Detailed information for compound 1439384

Basic information

Technical information
  • TDR Targets ID: 1439384
  • Name: MLS000064462
  • MW: 388.484 | Formula: C19H24N4O3S
  • H donors: 0 H acceptors: 3 LogP: 1.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(S(=O)(=O)N1CCN(CC1)C(=O)N(c1ccccc1)c1ccccc1)C
  • InChi: 1S/C19H24N4O3S/c1-20(2)27(25,26)22-15-13-21(14-16-22)19(24)23(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12H,13-16H2,1-2H3
  • InChiKey: YDLWDALWXVZVIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • SMR000078207
  • ZINC01126054
  • 4-[(dimethylamino)sulfonyl]-N,N-diphenyl-1-piperazinecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus flap endonuclease 1 0.0027 0.0045 0.0045
Echinococcus granulosus nuclear receptor nhr 48 0.0053 0.0211 0.0211
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0113 0.0594 0.0594
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0594 0.0594
Brugia malayi hypothetical protein 0.006 0.0252 0.0341
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0296
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0113 0.0594 0.0594
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0171 0.0232
Brugia malayi hypothetical protein 0.0038 0.0112 0.0152
Schistosoma mansoni retinoic acid receptor RXR 0.1581 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0252 0.0341
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.006 0.0252 0.0252
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0113 0.0594 0.0617
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0594 0.0594
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0252 0.0341
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0224 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0113 0.0594 0.0803
Echinococcus granulosus thyroid hormone receptor alpha 0.0053 0.0211 0.0211
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0252 0.0341
Loa Loa (eye worm) nuclear hormone receptor 0.0053 0.0211 0.0286
Loa Loa (eye worm) hypothetical protein 0.006 0.0252 0.0341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0113 0.0594 0.0594
Brugia malayi nuclear receptor RXR 0.0053 0.0211 0.0286
Loa Loa (eye worm) hypothetical protein 0.0113 0.0594 0.0803
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.004 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.034 0.034
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0113 0.0594 0.0803
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0053 0.0211 0.0286
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0296
Brugia malayi nuclear hormone receptor 0.0053 0.0211 0.0286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0224 0.0224
Onchocerca volvulus Protein ultraspiracle homolog 0.0113 0.0594 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0113 0.0594 0.0803
Brugia malayi Flap endonuclease-1 0.0027 0.0045 0.0061
Loa Loa (eye worm) hypothetical protein 0.0113 0.0594 0.0803
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0296
Brugia malayi nuclear receptor RXR 0.006 0.0252 0.0341
Brugia malayi orphan nuclear receptor NR2E1 0.0053 0.0211 0.0286
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0211 0.022
Entamoeba histolytica hypothetical protein 0.0038 0.0112 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0113 0.0594 0.0803
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0113 0.0594 0.0803
Brugia malayi photoreceptor-specific nuclear receptor 0.0113 0.0594 0.0803
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0224 0.0224
Echinococcus multilocularis FTZ F1 alpha 0.0113 0.0594 0.0617
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0224 0.0303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0224 0.0224
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0113 0.0594 0.0594
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.004 0.0054
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0296 0.04
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0082 0.0111
Schistosoma mansoni steroid hormone receptor ad4bp 0.0113 0.0594 0.0594
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.1174 0.7392 1
Echinococcus granulosus geminin 0.0178 0.1009 0.1009
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.006 0.0252 0.0262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0594 0.0617
Brugia malayi tailless protein 0.0053 0.0211 0.0286
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0113 0.0594 0.0594
Schistosoma mansoni hypothetical protein 0.0038 0.0112 0.0112
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.1174 0.7392 1
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0045 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0113 0.0594 0.0803
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.034 0.046
Brugia malayi RNA binding protein 0.0066 0.0296 0.04
Echinococcus multilocularis thyroid hormone receptor alpha 0.0113 0.0594 0.0617
Onchocerca volvulus Bile acid receptor homolog 0.0113 0.0594 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.1174 0.7392 0.7686
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0224 0.0303
Schistosoma mansoni nuclear receptor 0.0053 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0113 0.0594 0.0803
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0211 0.0211
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0053 0.0211 0.0211
Schistosoma mansoni coup transcription factor 0.0113 0.0594 0.0594
Echinococcus multilocularis dna polymerase eta 0.0047 0.0171 0.0178
Schistosoma mansoni hypothetical protein 0.0178 0.1009 0.1009
Schistosoma mansoni nuclear receptor nhr-48 0.0053 0.0211 0.0211
Brugia malayi conserved hypotetical protein 0.0053 0.0211 0.0286
Brugia malayi nuclear hormone receptor family member nhr-6 0.0053 0.0211 0.0286
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0047 0.0171 0.0232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Echinococcus granulosus transcription factor Dp 1 0.068 0.4224 0.4224
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0113 0.0594 0.0803
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0045 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0594 0.0803
Entamoeba histolytica hypothetical protein 0.0038 0.0112 0.0152
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.1174 0.7392 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0594 0.0803
Brugia malayi hypothetical protein 0.0026 0.004 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0113 0.0594 0.0803
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0171 0.0232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0594 0.0617
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0112 0.0112
Brugia malayi hypothetical protein 0.0053 0.0211 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0594 0.0803
Schistosoma mansoni flap endonuclease-1 0.0025 0.0029 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0594 0.0594
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.1174 0.7392 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0211 0.0211
Brugia malayi TAR-binding protein 0.0066 0.0296 0.04
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0112 0.0117
