Detailed information for compound 1437485

Basic information

Technical information
  • TDR Targets ID: 1437485
  • Name: K788-8633
  • MW: 602.1 | Formula: C32H28ClN3O5S
  • H donors: 0 H acceptors: 4 LogP: 4.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)N1CCN(CC1)C(=O)c1ccc2c(c1)N(Cc1cccc(c1)Cl)C(=O)c1c(S2(=O)=O)cccc1
  • InChi: 1S/C32H28ClN3O5S/c1-41-26-12-10-25(11-13-26)34-15-17-35(18-16-34)31(37)23-9-14-30-28(20-23)36(21-22-5-4-6-24(33)19-22)32(38)27-7-2-3-8-29(27)42(30,39)40/h2-14,19-20H,15-18,21H2,1H3
  • InChiKey: GEENQHWGAWHCCE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • NCGC00140656-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0661 0.6159 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.004 0.0231 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0439 0.0412
Schistosoma mansoni hypothetical protein 0.0165 0.1428 0.1404
Brugia malayi steroid hormone receptor 0.0076 0.0573 0.093
Echinococcus granulosus dna polymerase eta 0.0044 0.0266 0.0238
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0076 0.0573 0.093
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0661 0.6159 0.6394
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0036 0.019 0.0162
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0573 0.0568
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.018 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0076 0.0573 0.0889
Schistosoma mansoni coup transcription factor 0.0076 0.0573 0.0546
Echinococcus granulosus geminin 0.0165 0.1428 0.1404
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1226 0.1953
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0091 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Schistosoma mansoni hypothetical protein 0.0035 0.0184 0.0156
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0184 0.0156
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0275 0.0257
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0076 0.0573 0.0546
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0193 0.0172
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0091 0.0712
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0076 0.0573 0.0546
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0142 0.0185
Loa Loa (eye worm) hypothetical protein 0.004 0.0231 0.0331
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0661 0.6159 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0439 0.0428
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0036 0.019 0.0162
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.019 0.0162
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.004 0.0231 0.0204
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0028 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.019 0.0162
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0076 0.0573 0.0546
Brugia malayi Nuclear hormone receptor E75 0.0036 0.019 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0076 0.0573 0.093
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0076 0.0573 0.0568
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0076 0.0573 0.0568
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0184 0.0156
Brugia malayi conserved hypotetical protein 0.0036 0.019 0.0309
Echinococcus multilocularis transcription factor Dp 1 0.0382 0.3501 0.3622
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0083 0.009
Brugia malayi Pre-SET motif family protein 0.0251 0.2249 0.3652
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0661 0.6159 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0076 0.0573 0.0546
Brugia malayi nuclear receptor NHR-67 0.0036 0.019 0.0309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0573 0.0546
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0036 0.019 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0076 0.0573 0.0889
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Brugia malayi hypothetical protein 0.0035 0.0184 0.0298
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1023 0.9617 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0076 0.0573 0.0546
Leishmania major hypothetical protein, conserved 0.0025 0.0083 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0076 0.0573 0.0889
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0091 0.0103
Loa Loa (eye worm) hypothetical protein 0.0076 0.0573 0.0889
Brugia malayi ecdysteroid receptor 0.0076 0.0573 0.093
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0231 0.0375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0076 0.0573 0.0889
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0266 0.0387
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0573 0.0546
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0193 0.0172
Schistosoma mansoni zinc finger protein 0.0036 0.019 0.0162
Schistosoma mansoni RAR-like nuclear receptor 0.0076 0.0573 0.0546
Onchocerca volvulus Bile acid receptor homolog 0.0076 0.0573 0.1602
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0439 0.067
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.019 0.0169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0573 0.0568
Echinococcus granulosus tar DNA binding protein 0.0062 0.0439 0.0412
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0142 0.5333
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.004 0.0231 0.0204
