Detailed information for compound 1436456

Basic information

Technical information
  • TDR Targets ID: 1436456
  • Name: 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1- yl]-2-(4-ethylphenoxy)ethanone
  • MW: 382.453 | Formula: C22H26N2O4
  • H donors: 0 H acceptors: 1 LogP: 3.34 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)OCC(=O)N1CCN(CC1)Cc1ccc2c(c1)OCO2
  • InChi: 1S/C22H26N2O4/c1-2-17-3-6-19(7-4-17)26-15-22(25)24-11-9-23(10-12-24)14-18-5-8-20-21(13-18)28-16-27-20/h3-8,13H,2,9-12,14-16H2,1H3
  • InChiKey: QDZGZVHOJNCGAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-ethylphenoxy)ethanone
  • BAS 10195869
  • MLS000718663
  • SMR000290931
  • 1-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-2-(4-ethyl-phenoxy)-ethanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.007 0.0081
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0012
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0107 0.1219 0.1367
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0009 0.0046 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.007 0.0081
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0046 0.0054
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0107 0.1219 0.141
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0107 0.1219 0.1367
Brugia malayi proteasome subunit alpha type 4 0.0107 0.1219 0.1414
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0107 0.1219 0.1367
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.007 0.0066
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.1147 0.133
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.007 0.0545
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5834 0.5833
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0107 0.1219 0.1216
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.045 0.0521
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0327 0.3845 0.4434
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.007 0.0081
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0699 0.0696
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0327 0.3845 0.4434
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0009 0.0046 0.005
Echinococcus granulosus proteasome subunit beta t family 0.0107 0.1219 0.141
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0107 0.1219 0.141
Loa Loa (eye worm) hypothetical protein 0.0009 0.0046 0.0054
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Loa Loa (eye worm) proteasome subunit beta type 3 0.0107 0.1219 0.1414
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0045 0.0048
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0012
Toxoplasma gondii exonuclease III APE 0.0042 0.045 0.047
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0107 0.1219 0.1367
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0047 0.0051
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0728 0.8624 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0107 0.1219 0.1367
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0045 0.0042
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0107 0.1219 0.1367
Echinococcus multilocularis neutral sphingomyelinase 0.0009 0.0046 0.0043
Loa Loa (eye worm) PAS-3 protein 0.0107 0.1219 0.1414
Echinococcus multilocularis smad 0.0008 0.0045 0.0042
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0107 0.1219 0.1414
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.045 0.048
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0107 0.1219 0.141
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0107 0.1219 0.1376
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0003 0.0004
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0107 0.1219 0.1367
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0728 0.8624 1
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0009 0.0046 0.0054
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0107 0.1219 0.1414
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0107 0.1219 0.1367
Brugia malayi steroid hormone receptor 0.0011 0.007 0.0081
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0107 0.1219 0.1367
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.007 0.0077
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0107 0.1219 0.1367
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0009 0.0046 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.007 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.007 0.0081
Leishmania major proteasome beta 2 subunit, putative 0.0107 0.1219 0.1367
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.045 0.047
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0107 0.1219 0.1367
Onchocerca volvulus 0.0009 0.0046 0.0353
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Plasmodium vivax proteasome subunit beta type-7, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0358 0.0415
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0012
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0107 0.1219 0.1414
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0107 0.1219 0.1367
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0107 0.1219 0.1376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.007 0.0081
Leishmania major proteasome alpha 2 subunit, putative 0.0107 0.1219 0.1367
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0107 0.1219 0.1216
Echinococcus granulosus SAM and MBT domain containing protein 0.0056 0.0607 0.07
Schistosoma mansoni hypothetical protein 0.0494 0.5834 0.6764
Echinococcus granulosus proteasome subunit beta type 6 0.0107 0.1219 0.141
