Detailed information for compound 1436659

Basic information

Technical information
  • TDR Targets ID: 1436659
  • Name: ethyl 3-[(2,3-dimethoxybenzoyl)amino]-1-benzo furan-2-carboxylate
  • MW: 369.368 | Formula: C20H19NO6
  • H donors: 1 H acceptors: 2 LogP: 4.21 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1oc2c(c1NC(=O)c1cccc(c1OC)OC)cccc2
  • InChi: 1S/C20H19NO6/c1-4-26-20(23)18-16(12-8-5-6-10-14(12)27-18)21-19(22)13-9-7-11-15(24-2)17(13)25-3/h5-11H,4H2,1-3H3,(H,21,22)
  • InChiKey: OJGHPQIGVYACKI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • ethyl 3-[(2,3-dimethoxybenzoyl)amino]benzofuran-2-carboxylate
  • 3-[[(2,3-dimethoxyphenyl)-oxomethyl]amino]-2-benzofurancarboxylic acid ethyl ester
  • 3-[(2,3-dimethoxybenzoyl)amino]benzofuran-2-carboxylic acid ethyl ester
  • ethyl 3-[(2,3-dimethoxyphenyl)carbonylamino]-1-benzofuran-2-carboxylate
  • ZINC04162600
  • MLS000093009
  • SMR000028645

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus peregrin 0.0038 0.0238 0.0194
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0562 0.0518
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0934 0.9533 0.953
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.051 0.0631
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0048 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.0469 0.0576
Loa Loa (eye worm) hypothetical protein 0.0045 0.0314 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Echinococcus multilocularis FTZ F1 alpha 0.0069 0.0562 0.0518
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0057 0.001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0562 0.0702
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0069 0.0562 0.076
Brugia malayi PHD-finger family protein 0.003 0.0155 0.021
Schistosoma mansoni thyroid hormone receptor 0.0069 0.0562 0.0534
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0057 0.0022
Plasmodium vivax glutathione reductase, putative 0.0057 0.0435 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0057 0.0011
Echinococcus granulosus transcription factor Dp 1 0.0421 0.4213 0.4223
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0728 0.7392 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0069 0.0562 0.0518
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1345 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0728 0.7392 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0048 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0223 0.0301
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0223 0.024
Brugia malayi hypothetical protein 0.0037 0.0223 0.0301
Entamoeba histolytica hypothetical protein 0.0037 0.0222 0.0239
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0048 0.0019
Loa Loa (eye worm) hypothetical protein 0.0052 0.0377 0.0451
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0069 0.0562 0.0518
Entamoeba histolytica hypothetical protein 0.0037 0.0222 0.0239
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0217 0.4358
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.043 0.0386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.043 0.0401
Brugia malayi nuclear receptor RXR 0.0037 0.0223 0.0301
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0309 0.0266
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.245 0.3272
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0046 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.0069 0.0562 0.0518
Loa Loa (eye worm) steroid hormone receptor 0.0069 0.0562 0.0702
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0971 0.9912 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0046 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0064 0.051 0.0481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0069 0.0562 0.0702
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0048 0.0019
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0101 0.0075
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0048 0.0019
Giardia lamblia PHD finger protein 15 0.0035 0.0208 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0325 0.0439
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0069 0.0562 0.0523
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0182 0.0138
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0108 0.01
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0351 0.0309
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0069 0.0562 0.0523
Entamoeba histolytica hypothetical protein 0.0037 0.0222 0.0239
Brugia malayi jmjC domain containing protein 0.0045 0.0309 0.0418
Schistosoma mansoni hypothetical protein 0.0339 0.3357 0.3363
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0046 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0048 0.0019
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0117 0.0112
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0728 0.7392 0.7446
Schistosoma mansoni hypothetical protein 0.0037 0.0222 0.019
Brugia malayi hypothetical protein 0.0037 0.0223 0.0301
Brugia malayi ecdysone receptor 0.0033 0.0182 0.0246
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0325 0.028
Schistosoma mansoni tar DNA-binding protein 0.0064 0.051 0.0481
Schistosoma mansoni DNA polymerase eta 0.0045 0.0314 0.0283
Onchocerca volvulus Bile acid receptor homolog 0.0069 0.0562 0.1445
Loa Loa (eye worm) hypothetical protein 0.0069 0.0562 0.0702
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Brugia malayi Flap endonuclease-1 0.0026 0.0117 0.0159
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0117 0.1783
Onchocerca volvulus 0.0036 0.0217 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0069 0.0562 0.076
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0208 0.4132
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0108 0.01
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0306 0.0261
Echinococcus multilocularis tar DNA binding protein 0.0064 0.051 0.0466
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0223 0.0179
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0309 0.0358
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0728 0.7392 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0048 0.0019
