Detailed information for compound 1440509

Basic information

Technical information
  • TDR Targets ID: 1440509
  • Name: 3-methyl-5-morpholin-4-ylsulfonyl-N-[3-(trifl uoromethyl)phenyl]-1-benzofuran-2-carboxamide
  • MW: 468.446 | Formula: C21H19F3N2O5S
  • H donors: 1 H acceptors: 3 LogP: 3.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1oc2c(c1C)cc(cc2)S(=O)(=O)N1CCOCC1)Nc1cccc(c1)C(F)(F)F
  • InChi: 1S/C21H19F3N2O5S/c1-13-17-12-16(32(28,29)26-7-9-30-10-8-26)5-6-18(17)31-19(13)20(27)25-15-4-2-3-14(11-15)21(22,23)24/h2-6,11-12H,7-10H2,1H3,(H,25,27)
  • InChiKey: FURILVAVOWUINA-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-methyl-5-morpholinosulfonyl-N-[3-(trifluoromethyl)phenyl]benzofuran-2-carboxamide
  • 3-methyl-5-morpholinosulfonyl-N-[3-(trifluoromethyl)phenyl]-2-benzofurancarboxamide
  • EU-0030713
  • 3-methyl-5-(morpholin-4-ylsulfonyl)-N-[3-(trifluoromethyl)phenyl]-1-benzofuran-2-carboxamide
  • MLS000046286
  • SMR000031897

