Detailed information for compound 1440023

Basic information

Technical information
  • TDR Targets ID: 1440023
  • Name: 6-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1- yl]sulfonyl-3,4-dihydro-1H-quinolin-2-one
  • MW: 429.489 | Formula: C21H23N3O5S
  • H donors: 1 H acceptors: 3 LogP: 1.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1)ccc(c2)S(=O)(=O)N1CCN(CC1)Cc1ccc2c(c1)OCO2
  • InChi: 1S/C21H23N3O5S/c25-21-6-2-16-12-17(3-4-18(16)22-21)30(26,27)24-9-7-23(8-10-24)13-15-1-5-19-20(11-15)29-14-28-19/h1,3-5,11-12H,2,6-10,13-14H2,(H,22,25)
  • InChiKey: IGNUHSBRDJFBQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]sulfonyl]-3,4-dihydro-1H-quinolin-2-one
  • 6-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]sulfonyl-3,4-dihydrocarbostyril
  • SMR000023136
  • EU-0056919
  • MLS000086913
  • 6-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]sulfonyl}-3,4-dihydroquinolin-2(1H)-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin dm0 0.0033 0.2657 0.2772
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0074 0.8965 0.9587
Echinococcus granulosus g-protein coupled receptor 0.0027 0.1795 0.1841
Brugia malayi Serotonin receptor 0.0027 0.1795 0.1602
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.1795 0.0922
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.1795 0.0922
Echinococcus granulosus g protein coupled receptor 0.0027 0.1795 0.1841
Brugia malayi sulfakinin receptor protein 0.0027 0.1795 0.1602
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0074 0.8965 0.9587
Schistosoma mansoni tar DNA-binding protein 0.0076 0.9348 0.9278
Brugia malayi RNA binding protein 0.0076 0.9348 1
Schistosoma mansoni neuropeptide receptor 0.0027 0.1795 0.0922
Echinococcus multilocularis lamin 0.0033 0.2657 0.2772
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.1795 0.1602
Brugia malayi neuropeptide F receptor 0.0027 0.1795 0.1602
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni neuropeptide receptor 0.0027 0.1795 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.1795 0.1841
Echinococcus granulosus neuropeptide receptor 0.0027 0.1795 0.1841
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.1795 0.0922
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.1795 0.0922
Schistosoma mansoni amine GPCR 0.0027 0.1795 0.0922
Brugia malayi follicle stimulating hormone receptor 0.0027 0.1795 0.1602
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.2657 0.2561
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.4314 0.4562
Echinococcus multilocularis g protein coupled receptor 0.0027 0.1795 0.1841
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.1795 0.1841
Brugia malayi Dopamine receptor protein 2 0.0027 0.1795 0.1602
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.1795 0.1841
Echinococcus granulosus somatostatin receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.1795 0.1841
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Echinococcus multilocularis neuropeptide receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.2657 0.2842
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.1795 0.1841
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.1795 0.0922
Schistosoma mansoni lamin 0.0033 0.2657 0.1876
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.1795 0.0922
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.1795 0.1841
Schistosoma mansoni amine GPCR 0.0027 0.1795 0.0922
Echinococcus granulosus g protein coupled receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis serotonin receptor 0.0027 0.1795 0.1841
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.1795 0.1841
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0962 0.0941
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.1795 0.1841
Schistosoma mansoni hypothetical protein 0.0043 0.4314 0.3709
Loa Loa (eye worm) hypothetical protein 0.0016 0.0091 0.0097
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.1795 0.1841
Loa Loa (eye worm) RNA binding protein 0.0076 0.9348 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.1795 0.1602
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Brugia malayi intermediate filament protein 0.0033 0.2657 0.2561
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.4314 0.4562
Echinococcus granulosus fmrfamide receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.1795 0.0922
Echinococcus granulosus neuropeptide s receptor 0.0027 0.1795 0.1841
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Brugia malayi GnHR receptor homolog 0.0027 0.1795 0.1602
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.1795 0.0922
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.1795 0.1602
Echinococcus multilocularis somatostatin receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0032 0.2566 0.2745
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.1795 0.192
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0074 0.8965 0.9575
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.1795 0.192
Schistosoma mansoni tar DNA-binding protein 0.0076 0.9348 0.9278
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Brugia malayi G-protein coupled receptor 0.0027 0.1795 0.1602