Schistosoma mansoni zinc finger protein 0.0033 0.0182 0.0149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1194 0.8839
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0069 0.0562 0.0518
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0325 0.0294
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0208 0.0176
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0117 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0325 0.0294
Schistosoma mansoni nuclear receptor 0.0033 0.0182 0.0149
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0306 0.6651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0069 0.0562 0.0702
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0223 0.0191
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0222 0.0176
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0057 0.0022
Brugia malayi hypothetical protein 0.0017 0.0014 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0069 0.0562 0.0518
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0223 0.0177
Leishmania major DNA polymerase eta, putative 0.0045 0.0314 0.038
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0591 0.0552
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0306 0.0368
Brugia malayi PHD-finger family protein 0.0035 0.0208 0.0282
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.043 0.0389
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0048 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0069 0.0562 0.0702
Schistosoma mansoni hypothetical protein 0.0025 0.0101 0.0068
Loa Loa (eye worm) hypothetical protein 0.0069 0.0562 0.0702
Schistosoma mansoni tar DNA-binding protein 0.0064 0.051 0.0481
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Toxoplasma gondii thioredoxin reductase 0.0057 0.0435 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0016
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0306 0.0939
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0306 0.0368
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0435 0.0394
Echinococcus granulosus ecdysone induced protein 78C 0.0069 0.0562 0.0523
Schistosoma mansoni hypothetical protein 0.0339 0.3357 0.3363
Loa Loa (eye worm) hypothetical protein 0.0069 0.0562 0.0702
Brugia malayi nuclear receptor NHR-67 0.0033 0.0182 0.0246
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1345 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Loa Loa (eye worm) hypothetical protein 0.0085 0.0729 0.0929
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0435 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0069 0.0562 0.0702
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1345 1
Brugia malayi RNA binding protein 0.0064 0.051 0.069
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0306 0.0939
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0562 0.0523
Loa Loa (eye worm) RNA binding protein 0.0064 0.051 0.0631
Brugia malayi nuclear hormone receptor 0.0033 0.0182 0.0246
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1039 0.1006
Plasmodium falciparum flap endonuclease 1 0.0026 0.0117 0.1783
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0306 0.0368
Plasmodium vivax SET domain protein, putative 0.0036 0.0217 0.4358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0325 0.0294
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0314 0.038
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0728 0.7392 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0325 0.0282
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0069 0.0562 0.0523
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0069 0.0562 0.0534
Schistosoma mansoni inositol monophosphatase 0.0045 0.0306 0.0274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0182 0.0137
Echinococcus multilocularis peregrin 0.0038 0.0238 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0562 0.076
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0048 0.0124
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0435 0.053
Schistosoma mansoni flap endonuclease-1 0.0024 0.0091 0.0057
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0048 0.0019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0069 0.0562 0.0534
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0117 0.0112
Leishmania major trypanothione reductase 0.0057 0.0435 0.0545
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0728 0.7392 0.738
Loa Loa (eye worm) hypothetical protein 0.0049 0.0353 0.0418
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0293 0.025
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1039 0.0997
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0069 0.0562 0.0702
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0108 0.1556
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1345 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0562 0.076
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.051 0.069
Schistosoma mansoni RAR-like nuclear receptor 0.0069 0.0562 0.0534
Schistosoma mansoni bromodomain containing protein 0.0076 0.0636 0.0608
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0562 0.076
Loa Loa (eye worm) TAR-binding protein 0.0064 0.051 0.0631
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0108 0.1556
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0048 0.0015
Brugia malayi nuclear receptor RXR 0.0033 0.0182 0.0246
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Treponema pallidum NADH oxidase 0.002 0.0048 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0182 0.0138
Brugia malayi Bromodomain containing protein 0.0038 0.0238 0.0322
Loa Loa (eye worm) glutathione reductase 0.0057 0.0435 0.053
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0048 0.0065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0048 0.0077
Brugia malayi hypothetical protein 0.0033 0.0182 0.0246
Loa Loa (eye worm) hypothetical protein 0.0026 0.0108 0.0085
Brugia malayi nuclear receptor NHR-88 0.0069 0.0562 0.076
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0048 0.0014
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0174 0.019
Echinococcus granulosus zinc finger protein 0.0024 0.0088 0.0043
Trypanosoma brucei trypanothione reductase 0.0057 0.0435 0.0545