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0228 0.2658 0.3079
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0047 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.007 0.0081
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0728 0.8624 1
Toxoplasma gondii peptidase, T1 family protein 0.0107 0.1219 0.1367
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.0607 0.0604
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0107 0.1219 0.1376
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0107 0.1219 0.141
Toxoplasma gondii proteasome subunit 0.0107 0.1219 0.1367
Leishmania major proteasome beta 5 subunit, putative 0.0728 0.8624 1
Brugia malayi Proteasome A-type and B-type family protein 0.0107 0.1219 0.1414
Loa Loa (eye worm) mbt repeat family protein 0.0056 0.0607 0.0704
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.007 0.0081
Brugia malayi proteasome subunit beta type 1 0.0157 0.1819 0.2109
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0003 0.0004
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0728 0.8624 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0107 0.1219 0.1367
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0107 0.1219 0.1367
Leishmania major proteasome beta 7 subunit, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1425 0.1652
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0327 0.3845 0.4428
Schistosoma mansoni smad 0.0008 0.0045 0.0048
Brugia malayi Proteasome A-type and B-type family protein 0.0107 0.1219 0.1414
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.007 0.0081
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0107 0.1219 0.1367
Echinococcus granulosus Proteasome subunit alpha beta 0.0107 0.1219 0.141
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.007 0.0077
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.007 0.0077
Leishmania major proteasome beta 3 subunit, putative 0.0107 0.1219 0.1367
Brugia malayi proteasome subunit alpha type 2 0.0107 0.1219 0.1414
Giardia lamblia 20S proteasome alpha subunit 2 0.0107 0.1219 0.1367
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0107 0.1219 0.1367
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0012
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0107 0.1219 0.1367
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0327 0.3845 0.4456
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0607 0.07
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0107 0.1219 0.1367
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0107 0.1219 0.1367
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.007 0.0081
Brugia malayi conserved hypotetical protein 0.0005 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0081
Echinococcus multilocularis traf and tnf receptor associated protein 0.0009 0.0046 0.0043
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0107 0.1219 0.1367
Schistosoma mansoni coup transcription factor 0.0011 0.007 0.0077
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0046 0.0054
Mycobacterium ulcerans proteasome PrcB 0.0728 0.8624 1
Brugia malayi nuclear receptor NHR-67 0.0005 0.0003 0.0004
Leishmania major proteasome alpha 3 subunit, putative 0.0107 0.1219 0.1367
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0728 0.0794
Toxoplasma gondii proteasome beta subunit 0.0107 0.1219 0.1367
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0107 0.1219 0.1367
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0107 0.1219 0.1216
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0107 0.1219 0.1367
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0157 0.1819 0.2074
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0107 0.1219 0.1376
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.007 0.0081
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0107 0.1219 0.141
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0107 0.1219 0.1376
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0157 0.1819 0.2066
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0081
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0107 0.1219 0.1414
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0699 0.0807
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.1147 0.1327
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.007 0.0081
Trypanosoma cruzi 20S proteasome subunit 0.0327 0.3845 0.4428
Loa Loa (eye worm) hypothetical protein 0.0009 0.0046 0.0054
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.001 0.0007
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0045 0.0048
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0009 0.0046 0.001
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0107 0.1219 0.1376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.007 0.0081
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0327 0.3845 0.4456
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0157 0.1819 0.2066
Schistosoma mansoni ap endonuclease 0.0042 0.045 0.0518
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0107 0.1219 0.1367
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.007 0.0081
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.007 0.0081
Brugia malayi hypothetical protein 0.0006 0.001 0.0012
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0107 0.1219 0.1367
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0107 0.1219 0.1376
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.045 0.047
Brugia malayi proteasome subunit alpha type 1 0.0107 0.1219 0.1414
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0107 0.1219 0.1367
