Detailed information for compound 1437119

Basic information

Technical information
  • TDR Targets ID: 1437119
  • Name: (3-chloro-6-nitro-1-benzothiophen-2-yl)-(3-me thylpiperidin-1-yl)methanone
  • MW: 338.809 | Formula: C15H15ClN2O3S
  • H donors: 0 H acceptors: 3 LogP: 4.47 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCN(C1)C(=O)c1sc2c(c1Cl)ccc(c2)[N+](=O)[O-]
  • InChi: 1S/C15H15ClN2O3S/c1-9-3-2-6-17(8-9)15(19)14-13(16)11-5-4-10(18(20)21)7-12(11)22-14/h4-5,7,9H,2-3,6,8H2,1H3
  • InChiKey: AIIBDHVBUAAFRX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3-chloro-6-nitro-benzothiophen-2-yl)-(3-methyl-1-piperidyl)methanone
  • (3-chloro-6-nitro-2-benzothiophenyl)-(3-methyl-1-piperidinyl)methanone
  • AK-968/12572005
  • MLS000577706
  • SMR000187089
  • 1-[(3-chloro-6-nitro-1-benzothien-2-yl)carbonyl]-3-methylpiperidine
  • CBMicro_032415
  • IVK/8137980
  • BIM-0032379.P001
  • Oprea1_613469

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Sus scrofa Calpain 2 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus family C2 unassigned peptidase C02 family Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis calpain family protein 1, d Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K08585 calpain, invertebrate, putative Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Calpain-A, putative Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Calpain-1 catalytic subunit, putative Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus calpain A Calpain 2   324 aa 297 aa 27.6 %
Echinococcus granulosus calpain Calpain 2   324 aa 322 aa 31.7 %
Plasmodium vivax hypothetical protein, conserved Calpain 2   324 aa 277 aa 19.9 %
Schistosoma japonicum Calpain-9, putative Calpain 2   324 aa 275 aa 27.6 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Echinococcus multilocularis calpain Calpain 2   324 aa 320 aa 31.9 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Schistosoma mansoni calpain C (C02 family) Calpain 2   324 aa 319 aa 27.3 %
Echinococcus multilocularis hypothetical protein Calpain 2   324 aa 297 aa 27.9 %
Schistosoma mansoni calpain (C02 family) Calpain 2   324 aa 318 aa 24.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.041 0.041
Brugia malayi Polyprenyl synthetase family protein 0.0332 0.2653 0.2653
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.0101 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0583 0.0583
Schistosoma mansoni hypothetical protein 0.0038 0.0271 0.0271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0026
Schistosoma mansoni trans-prenyltransferase 0.0332 0.2653 0.2653
Leishmania major cytochrome p450-like protein 0.0017 0.0101 0.0101
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0026
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0101 0.0101
Leishmania major cytochrome p450-like protein 0.0028 0.0187 0.0187
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1238 1 1
Schistosoma mansoni hypothetical protein 0.0038 0.0271 0.0271
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.0101 0.0101
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.0101 0.0101
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.0101 0.0101
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2278 0.2278
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0557 0.0557
Trypanosoma cruzi polyprenyl synthase, putative 0.0412 0.3303 0.3303
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.0101 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0583 0.0583
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1238 1 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.0101 0.0101
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1238 1 1
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0332 0.2653 0.2653
Echinococcus multilocularis 0.0017 0.0101 0.0101
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0026 0.0026
Echinococcus granulosus calpain 5 0.0023 0.015 0.015
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0078 0.0593 0.0593
Schistosoma mansoni calpain (C02 family) 0.0023 0.015 0.015
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0332 0.2653 0.2653
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0026
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0101 0.0101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0026
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0332 0.2653 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0101 0.0101
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0557 0.0557
Trypanosoma brucei antigen, putative 0.0023 0.015 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0026
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.0101 0.0101
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0332 0.2653 0.2653
Echinococcus multilocularis calpain A 0.0082 0.0625 0.0625
Trypanosoma brucei calpain-like protein, putative 0.0023 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0082 0.063 0.063
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0412 0.3303 0.3303
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0023 0.015 0.015
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3969 0.3969
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0082 0.0625 0.0625
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.015 0.015
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1238 1 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.0187 0.0187
Loa Loa (eye worm) polyprenyl synthetase 0.1238 1 1
Schistosoma mansoni hypothetical protein 0.0058 0.0435 0.0435
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0101 0.038
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0332 0.2653 0.2653
Schistosoma mansoni cpg binding protein 0.0037 0.026 0.026
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.0101 0.0101
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0049 0.0049
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0101 0.0101
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0557 0.0557
Schistosoma mansoni calpain-7 (C02 family) 0.0023 0.015 0.015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0026
Brugia malayi calpain 5 0.0023 0.015 0.015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0557 0.0557
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2278 0.2278
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.0101 0.0101
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0271 0.0271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0026
Brugia malayi TAR-binding protein 0.0076 0.0583 0.0583
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0412 0.3303 0.3303
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0939 0.0939
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0048 0.0048
Brugia malayi calpain family protein 1 0.0078 0.0593 0.0593