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0217 0.0171
Schistosoma mansoni retinoic acid receptor RXR 0.0971 0.9912 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0182 0.0246
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0208 0.0164
Brugia malayi TAR-binding protein 0.0064 0.051 0.069
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0125 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Onchocerca volvulus 0.0286 0.281 1
Echinococcus multilocularis zinc finger protein 0.0024 0.0088 0.0042
Schistosoma mansoni hypothetical protein 0.0035 0.0208 0.0176
Brugia malayi Thioredoxin reductase 0.0057 0.0435 0.0589
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0182 0.0138
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0223 0.0301
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0435 0.0391
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0257 0.1624
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0117 0.0112
Loa Loa (eye worm) hypothetical protein 0.0069 0.0562 0.0702
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0325 0.028
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0306 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0217 0.0185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0048 0.0019
Brugia malayi hypothetical protein 0.0033 0.0182 0.0246
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0182 0.0138
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0793 0.0768
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.0016
Brugia malayi conserved hypotetical protein 0.0033 0.0182 0.0246
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1194 0.8839
Schistosoma mansoni zinc finger protein 0.0024 0.0088 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0069 0.0562 0.0702
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0108 0.1556
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.024
Brugia malayi Inositol-1 0.0045 0.0306 0.0413
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0597 0.075
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0351 0.0306
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0117 0.0097
Brugia malayi nuclear hormone receptor 0.0069 0.0562 0.076
Entamoeba histolytica hypothetical protein 0.0037 0.0222 0.0239
Schistosoma mansoni inositol monophosphatase 0.0045 0.0306 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Brugia malayi Pre-SET motif family protein 0.0036 0.0217 0.0293
Loa Loa (eye worm) hypothetical protein 0.0035 0.0208 0.022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0325 0.0379
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0306 0.0939
Brugia malayi ecdysteroid receptor 0.0069 0.0562 0.076
Brugia malayi hypothetical protein 0.0026 0.0108 0.0147
Trichomonas vaginalis set domain proteins, putative 0.0286 0.281 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0182 0.0137
Onchocerca volvulus Protein ultraspiracle homolog 0.0069 0.0562 0.1445
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0435 0.0545
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0285 0.024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0069 0.0562 0.0534
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0069 0.0562 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0069 0.0562 0.076
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0182 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0182 0.0137
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0293 0.0248
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0309 0.0278
Echinococcus granulosus geminin 0.0339 0.3357 0.3356
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0562 0.076
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0435 0.2996
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0046 0.0016
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0064 0.0025
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0182 0.0137
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0182 0.0185
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0182 0.0149
Echinococcus granulosus flap endonuclease 1 0.0026 0.0117 0.0072
Loa Loa (eye worm) hypothetical protein 0.0069 0.0562 0.0702
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0069 0.0562 0.0534
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0048 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1194 0.8839
Schistosoma mansoni thyroid hormone receptor 0.0069 0.0562 0.0534
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0048 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0069 0.0562 0.0518
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0016
Echinococcus granulosus tar DNA binding protein 0.0064 0.051 0.047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0223 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0064 0.051 0.0481
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0046 0.0016
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0048 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0069 0.0562 0.076
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0728 0.7392 1
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0208 0.022
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0182 0.0185
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0048 0.0019
Onchocerca volvulus Alhambra homolog 0.0035 0.0208 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0174 0.3258
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0117 0.1783
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0208 0.0163
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0048 0.0007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0048 0.0019
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0182 0.0246
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0306 1
Schistosoma mansoni coup transcription factor 0.0069 0.0562 0.0534
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0182 0.0137
Brugia malayi jmjC domain containing protein 0.0115 0.1039 0.1405
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0309 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0069 0.0562 0.076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.043 0.0401
