Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pseudomonas aeruginosa | Beta Lactamase | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4432 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.8931 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4432 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4432 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4432 | 0.4963 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.016 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.8931 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4432 | 0.4963 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4432 | 0.4963 |
Trypanosoma brucei | beta lactamase | 0.0077 | 0.446 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0077 | 0.446 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4432 | 0.4963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4432 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4432 | 0.4963 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4432 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4432 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4432 | 0.4963 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4432 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.8931 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.823 uM | PubChem BioAssay. FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify epi-absorbance assay artifacts. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | = 13.1 uM | PubChem BioAssay. Epi-absorbance-based dose response biochemical high throughput screening assay for selective inhibitors of VIM-2 metallo-beta-lactamase. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | > 59.64 uM | PubChem BioAssay. Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of TEM-1 serine-beta-lactamase. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | > 59.64 uM | PubChem BioAssay. FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (binding) | > 59.64 uM | PubChem BioAssay. Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Inhibition (binding) | = 41 % | Inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate at 50 uM by spectrofluorimetric analysis | ChEMBL. | 22524450 |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.