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0187 0.0187
Schistosoma mansoni hypothetical protein 0.0038 0.0271 0.0271
Leishmania major cytochrome p450-like protein 0.0017 0.0101 0.0101
Brugia malayi Cytochrome P450 family protein 0.004 0.0288 0.0288
Echinococcus multilocularis calpain 0.0023 0.015 0.015
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0023 0.015 0.015
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.6722 0.6722
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0026
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0332 0.2653 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.0187 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0583 0.0583
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.0101 0.0101
Entamoeba histolytica calpain large subunit domain III containing protein 0.0023 0.015 0.0565
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0271
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0101 0.0101
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0332 0.2653 0.2653
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.041 0.041
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.0101 0.0101
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.0101 0.0101
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0032
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1238 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0557 0.0557
Echinococcus granulosus microtubule associated protein 2 0.0833 0.6722 0.6722
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0023 0.015 0.015
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.0101 0.0101
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0023 0.015 0.015
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.0101 0.0101
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0332 0.2653 0.2653
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.015 0.015
Echinococcus granulosus cpg binding protein 0.0037 0.026 0.026
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0583 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0026
Trypanosoma brucei calpain-like protein, putative 0.0023 0.015 0.015
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0557 0.0557
Onchocerca volvulus 0.0035 0.0243 0.5602
Schistosoma mansoni glutathione synthetase 0.0332 0.2653 0.2653
Trypanosoma brucei calpain-like protein, putative 0.0023 0.015 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0026
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0412 0.3303 0.3303
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.0101 0.0101
Brugia malayi calpain 7 0.0023 0.015 0.015
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0332 0.2653 0.2653
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.0101 0.0101
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0032 0.0032
Brugia malayi cytochrome P450 0.0017 0.0101 0.0101
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0412 0.3303 0.3303
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.012 0.0939 0.0939
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0939 0.0939
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0332 0.2653 0.2653
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0048
Brugia malayi calpain family protein 1 0.0078 0.0593 0.0593
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0082 0.0625 0.0625
Leishmania major kinesin, putative 0.0023 0.015 0.015
Giardia lamblia Farnesyl diphosphate synthase 0.1238 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0271 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0026
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.015 0.015
Echinococcus granulosus calpain 7 C02 family 0.0023 0.015 0.015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0003 0.0003
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.0101 0.0101
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0332 0.2653 0.2653
Loa Loa (eye worm) polyprenyl synthetase 0.0332 0.2653 0.2653
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0271 0.0271
Trypanosoma brucei calpain-like protein, putative 0.0023 0.015 0.015
Echinococcus granulosus calpain A 0.0082 0.0625 0.0625
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1238 1 1
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0332 0.2653 0.2653
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.041 0.041
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.0101 0.0101
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.041 0.041
Schistosoma mansoni cytochrome P450 0.0017 0.0101 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.0101 0.0101
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.0101 0.0101
Schistosoma mansoni calpain-7 (C02 family) 0.0023 0.015 0.015
Echinococcus multilocularis hypothetical protein 0.0023 0.015 0.015
Brugia malayi Cytochrome P450 family protein 0.0017 0.0101 0.0101
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0332 0.2653 1
Brugia malayi RNA binding protein 0.0076 0.0583 0.0583
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.0101 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.0101 0.0101
Onchocerca volvulus 0.0058 0.0435 1
Echinococcus multilocularis GPCR, family 2 0.0038 0.0271 0.0271
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0435 0.0435
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0583 0.0583
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.0101 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.0101 0.0101
Mycobacterium leprae putative cytochrome p450 0.0017 0.0101 0.038
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.0101 0.0101
Trypanosoma cruzi polyprenyl synthase, putative 0.0412 0.3303 0.3303
Schistosoma mansoni hypothetical protein 0.0082 0.063 0.063
Echinococcus granulosus calpain A 0.0023 0.015 0.015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.041 0.041
Treponema pallidum octaprenyl-diphosphate synthase 0.0412 0.3303 0.5
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0332 0.2653 0.2653
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0332 0.2653 1
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0271 0.0271
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0023 0.015 0.015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.041 0.041
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.015 0.015
Schistosoma mansoni cpg binding protein 0.0037 0.026 0.026
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.0101 0.0101
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0557 0.0557
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.6722 0.6722
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0078 0.0593 0.0593
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0332 0.2653 0.2653
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0023 0.015 0.015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0939 0.0939