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0048 0.0019
Leishmania major DNA polymerase eta, putative 0.0032 0.0174 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Loa Loa (eye worm) hypothetical protein 0.0046 0.0324 0.0378
Loa Loa (eye worm) DR-78 0.0033 0.0182 0.0185
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0182 0.0149
Plasmodium falciparum phd finger protein, putative 0.0035 0.0208 0.4132
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0182 0.0185
Brugia malayi nuclear receptor NHR-88 0.0033 0.0182 0.0246
Plasmodium falciparum glutathione reductase 0.0057 0.0435 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0048 0.0019
Brugia malayi hypothetical protein 0.0037 0.0222 0.03
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0728 0.7392 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.024
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0108 0.01
Schistosoma mansoni tar DNA-binding protein 0.0064 0.051 0.0481
Brugia malayi Bromodomain containing protein 0.0091 0.0782 0.1058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0562 0.0518
Loa Loa (eye worm) hypothetical protein 0.0057 0.043 0.0523
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0182 0.0149
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0591 0.0547
Echinococcus multilocularis geminin 0.0339 0.3357 0.3326
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1194 0.8839
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0048 0.0077
Echinococcus granulosus dna polymerase eta 0.0045 0.0314 0.0272
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0117 0.0097
Echinococcus granulosus FTZ F1 alpha 0.0069 0.0562 0.0523
Brugia malayi tailless protein 0.0033 0.0182 0.0246
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0182 0.0149
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0125 0.008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Echinococcus multilocularis dna polymerase eta 0.0045 0.0314 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0069 0.0562 0.076
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0203 0.0159
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0562 0.076
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0562 0.0534
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0728 0.7392 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0562 0.0702
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0208 0.4132
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0117 0.0257
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1194 0.8839
Trypanosoma brucei unspecified product 0.002 0.0046 0.0016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.024
Mycobacterium tuberculosis Probable reductase 0.013 0.1194 0.8839
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0306 0.0263
Brugia malayi Steroid receptor seven-up type 2 0.0069 0.0562 0.076
Brugia malayi Pre-SET motif family protein 0.0251 0.245 0.3314
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0046 0.0062
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0108 0.1556
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0314 0.0425
Brugia malayi steroid hormone receptor 0.0069 0.0562 0.076
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0046 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0048 0.0019
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0117 0.4385
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0728 0.7392 0.7449
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0314 0.038
Brugia malayi Bromodomain containing protein 0.0046 0.0323 0.0437
Brugia malayi Nuclear hormone receptor-like 1 0.0069 0.0562 0.076
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0125 0.0092
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0048 0.0019
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0208 0.4132
Brugia malayi photoreceptor-specific nuclear receptor 0.0069 0.0562 0.076
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0182 0.0246
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0217 0.0185
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0562 0.0523
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0306 0.0353
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0069 0.0562 0.1445
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0182 0.0246
Onchocerca volvulus 0.0069 0.0562 0.1445
Loa Loa (eye worm) inositol-1 0.0045 0.0306 0.0353
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0069 0.0562 0.0534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0069 0.0562 0.0702
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0182 0.0246
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0182 0.0138
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0306 0.0368
Loa Loa (eye worm) hypothetical protein 0.0069 0.0562 0.0702
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0182 0.0246
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0069 0.0562 0.0534
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0069 0.0562 0.0534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0325 0.0282
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0182 0.0138
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1194 0.8614
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0046 0.0016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0222 0.0178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0048 0.0019
Plasmodium falciparum thioredoxin reductase 0.0057 0.0435 1
Echinococcus multilocularis transcription factor Dp 1 0.0421 0.4213 0.4186
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0048 0.5
Leishmania major hypothetical protein, conserved 0.0026 0.0108 0.01
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0222 0.019
Schistosoma mansoni nuclear receptor 0.0033 0.0182 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0562 0.076
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0069 0.0562 0.076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0182 0.0185
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0048 0.0007
Brugia malayi glutathione reductase 0.0057 0.0435 0.0589

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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