7512 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0022 0.0018
Schistosoma mansoni ets-related 0.0265 0.5607 0.5605
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0022 0.0018
Onchocerca volvulus 0.0016 0.0162 0.0272
Echinococcus granulosus muscleblind protein 0.0146 0.3013 0.301
Loa Loa (eye worm) hypothetical protein 0.0037 0.0633 0.063
Brugia malayi hypothetical protein 0.0148 0.3046 0.5429
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0162 0.0216
Loa Loa (eye worm) hypothetical protein 0.0037 0.0633 0.063
Brugia malayi Ets-domain containing protein 0.0013 0.0099 0.017
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.0363 0.5714
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0022 0.0033
Loa Loa (eye worm) beta-lactamase 0.0037 0.0633 0.063
Trichomonas vaginalis protein kinase inhibitor, putative 0.0074 0.1434 0.1909
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0363 0.5714
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0099 0.0095
Echinococcus granulosus peregrin 0.0035 0.059 0.0586
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7512 1
Trypanosoma cruzi hypothetical protein 0.008 0.157 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0022 0.0018
Brugia malayi Ets-domain containing protein 0.0087 0.1728 0.3077
Loa Loa (eye worm) aminopeptidase N 0.0025 0.0363 0.036
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0022 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0073 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0162 0.0158
Echinococcus multilocularis serotonin receptor 0.0254 0.5364 0.5362
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0099 0.0095
Brugia malayi beta-lactamase family protein 0.0037 0.0633 0.1123
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1026 0.1825
Onchocerca volvulus Huntingtin homolog 0.0148 0.3046 0.5885
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0099 0.0095
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0363 0.1955
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0363 0.0484
Loa Loa (eye worm) hypothetical protein 0.0025 0.0363 0.036
Loa Loa (eye worm) hypothetical protein 0.0146 0.3013 0.301
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.007 0.0066
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0022 0.0018
Echinococcus multilocularis sentrin specific protease 7 0.0016 0.0162 0.0158
Echinococcus multilocularis muscleblind protein 0.0146 0.3013 0.301
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0099 0.0095
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.007 0.0066
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0099 0.0095
Brugia malayi follicle stimulating hormone receptor 0.0244 0.5141 0.9169
Echinococcus granulosus protein kinase C gamma type 0.0048 0.0866 0.0862
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0022 0.0018
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0022 0.0033
Trypanosoma cruzi Aminopeptidase M1, putative 0.0025 0.0363 0.1955
Brugia malayi hypothetical protein 0.0068 0.13 0.2313
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.1728 0.1725
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.007 0.0066
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0163 0.337 0.3367
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1406 0.1403
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0363 0.1955
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7512 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0363 0.036
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.007 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0159 0.0155
Brugia malayi hypothetical protein 0.0068 0.13 0.2313
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0363 0.5208
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0018
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0022 0.0018
Plasmodium vivax sentrin-specific protease 1, putative 0.0016 0.0162 0.0747
Onchocerca volvulus 0.0068 0.13 0.2487
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0022 0.0033
Entamoeba histolytica aminopeptidase, putative 0.0025 0.0363 0.0479
Brugia malayi Pre-SET motif family protein 0.0215 0.4507 0.8037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0633 0.063
Echinococcus granulosus transient receptor potential cation channel 0.0166 0.3442 0.3439
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0025 0.0363 0.036
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.007 0.0066
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0022 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0495 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0022 0.0018
Mycobacterium ulcerans lipase LipD 0.0037 0.0633 0.0839
Loa Loa (eye worm) hypothetical protein 0.0068 0.13 0.1297
Echinococcus granulosus RUN 0.0068 0.13 0.1297
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0099 0.0095
Brugia malayi jmjC domain containing protein 0.0011 0.007 0.0119
Onchocerca volvulus 0.0037 0.0633 0.1189
Loa Loa (eye worm) hypothetical protein 0.0075 0.1452 0.1448
Plasmodium vivax hypothetical protein, conserved 0.0035 0.059 0.4224
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.1728 0.1725
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0099 0.0095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0633 0.1123
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.007 0.0066
Toxoplasma gondii ABC1 family protein 0.0037 0.0633 1
Trypanosoma brucei SUMO1/Ulp2, putative 0.0016 0.0162 0.2516
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0363 0.1955
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0022 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0022 0.0018
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0016 0.0162 0.0612
Echinococcus multilocularis Polycystic kidney disease protein 0.0068 0.13 0.1297
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1026 0.1023
Schistosoma mansoni loxhd1 0.0068 0.13 0.1297
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0098 0.0168
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0363 0.1955
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0633 0.0839
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0022 0.0033
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0633 0.0843
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0495 0.0491
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.008 0.157 0.2795
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0633 0.0843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7512 1
Brugia malayi ecdysteroid receptor 0.0009 0.0022 0.0033
Trichomonas vaginalis set domain proteins, putative 0.0245 0.5154 0.6862
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0022 0.0018
Echinococcus granulosus biogenic amine 5HT receptor 0.0254 0.5364 0.5362
Echinococcus granulosus aminopeptidase N 0.0025 0.0363 0.036
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0633 0.0843
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0495 0.0491
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0633 0.063
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.7512 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0363 0.0484
Echinococcus granulosus sentrin specific protease 8 0.008 0.157 0.1566
Brugia malayi Pre-SET motif family protein 0.0031 0.0495 0.0876
Loa Loa (eye worm) hypothetical protein 0.0146 0.3013 0.301
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.0095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7512 1
Schistosoma mansoni atypical protein kinase C 0.0014 0.0132 0.0128
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0022 0.0018
