Detailed information for compound 143809

Basic information

Technical information
  • TDR Targets ID: 143809
  • Name: 4-phenyl-4-[4-(trifluoromethyl)phenoxy]piperi dine
  • MW: 321.337 | Formula: C18H18F3NO
  • H donors: 1 H acceptors: 0 LogP: 4.19 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1ccc(cc1)OC1(CCNCC1)c1ccccc1)(F)F
  • InChi: 1S/C18H18F3NO/c19-18(20,21)15-6-8-16(9-7-15)23-17(10-12-22-13-11-17)14-4-2-1-3-5-14/h1-9,22H,10-13H2
  • InChiKey: JWKCCFYYFVIFTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis allatostatin A receptor 0.0033 0.124 0.1864
Echinococcus multilocularis tar DNA binding protein 0.0136 0.6653 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.124 0.1864
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.124 0.1864
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0033 0.124 0.124
Brugia malayi RE15519p 0.0033 0.124 0.124
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.124 0.1864
Schistosoma mansoni tar DNA-binding protein 0.0136 0.6653 1
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.6345 0.6345
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.124 0.124
Schistosoma mansoni hypothetical protein 0.0033 0.124 0.1864
Echinococcus multilocularis neuropeptide receptor 0.0033 0.124 0.1864
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus g protein coupled receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis G protein coupled receptor 139 0.0033 0.124 0.1864
Brugia malayi putative neuropeptide receptor 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Schistosoma mansoni tar DNA-binding protein 0.0136 0.6653 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.124 0.1864
Schistosoma mansoni amine GPCR 0.0033 0.124 0.1864
Echinococcus multilocularis somatostatin receptor 0.0033 0.124 0.1864
Schistosoma mansoni amine GPCR 0.0033 0.124 0.1864
Schistosoma mansoni hypothetical protein 0.0051 0.2208 0.3318
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi G-protein coupled receptor 0.0033 0.124 0.124
Brugia malayi follicle stimulating hormone receptor 0.0033 0.124 0.124
Onchocerca volvulus 0.0033 0.124 0.1195
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.124 0.1864
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.2208 0.3318
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0033 0.124 0.1195
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0051 0.0051
Schistosoma mansoni opsin-like receptor 0.0033 0.124 0.1864
Echinococcus granulosus g protein coupled receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.124 0.1864
Onchocerca volvulus Neuropeptide F receptor homolog 0.0033 0.124 0.1195
Schistosoma mansoni dep domain containing protein 0.001 0.0051 0.0077
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi larval opioid receptor 0.0033 0.124 0.124
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.798 0.798
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.124 0.124
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.124 0.124
Onchocerca volvulus 0.0033 0.124 0.1195
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.124 0.1864
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.2208 0.3318
Schistosoma mansoni dishevelled 0.001 0.0051 0.0077
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.124 0.1864
Echinococcus granulosus neuropeptide receptor 0.0033 0.124 0.1864
Schistosoma mansoni biogenic amine receptor 0.0033 0.124 0.1864
Schistosoma mansoni neuropeptide receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.124 0.124
Echinococcus granulosus g protein coupled receptor 0.0033 0.124 0.1864
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.124 0.1864
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.124 0.1864
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0051 0.0077
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0051 0.0077
Echinococcus multilocularis serotonin receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis neuropeptide receptor A26 0.0033 0.124 0.1864
Schistosoma mansoni neuropeptide receptor 0.0033 0.124 0.1864
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.124 0.1864
Echinococcus multilocularis g protein coupled receptor 0.0033 0.124 0.1864
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.124 0.1864
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.5308 0.5308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.124 0.1864
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus tar DNA binding protein 0.0136 0.6653 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.2208 0.2208
Schistosoma mansoni biogenic amine receptor 0.0033 0.124 0.1864
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.124 0.1864
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.124 0.1864
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0051 0.0051
Schistosoma mansoni biogenic amine receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0051 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0136 0.6653 1
Schistosoma mansoni myosin xvIII 0.0033 0.124 0.1864
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.124 0.124
Echinococcus multilocularis fmrfamide receptor 0.0033 0.124 0.1864
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.124 0.1864
Brugia malayi G-protein coupled receptor 0.0033 0.124 0.124
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0161 0.798 0.798
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.124 0.1864
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.124 0.1864