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0107 0.1219 0.1367
Plasmodium vivax proteasome subunit beta type-2, putative 0.0327 0.3845 0.4428
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0107 0.1219 0.141
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0056 0.0607 0.07
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0003 0.0004
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0107 0.1219 0.141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Plasmodium vivax proteasome subunit beta type-1, putative 0.0157 0.1819 0.2066
Brugia malayi tailless protein 0.0005 0.0003 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.007 0.0077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.007 0.0077
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0046 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.007 0.0077
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5834 0.6764
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0107 0.1219 0.1367
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0009 0.0046 0.001
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0107 0.1219 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0012
Trypanosoma brucei proteasome alpha 7 subunit 0.0107 0.1219 0.1367
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0107 0.1219 0.1367
Onchocerca volvulus 0.0035 0.0358 0.2915
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.001 0.0008
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0728 0.8624 1
Schistosoma mansoni Smad4 0.0008 0.0045 0.0048
Loa Loa (eye worm) proteasome subunit beta type 2 0.0327 0.3845 0.4458
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0081
Loa Loa (eye worm) Smad1 0.0008 0.0045 0.0052
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0327 0.3845 0.4428
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.045 0.047
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0045 0.0048
Echinococcus granulosus synaptojanin 1 0.0009 0.0046 0.005
Brugia malayi MH2 domain containing protein 0.0008 0.0045 0.0052
Schistosoma mansoni cpg binding protein 0.0037 0.0381 0.0438
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0047 0.0051
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.007 0.0077
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.007 0.0077
Brugia malayi hypothetical protein 0.0005 0.0003 0.0004
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0107 0.1219 0.1367
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.007 0.0066
Brugia malayi hypothetical protein 0.0005 0.0003 0.0004
Giardia lamblia 20S proteasome alpha subunit 4 0.0107 0.1219 0.1367
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0009 0.0046 0.001
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0107 0.1219 0.1367
Schistosoma mansoni hypothetical protein 0.0346 0.4075 0.4723
Brugia malayi Proteasome subunit alpha type 1 0.0107 0.1219 0.1414
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0728 0.8624 1
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.007 0.0545
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0107 0.1219 0.1367
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0157 0.1819 0.2066
Giardia lamblia Proteasome subunit beta type 2 0.0327 0.3845 0.4428
Brugia malayi hypothetical protein 0.0006 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0056 0.0607 0.0704
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.007 0.0077
Leishmania major proteasome alpha 7 subunit, putative 0.0107 0.1219 0.1367
Plasmodium falciparum proteasome subunit beta type-4 0.0107 0.1219 0.1367
Brugia malayi Smad1 0.0008 0.0045 0.0052
Brugia malayi Proteasome A-type and B-type family protein 0.0728 0.8624 1
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0107 0.1219 0.1367
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0072 0.0084
Brugia malayi proteasome subunit beta type 2 0.0327 0.3845 0.4458
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.007 0.0077
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0081
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0003 0.0004
Loa Loa (eye worm) MBCTL1 0.0063 0.0699 0.081
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0107 0.1219 0.1414
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0107 0.1219 0.1367
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0107 0.1219 0.1367
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.045 0.047
Brugia malayi nuclear hormone receptor 0.0011 0.007 0.0081
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0009 0.0046 0.001
Echinococcus granulosus proteasome prosome macropain 0.0728 0.8624 1
Echinococcus granulosus FTZ F1 alpha 0.0011 0.007 0.0077
Brugia malayi CCR4 0.0009 0.0046 0.0054
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0107 0.1219 0.1367
Toxoplasma gondii heat shock protein hslv, putative 0.0107 0.1219 0.1367
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0107 0.1219 0.141
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0107 0.1219 0.141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.1147 0.1327
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0728 0.8624 1
Trichomonas vaginalis Phospholipase C precursor, putative 0.0009 0.0046 0.001
Brugia malayi nuclear receptor RXR 0.0006 0.001 0.0012
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0046 0.0054
Echinococcus granulosus subfamily T1A non peptidase ue 0.0107 0.1219 0.141
Schistosoma mansoni thyroid hormone receptor 0.0011 0.007 0.0077
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0081