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0026
Loa Loa (eye worm) calpain 0.0023 0.015 0.015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0271 0.0271
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0332 0.2653 0.2653
Trypanosoma cruzi kinesin, putative 0.0023 0.015 0.015
Brugia malayi CXXC zinc finger family protein 0.0035 0.0243 0.0243
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1238 1 1
Echinococcus multilocularis cpg binding protein 0.0037 0.026 0.026
Brugia malayi hypothetical protein 0.0286 0.2278 0.2278
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0332 0.2653 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.041 0.041
Leishmania major farnesyl pyrophosphate synthase 0.1238 1 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0082 0.0625 0.0625
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0187 0.0187
Echinococcus granulosus calpain 0.0023 0.015 0.015
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0023 0.015 0.015
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0187 0.0187
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.0101 0.0101
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.0101 0.0101
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0101 0.0101
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0032 0.0032
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0026 0.0026
Trichomonas vaginalis helicase, putative 0.0008 0.0026 0.0026
Plasmodium vivax calpain, putative 0.0023 0.015 0.015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.0494 0.3969 0.3969
Leishmania major solanesyl-diphosphate synthase, putative 0.0332 0.2653 0.2653
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0332 0.2653 0.2653
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0332 0.2653 0.2653
Echinococcus multilocularis calpain family protein 1, d 0.0055 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0078 0.0593 0.0593
Onchocerca volvulus 0.0055 0.0405 0.9328
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0557 0.0557
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0332 0.2653 0.2653
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0557 0.0557
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1238 1 1
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1238 1 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.0101 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0286 0.2278 0.2278
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0055 0.0405 0.0405
Echinococcus granulosus tar DNA binding protein 0.0076 0.0583 0.0583
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0023 0.015 0.015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.041 0.041
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1238 1 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0583 0.0583
Echinococcus multilocularis calpain 5 0.0023 0.015 0.015
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.0101 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.0101 0.0101
Schistosoma mansoni hypothetical protein 0.0038 0.0271 0.0271
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.0101 0.0101
Echinococcus granulosus GPCR family 2 0.0038 0.0271 0.0271
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0559 0.0559
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1238 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0583 0.0583
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0557 0.0557
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3969 0.3969
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0032 0.0032
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0023 0.015 0.015
Schistosoma mansoni Mername-AA248 (C02 family) 0.0023 0.015 0.015
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1238 1 1
Leishmania major polyprenyl synthase, putative 0.0412 0.3303 0.3303
Schistosoma mansoni cpg binding protein 0.0035 0.0243 0.0243
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.0101 0.0101
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.0101 0.0101
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0023 0.015 0.015
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1238 1 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.0101 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.0101 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.0101 0.0101
Trypanosoma brucei kinesin, putative 0.0023 0.015 0.015
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.0101 0.0101
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0082 0.0625 0.0625
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1238 1 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0435 0.0435
Echinococcus multilocularis calpain 7 (C02 family) 0.0023 0.015 0.015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.041 0.041
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0187 0.0187
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0055 0.0405 0.0405
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0332 0.2653 1
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0187 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0243 0.0243
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0101 0.0101
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0412 0.3303 0.3303
Loa Loa (eye worm) RNA binding protein 0.0076 0.0583 0.0583
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0187 0.0187
Trypanosoma cruzi kinesin, putative 0.0023 0.015 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0017 0.0101 0.0101
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0187 0.0187
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0049 0.0049
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0023 0.015 0.015
Loa Loa (eye worm) cytochrome P450 0.0017 0.0101 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.0101 0.0101
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.0101 0.0101
Loa Loa (eye worm) calpain family protein 1 0.0078 0.0593 0.0593
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0332 0.2653 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0032
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1238 1 1
Loa Loa (eye worm) calpain 5 0.0023 0.015 0.015
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0405 0.0405
Schistosoma mansoni calpain C (C02 family) 0.0023 0.015 0.015
Entamoeba histolytica protein kinase, putative 0.0023 0.015 0.0565

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.981071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 17.7827941 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) = 7.613643101 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)] ChEMBL. No reference
Potency (functional) = 0.4467 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.