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.124 0.1864
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.124 0.1864
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.124 0.1864
Echinococcus granulosus neuropeptide receptor A26 0.0033 0.124 0.1864
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.124 0.1864
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.124 0.1864
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.798 0.798
Schistosoma mansoni hypothetical protein 0.0033 0.124 0.1864
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.124 0.124
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.124 0.1864
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.124 0.124
Onchocerca volvulus 0.0033 0.124 0.1195
Echinococcus granulosus GPCR family 2 0.0051 0.2208 0.3318
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.2208 0.3318
Schistosoma mansoni amine GPCR 0.0033 0.124 0.1864
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.124 0.1864
Onchocerca volvulus 0.0033 0.124 0.1195
Schistosoma mansoni opsin-like receptor 0.0033 0.124 0.1864
Onchocerca volvulus 0.0033 0.124 0.1195
Onchocerca volvulus 0.0033 0.124 0.1195
Brugia malayi hypothetical protein 0.001 0.0051 0.0051
Echinococcus multilocularis GPCR, family 2 0.0051 0.2208 0.3318
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.124 0.1864
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.124 0.1864
Toxoplasma gondii hypothetical protein 0.001 0.0051 0.5
Schistosoma mansoni amine GPCR 0.0033 0.124 0.1864
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.124 0.1864
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.124 0.1864
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.124 0.1864
Brugia malayi Melatonin receptor type 1A 0.0033 0.124 0.124
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0051 0.0051
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.124 0.1864
Schistosoma mansoni hypothetical protein 0.0051 0.2208 0.3318
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.124 0.1864
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.124 0.1864
Onchocerca volvulus 0.0033 0.124 0.1195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.124 0.1864
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.2208 0.2208
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.124 0.1864
Schistosoma mansoni hypothetical protein 0.0033 0.124 0.1864
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.124 0.1864
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.124 0.1864
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0051 0.0077
Echinococcus granulosus fmrfamide receptor 0.0033 0.124 0.1864
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.124 0.1864
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.124 0.1864
Onchocerca volvulus 0.0033 0.124 0.1195
Brugia malayi Serotonin receptor 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.02 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.124 0.1864
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.124 0.1864
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.124 0.1864
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0051 0.0077
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.6653 0.6653
Schistosoma mansoni hypothetical protein 0.0051 0.2208 0.3318
Echinococcus multilocularis g protein coupled receptor 0.0033 0.124 0.1864
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.124 0.1864
Onchocerca volvulus 0.0033 0.124 0.1195
Schistosoma mansoni hypothetical protein 0.0033 0.124 0.1864
Brugia malayi MH2 domain containing protein 0.013 0.6345 0.6345
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.124 0.1864
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus hypothetical protein 0.0033 0.124 0.1864
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.124 0.124
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.124 0.124
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi RNA binding protein 0.0136 0.6653 0.6653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.124 0.1864
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.124 0.124
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0051 0.0077
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.124 0.124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.124 0.1864
Echinococcus granulosus sex peptide receptor 0.0033 0.124 0.1864
Onchocerca volvulus 0.0033 0.124 0.1195
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.6345 0.6345
Echinococcus multilocularis serotonin receptor 0.0033 0.124 0.1864
Brugia malayi TAR-binding protein 0.0136 0.6653 0.6653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.124 0.1864
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.124 0.124
Brugia malayi Latrophilin receptor protein 2 0.0051 0.2208 0.2208
Brugia malayi hypothetical protein 0.001 0.0051 0.0051
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0051 0.0077
Loa Loa (eye worm) hypothetical protein 0.011 0.5308 0.5308
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Brugia malayi Dopamine receptor protein 1 0.0033 0.124 0.124
Echinococcus multilocularis neuropeptide s receptor 0.0033 0.124 0.1864
Echinococcus granulosus neuropeptide s receptor 0.0033 0.124 0.1864
Echinococcus granulosus orexin receptor type 2 0.0033 0.124 0.1864
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0051 0.0077
Brugia malayi neuropeptide F receptor 0.0033 0.124 0.124
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.124 0.1864