Brugia malayi Nuclear hormone receptor E75 0.0036 0.019 0.0309
Entamoeba histolytica hypothetical protein 0.0035 0.0184 0.0254
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0439 0.0412
Echinococcus multilocularis dna polymerase eta 0.0044 0.0266 0.0248
Brugia malayi orphan nuclear receptor NR2E1 0.0036 0.019 0.0309
Onchocerca volvulus Protein ultraspiracle homolog 0.0076 0.0573 0.1602
Brugia malayi nuclear hormone receptor family member nhr-6 0.0036 0.019 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0076 0.0573 0.093
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0275 0.0402
Loa Loa (eye worm) DR-78 0.0036 0.019 0.0264
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0076 0.0573 0.0546
Loa Loa (eye worm) nuclear receptor NHR-67 0.0036 0.019 0.0264
Loa Loa (eye worm) nuclear hormone receptor 0.0036 0.019 0.0264
Schistosoma mansoni DNA polymerase eta 0.0044 0.0266 0.0238
Brugia malayi hypothetical protein 0.0036 0.019 0.0309
Loa Loa (eye worm) hypothetical protein 0.0076 0.0573 0.0889
Echinococcus multilocularis FTZ F1 alpha 0.0076 0.0573 0.0568
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0661 0.6159 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0036 0.019 0.0309
Echinococcus granulosus thyroid hormone receptor alpha 0.0036 0.019 0.0162
Schistosoma mansoni nuclear receptor nhr-48 0.0036 0.019 0.0162
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0076 0.0573 0.0546
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0091 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0076 0.0573 0.093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0076 0.0573 0.093
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0083 0.009
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0076 0.0573 0.093
Schistosoma mansoni thyroid hormone receptor 0.0076 0.0573 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0439 0.0412
Echinococcus multilocularis ecdysone induced protein 78C 0.0076 0.0573 0.0568
Brugia malayi Nuclear hormone receptor-like 1 0.0076 0.0573 0.093
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0083 0.009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0076 0.0573 0.1602
Entamoeba histolytica hypothetical protein 0.0035 0.0184 0.0254
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0661 0.6159 0.6149
Echinococcus granulosus FTZ F1 alpha 0.0076 0.0573 0.0546
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.7809 0.7803
Echinococcus granulosus transcription factor Dp 1 0.0382 0.3501 0.3483
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0036 0.019 0.0264
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0193 0.0165
Brugia malayi nuclear receptor NHR-88 0.0036 0.019 0.0309
Loa Loa (eye worm) hypothetical protein 0.0076 0.0573 0.0889
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0193 0.0165
Brugia malayi nuclear hormone receptor 0.0076 0.0573 0.093
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.7809 0.8115
Brugia malayi nuclear hormone receptor 0.0036 0.019 0.0309
Loa Loa (eye worm) hypothetical protein 0.004 0.0231 0.0331
Onchocerca volvulus 0.0036 0.0193 0.001
Brugia malayi nuclear receptor NHR-88 0.0076 0.0573 0.093
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Brugia malayi nuclear receptor RXR 0.0036 0.019 0.0309
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0028 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0076 0.0573 0.093
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0439 0.0712
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0076 0.0573 0.0546
Leishmania major DNA polymerase eta, putative 0.0031 0.0142 0.0185
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0076 0.0573 0.0568
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0439 0.0412
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0091 0.0712
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0193 0.0165
Echinococcus granulosus microtubule associated protein 2 0.0833 0.7809 0.7803
Loa Loa (eye worm) steroid hormone receptor 0.0076 0.0573 0.0889
Onchocerca volvulus 0.0286 0.2581 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0573 0.0889
Leishmania major DNA polymerase eta, putative 0.0044 0.0266 0.0387
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0076 0.0573 0.0889
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0661 0.6159 0.6149
Brugia malayi hypothetical protein 0.0036 0.019 0.0309
Brugia malayi nuclear receptor RXR 0.004 0.0231 0.0375
Loa Loa (eye worm) hypothetical protein 0.0044 0.0266 0.0387
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Brugia malayi hypothetical protein 0.004 0.0231 0.0375
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0076 0.0573 0.093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0076 0.0573 0.0889
Loa Loa (eye worm) hypothetical protein 0.0076 0.0573 0.0889
Loa Loa (eye worm) hypothetical protein 0.0076 0.0573 0.0889
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0266 0.0431
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0573 0.0546
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.019 0.0169
Onchocerca volvulus 0.0076 0.0573 0.1602
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0275 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0076 0.0573 0.093
Loa Loa (eye worm) hypothetical protein 0.0076 0.0573 0.0889
