Detailed information for compound 1438742

Basic information

Technical information
  • TDR Targets ID: 1438742
  • Name: 2-[(4-bromophenyl)methyl]-5-(4-methylsulfanyl phenyl)tetrazole
  • MW: 361.26 | Formula: C15H13BrN4S
  • H donors: 0 H acceptors: 3 LogP: 4.58 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)c1nnn(n1)Cc1ccc(cc1)Br
  • InChi: 1S/C15H13BrN4S/c1-21-14-8-4-12(5-9-14)15-17-19-20(18-15)10-11-2-6-13(16)7-3-11/h2-9H,10H2,1H3
  • InChiKey: FLGIGRSQYVQARZ-UHFFFAOYSA-N  


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Synonyms

  • 2-[(4-bromophenyl)methyl]-5-[4-(methylthio)phenyl]tetrazole
  • 2-(4-bromobenzyl)-5-[4-(methylthio)phenyl]tetrazole
  • 2-[(4-bromophenyl)methyl]-5-(4-methylsulfanylphenyl)-1,2,3,4-tetrazole
  • ZINC01115891
  • 2-(4-bromobenzyl)-5-[4-(methylthio)phenyl]-2H-tetrazole
  • MLS000535003
  • SMR000142439

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica aldose reductase, putative 0.0219 0.778 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0219 0.778 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0219 0.778 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.1218 0.0903
Brugia malayi hypothetical protein 0.003 0.0707 0.0909
Loa Loa (eye worm) hypothetical protein 0.0043 0.1218 0.1565
Brugia malayi Animal haem peroxidase family protein 0.003 0.0707 0.0909
Loa Loa (eye worm) hypothetical protein 0.0029 0.0661 0.085
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0368 0.0473
Trichomonas vaginalis aldo/keto reductase, putative 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0368 0.0473
Loa Loa (eye worm) oxidoreductase 0.0219 0.778 1
Echinococcus granulosus peroxidasin 0.003 0.0707 0.0909
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0661 0.0367
Echinococcus multilocularis peroxidasin 0.003 0.0707 0.0909
Trypanosoma cruzi aldo/keto reductase, putative 0.0219 0.778 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0219 0.778 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0219 0.778 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0219 0.778 1
Schistosoma mansoni potassium channel beta 0.0219 0.778 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0661 0.085
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0368 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0368 0.0473
Leishmania major aldo-keto reductase-like protein 0.0219 0.778 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1218 0.112
Entamoeba histolytica alcohol dehydrogenase, putative 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Loa Loa (eye worm) oxidoreductase 0.0219 0.778 1
Onchocerca volvulus 0.003 0.0707 0.0458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0368 0.0473
Onchocerca volvulus 0.0029 0.0661 0.0395
Trichomonas vaginalis aldo/keto reductase, putative 0.0219 0.778 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.1218 0.112
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0219 0.778 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0368 0.0473
Loa Loa (eye worm) oxidoreductase 0.0219 0.778 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1658 0.2132
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0368 0.0473
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0368 0.0473
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0219 0.778 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.1218 0.0903
Entamoeba histolytica aldose reductase, putative 0.0219 0.778 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0368 0.0473
Mycobacterium tuberculosis Conserved protein 0.0219 0.778 0.77
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0368 0.0473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0368 0.0473
Brugia malayi ecdysteroid receptor 0.0021 0.0368 0.0473
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0368 0.0473
Onchocerca volvulus Peroxidase homolog 0.003 0.0707 0.0458
Onchocerca volvulus Chorion peroxidase homolog 0.003 0.0707 0.0458
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0219 0.778 1
Brugia malayi steroid hormone receptor 0.0021 0.0368 0.0473
Loa Loa (eye worm) hypothetical protein 0.0043 0.1218 0.1565
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0368 0.0473
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0368 0.0473
Mycobacterium tuberculosis Conserved protein 0.0043 0.1218 0.0903
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.1218 0.0903
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0368 0.0473
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.0501
Mycobacterium ulcerans hypothetical protein 0.0029 0.0661 0.0367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1658 0.2132
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0368 0.0473
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0368 0.0473
Brugia malayi NADH-dependent xylose reductase 0.0219 0.778 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0219 0.778 1
Brugia malayi nuclear hormone receptor 0.0021 0.0368 0.0473
Loa Loa (eye worm) beta-lactamase 0.0043 0.1218 0.1565
Echinococcus multilocularis aldo keto reductase 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0661 0.085
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0707 0.0909
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0368 0.0473
Schistosoma mansoni pol-related 0.0219 0.778 1
Mycobacterium ulcerans hypothetical protein 0.0219 0.778 1
Onchocerca volvulus 0.0043 0.1218 0.1146
Onchocerca volvulus Peroxidasin homolog 0.003 0.0707 0.0458
Schistosoma mansoni peroxidasin 0.003 0.0707 0.0909
Loa Loa (eye worm) hypothetical protein 0.0043 0.1218 0.1565