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.1795 0.1602
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0962 0.0941
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni neuropeptide receptor 0.0027 0.1795 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Brugia malayi Dopamine receptor 0.0027 0.1795 0.1602
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.1795 0.1841
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis g protein coupled receptor 0.0027 0.1795 0.1841
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis fmrfamide receptor 0.0027 0.1795 0.1841
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis g protein coupled receptor 0.0027 0.1795 0.1841
Schistosoma mansoni tar DNA-binding protein 0.0076 0.9348 0.9278
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.1795 0.1602
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0354 0.0379
Schistosoma mansoni biogenic amine receptor 0.0027 0.1795 0.0922
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.1795 0.1841
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.1795 0.1602
Schistosoma mansoni opsin-like receptor 0.0027 0.1795 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus intermediate filament protein 0.0033 0.2657 0.2772
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.1795 0.1841
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus serotonin receptor 0.0027 0.1795 0.1841
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.1795 0.1841
Echinococcus granulosus g protein coupled receptor 0.0027 0.1795 0.1841
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.1795 0.0922
Brugia malayi TAR-binding protein 0.0076 0.9348 1
Echinococcus multilocularis musashi 0.0033 0.2657 0.2772
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.1795 0.1602
Schistosoma mansoni hypothetical protein 0.0027 0.1795 0.0922
Schistosoma mansoni opsin-like receptor 0.0027 0.1795 0.0922
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0962 0.1029
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni hypothetical protein 0.0027 0.1795 0.0922
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.9348 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0027 0.1795 0.0922
Brugia malayi Serotonin receptor 0.0027 0.1795 0.1602
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Echinococcus multilocularis neuropeptide receptor 0.0027 0.1795 0.1841
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.1795 0.1841
Onchocerca volvulus 0.0033 0.2657 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus multilocularis lamin dm0 0.0033 0.2657 0.2772
Echinococcus granulosus sex peptide receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.1795 0.192
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.1795 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.1795 0.1841
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.1795 0.192
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.1795 0.192
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.1795 0.1841
Entamoeba histolytica hypothetical protein 0.0043 0.4314 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.1795 0.192
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.1795 0.1841
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0962 0.0941
Echinococcus multilocularis allatostatin A receptor 0.0027 0.1795 0.1841
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.1795 0.0922
Schistosoma mansoni amine GPCR 0.0027 0.1795 0.0922
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.1795 0.1841
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.4314 0.3709
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.1795 0.0922
Entamoeba histolytica hypothetical protein 0.0043 0.4314 0.5
Echinococcus granulosus tar DNA binding protein 0.0076 0.9348 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.1795 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Brugia malayi neuropeptide F receptor 0.0027 0.1795 0.1602
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Schistosoma mansoni tar DNA-binding protein 0.0076 0.9348 0.9278
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Brugia malayi G-protein coupled receptor 0.0027 0.1795 0.1602
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus orexin receptor type 2 0.0027 0.1795 0.1841
Echinococcus multilocularis tar DNA binding protein 0.0076 0.9348 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.1795 0.1841
Brugia malayi RE15519p 0.0027 0.1795 0.1602
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0962 0.0941
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus multilocularis serotonin receptor 0.0027 0.1795 0.1841
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.1795 0.0922
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.1795 0.192
Echinococcus granulosus hypothetical protein 0.0027 0.1795 0.1841
Schistosoma mansoni voltage-gated potassium channel 0.0081 1 1
Brugia malayi ORL1-like opioid receptor 0.0027 0.1795 0.1602
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.1795 0.1841
