Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0611 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Echinococcus granulosus | FTZ F1 alpha | 0.0152 | 0.4981 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0152 | 0.4981 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0072 | 0.1652 | 0.2451 |
Schistosoma mansoni | zinc finger protein | 0.0072 | 0.1652 | 0.3317 |
Brugia malayi | tailless protein | 0.0072 | 0.1652 | 0.2451 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0152 | 0.4981 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0152 | 0.4981 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0152 | 0.4981 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0152 | 0.4981 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0088 | 0.2325 | 0.4384 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0072 | 0.1652 | 0.2962 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4981 | 0.7389 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0072 | 0.1652 | 0.2962 |
Brugia malayi | ecdysteroid receptor | 0.0152 | 0.4981 | 0.7389 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0134 | 0.421 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0072 | 0.1652 | 0.2451 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0072 | 0.1652 | 0.3317 |
Brugia malayi | nuclear hormone receptor | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | ecdysone receptor | 0.0072 | 0.1652 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | nuclear receptor NHR-67 | 0.0072 | 0.1652 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.008 | 0.2009 | 0.298 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2009 | 0.298 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0152 | 0.4981 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0152 | 0.4981 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2009 | 0.298 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2009 | 0.298 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0072 | 0.1652 | 0.2962 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0152 | 0.4981 | 0.7389 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0152 | 0.4981 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0273 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0088 | 0.2325 | 0.3449 |
Brugia malayi | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2009 | 0.298 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.008 | 0.2009 | 0.298 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.008 | 0.2009 | 0.4033 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0088 | 0.2325 | 0.4667 |
Brugia malayi | hypothetical protein | 0.008 | 0.2009 | 0.298 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0144 | 0.4656 | 0.9313 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0088 | 0.2325 | 0.4384 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0072 | 0.1652 | 0.2962 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0152 | 0.4981 | 0.7389 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0152 | 0.4981 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0072 | 0.1652 | 0.3317 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0152 | 0.4981 | 0.7389 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0273 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0072 | 0.1652 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4981 | 0.7389 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0152 | 0.4981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0152 | 0.4981 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0152 | 0.4981 | 0.7389 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0072 | 0.1652 | 0.2962 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0072 | 0.1652 | 0.2962 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.008 | 0.2009 | 0.3716 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0134 | 0.421 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0152 | 0.4981 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0047 | 0.0611 | 0.0906 |
Brugia malayi | hypothetical protein | 0.008 | 0.2009 | 0.298 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0072 | 0.1652 | 0.2962 |
Brugia malayi | jmjC domain containing protein | 0.0088 | 0.2325 | 0.3449 |
Brugia malayi | jmjC domain containing protein | 0.0144 | 0.4656 | 0.6908 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0152 | 0.4981 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0152 | 0.4981 | 0.7389 |
Schistosoma mansoni | nuclear receptor | 0.0072 | 0.1652 | 0.3317 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0047 | 0.0611 | 0.0906 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0152 | 0.4981 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0072 | 0.1652 | 0.2962 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | nuclear hormone receptor | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0047 | 0.0611 | 0.0906 |
Schistosoma mansoni | jumonji domain containing protein | 0.0126 | 0.3896 | 0.7822 |
Schistosoma mansoni | nuclear hormone receptor | 0.0072 | 0.1652 | 0.3317 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0152 | 0.4981 | 1 |
Brugia malayi | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0072 | 0.1652 | 0.2962 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0152 | 0.4981 | 0.5367 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0195 | 0.6741 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0056 | 0.1012 | 0.1501 |
Schistosoma mansoni | thyroid hormone receptor | 0.0152 | 0.4981 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | steroid hormone receptor | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | nuclear receptor NHR-88 | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0072 | 0.1652 | 0.2451 |
Onchocerca volvulus | 0.0152 | 0.4981 | 0.5367 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0152 | 0.4981 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0152 | 0.4981 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0152 | 0.4981 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0072 | 0.1652 | 0.3317 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0152 | 0.4981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Loa Loa (eye worm) | DR-78 | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | Pre-SET motif family protein | 0.0195 | 0.6741 | 1 |
Onchocerca volvulus | 0.0222 | 0.7854 | 1 | |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0144 | 0.4656 | 0.9313 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0152 | 0.4981 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0072 | 0.1652 | 0.3317 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0273 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0273 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0152 | 0.4981 | 0.7389 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0152 | 0.4981 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0152 | 0.4981 | 0.7389 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0273 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0152 | 0.4981 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0152 | 0.4981 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0152 | 0.4981 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0152 | 0.4981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0152 | 0.4981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1223 | 0.1815 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0072 | 0.1652 | 0.2962 |
Schistosoma mansoni | nuclear hormone receptor | 0.0152 | 0.4981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4981 | 0.7389 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0152 | 0.4981 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.008 | 0.2009 | 0.3716 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0152 | 0.4981 | 0.7389 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.008 | 0.2009 | 0.4033 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0152 | 0.4981 | 0.5367 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0072 | 0.1652 | 0.2962 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0072 | 0.1652 | 0.2451 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0152 | 0.4981 | 0.7389 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0152 | 0.4981 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0072 | 0.1652 | 0.2451 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0134 | 0.421 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1652 | 0.2451 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4981 | 0.7389 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.2009 | 0.298 |
Schistosoma mansoni | nuclear hormone receptor | 0.0072 | 0.1652 | 0.3317 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0152 | 0.4981 | 0.5367 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0273 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.008 | 0.2009 | 0.298 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0088 | 0.2325 | 0.4667 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4981 | 0.7389 |
Brugia malayi | nuclear receptor RXR | 0.008 | 0.2009 | 0.298 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0072 | 0.1652 | 0.2962 |
Brugia malayi | conserved hypotetical protein | 0.0072 | 0.1652 | 0.2451 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0273 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0273 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0273 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0273 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 53 % | Percentage inhibition in mouse by using Croton oil-inflamed mouse ear test (topical dosing). | ChEMBL. | 8410971 |
Inhibition (functional) | = 53 % | Percentage inhibition in mouse by using Croton oil-inflamed mouse ear test (topical dosing). | ChEMBL. | 8410971 |
Latency (functional) | = 12 | Latency time measured by mouse hot plate test after subcutaneous administration at 200 mg/kg | ChEMBL. | 8410971 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.