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0219 0.778 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0661 0.0367
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0219 0.778 1
Entamoeba histolytica aldose reductase, putative 0.0219 0.778 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0219 0.778 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0368 0.0473
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Brugia malayi beta-lactamase family protein 0.0043 0.1218 0.1565
Plasmodium vivax aldehyde reductase, putative 0.0219 0.778 1
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.1218 0.0903
Toxoplasma gondii aldo-keto reductase 0.0219 0.778 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1658 0.2132
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.0501
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0368 0.0473
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0368 0.0473
Echinococcus granulosus aldo keto reductase 0.0219 0.778 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0661 0.0367
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0368 0.0473
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.0501
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0368 0.0473
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0219 0.778 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0368 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0368 0.0473
Trypanosoma brucei aldo/keto reductase, putative 0.0219 0.778 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0368 0.0473
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0661 0.085
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Echinococcus multilocularis voltage gated potassium channel subunit 0.0219 0.778 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0219 0.778 1
Onchocerca volvulus 0.0043 0.1218 0.1146
Loa Loa (eye worm) hypothetical protein 0.0043 0.1218 0.1565
Schistosoma mansoni aldo-keto reductase 0.0219 0.778 1
Echinococcus multilocularis aldo keto reductase 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0368 0.0473
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.1218 0.0903
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0368 0.0473
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0707 0.0909
Onchocerca volvulus 0.0219 0.778 1
Onchocerca volvulus 0.0219 0.778 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1658 0.2132
Trypanosoma cruzi aldo-keto reductase 0.0219 0.778 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0368 0.0473
Onchocerca volvulus 0.003 0.0707 0.0458
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0368 0.0473
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0368 0.0473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0368 0.0473
Trypanosoma cruzi aldo/keto reductase, putative 0.0219 0.778 1
Giardia lamblia Aldose reductase 0.0219 0.778 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0661 0.085
Onchocerca volvulus Peroxidasin homolog 0.003 0.0707 0.0458
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0368 0.0473
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0368 0.0473
Loa Loa (eye worm) hypothetical protein 0.0021 0.0368 0.0473
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1218 0.1565
Trypanosoma brucei prostaglandin f synthase 0.0219 0.778 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0661 0.0326
Brugia malayi Peroxidasin 0.003 0.0707 0.0909
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0661 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.778 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0368 0.0473
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0368 0.0473
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0368 0.0473
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.1218 0.112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0368 0.0473
Echinococcus multilocularis aldo keto reductase 0.0219 0.778 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.1218 0.112
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0219 0.778 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.1218 0.0782
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0368 0.0473
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Onchocerca volvulus 0.0219 0.778 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0219 0.778 1
Mycobacterium leprae Probable lipase LipE 0.0043 0.1218 0.0782
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.1218 0.0903
Loa Loa (eye worm) oxidoreductase 0.0219 0.778 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0368 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0368 0.0473
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0219 0.778 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0368 0.0473
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0368 0.0473
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.0501
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0661 0.0326
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1218 0.1565
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Loa Loa (eye worm) oxidoreductase 0.0219 0.778 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0219 0.778 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1218 0.1565
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0707 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0368 0.0473
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Trypanosoma brucei aldo-keto reductase, putative 0.0219 0.778 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0368 0.0473