Echinococcus granulosus allatostatin A receptor 0.0027 0.1795 0.1841
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.1795 0.1841
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.8224 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni lamin 0.0033 0.2657 0.1876
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.8224 0.5
Brugia malayi putative neuropeptide receptor 0.0027 0.1795 0.1602
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.1795 0.1841
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.1795 0.1602
Schistosoma mansoni amine GPCR 0.0027 0.1795 0.0922
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis neuropeptide receptor A26 0.0027 0.1795 0.1841
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.1795 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus neuropeptide receptor A26 0.0027 0.1795 0.1841
Schistosoma mansoni hypothetical protein 0.0027 0.1795 0.0922
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.1795 0.0922
Entamoeba histolytica hypothetical protein 0.0043 0.4314 0.5
Schistosoma mansoni myosin xvIII 0.0027 0.1795 0.0922
Schistosoma mansoni biogenic amine receptor 0.0027 0.1795 0.0922
Echinococcus multilocularis orexin receptor type 2 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0033 0.2657 0.2842
Schistosoma mansoni neuropeptide receptor 0.0027 0.1795 0.0922
Echinococcus granulosus neuropeptide receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni biogenic amine receptor 0.0027 0.1795 0.0922
Brugia malayi Dopamine receptor protein 1 0.0027 0.1795 0.1602
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Loa Loa (eye worm) TAR-binding protein 0.0076 0.9348 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.1795 0.0922
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.1795 0.0922
Brugia malayi hypothetical protein 0.0043 0.4314 0.4403
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.1795 0.0922
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Brugia malayi larval opioid receptor 0.0027 0.1795 0.1602
Brugia malayi AKH receptor 0.0027 0.1795 0.1602
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.1795 0.0922
Echinococcus granulosus lamin 0.0033 0.2657 0.2772
Echinococcus multilocularis sex peptide receptor 0.0027 0.1795 0.1841
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis fmrfamide receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.1795 0.192
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.1795 0.0922
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.1795 0.1841
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0074 0.8965 0.9591
Brugia malayi G protein-coupled receptor 0.0027 0.1795 0.1602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.1795 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.1795 0.0922
Loa Loa (eye worm) hypothetical protein 0.0064 0.7477 0.7999
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.9348 1
Brugia malayi Melatonin receptor type 1A 0.0027 0.1795 0.1602
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.1795 0.0922
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0962 0.0675
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.1795 0.1841
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0027 0.1795 0.1841
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.1795 0.1841
Loa Loa (eye worm) intermediate filament protein 0.0033 0.2657 0.2842
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.1795 0.1841
Schistosoma mansoni intermediate filament proteins 0.0033 0.2657 0.1876
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.1795 0.0922
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.1795 0.1841
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.1795 0.1841
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.1795 0.0922
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.1795 0.192
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.1795 0.1841
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.1795 0.1841
Schistosoma mansoni histamine h1 receptor 0.0027 0.1795 0.0922
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.1795 0.0922
Schistosoma mansoni amine GPCR 0.0027 0.1795 0.0922
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Entamoeba histolytica hypothetical protein 0.0043 0.4314 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.1795 0.192
Schistosoma mansoni hypothetical protein 0.0027 0.1795 0.0922
Schistosoma mansoni adenoreceptor 0.0027 0.1795 0.0922
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.1795 0.0922
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Onchocerca volvulus 0.0033 0.2657 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.1795 0.1841
Schistosoma mansoni opsin-like receptor 0.0027 0.1795 0.0922
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.1795 0.1841
Loa Loa (eye worm) hypothetical protein 0.0027 0.1795 0.192
Brugia malayi hypothetical protein 0.0027 0.1795 0.1602
Schistosoma mansoni tar DNA-binding protein 0.0076 0.9348 0.9278

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.9093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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