Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | notch-like transmembrane receptor | 0.0398 | 0.2883 | 0.2883 |
Onchocerca volvulus | Dual oxidase homolog | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Onchocerca volvulus | 0.1233 | 1 | 1 | |
Loa Loa (eye worm) | Notch2 | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | EGF-like domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1233 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.1233 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.1233 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | Animal haem peroxidase family protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Schistosoma mansoni | peroxidasin | 0.1233 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Onchocerca volvulus | 0.1233 | 1 | 1 | |
Brugia malayi | Blistered cuticle protein 3 | 0.1233 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1233 | 1 | 1 |
Onchocerca volvulus | 0.1233 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | EGF-like domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Onchocerca volvulus | Peroxidasin homolog | 0.1233 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1233 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | EGF-like domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0398 | 0.2883 | 0.2883 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | Muscle positioning protein 4 | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0398 | 0.2883 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | Peroxidasin | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Echinococcus multilocularis | peroxidasin | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Onchocerca volvulus | Peroxidase homolog | 0.1233 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | Animal haem peroxidase family protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1233 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.1233 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0398 | 0.2883 | 0.5 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0398 | 0.2883 | 0.2883 |
Echinococcus granulosus | peroxidasin | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.1872 | 0.1872 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Brugia malayi | EGF-like domain containing protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | notch protein | 0.0398 | 0.2883 | 0.2883 |
Loa Loa (eye worm) | hypothetical protein | 0.1233 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1233 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.1872 | 0.1872 |
Loa Loa (eye worm) | hypothetical protein | 0.0398 | 0.2883 | 0.2883 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.