Detailed information for compound 143792

Basic information

Technical information
  • TDR Targets ID: 143792
  • Name: N-(4-bromophenyl)-N'-phenylhexanediamide
  • MW: 375.26 | Formula: C18H19BrN2O2
  • H donors: 2 H acceptors: 2 LogP: 3.24 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Br)CCCCC(=O)Nc1ccccc1
  • InChi: 1S/C18H19BrN2O2/c19-14-10-12-16(13-11-14)21-18(23)9-5-4-8-17(22)20-15-6-2-1-3-7-15/h1-3,6-7,10-13H,4-5,8-9H2,(H,20,22)(H,21,23)
  • InChiKey: UAUZIQTUZRSWCZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromophenyl)-N'-phenyl-hexanediamide
  • N-(4-bromophenyl)-N'-phenyl-adipamide
  • AIDS-070239
  • AIDS070239
  • N'-(4-Bromophenyl)-N-phenylhexane-1,6-diamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.026 0.0773 1
Brugia malayi MH2 domain containing protein 0.0197 0.0561 0.0561
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0084 0.0177 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0706 0.2281 0.656
Brugia malayi MH1 domain containing protein 0.0109 0.0262 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.1058 0.3472 0.3472
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.026 0.0773 1
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0013 0.0023
Schistosoma mansoni dishevelled 0.0035 0.0011 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0013 0.002
Brugia malayi DIX domain containing protein 0.0035 0.0011 0.0011
Brugia malayi MH2 domain containing protein 0.2897 0.9692 0.9692
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0039 0.0026 0.1464
Echinococcus granulosus TGF beta signal transducer SmadC 0.0197 0.0561 0.0983
Brugia malayi hypothetical protein 0.0039 0.0026 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0013 0.0013
Chlamydia trachomatis DNA ligase 0.0039 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0945 0.3091 0.3091
Giardia lamblia NADPH oxidoreductase, putative 0.0084 0.0177 1
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Schistosoma mansoni tar DNA-binding protein 0.1717 0.5701 0.8381
Brugia malayi nuclear receptor NHR-88 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0945 0.3091 0.3091
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Echinococcus granulosus smad 0.0197 0.0561 0.0983
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.026 0.0773 0.1357
Loa Loa (eye worm) MH2 domain-containing protein 0.0197 0.0561 0.0561
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0039 0.0026 0.1464
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0013 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0157 0.0423 0.5401
Schistosoma mansoni tar DNA-binding protein 0.1717 0.5701 0.8381
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Brugia malayi MH1 domain containing protein 0.0197 0.0561 0.0561
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0013 0.0013
Echinococcus granulosus mothers against decapentaplegic 6 0.0088 0.0191 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0026 0.1464
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0035 0.0011 0.0019
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0039 0.0026 0.1464
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0945 0.3091 0.5422
Schistosoma mansoni topbp1 0.0039 0.0026 0.0038
Schistosoma mansoni smad 0.0197 0.0561 0.0824
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Echinococcus granulosus FTZ F1 alpha 0.0712 0.2302 0.4038
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0084 0.0177 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.026 0.0773 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0035 0.0011 0.0019
Schistosoma mansoni hypothetical protein 0.0945 0.3091 0.4544
Echinococcus granulosus Pleckstrin G protein interacting region 0.0035 0.0011 0.0019
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0179 0.0499 0.0499
Brugia malayi MH2 domain containing protein 0.0088 0.0191 0.0191
Giardia lamblia NADPH oxidoreductase, putative 0.0084 0.0177 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0088 0.0191 0.0191
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0039 0.0026 1
Toxoplasma gondii isocitrate dehydrogenase 0.026 0.0773 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0013 0.0013
Toxoplasma gondii ATPase, AAA family protein 0.0039 0.0026 0.02
Trypanosoma cruzi PAB1-binding protein , putative 0.0157 0.0423 0.5307
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0013 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0013 0.0013
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0039 0.0026 1
Loa Loa (eye worm) MH2 domain-containing protein 0.2897 0.9692 0.9692
Schistosoma mansoni chromosome transmission fidelity factor 0.0039 0.0026 0.0038
Schistosoma mansoni Smad4 0.0088 0.0191 0.0281
Brugia malayi ecdysteroid receptor 0.0036 0.0013 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0013 0.002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0013 0.0023
Echinococcus multilocularis smad 0.0197 0.0561 0.0983
Loa Loa (eye worm) isocitrate dehydrogenase 0.026 0.0773 0.0773
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0035 0.0011 0.0011
Echinococcus multilocularis replication factor c subunit 1 0.0039 0.0026 0.0045
Brugia malayi regulator of G-protein signaling egl-10 0.0035 0.0011 0.0011
Brugia malayi hypothetical protein 0.0039 0.0026 0.0026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0013 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Echinococcus multilocularis GPCR, family 2 0.0945 0.3091 0.5422
Plasmodium falciparum ataxin-2 like protein, putative 0.0157 0.0423 0.5307
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0013 0.0023
Echinococcus granulosus regulator of G protein signaling 7 0.0035 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.026 0.0773 1
