Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | steroid hormone receptor | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0025 | 0.02 |
Schistosoma mansoni | nuclear hormone receptor | 0.0034 | 0.0319 | 0.2315 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0024 | 0.0142 | 0.1028 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0084 | 0.1237 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0034 | 0.0319 | 0.2315 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0025 | 0.02 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0034 | 0.0319 | 0.2315 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0025 | 0.02 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0034 | 0.0319 | 0.2315 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0319 | 0.258 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0024 | 0.0142 | 0.1145 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0025 | 0.02 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0025 | 0.02 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0034 | 0.0319 | 0.2315 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0034 | 0.0319 | 0.258 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0024 | 0.0142 | 0.1145 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0084 | 0.1237 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0319 | 0.258 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0034 | 0.0319 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0034 | 0.0319 | 0.258 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0079 | 0.1135 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0034 | 0.0319 | 0.258 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0563 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 0.0319 | 0.258 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0034 | 0.0319 | 0.258 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0018 | 0.0025 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0034 | 0.0319 | 0.2315 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1033 | 0.8354 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0018 | 0.0025 | 0.02 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | ecdysteroid receptor | 0.0034 | 0.0319 | 0.258 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0034 | 0.0319 | 0.2315 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0034 | 0.0319 | 0.2315 |
Echinococcus granulosus | FTZ F1 alpha | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0034 | 0.0319 | 0.2315 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0034 | 0.0319 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0018 | 0.0025 | 0.02 |
Schistosoma mansoni | coup transcription factor | 0.0034 | 0.0319 | 0.2315 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0025 | 0.02 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0092 | 0.1378 | 1 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0563 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 0.0319 | 0.5 | |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0554 | 0.985 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0018 | 0.0025 | 0.02 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0034 | 0.0319 | 0.258 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.0025 | 0.02 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0034 | 0.0319 | 0.258 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0319 | 0.258 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0034 | 0.0319 | 0.258 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0018 | 0.0025 | 0.02 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0024 | 0.0142 | 0.1145 |
Echinococcus granulosus | voltage gated potassium channel | 0.0024 | 0.0142 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0024 | 0.0142 | 0.1028 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0092 | 0.1378 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0034 | 0.0319 | 0.258 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0563 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0079 | 0.1135 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0034 | 0.0319 | 0.2315 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | nuclear receptor NHR-88 | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 0.0319 | 0.258 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.0025 | 0.02 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0084 | 0.1237 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0142 | 0.1145 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0034 | 0.0319 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0034 | 0.0319 | 0.2315 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0084 | 0.1237 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0024 | 0.0142 | 0.1145 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0034 | 0.0319 | 0.258 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0018 | 0.0025 | 0.0179 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0319 | 0.258 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0034 | 0.0319 | 0.258 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0025 | 0.02 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 0.0319 | 0.2315 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = 38 % | Inactivation process of guinea pig cardiac Na channels expressed in xenopus oocytes was determined by measuring increase in current integral in presence of compound versus control at 10 uM | ChEMBL. | 7629798 |
Change (functional) | = 38 % | Inactivation process of guinea pig cardiac Na channels expressed in xenopus oocytes was determined by measuring increase in current integral in presence of compound versus control at 10 uM | ChEMBL. | 7629798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.