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) hypothetical protein 0.0009 0.0046 0.0054
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0107 0.1219 0.1367
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.001 0.0008
Plasmodium falciparum proteasome subunit beta type-5 0.0728 0.8624 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0107 0.1219 0.1367
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0009 0.0046 0.0043
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0107 0.1219 0.1216
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0081
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0107 0.1219 0.1414
Giardia lamblia 20S proteasome alpha subunit 5 0.0107 0.1219 0.1367
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.1147 0.133
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0107 0.1219 0.1367
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0107 0.1219 0.1367
Giardia lamblia Proteasome subunit beta type 1 0.0157 0.1819 0.2066
Plasmodium vivax proteasome subunit beta type-3, putative 0.0107 0.1219 0.1367
Schistosoma mansoni synaptojanin 0.0009 0.0046 0.005
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0327 0.3845 0.4428
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0699 0.0696
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0107 0.1219 0.1367
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0728 0.8624 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.007 0.0066
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0072 0.0069
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0003 0.0004
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0056 0.0607 0.4965
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0107 0.1219 0.1216
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0699 0.0807
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.007 0.0066
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.007 0.0077
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0046 0.0054
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0157 0.1819 0.2106
Trypanosoma brucei proteasome beta 6 subunit 0.0157 0.1819 0.2066
Schistosoma mansoni ap endonuclease 0.0042 0.045 0.0518
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0107 0.1219 0.141
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0107 0.1219 0.1367
Echinococcus multilocularis proteasome subunit alpha type 2 0.0107 0.1219 0.1216
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0107 0.1219 0.1367
Onchocerca volvulus 0.0009 0.0046 0.0353
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.007 0.0066
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0046 0.0054
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0107 0.1219 0.141
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.045 0.0521
Leishmania major proteasome beta-1 subunit, putative 0.0107 0.1219 0.1367
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.1219 0.1367
Brugia malayi ecdysone receptor 0.0005 0.0003 0.0004
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0009 0.0046 0.001
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0107 0.1219 0.1367
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.045 0.0518
Brugia malayi mbt repeat family protein 0.0056 0.0607 0.0704
Loa Loa (eye worm) hypothetical protein 0.0009 0.0046 0.0054
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0107 0.1219 0.1367
Toxoplasma gondii proteasome subunit alpha1, putative 0.0107 0.1219 0.1367
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.045 0.047
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0107 0.1219 0.141
Schistosoma mansoni nocturnin 0.0009 0.0046 0.005
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0107 0.1219 0.1376
Echinococcus granulosus neutral sphingomyelinase 0.0009 0.0046 0.005
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0107 0.1219 0.1367
Echinococcus granulosus Smad4 0.0008 0.0045 0.0048
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0327 0.3845 0.4456
Toxoplasma gondii proteasome subunit alpha type, putative 0.0107 0.1219 0.1367
Giardia lamblia 20S proteasome alpha subunit 6 0.0107 0.1219 0.1367
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.007 0.0545
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1425 0.1652
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0107 0.1219 0.1367
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.045 0.047
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0107 0.1219 0.141
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0107 0.1219 0.1367
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0107 0.1219 0.1376
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0009 0.0046 0.001
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0107 0.1219 0.1367
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0157 0.1819 0.2106
Echinococcus multilocularis synaptojanin 1 0.0009 0.0046 0.0043
Mycobacterium ulcerans proteasome PrcA 0.0107 0.1219 0.0941
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0009 0.0046 0.0043
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0107 0.1219 0.1367
Leishmania major proteasome alpha 1 subunit, putative 0.0107 0.1219 0.1367
Brugia malayi mbt repeat family protein 0.0056 0.0607 0.0704
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.001 0.0008
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0228 0.2658 0.2655
Brugia malayi proteasome subunit beta type 3 0.0107 0.1219 0.1414
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) hypothetical protein 0.0063 0.0699 0.081
