Detailed information for compound 1436977

Basic information

Technical information
  • TDR Targets ID: 1436977
  • Name: 5-methoxy-2-methyl-6-methylsulfanyl-1,3-benzo thiazole
  • MW: 225.33 | Formula: C10H11NOS2
  • H donors: 0 H acceptors: 1 LogP: 3.26 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2nc(sc2cc1SC)C
  • InChi: 1S/C10H11NOS2/c1-6-11-7-4-8(12-2)10(13-3)5-9(7)14-6/h4-5H,1-3H3
  • InChiKey: GWLKCQDLVAXDDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-methoxy-2-methyl-6-(methylthio)-1,3-benzothiazole
  • STK004034
  • ZINC00185388
  • MLS000052995
  • SMR000068951
  • 5-Methoxy-2-methyl-6-methylsulfanyl-benzothiazole
  • BAS 00009480

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Methyltransferase-like protein 4 0.0211 0.1307 0.1245
Schistosoma mansoni acyl carrier protein 0.0071 0.0194 0.0996
Loa Loa (eye worm) hypothetical protein 0.1155 0.8802 1
Mycobacterium ulcerans polyketide synthase MbtC 0.0176 0.1028 0.1101
Mycobacterium ulcerans fatty acid synthase Fas 0.022 0.1379 0.1564
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0107 0.0485 0.0384
Schistosoma mansoni hypothetical protein 0.0114 0.0535 0.3753
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0723 0.5367 0.6827
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0542 0.3935 0.4938
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0679 0.5022 0.6371
Brugia malayi Phosphopantetheine attachment site family protein 0.0071 0.0194 0.0124
Loa Loa (eye worm) hypothetical protein 0.0052 0.0041 0.0047
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0239 0.0272
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0071 0.0194 0.0124
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0204 0.1398
Brugia malayi AMP-binding enzyme family protein 0.0215 0.1342 0.128
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0176 0.1028 1
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0176 0.1028 1
Giardia lamblia Methyltransferase like 2 0.0211 0.1307 0.5
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0176 0.1028 0.1101
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0542 0.3935 0.4938
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0239 0.0272
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0723 0.5367 0.6827
Brugia malayi AMP-binding enzyme family protein 0.0655 0.4827 0.479
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1026 0.7771 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0584 0.4265 0.5373
Loa Loa (eye worm) fatty acid synthase 0.0691 0.5118 0.5815
Plasmodium vivax hypothetical protein, conserved 0.01 0.0429 0.2822
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0655 0.4827 0.6114
Toxoplasma gondii kringle domain-containing protein 0.0114 0.0535 0.0659
Loa Loa (eye worm) hypothetical protein 0.0085 0.031 0.0352
Echinococcus multilocularis tissue type plasminogen activator 0.0114 0.0535 0.4848
Echinococcus multilocularis AMP dependent ligase 0.0071 0.0194 0.1287
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0171 0.0991 0.1052
Mycobacterium leprae Polyketide synthase Pks13 0.1026 0.7771 1
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0176 0.1028 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0283 0.1881 0.2226
Loa Loa (eye worm) hypothetical protein 0.0371 0.2577 0.2928
Mycobacterium ulcerans polyketide synthase 0.0723 0.5367 0.6827
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0176 0.1028 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0107 0.0485 0.0384
Toxoplasma gondii type I fatty acid synthase, putative 0.0723 0.5367 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0679 0.5022 0.6371
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0679 0.5022 0.6371
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0679 0.5022 0.6371
Mycobacterium ulcerans Type I modular polyketide synthase 0.0679 0.5022 0.6371
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0584 0.4265 0.5373
Brugia malayi RNA binding protein 0.0076 0.0239 0.017
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0239 0.1364
Onchocerca volvulus Fatty acid synthase homolog 0.1263 0.9655 1
Echinococcus granulosus AMP dependent ligase 0.0071 0.0194 0.1287
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0239 0.1364
Mycobacterium ulcerans polyketide synthase Pks9 0.0442 0.3138 0.3886
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0107 0.0485 0.0384
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0071 0.0194 0.022
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0239 0.1364
Mycobacterium ulcerans Type I modular polyketide synthase 0.0679 0.5022 0.6371
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.01 0.0429 0.2822
Schistosoma mansoni bromodomain containing protein 0.0076 0.0239 0.1359
Mycobacterium ulcerans thioesterase 0.0584 0.4265 0.5373
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0071 0.0194 0.0124
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0679 0.5022 0.6371
Mycobacterium tuberculosis Hypothetical protein 0.0211 0.1307 0.1469
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0176 0.1028 1
Mycobacterium ulcerans polyketide synthase MbtD 0.0215 0.1342 0.1515
Schistosoma mansoni hypothetical protein 0.0071 0.0194 0.0996
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0194 0.5
Loa Loa (eye worm) acyl carrier protein 0.0071 0.0194 0.022
