TDR Targets

Basic information

Technical information

TDR Targets ID: 1439210
Name: (5-ethyl-4-methylthiophen-2-yl)-[4-(4-fluorop henyl)piperazin-1-yl]methanone
MW: 332.436 | Formula: C18H21FN2OS
H donors: 0 H acceptors: 1 LogP: 4.29 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCc1sc(cc1C)C(=O)N1CCN(CC1)c1ccc(cc1)F
InChi: 1S/C18H21FN2OS/c1-3-16-13(2)12-17(23-16)18(22)21-10-8-20(9-11-21)15-6-4-14(19)5-7-15/h4-7,12H,3,8-11H2,1-2H3
InChiKey: IVWZUWZOGJNSIU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5-ethyl-4-methyl-2-thienyl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone
(5-ethyl-4-methyl-2-thienyl)-[4-(4-fluorophenyl)-1-piperazinyl]methanone
(5-ethyl-4-methyl-thiophen-2-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone
ZINC03486908
T5332621

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	TAR-binding protein	0.0076	0.0749	0.1558
Trichomonas vaginalis	glutaminase, putative	0.0266	0.3483	0.8552
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0498	0.0408
Brugia malayi	hypothetical protein	0.0147	0.1767	0.3678
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0098	0.1063	0.2265
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0304	0.4031	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0408	0.085
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0098	0.1063	0.0979
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0102	0.1118	0.1804
Echinococcus multilocularis	carbonic anhydrase	0.0168	0.2069	0.1994
Echinococcus granulosus	carbonic anhydrase	0.0168	0.2069	0.2007
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0244	0.1181
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0883	0.1838
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.0234	0.0158
Trypanosoma brucei	polo-like protein kinase	0.0098	0.1063	0.2214
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0498	0.2409
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.0421	0.033
Onchocerca volvulus		0.0147	0.1767	0.5386
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.1063	0.2214
Brugia malayi	mbt repeat family protein	0.0046	0.0316	0.0657
Mycobacterium tuberculosis	Probable dehydrogenase	0.0092	0.097	0.0823
Echinococcus granulosus	carbonic anhydrase	0.0168	0.2069	0.2007
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0102	0.1118	0.0987
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0244	0.0264
Trypanosoma cruzi	polo-like protein kinase, putative	0.0098	0.1063	0.2214
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0667	0.9259	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0408	0.0333
Schistosoma mansoni	kinase	0.005	0.0366	0.0275
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0749	0.0661
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.4031	1
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0183	0.2284	0.2224
Trypanosoma brucei	trypanothione reductase	0.004	0.0226	0.0471
Schistosoma mansoni	lipoxygenase	0.0054	0.0421	0.033
Plasmodium vivax	SET domain protein, putative	0.0031	0.0094	0.0102
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0098	0.1063	0.2214
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.1624	0.1558
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0149	0.1788	0.1729
Brugia malayi	glutaminase DH11.1	0.0266	0.3483	0.725
Loa Loa (eye worm)	hypothetical protein	0.0168	0.2069	0.4307
Giardia lamblia	Kinase, PLK	0.0098	0.1063	0.2265
Loa Loa (eye worm)	glutaminase	0.0266	0.3483	0.725
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0168	0.2069	0.4307
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.0667	0.9259	1
Loa Loa (eye worm)	glutaminase 2	0.0266	0.3483	0.725
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0667	0.9259	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.1063	0.2163
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0358	0.4804	1
Loa Loa (eye worm)	acetyltransferase	0.0141	0.1681	0.3498
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0883	0.1838
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.1063	0.2163
Echinococcus granulosus	geminin	0.0377	0.5082	0.5044
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0749	0.0661
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0348	0.0273
Treponema pallidum	fructose-bisphosphate aldolase	0.0304	0.4031	0.5
Echinococcus multilocularis	carbonic anhydrase	0.0168	0.2069	0.1994
Schistosoma mansoni	carbonic anhydrase-related	0.0168	0.2069	0.1994
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.0226	0.0471
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0149	0.1788	1
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.0667	0.9259	1
Brugia malayi	mbt repeat family protein	0.0046	0.0316	0.0657
Trypanosoma brucei	carbonic anhydrase-like protein	0.0358	0.4804	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0358	0.4804	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0408	0.0317
Schistosoma mansoni	carbonic anhydrase-related	0.0168	0.2069	0.1994
Onchocerca volvulus		0.0247	0.32	1
Entamoeba histolytica	fatty acid elongase, putative	0.0087	0.0895	0.1824
Trichomonas vaginalis	set domain proteins, putative	0.0247	0.32	0.7805
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0168	0.2069	0.4307
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0408	0.085
Brugia malayi	Thioredoxin reductase	0.004	0.0226	0.0471
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0498	0.0408
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0358	0.4804	1
Leishmania major	trypanothione reductase	0.004	0.0226	0.0471
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0098	0.1063	0.3121
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0498	0.0408
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0316	0.0224
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0358	0.4804	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0098	0.1063	0.2214
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1767	0.3678
Echinococcus granulosus	carbonic anhydrase	0.0168	0.2069	0.2007
Leishmania major	carbonic anhydrase-like protein	0.0358	0.4804	1
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.0667	0.9259	1
Schistosoma mansoni	carbonic anhydrase-related	0.0168	0.2069	0.1994
Echinococcus multilocularis	microtubule associated protein 2	0.0718	1	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.2769	0.5763
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.1063	0.2163
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0408	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0316	0.0657
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.1063	0.0979
Brugia malayi	Pre-SET motif family protein	0.0217	0.2769	0.5763
Brugia malayi	glutathione reductase	0.004	0.0226	0.0471
Entamoeba histolytica	fatty acid elongase, putative	0.0087	0.0895	0.1824