Echinococcus granulosus traf and tnf receptor associated protein 0.0009 0.0046 0.005
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0107 0.1219 0.1367
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.007 0.0081
Schistosoma mansoni smad1 5 8 and 0.0008 0.0045 0.0048
Brugia malayi Proteasome A-type and B-type family protein 0.0107 0.1219 0.1414
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.1219 0.1367
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0107 0.1219 0.141
Trypanosoma brucei proteasome beta 7 subunit 0.0107 0.1219 0.1367
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.1147 0.1327
Echinococcus multilocularis SAM and MBT domain containing protein 0.0056 0.0607 0.0604
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0107 0.1219 0.1216
Brugia malayi ecdysteroid receptor 0.0011 0.007 0.0081
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.007 0.0066
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0107 0.1219 0.1367
Leishmania major proteasome beta 2 subunit, putative 0.0327 0.3845 0.4428
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.045 0.0446
Echinococcus multilocularis deoxyribonuclease 1 2 0.0009 0.0046 0.0043
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0107 0.1219 0.1367
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.007 0.0077
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0107 0.1219 0.1414
Echinococcus multilocularis proteasome subunit alpha type 6 0.0107 0.1219 0.1216
Echinococcus multilocularis proteasome (prosome, macropain) 0.0728 0.8624 0.8624
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0107 0.1219 0.141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.007 0.0081
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.007 0.0081
Brugia malayi MH2 domain containing protein 0.0124 0.1425 0.1652
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0107 0.1219 0.1414
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0107 0.1219 0.1367
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0107 0.1219 0.1367
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0046 0.0054
Onchocerca volvulus Putative neutral sphingomyelinase 0.0009 0.0046 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.007 0.0081
Echinococcus granulosus proteasome subunit alpha type 2 0.0107 0.1219 0.141
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.1219 0.1367
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0107 0.1219 0.1367
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.007 0.0077
Schistosoma mansoni neutral sphingomyelinase 0.0009 0.0046 0.005
Brugia malayi nuclear receptor RXR 0.0005 0.0003 0.0004
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0003 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.007 0.0077
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0157 0.1819 0.2066
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0107 0.1219 0.1376
Echinococcus multilocularis proteasome subunit beta type 6 0.0107 0.1219 0.1216
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.007 0.0066
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.1219 0.1367
Schistosoma mansoni synaptojanin 0.0009 0.0046 0.005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.045 1
Loa Loa (eye worm) DR-78 0.0005 0.0003 0.0004
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0046 0.0054
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0107 0.1219 0.1216
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.007 0.0066
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.0607 0.07
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0046 0.0054
Brugia malayi Proteasome subunit alpha type 7-1 0.0107 0.1219 0.1414
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0157 0.1819 0.1816
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0107 0.1219 0.1367
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0081
Giardia lamblia Proteasome subunit beta type 3 0.0107 0.1219 0.1367
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0107 0.1219 0.141
Plasmodium vivax proteasome subunit beta type-4, putative 0.0107 0.1219 0.1367
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0699 0.0807
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0046 0.0054
Echinococcus multilocularis Smad4 0.0008 0.0045 0.0042
Echinococcus granulosus Proteasome subunit alpha type 7 0.0107 0.1219 0.141
Toxoplasma gondii proteasome subunit beta type, putative 0.0728 0.8624 1
Schistosoma mansoni cpg binding protein 0.0035 0.0358 0.0411
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0327 0.3845 0.4428
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.1147 0.1144
Schistosoma mansoni smad1 5 8 and 0.0008 0.0045 0.0048
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.045 0.048
Leishmania major proteasome alpha 1 subunit, putative 0.0107 0.1219 0.1367
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0046 0.0054
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0045 0.0042
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0045 0.0052
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0699 0.081
Schistosoma mansoni cpg binding protein 0.0037 0.0381 0.0438
Schistosoma mansoni nuclear hormone receptor 0.0011 0.007 0.0077
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0009 0.0046 0.0054
Plasmodium vivax proteasome subunit beta type-6, putative 0.0107 0.1219 0.1367
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.007 0.0081
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0047 0.0044
Echinococcus granulosus smad 0.0008 0.0045 0.0048
Brugia malayi CXXC zinc finger family protein 0.0035 0.0358 0.0415