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.124 0.1864
Loa Loa (eye worm) RNA binding protein 0.0136 0.6653 0.6653
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0051 0.0051
Brugia malayi Serotonin receptor 0.0033 0.124 0.124
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.124 0.1864
Brugia malayi DIX domain containing protein 0.001 0.0051 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.124 0.1864
Schistosoma mansoni neuropeptide receptor 0.0033 0.124 0.1864
Schistosoma mansoni amine GPCR 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi AKH receptor 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.124 0.1864
Brugia malayi GnHR receptor homolog 0.0033 0.124 0.124
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.124 0.1864
Schistosoma mansoni histamine h1 receptor 0.0033 0.124 0.1864
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.124 0.124
Loa Loa (eye worm) TAR-binding protein 0.0136 0.6653 0.6653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Onchocerca volvulus 0.0033 0.124 0.1195
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.124 0.1864
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.124 0.1864
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Onchocerca volvulus 0.0033 0.124 0.1195
Brugia malayi ORL1-like opioid receptor 0.0033 0.124 0.124
Echinococcus multilocularis orexin receptor type 2 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.124 0.1864
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.124 0.1864
Onchocerca volvulus 0.0033 0.124 0.1195
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Schistosoma mansoni adenoreceptor 0.0033 0.124 0.1864
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.124 0.1864
Echinococcus granulosus neuropeptide receptor 0.0033 0.124 0.1864
Echinococcus granulosus allatostatin A receptor 0.0033 0.124 0.1864
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.124 0.1864
Schistosoma mansoni neuropeptide receptor 0.0033 0.124 0.1864
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.124 0.1864
Schistosoma mansoni hypothetical protein 0.0051 0.2208 0.3318
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Schistosoma mansoni hypothetical protein 0.011 0.5308 0.7979
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.124 0.1864
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0051 0.0077
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.124 0.1864
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.124 0.1864
Schistosoma mansoni tar DNA-binding protein 0.0136 0.6653 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis sex peptide receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.124 0.1864
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0051 0.0077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.124 0.1864
Brugia malayi sulfakinin receptor protein 0.0033 0.124 0.124
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.124 0.1864
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.124 0.1864
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.6653 0.6653
Schistosoma mansoni tar DNA-binding protein 0.0136 0.6653 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.798 0.798
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus granulosus somatostatin receptor 0.0033 0.124 0.1864
Onchocerca volvulus 0.0033 0.124 0.1195
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Brugia malayi Dopamine receptor protein 2 0.0033 0.124 0.124
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0051 0.0077
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Onchocerca volvulus 0.0033 0.124 0.1195
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.124 0.1864
Echinococcus multilocularis fmrfamide receptor 0.0033 0.124 0.1864
Echinococcus granulosus serotonin receptor 0.0033 0.124 0.1864
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.124 0.1864
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.124 0.124
Brugia malayi hypothetical protein 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Schistosoma mansoni regulator of G protein signaling 0.001 0.0051 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.124 0.1864
Echinococcus granulosus g-protein coupled receptor 0.0033 0.124 0.1864
Brugia malayi neuropeptide F receptor 0.0033 0.124 0.124
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.124 0.1864
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0051 0.0077
Onchocerca volvulus 0.0033 0.124 0.1195
Brugia malayi Dopamine receptor 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0033 0.124 0.124
Echinococcus multilocularis neuropeptide receptor 0.0033 0.124 0.1864
Schistosoma mansoni dishevelled 0.001 0.0051 0.0077
Onchocerca volvulus 0.0033 0.124 0.1195
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.2208 0.3318
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0051 0.2208 0.2208
Schistosoma mansoni opsin-like receptor 0.0033 0.124 0.1864
Echinococcus multilocularis g protein coupled receptor 0.0033 0.124 0.1864
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0051 0.0077
Brugia malayi G protein-coupled receptor 0.0033 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.0051
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.124 0.1864

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 580 nM Tested in vitro for inhibition of Serotonin uptake ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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