Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0047 | 0.0073 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0278 | 0.2987 | 0.2935 |
Echinococcus granulosus | acetylcholinesterase | 0.0278 | 0.2987 | 0.2935 |
Schistosoma mansoni | acetylcholinesterase | 0.0047 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0073 | 0.0244 |
Echinococcus granulosus | carboxylesterase 5A | 0.0278 | 0.2987 | 0.2935 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0047 | 0.0073 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0047 | 0.0073 | 0.0073 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.024 | 0.0805 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0073 | 0.0073 |
Brugia malayi | Carboxylesterase family protein | 0.0278 | 0.2987 | 1 |
Onchocerca volvulus | 0.0047 | 0.0073 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0278 | 0.2987 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.2987 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0278 | 0.2987 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.2987 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0278 | 0.2987 | 0.2935 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0073 | 0.0244 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0278 | 0.2987 | 0.2987 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0073 | 0.0073 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0278 | 0.2987 | 0.2935 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0047 | 0.0073 | 0.0073 |
Onchocerca volvulus | 0.0047 | 0.0073 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0073 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0073 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0073 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0073 | 0.0244 |
Schistosoma mansoni | gliotactin | 0.0047 | 0.0073 | 0.0073 |
Echinococcus multilocularis | acetylcholinesterase | 0.0278 | 0.2987 | 0.2935 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0047 | 0.0073 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0073 | 0.0244 |
Onchocerca volvulus | 0.0047 | 0.0073 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0073 | 0.0244 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0278 | 0.2987 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0073 | 0.0244 |
Onchocerca volvulus | 0.0047 | 0.0073 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0047 | 0.0073 | 0.0073 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0047 | 0.0073 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0073 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0073 | 0.0244 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.024 | 0.0805 |
Brugia malayi | Carboxylesterase family protein | 0.0047 | 0.0073 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.024 | 0.0805 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0047 | 0.0073 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0047 | 0.0073 | 0.0244 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0047 | 0.0073 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.024 | 0.0805 |
Onchocerca volvulus | 0.0047 | 0.0073 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0047 | 0.0073 | 0.0244 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.