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0749	0.0661
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0498	0.0301
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0092	0.097	0.0823
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0749	0.0661
Schistosoma mansoni	microtubule-associated protein tau	0.0718	1	1
Entamoeba histolytica	fatty acid elongase, putative	0.0087	0.0895	0.1824
Loa Loa (eye worm)	carbonic anhydrase 3	0.0358	0.4804	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.4031	1
Schistosoma mansoni	eyes absent homolog	0.0086	0.0883	0.0796
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0092	0.097	0.0823
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0316	0.0224
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0749	0.1558
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.4031	1
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.0226	0.0471
Schistosoma mansoni	hypothetical protein	0.0282	0.3716	0.3656
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0094	0.0455
Echinococcus multilocularis	carbonic anhydrase II	0.0358	0.4804	0.4755
Mycobacterium tuberculosis	Probable reductase	0.0092	0.097	0.0823
Entamoeba histolytica	fatty acid elongase, putative	0.0087	0.0895	0.1824
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0244	0.1181
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0408	0.0333
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0498	0.1038
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0749	0.0676
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0749	0.0661
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0168	0.2069	0.4307
Schistosoma mansoni	carbonic anhydrase	0.0168	0.2069	0.1994
Toxoplasma gondii	hypothetical protein	0.0168	0.2069	1
Loa Loa (eye worm)	hypothetical protein	0.0168	0.2069	0.4307
Mycobacterium tuberculosis	Probable oxidoreductase	0.0102	0.1118	0.0987
Brugia malayi	serine/threonine-protein kinase plk-2	0.0098	0.1063	0.2214
Plasmodium falciparum	glutathione reductase	0.004	0.0226	0.0245
Loa Loa (eye worm)	glutathione reductase	0.004	0.0226	0.0471
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.4031	1
Entamoeba histolytica	fatty acid elongase, putative	0.0087	0.0895	0.1824
Giardia lamblia	Fructose-bisphosphate aldolase	0.0304	0.4031	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.0234	0.0141
Toxoplasma gondii	thioredoxin reductase	0.004	0.0226	0.1094
Schistosoma mansoni	glutaminase	0.0266	0.3483	0.3421
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0316	0.024
Plasmodium vivax	glutathione reductase, putative	0.004	0.0226	0.0245
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0358	0.4804	0.4755
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.0226	0.0245
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0316	0.024
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.1063	0.2163
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.1063	0.2163
Schistosoma mansoni	hypothetical protein	0.0168	0.2069	0.1994
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0348	0.0273
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0168	0.2069	0.4307
Plasmodium falciparum	thioredoxin reductase	0.004	0.0226	0.0245
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0316	0.0224
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0168	0.2069	0.4307
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0749	0.0661
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0667	0.9259	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0244	0.0168
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0358	0.4804	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0304	0.4031	1
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.0667	0.9259	1
Schistosoma mansoni	hypothetical protein	0.0377	0.5082	0.5035
Mycobacterium ulcerans	glutaminase	0.0266	0.3483	0.3407
Onchocerca volvulus		0.0046	0.0316	0.0713
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0749	0.1558
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.4031	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0092	0.097	0.0823
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.1681	0.1602
Brugia malayi	RNA binding protein	0.0076	0.0749	0.1558
Loa Loa (eye worm)	hypothetical protein	0.0168	0.2069	0.4307
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.1681	0.1602
Echinococcus multilocularis	carbonic anhydrase	0.0168	0.2069	0.1994
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.1681	0.3498
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.4031	1
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0749	0.1558
Brugia malayi	hypothetical protein	0.0086	0.0883	0.1838
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0749	0.1558
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.0421	0.0346
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.1063	0.2163
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.1063	0.2163
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0092	0.097	0.0823
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0316	0.0657
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0316	0.0224
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0408	0.0317
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0094	0.0017
Brugia malayi	Pre-SET motif family protein	0.0031	0.0094	0.0196
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.4031	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0316	0.0224
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0358	0.4804	0.4755
Echinococcus granulosus	carbonic anhydrase II	0.0358	0.4804	0.4764
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0316	0.0713
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0098	0.1063	0.0994
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0149	0.1788	0.1472
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.4031	1
Echinococcus multilocularis	geminin	0.0377	0.5082	0.5035
Loa Loa (eye worm)	MBCTL1	0.0053	0.0408	0.085
Schistosoma mansoni	hypothetical protein	0.0377	0.5082	0.5035
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0195	0.021
Chlamydia trachomatis	oxoacyl-ACP synthase III	0.0667	0.9259	0.5
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0102	0.1118	0.0987
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0168	0.2069	0.4307
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0498	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0094	0.0196
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0183	0.2284	0.2211
Plasmodium falciparum	carbonic anhydrase	0.0168	0.2069	0.2235

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.2387 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1602096

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1439210