Leishmania major prostaglandin f synthase, putative 0.0219 0.778 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0219 0.778 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0661 0.0367
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0661 0.0367
Mycobacterium tuberculosis Conserved protein 0.0043 0.1218 0.0903
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Echinococcus granulosus hypothetical protein 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.039 0.0501
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Toxoplasma gondii aldose reductase, putative 0.0219 0.778 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0219 0.778 0.77
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1658 0.2132
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0368 0.0473
Brugia malayi beta-lactamase family protein 0.0043 0.1218 0.1565
Echinococcus granulosus aldo keto reductase 0.0219 0.778 1
Giardia lamblia Aldose reductase 0.0219 0.778 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0368 0.0473
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0368 0.0473
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1218 0.1565
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Brugia malayi beta-lactamase 0.0043 0.1218 0.1565
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1218 0.1565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0368 0.0473
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Schistosoma mansoni aldo-keto reductase 0.0219 0.778 1
Mycobacterium leprae Possible oxidoreductase 0.0219 0.778 1
Brugia malayi Animal haem peroxidase family protein 0.003 0.0707 0.0909
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.1218 0.0903
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1218 0.1565
Mycobacterium ulcerans lipase LipD 0.0043 0.1218 0.112
Onchocerca volvulus 0.0219 0.778 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Plasmodium falciparum aldehyde reductase, putative 0.0219 0.778 1
Loa Loa (eye worm) animal heme peroxidase 0.003 0.0707 0.0909
Mycobacterium ulcerans hypothetical protein 0.0043 0.1218 0.112
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0661 0.085
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0368 0.0473
Brugia malayi Animal haem peroxidase family protein 0.003 0.0707 0.0909
Loa Loa (eye worm) hypothetical protein 0.0219 0.778 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0368 0.0473
Brugia malayi nuclear receptor NHR-88 0.0021 0.0368 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1658 0.2132
Schistosoma mansoni peroxidasin 0.003 0.0707 0.0909
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0219 0.778 1
Schistosoma mansoni coup transcription factor 0.0021 0.0368 0.0473
Loa Loa (eye worm) blistered cuticle protein 3 0.003 0.0707 0.0909
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0219 0.778 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.039 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0661 0.0367
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.039 0.5
Brugia malayi Animal haem peroxidase family protein 0.003 0.0707 0.0909
Brugia malayi Animal haem peroxidase family protein 0.003 0.0707 0.0909
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0368 0.0473
Brugia malayi Blistered cuticle protein 3 0.003 0.0707 0.0909
Onchocerca volvulus 0.0219 0.778 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0368 0.0473
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1658 0.2132
Loa Loa (eye worm) hypothetical protein 0.0043 0.1218 0.1565
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0368 0.0473
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0368 0.0473
Onchocerca volvulus Peroxidase homolog 0.003 0.0707 0.0458
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Onchocerca volvulus 0.003 0.0707 0.0458
Loa Loa (eye worm) hypothetical protein 0.0021 0.0368 0.0473
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0219 0.778 1
Leishmania major hypothetical protein, conserved 0.0043 0.1218 0.0782
Loa Loa (eye worm) hypothetical protein 0.003 0.0707 0.0909
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1658 0.2132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0368 0.0473
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.1218 0.0903
Onchocerca volvulus Dual oxidase homolog 0.003 0.0707 0.0458
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0219 0.778 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0219 0.778 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0219 0.778 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0368 0.0473
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0219 0.778 1
Onchocerca volvulus 0.0043 0.1218 0.1146
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0219 0.778 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0219 0.778 1
Echinococcus multilocularis aldo keto reductase 0.0219 0.778 1
Plasmodium falciparum aldo-keto reductase, putative 0.0219 0.778 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0368 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1658 0.2132
Onchocerca volvulus 0.0219 0.778 1
Mycobacterium ulcerans oxidoreductase 0.0219 0.778 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0368 0.0473
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.778 1
Echinococcus granulosus aldo keto reductase 0.0219 0.778 1
Onchocerca volvulus 0.0219 0.778 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1218 0.1565
Loa Loa (eye worm) hypothetical protein 0.0021 0.0368 0.0473

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5104 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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