Onchocerca volvulus 0.0039 0.0026 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0013 0.0023
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0088 0.0191 0.0523
Loa Loa (eye worm) MH1 domain-containing protein 0.0088 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0088 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0026 0.1464
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1717 0.5701 0.5701
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0013 0.0023
Echinococcus granulosus segment polarity protein dishevelled 0.0035 0.0011 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0013 0.0013
Brugia malayi steroid hormone receptor 0.0036 0.0013 0.0013
Schistosoma mansoni smad1 5 8 and 0.0197 0.0561 0.0824
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0013 0.0023
Echinococcus multilocularis tar DNA binding protein 0.1717 0.5701 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0026 0.1464
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.0013 0.0023
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0013 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0013 0.0023
Schistosoma mansoni tar DNA-binding protein 0.1717 0.5701 0.8381
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0013 0.0023
Brugia malayi hypothetical protein 0.1058 0.3472 0.3472
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0179 0.0499 0.0734
Loa Loa (eye worm) nuclear factor I 0.0109 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.2988 1 1
Schistosoma mansoni topbp1 0.0039 0.0026 0.0038
Echinococcus multilocularis regulator of G protein signaling 7 0.0035 0.0011 0.0019
Brugia malayi TAR-binding protein 0.1717 0.5701 0.5701
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.007 0.0131 0.0229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0013 0.0023
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0013 0.0023
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0084 0.0177 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0013 0.0013
Plasmodium vivax ataxin-2 like protein, putative 0.0157 0.0423 0.5307
Trypanosoma cruzi PAB1-binding protein , putative 0.0157 0.0423 0.5307
Brugia malayi topoisomerase 0.0039 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0013 0.0013
Brugia malayi hypothetical protein 0.0157 0.0423 0.0423
Brugia malayi Calcitonin receptor-like protein seb-1 0.2988 1 1
Schistosoma mansoni smad 0.0088 0.0191 0.0281
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0011
Loa Loa (eye worm) TAR-binding protein 0.1717 0.5701 0.5701
Schistosoma mansoni hypothetical protein 0.2042 0.6802 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0179 0.0499 0.0499
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.026 0.0773 0.1357
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.026 0.0773 0.1137
Brugia malayi hypothetical protein 0.0101 0.0235 0.0235
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0013 0.002
Giardia lamblia NADPH oxidoreductase, putative 0.0084 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.0499 0.0499
Echinococcus multilocularis nibrin 0.0039 0.0026 0.0045
Brugia malayi MH1 domain containing protein 0.0197 0.0561 0.0561
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0035 0.0011 0.0016
Echinococcus granulosus mothers against decapentaplegic 5 0.0197 0.0561 0.0983
Brugia malayi Latrophilin receptor protein 2 0.0945 0.3091 0.3091
Loa Loa (eye worm) hypothetical protein 0.0157 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0011
Brugia malayi Pax transcription activation domain interacting protein 0.0039 0.0026 0.0026
Leishmania major hypothetical protein, conserved 0.0157 0.0423 0.5464
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0026 0.1464
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.026 0.0773 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.026 0.0773 0.1357
Echinococcus granulosus mothers against decapentaplegic 2 0.0088 0.0191 0.0336
Schistosoma mansoni dishevelled 0.0035 0.0011 0.0016
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0039 0.0026 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0013 0.002
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0035 0.0011 0.0011
Schistosoma mansoni tar DNA-binding protein 0.1717 0.5701 0.8381
Schistosoma mansoni smad1 5 8 and 0.0197 0.0561 0.0824
Loa Loa (eye worm) hypothetical protein 0.2042 0.6802 0.6802
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0013 0.0013
Loa Loa (eye worm) MH1 domain-containing protein 0.0197 0.0561 0.0561
Schistosoma mansoni DNA ligase IV 0.0039 0.0026 0.0038
Schistosoma mansoni hypothetical protein 0.0945 0.3091 0.4544
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0197 0.0561 0.0824
Onchocerca volvulus 0.1058 0.3472 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0039 0.0026 0.02
Plasmodium falciparum ataxin-2 like protein, putative 0.0157 0.0423 0.5307
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.026 0.0773 0.1357
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0013 0.0023
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0013 0.002
Toxoplasma gondii isocitrate dehydrogenase 0.026 0.0773 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0013 0.0013
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0039 0.0026 0.0026
Echinococcus multilocularis mothers against decapentaplegic 5 0.0197 0.0561 0.0983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0013 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.026 0.0773 0.1357
Schistosoma mansoni dep domain containing protein 0.0035 0.0011 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0026 0.1464
Brugia malayi RNA binding protein 0.1717 0.5701 0.5701
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0945 0.3091 0.3091
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0945 0.3091 0.5422