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0239 0.1364
Brugia malayi Bromodomain containing protein 0.0091 0.0351 0.0282
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0655 0.4827 0.5484
Echinococcus granulosus tar DNA binding protein 0.0076 0.0239 0.1763
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0107 0.0485 0.0384
Mycobacterium ulcerans polyketide synthase 0.0679 0.5022 0.6371
Leishmania major hypothetical protein, conserved 0.0114 0.0535 0.3061
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0176 0.1028 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0723 0.5367 0.6827
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0176 0.1028 1
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0215 0.1342 0.1515
Mycobacterium ulcerans thioesterase TesA 0.0584 0.4265 0.5373
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0176 0.1028 0.1101
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0194 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0723 0.5367 0.6827
Brugia malayi TAR-binding protein 0.0076 0.0239 0.017
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0176 0.1028 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0679 0.5022 0.6371
Loa Loa (eye worm) hypothetical protein 0.0107 0.0485 0.0551
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0454 0.3239 0.5886
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0239 0.1364
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0354 0.2442 0.4346
Mycobacterium ulcerans Type I modular polyketide synthase 0.0679 0.5022 0.6371
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0679 0.5022 0.4986
Plasmodium falciparum cysteine repeat modular protein 1 0.0114 0.0535 0.4087
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0176 0.1028 0.1168
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0723 0.5367 0.6827
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0723 0.5367 0.6827
Brugia malayi Protein kinase domain containing protein 0.0114 0.0535 0.0467
Echinococcus granulosus acyl carrier protein mitochondrial 0.0071 0.0194 0.1287
Leishmania major hypothetical protein, conserved 0.0211 0.1307 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0023 0.0026
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0442 0.3138 0.3886
Echinococcus granulosus NADH dehydrogenase 0.0071 0.0194 0.1287
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0442 0.3138 0.3886
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.0535 0.4087
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0219 0.1373 0.1556
Onchocerca volvulus 0.1219 0.9309 0.9635
Mycobacterium ulcerans polyketide synthase Pks13 0.1026 0.7771 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0679 0.5022 0.6371
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.022 0.1379 0.1564
Loa Loa (eye worm) acyl carrier protein 0.0322 0.2189 0.2487
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.022 0.1379 0.1564
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0176 0.1028 0.749
Loa Loa (eye worm) hypothetical protein 0.0107 0.0485 0.0551
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0114 0.0535 0.4087
Onchocerca volvulus 0.0655 0.4827 0.4897
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0204 0.1398
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0551 0.4009 0.5034
Treponema pallidum acyl carrier protein 0.0071 0.0194 0.5
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0176 0.1028 0.774
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.1307 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.0114 0.0535 0.0607
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0239 0.1763
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0071 0.008
Echinococcus multilocularis NADH dehydrogenase 0.0071 0.0194 0.1287
Toxoplasma gondii type I fatty acid synthase 0.0107 0.0485 0.0563
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0176 0.1028 0.1612
Loa Loa (eye worm) RNA binding protein 0.0076 0.0239 0.0272
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0107 0.0485 0.0384
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0071 0.0194 0.1287
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0398 0.2793 0.343
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0723 0.5367 0.6827
Onchocerca volvulus 0.0114 0.0535 0.036
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0679 0.5022 0.6371
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0239 0.017
Toxoplasma gondii type I fatty acid synthase, putative 0.0499 0.359 0.6565
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1026 0.7771 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0723 0.5367 0.6827
Echinococcus granulosus tissue type plasminogen activator 0.0114 0.0535 0.4848
Brugia malayi Kringle domain containing protein 0.0114 0.0535 0.0467
Schistosoma mansoni methyltransferase-related 0.0211 0.1307 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0542 0.3935 0.4938
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0176 0.1028 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0176 0.1028 0.0964
Loa Loa (eye worm) hypothetical protein 0.0114 0.0535 0.0607
Mycobacterium tuberculosis Conserved protein 0.0211 0.1307 0.1469
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0503 0.3626 0.453

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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