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0594 0.0803
Leishmania major DNA polymerase eta, putative 0.0047 0.0171 0.0232
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0211 0.0286
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0211 0.0211
Echinococcus granulosus dna polymerase eta 0.0047 0.0171 0.0171
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0113 0.0594 0.0594
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.034 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.006 0.0252 0.0252
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.034 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0053 0.0211 0.0211
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0211 0.022
Brugia malayi hypothetical protein 0.006 0.0252 0.0341
Loa Loa (eye worm) steroid hormone receptor 0.0113 0.0594 0.0803
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0053 0.0211 0.0211
Onchocerca volvulus 0.0113 0.0594 1
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0045 1
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0296 0.0308
Loa Loa (eye worm) hypothetical protein 0.006 0.0252 0.0341
Echinococcus multilocularis nuclear receptor nhr 48 0.0053 0.0211 0.022
Echinococcus multilocularis ecdysone induced protein 78C 0.0113 0.0594 0.0617
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0296 0.0296
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0045 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Loa Loa (eye worm) DR-78 0.0053 0.0211 0.0286
Echinococcus granulosus tar DNA binding protein 0.0066 0.0296 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0113 0.0594 0.0803
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0113 0.0594 0.0803
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0112 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0113 0.0594 0.0803
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0594 0.0803
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0224 0.0233
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0113 0.0594 0.0594
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0053 0.0211 0.022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0113 0.0594 0.0594
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.004 0.0054
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.034 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.034 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.1174 0.7392 0.7392
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0045 0.0061
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.1174 0.7392 0.7392
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0054
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0113 0.0594 0.0617
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0113 0.0594 0.0594
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0296 0.04
Brugia malayi nuclear receptor NHR-88 0.0113 0.0594 0.0803
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0113 0.0594 0.0803
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0113 0.0594 0.0594
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0113 0.0594 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.034 1
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0211 0.0286
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Schistosoma mansoni DNA polymerase eta 0.0047 0.0171 0.0171
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0053 0.0211 0.0286
Loa Loa (eye worm) hypothetical protein 0.006 0.0252 0.0341
Loa Loa (eye worm) nuclear receptor NHR-67 0.0053 0.0211 0.0286
Schistosoma mansoni RAR-like nuclear receptor 0.0113 0.0594 0.0594
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.034 0.034
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1174 0.7392 1
Brugia malayi ecdysteroid receptor 0.0113 0.0594 0.0803
Entamoeba histolytica hypothetical protein 0.0038 0.0112 0.0152
Brugia malayi nuclear receptor NHR-67 0.0053 0.0211 0.0286
Plasmodium falciparum flap endonuclease 1 0.0027 0.0045 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0594 0.0803
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0045 0.0061
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0045 0.0187
Loa Loa (eye worm) hypothetical protein 0.006 0.0252 0.0341
Brugia malayi Steroid receptor seven-up type 2 0.0113 0.0594 0.0803
Schistosoma mansoni zinc finger protein 0.0053 0.0211 0.0211
Brugia malayi Nuclear hormone receptor-like 1 0.0113 0.0594 0.0803
Brugia malayi steroid hormone receptor 0.0113 0.0594 0.0803
Loa Loa (eye worm) hypothetical protein 0.0113 0.0594 0.0803
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0045 0.0061
Schistosoma mansoni nuclear hormone receptor 0.0113 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0113 0.0594 0.0803
Loa Loa (eye worm) hypothetical protein 0.0113 0.0594 0.0803
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1174 0.7392 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0211 0.0211
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0296 0.04
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0113 0.0594 0.0803
Brugia malayi nuclear hormone receptor 0.0113 0.0594 0.0803
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.006 0.0252 0.0341
Brugia malayi ecdysone receptor 0.0053 0.0211 0.0286
Entamoeba histolytica hypothetical protein 0.0038 0.0112 0.0152
Echinococcus multilocularis transcription factor Dp 1 0.068 0.4224 0.4392
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0045 0.0047
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1521 0.9618 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0113 0.0594 0.0617
Leishmania major hypothetical protein, conserved 0.0026 0.004 0.0054
Brugia malayi hypothetical protein 0.0053 0.0211 0.0286
Leishmania major DNA polymerase eta, putative 0.0033 0.0082 0.0111
Loa Loa (eye worm) hypothetical protein 0.0113 0.0594 0.0803
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.034 0.0354
Brugia malayi nuclear hormone receptor family member odr-7 0.0053 0.0211 0.0286
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0113 0.0594 0.0617
Echinococcus granulosus ecdysone induced protein 78C 0.0113 0.0594 0.0594
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1174 0.7392 1
Echinococcus multilocularis geminin 0.0178 0.1009 0.1049
Schistosoma mansoni nuclear receptor 0.0053 0.0211 0.0211
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0045 0.0061
Loa Loa (eye worm) hypothetical protein 0.0113 0.0594 0.0803
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.034 0.034
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0171 0.0232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0082 0.14
Echinococcus granulosus FTZ F1 alpha 0.0113 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0053 0.0211 0.0286
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0594 0.0803
Brugia malayi nuclear receptor NHR-88 0.0053 0.0211 0.0286
Loa Loa (eye worm) RNA binding protein 0.0066 0.0296 0.04
Schistosoma mansoni hypothetical protein 0.0178 0.1009 0.1009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0211 0.022

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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