Onchocerca volvulus Alhambra homolog 0.0035 0.059 0.1105
Giardia lamblia PHD finger protein 15 0.0035 0.059 0.0582
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.0162 0.2516
Leishmania major hypothetical protein, conserved 0.0037 0.0633 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0022 0.0018
Echinococcus multilocularis peregrin 0.0035 0.059 0.0586
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.059 0.931
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0633 0.4577
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.007 0.0066
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.059 0.0586
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.008 0.157 0.209
Brugia malayi beta-lactamase family protein 0.0037 0.0633 0.1123
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0467 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0751 0.0748
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0099 0.0095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0022 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0022 0.0018
Schistosoma mansoni polycystin 1-related 0.0068 0.13 0.1297
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0099 0.0095
Brugia malayi DnaJ domain containing protein 0.0074 0.1434 0.2553
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0099 0.0095
Loa Loa (eye worm) hypothetical protein 0.0016 0.0162 0.0158
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.0866 0.0862
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.4507 0.4505
Schistosoma mansoni lipoxygenase 0.0208 0.435 0.4348
Brugia malayi nuclear hormone receptor 0.0009 0.0022 0.0033
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0363 0.5208
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0363 0.2384
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1026 0.1023
Onchocerca volvulus 0.0245 0.516 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0162 0.0211
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0099 0.017
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.0994 0.099
Brugia malayi jmjC domain containing protein 0.0043 0.0751 0.1334
Loa Loa (eye worm) hypothetical protein 0.0044 0.0786 0.0783
Plasmodium vivax sentrin-specific protease 2, putative 0.0016 0.0162 0.0747
Echinococcus granulosus dnaJ subfamily C 6 0.0074 0.1434 0.1431
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0016 0.0162 0.5
Schistosoma mansoni gabp alpha 0.0087 0.1728 0.1725
Echinococcus multilocularis dnaJ subfamily C 6 0.0074 0.1434 0.1431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0022 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0022 0.0033
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0162 0.0216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0633 0.063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1026 0.1023
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0363 0.1955
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0022 0.0018
Echinococcus multilocularis phd:f box containing protein 0.0011 0.007 0.0066
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.1728 0.1725
Echinococcus granulosus sentrin specific protease 1 0.0016 0.0162 0.0158
Trichomonas vaginalis Sentrin-specific protease, putative 0.008 0.157 0.209
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0022 0.0018
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0689 0.0685
Loa Loa (eye worm) hypothetical protein 0.0035 0.059 0.0586
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.059 0.0586
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.0363 0.2384
Echinococcus multilocularis serotonin receptor 0.0254 0.5364 0.5362
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0022 0.0033
Echinococcus granulosus protein kinase c epsilon type 0.0015 0.0159 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0162 0.0216
Brugia malayi hypothetical protein 0.0025 0.0363 0.0642
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0633 0.063
Brugia malayi hypothetical protein 0.0215 0.4502 0.8028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1026 0.1023
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0633 0.0839
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0022 0.0018
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0363 0.5714
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0016 0.0162 0.0216
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.059 0.0586
Onchocerca volvulus 0.0068 0.13 0.2487
Echinococcus granulosus protein kinase c iota type 0.0014 0.0132 0.0128
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0751 0.0748
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0016 0.0162 0.0211
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0004 0.0005
Brugia malayi Fli-1 protein 0.0265 0.5607 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0363 0.5208
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0099 0.0095
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0467 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1026 0.1023
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0363 0.1955
Plasmodium vivax SET domain protein, putative 0.0031 0.0495 0.3451
Echinococcus granulosus protein C ets 2 0.0013 0.0099 0.0095
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0363 0.036
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0066
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0016 0.0162 0.2516
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0022 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0022 0.0033
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0022 0.0018
Loa Loa (eye worm) fli-1 protein 0.0265 0.5607 0.5605
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0495 0.0491
Loa Loa (eye worm) hypothetical protein 0.006 0.1138 0.1134
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0994 0.099
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0018
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.5141 0.5139
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0751 0.0748
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0099 0.0095
Loa Loa (eye worm) Ulp1 protease 0.0016 0.0162 0.0158
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0363 0.0642
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0363 0.5714

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.12370029 um PUBCHEM_BIOASSAY: Estrogen Receptor-beta Coactivator Binding Inhibitors ELISA Secondary Assay. (Class of assay: confirmatory) [Related pubchem assays: 633 (Primary screen preceding this ELISA dose response confirmation assay.), 733 (Primary dose response assay preceding this ELISA dose response confirmation assay.)] ChEMBL. No reference
IC50 (binding) = 3.20005 um PUBCHEM_BIOASSAY: Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 633 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
IC50 (functional) 16.39 uM PUBCHEM_BIOASSAY: Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1909, AID2102, AID2501, AID2615, AID2775, AID449729, AID485276, AID485288] ChEMBL. No reference
IC50 (functional) 19.1 uM PubChem BioAssay. Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 25.1 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using Nedd8 Protein Substrate. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 40.74 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0562 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction: HTRF assay against cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 12.5594 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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