Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 10 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | hydroxysteroid (17-beta) dehydrogenase 10 | 252 aa | 251 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0069 | 1 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.3146 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0033 | 0.3146 | 0.2917 |
Onchocerca volvulus | 0.0033 | 0.3146 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3146 | 0.3446 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0069 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0323 | 0.0354 |
Echinococcus granulosus | lamin | 0.0033 | 0.3146 | 0.3146 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0069 | 1 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0069 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.3146 | 0.3146 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0069 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.3146 | 0.3446 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.3146 | 0.3446 |
Echinococcus multilocularis | musashi | 0.0033 | 0.3146 | 0.3146 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.3146 | 0.3146 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0065 | 0.9129 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3035 | 0.3324 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.3146 | 0.2917 |
Echinococcus multilocularis | lamin | 0.0033 | 0.3146 | 0.3146 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0069 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0069 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.3146 | 0.3146 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.7943 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.