Echinococcus granulosus nuclear receptor nhr 48 0.0036 0.019 0.0162
Brugia malayi ecdysone receptor 0.0036 0.019 0.0309
Brugia malayi Pre-SET motif family protein 0.0036 0.0193 0.0313
Schistosoma mansoni nuclear hormone receptor 0.0036 0.019 0.0162
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1226 0.1953
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0661 0.6159 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0439 0.067
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0036 0.019 0.0169
Brugia malayi hypothetical protein 0.0025 0.0083 0.0135
Schistosoma mansoni nuclear receptor 0.0036 0.019 0.0162
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0076 0.0573 0.0546
Brugia malayi tailless protein 0.0036 0.019 0.0309
Schistosoma mansoni hypothetical protein 0.0165 0.1428 0.1404
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0091 0.0103
Echinococcus multilocularis geminin 0.0165 0.1428 0.146
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Entamoeba histolytica hypothetical protein 0.0035 0.0184 0.0254
Schistosoma mansoni thyroid hormone receptor 0.0076 0.0573 0.0546
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0076 0.0573 0.0546
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0076 0.0573 0.093
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0661 0.6159 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0076 0.0573 0.093
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0091 0.0103
Plasmodium vivax SET domain protein, putative 0.0036 0.0193 1
Brugia malayi hypothetical protein 0.004 0.0231 0.0375
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Echinococcus multilocularis nuclear receptor nhr 48 0.0036 0.019 0.0169
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0661 0.6159 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0275 0.0247
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.004 0.0231 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0275 0.0257
Loa Loa (eye worm) hypothetical protein 0.004 0.0231 0.0331
Brugia malayi TAR-binding protein 0.0062 0.0439 0.0712
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0076 0.0573 0.0546
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0091 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0193 0.0165
Brugia malayi Steroid receptor seven-up type 2 0.0076 0.0573 0.093
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0028 0.0046
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0091 0.0103
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2581 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0028 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.1063 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0275 0.0247
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0266 0.0387
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0193 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2249 0.3622
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0076 0.0573 0.093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.019 0.0169
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0231 0.0204
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.019 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0076 0.0573 0.0889
Plasmodium falciparum flap endonuclease 1 0.0025 0.0091 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0275 0.0247
Brugia malayi RNA binding protein 0.0062 0.0439 0.0712
Schistosoma mansoni flap endonuclease-1 0.0023 0.0068 0.004
Entamoeba histolytica hypothetical protein 0.0035 0.0184 0.0254
Loa Loa (eye worm) hypothetical protein 0.0036 0.019 0.0264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0275 0.0247
Loa Loa (eye worm) hypothetical protein 0.0036 0.0193 0.0268
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0193 0.0165
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0091 0.0246
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0439 0.0412
Echinococcus granulosus ecdysone induced protein 78C 0.0076 0.0573 0.0546
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0076 0.0573 0.0568
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0184 0.0162
Echinococcus multilocularis thyroid hormone receptor alpha 0.0076 0.0573 0.0568
Loa Loa (eye worm) hypothetical protein 0.004 0.0231 0.0331
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0231 0.0375
Loa Loa (eye worm) hypothetical protein 0.004 0.0231 0.0331
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0028 0.5
Brugia malayi MH2 domain containing protein 0.0144 0.1226 0.199
Schistosoma mansoni nuclear receptor 0.0036 0.019 0.0162
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0439 0.067
Schistosoma mansoni nuclear hormone receptor 0.0036 0.019 0.0162
Echinococcus granulosus flap endonuclease 1 0.0025 0.0091 0.0063
Brugia malayi Flap endonuclease-1 0.0025 0.0091 0.0148
Brugia malayi photoreceptor-specific nuclear receptor 0.0076 0.0573 0.093
Loa Loa (eye worm) hypothetical protein 0.0076 0.0573 0.0889
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0076 0.0573 0.093
Brugia malayi nuclear hormone receptor family member odr-7 0.0036 0.019 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0275 0.0247

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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