Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0239 | 0.4551 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0906 | 0.0906 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0503 | 1 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0906 | 0.0906 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0503 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0503 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0503 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0906 | 0.0906 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0747 | 0.0747 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0503 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0456 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.085 | 0.085 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0747 | 0.0747 |
Echinococcus granulosus | thymidylate synthase | 0.0503 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0906 | 0.0906 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0747 | 0.0747 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0747 | 0.0747 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0503 | 1 | 1 |
Onchocerca volvulus | 0.0503 | 1 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0503 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0503 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0503 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0503 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0747 | 0.0747 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0747 | 0.0747 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0906 | 0.0906 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0906 | 0.0906 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0906 | 0.0906 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.085 | 0.085 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0503 | 1 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0906 | 0.0906 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0906 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.212 | 0.212 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.085 | 0.085 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0906 | 0.0906 |
Brugia malayi | hypothetical protein | 0.0122 | 0.212 | 0.212 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0456 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.212 | 0.212 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0906 | 0.0906 |
Brugia malayi | hypothetical protein | 0.0239 | 0.4551 | 0.4551 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0503 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0747 | 0.0747 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0906 | 0.0906 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0456 | 0.0456 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0747 | 0.0747 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0906 | 0.0906 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.085 | 0.085 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0033 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.