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0013 0.0013
Brugia malayi latrophilin 2 splice variant baaae 0.2042 0.6802 0.6802
Echinococcus multilocularis FTZ F1 alpha 0.0179 0.0499 0.0876
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0262 0.0262
Schistosoma mansoni smad1 5 8 and 0.0197 0.0561 0.0824
Loa Loa (eye worm) transcription factor SMAD2 0.2897 0.9692 0.9692
Echinococcus multilocularis regulator of G protein signaling 7 0.0035 0.0011 0.0019
Schistosoma mansoni hypothetical protein 0.007 0.0131 0.0192
Brugia malayi hypothetical protein 0.0035 0.0011 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0013 0.0013
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0035 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0013 0.002
Trichomonas vaginalis replication factor C large subunit, putative 0.0039 0.0026 0.1464
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0179 0.0499 0.0876
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Brugia malayi N-terminal motif family protein 0.0706 0.2281 0.2281
Echinococcus granulosus GPCR family 2 0.0945 0.3091 0.5422
Echinococcus multilocularis mothers against decapentaplegic 6 0.0088 0.0191 0.0336
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0013 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Echinococcus granulosus regulator of G protein signaling 7 0.0035 0.0011 0.0019
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.026 0.0773 1
Brugia malayi RNA recognition motif domain containing protein 0.1717 0.5701 0.5701
Loa Loa (eye worm) MH2 domain-containing protein 0.0088 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Echinococcus multilocularis mothers against decapentaplegic 2 0.0088 0.0191 0.0336
Brugia malayi isocitrate dehydrogenase 0.026 0.0773 0.0773
Schistosoma mansoni hypothetical protein 0.0945 0.3091 0.4544
Brugia malayi DKFZp564C0469 protein 0.0039 0.0026 0.0026
Brugia malayi MH2 domain containing protein 0.0197 0.0561 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0039 0.0026 1
Schistosoma mansoni coup transcription factor 0.0036 0.0013 0.002
Loa Loa (eye worm) RNA binding protein 0.1717 0.5701 0.5701
Treponema pallidum DNA ligase (lig) 0.0039 0.0026 0.5
Schistosoma mansoni Smad4 0.0197 0.0561 0.0824
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0013 0.002
Schistosoma mansoni z-protein (S1r protein) 0.0035 0.0011 0.0016
Echinococcus multilocularis Smad4 0.0197 0.0561 0.0983
Brugia malayi Smad1 0.0197 0.0561 0.0561
Schistosoma mansoni hypothetical protein 0.0945 0.3091 0.4544
Loa Loa (eye worm) Smad1 0.0197 0.0561 0.0561
Trypanosoma brucei PAB1-binding protein , putative 0.0157 0.0423 0.5307
Brugia malayi Isocitrate dehydrogenase 0.026 0.0773 0.0773
Echinococcus granulosus Smad4 0.0197 0.0561 0.0983
Schistosoma mansoni regulator of G protein signaling 0.0035 0.0011 0.0016
Brugia malayi hypothetical protein 0.0035 0.0011 0.0011
Echinococcus granulosus replication factor c subunit 1 0.0039 0.0026 0.0045
Brugia malayi nuclear hormone receptor 0.0036 0.0013 0.0013
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.026 0.0773 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0013 0.0023
Brugia malayi MH1 domain containing protein 0.0109 0.0262 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0013 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0706 0.2281 0.2281
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0039 0.0026 0.1464
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0945 0.3091 0.5422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Trypanosoma brucei isocitrate dehydrogenase, putative 0.026 0.0773 1
Loa Loa (eye worm) DIX domain-containing protein 0.0035 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0106 0.599
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0197 0.0561 0.0983
Schistosoma mansoni hypothetical protein 0.0144 0.0379 0.0557
Echinococcus granulosus tar DNA binding protein 0.1717 0.5701 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0013 0.002
Echinococcus granulosus nibrin 0.0039 0.0026 0.0045
Entamoeba histolytica hypothetical protein 0.0039 0.0026 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0013 0.0013
Schistosoma mansoni Smad4 0.0088 0.0191 0.0281
Echinococcus granulosus segment polarity protein dishevelled 0.0035 0.0011 0.0019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2988 1 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0035 0.0011 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0013 0.002
Echinococcus multilocularis isocitrate dehydrogenase 0.026 0.0773 0.1357
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0945 0.3091 0.5422
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0179 0.0499 0.0876
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.007 0.0131 0.0229
Onchocerca volvulus 0.0036 0.0013 0.0008
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0013 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0177 1
Schistosoma mansoni tar DNA-binding protein 0.1717 0.5701 0.8381

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) uM Evaluated for inhibition of HIV-2 reverse transcriptase; Inactive means <50% inhibition at 100 ug/mL concentration ChEMBL. 9873592
IC50 (binding) uM Evaluated for inhibition of HIV-1 reverse transcriptase; Inactive means <50% inhibition at 100 ug/mL concentration ChEMBL. 9873592
IC50 (binding) NA 0 uM Evaluated for inhibition of HIV-1 reverse transcriptase; Inactive means <50% inhibition at 100 ug/mL concentration ChEMBL. 9873592
IC50 (binding) NA 0 uM Evaluated for inhibition of HIV-2 reverse transcriptase; Inactive means <50% inhibition at 100 ug/mL concentration ChEMBL. 9873592

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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