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0107 0.1219 0.1376
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0107 0.1219 0.1376
Schistosoma mansoni thyroid hormone receptor 0.0011 0.007 0.0077
Brugia malayi nuclear hormone receptor 0.0005 0.0003 0.0004
Echinococcus multilocularis proteasome subunit beta type 7 0.0107 0.1219 0.1216
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0107 0.1219 0.1367
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0107 0.1219 0.1216
Brugia malayi proteasome subunit alpha type 6 0.0107 0.1219 0.1414
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0607 0.07
Onchocerca volvulus 0.0056 0.0607 0.4965
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0728 0.8624 1
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0107 0.1219 0.1414
Echinococcus multilocularis cpg binding protein 0.0037 0.0381 0.0378
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0107 0.1219 0.1367
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0009 0.0046 0.005
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0046 0.0054
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0107 0.1219 0.1367
Giardia lamblia 20S proteasome alpha subunit 7 0.0107 0.1219 0.1367
Brugia malayi 20S proteasome alpha5 subunit 0.0107 0.1219 0.1414
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.045 0.047
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.001 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.1147 0.1327
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0003 0.0004
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0157 0.1819 0.2066
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0107 0.1219 0.141
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0821 0.0949
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.1147 0.1327
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.001 0.0012
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0327 0.3845 0.4428
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0003 0.0004
Giardia lamblia 20S proteasome alpha subunit 3 0.0107 0.1219 0.1367
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0009 0.0046 0.0054
Onchocerca volvulus 0.0011 0.007 0.0545
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0107 0.1219 0.1367
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.1219 0.1367
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.001 0.0012
Brugia malayi MH1 domain containing protein 0.0008 0.0045 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.007 0.0081
Leishmania major proteasome alpha 7 subunit, putative 0.0107 0.1219 0.1367
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.045 0.047
Echinococcus granulosus cpg binding protein 0.0037 0.0381 0.0438
Brugia malayi MH2 domain containing protein 0.0008 0.0045 0.0052
Giardia lamblia 20S proteasome alpha subunit 1 0.0107 0.1219 0.1367
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0107 0.1219 0.1367
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.045 0.047
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0107 0.1219 0.1367
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0107 0.1219 0.1367
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0107 0.1219 0.1367
Schistosoma mansoni cript-related 0.0009 0.0046 0.005
Brugia malayi proteasome subunit alpha type 3 0.0107 0.1219 0.1414
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.007 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.007 0.0081
Brugia malayi nuclear receptor NHR-88 0.0005 0.0003 0.0004
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0107 0.1219 0.141
Echinococcus granulosus proteasome subunit alpha type 6 0.0107 0.1219 0.141
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0107 0.1219 0.1367
Schistosoma mansoni carbon catabolite repressor protein 0.0009 0.0046 0.005
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0009 0.0046 0.005
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0157 0.1819 0.2066
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0327 0.3845 0.3843
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0107 0.1219 0.1367
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0107 0.1219 0.1216
Loa Loa (eye worm) hypothetical protein 0.0005 0.0003 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0045 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.1147 0.1144
Brugia malayi nuclear receptor NHR-88 0.0011 0.007 0.0081
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0071 0.0082
Plasmodium vivax proteasome subunit beta type-5, putative 0.0728 0.8624 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.007 0.0077
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.007 0.0077
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0107 0.1219 0.1367
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0728 0.8624 1
Onchocerca volvulus Notchless protein homolog 0.0107 0.1219 1
Loa Loa (eye worm) proteasome subunit beta type 1 0.0157 0.1819 0.2109
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0107 0.1219 0.1367
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0047 0.0051
Schistosoma mansoni smad1 5 8 and 0.0008 0.0045 0.0048
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0107 0.1219 0.1367
Echinococcus granulosus proteasome subunit beta type 7 0.0107 0.1219 0.141
Brugia malayi MH1 domain containing protein 0.0008 0.0045 0.0052
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0107 0.1219 0.1367

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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