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0698 0.8343 1
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0085 0.0867 0.0952
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0085 0.0867 0.0952
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.008 0.008
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0085 0.0867 0.0952
Leishmania major cathepsin L-like protease 0.0077 0.0773 0.0839
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0085 0.0867 0.0952
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0085 0.0867 0.0867
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0085 0.0867 0.0946
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0378 0.0213
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0085 0.0867 0.0814
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0507 0.0507
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0085 0.0867 0.0867
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0378 0.0378
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0085 0.0867 0.0952
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.016 0.179 0.179
Trypanosoma brucei proteasome beta 7 subunit 0.0085 0.0867 0.0814
Leishmania major proteasome beta 7 subunit, putative 0.0085 0.0867 0.0952
Brugia malayi Proteasome A-type and B-type family protein 0.0085 0.0867 0.096
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0085 0.0867 0.0952
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0085 0.0867 0.0814
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0698 0.8343 1
Giardia lamblia 20S proteasome alpha subunit 3 0.0085 0.0867 0.0946
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0698 0.8343 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0085 0.0867 0.0952
Trypanosoma brucei proteasome beta 6 subunit 0.0239 0.2747 0.3123
Giardia lamblia 20S proteasome alpha subunit 7 0.0085 0.0867 0.0946
Leishmania major pyruvate kinase 0.004 0.0325 0.0296
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0085 0.0867 0.0867
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0085 0.0867 0.0867
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0083 0.0843 0.0923
Toxoplasma gondii proteasome subunit beta type 2, putative 0.016 0.179 0.2069
Leishmania major proteasome alpha 1 subunit, putative 0.0085 0.0867 0.0952
Brugia malayi proteasome subunit alpha type 2 0.0085 0.0867 0.096
Leishmania major cathepsin L-like protease 0.0077 0.0773 0.0839
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0085 0.0867 0.0952
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0205 0.0151
Echinococcus multilocularis proteasome (prosome, macropain) 0.0698 0.8343 0.8343
Toxoplasma gondii proteasome subunit beta type, putative 0.0698 0.8343 1
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0085 0.0867 0.0952
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0085 0.0867 0.0952
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0085 0.0867 0.0952
Echinococcus granulosus subfamily T1A non peptidase ue 0.0085 0.0867 0.0867
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0085 0.0867 0.0946
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0085 0.0867 0.0867
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0085 0.0867 0.0952
Echinococcus granulosus pyruvate kinase 0.004 0.0325 0.0325
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0085 0.0867 0.0814
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0176 0.0116
Echinococcus multilocularis cysteine protease 0.002 0.008 0.008
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0085 0.0867 0.0952
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0085 0.0867 0.0952
Brugia malayi proteasome subunit alpha type 3 0.0085 0.0867 0.096
Entamoeba histolytica hypothetical protein 0.0043 0.0363 0.0343
Plasmodium vivax proteasome subunit beta type-7, putative 0.0085 0.0867 0.0952
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0085 0.0867 0.0952
Echinococcus granulosus pyruvate kinase 0.004 0.0325 0.0325
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0584 0.0584
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0085 0.0867 0.0952
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0205 0.0151
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.008 0.008
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0085 0.0867 0.0952
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0698 0.8343 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0572 0.0595
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0085 0.0867 0.0867
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0085 0.0867 0.0952
Leishmania major proteasome beta 3 subunit, putative 0.0085 0.0867 0.0952
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Schistosoma mansoni pyruvate kinase 0.004 0.0325 0.0325
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0773 0.0839
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0273 0.0273
Leishmania major proteasome beta 2 subunit, putative 0.016 0.179 0.2069
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0085 0.0867 0.0867
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0085 0.0867 0.5
Brugia malayi Pre-SET motif family protein 0.0251 0.29 0.3418
Brugia malayi proteasome subunit beta type 3 0.0085 0.0867 0.096
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0273 0.0234
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0325 0.0296
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0273 0.0273
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0085 0.0867 0.0952
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0085 0.0867 0.0952
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0239 0.2747 0.3227
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0085 0.0867 0.0867
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.0086 0.0007
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0584 0.061
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0085 0.0867 0.0952
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0584 0.061
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0239 0.2747 0.3227
Plasmodium vivax proteasome subunit beta type-4, putative 0.0085 0.0867 0.0952
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0151
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0085 0.0867 0.0952
Plasmodium vivax proteasome subunit beta type-2, putative 0.016 0.179 0.2069
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0085 0.0867 0.0952
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0378 0.0378
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0085 0.0867 0.0814
Echinococcus granulosus proteasome prosome macropain subunit beta 0.016 0.179 0.179
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0085 0.0867 0.0867
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0085 0.0867 0.0952
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0698 0.8343 1
Plasmodium vivax proteasome subunit beta type-5, putative 0.0698 0.8343 1
Leishmania major proteasome alpha 2 subunit, putative 0.0085 0.0867 0.0952
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0363 0.0363
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0773 0.0839
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0085 0.0867 0.0952
Giardia lamblia Pyruvate kinase 0.004 0.0325 0.029
Echinococcus granulosus adhesion regulating molecule 1 0.0083 0.0843 0.0843
Giardia lamblia 20S proteasome alpha subunit 5 0.0085 0.0867 0.0946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0507 0.0507
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0584 0.061
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0085 0.0867 0.0952
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0325 0.0304
Brugia malayi Cathepsin L-like precursor 0.002 0.008 0.0008
Toxoplasma gondii proteasome subunit alpha type, putative 0.0085 0.0867 0.0952
Echinococcus granulosus proteasome subunit beta type 7 0.0085 0.0867 0.0867
Brugia malayi proteasome subunit beta type 1 0.0239 0.2747 0.3233
Loa Loa (eye worm) hypothetical protein 0.0083 0.0843 0.0923
Plasmodium falciparum pyruvate kinase 2 0.0021 0.0086 0.0007
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0085 0.0867 0.0952
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0507 0.0517
Toxoplasma gondii proteasome beta subunit 0.0085 0.0867 0.0952
Echinococcus multilocularis pyruvate kinase 0.004 0.0325 0.0325
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0085 0.0867 0.0952
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0698 0.8343 1
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0085 0.0867 0.0867
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0085 0.0867 0.0952
Brugia malayi proteasome subunit beta type 2 0.016 0.179 0.2076
Onchocerca volvulus 0.0036 0.0273 0.0595
Brugia malayi Cathepsin L-like precursor 0.002 0.008 0.0008
Plasmodium falciparum pyruvate kinase 0.004 0.0325 0.0296
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0085 0.0867 0.0867
Giardia lamblia 20S proteasome alpha subunit 4 0.0085 0.0867 0.0946
Brugia malayi Proteasome subunit alpha type 1 0.0085 0.0867 0.096
Echinococcus multilocularis cysteine protease 0.002 0.008 0.008
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0085 0.0867 0.0867
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0085 0.0867 0.0867
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0273 0.0273
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0239 0.2747 0.3227
Loa Loa (eye worm) hypothetical protein 0.0036 0.0273 0.0234
Brugia malayi proteasome subunit alpha type 1 0.0085 0.0867 0.096
Brugia malayi Proteasome subunit alpha type 7-1 0.0085 0.0867 0.096
Echinococcus granulosus proteasome subunit beta type 6 0.0085 0.0867 0.0867
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0205 0.0151
Brugia malayi proteasome subunit alpha type 6 0.0085 0.0867 0.096
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0085 0.0867 0.0952
Toxoplasma gondii proteasome subunit 0.0085 0.0867 0.0952
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0205 0.0151
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0085 0.0867 0.0867
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0239 0.2747 0.2747
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0085 0.0867 0.0952
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0085 0.0867 0.0952
Plasmodium vivax pyruvate kinase 2, putative 0.0021 0.0086 0.0007
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0584 0.061
Onchocerca volvulus Notchless protein homolog 0.0085 0.0867 0.2427
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.016 0.179 0.179
Plasmodium vivax pyruvate kinase, putative 0.004 0.0325 0.0296
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0085 0.0867 0.0952
Echinococcus granulosus pyruvate kinase 0.0021 0.0086 0.0086
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0584 0.0584
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0085 0.0867 0.0952
Toxoplasma gondii proteasome subunit alpha1, putative 0.0085 0.0867 0.0952
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0085 0.0867 0.0952
Trypanosoma brucei proteasome subunit beta type-2, putative 0.016 0.179 0.1947
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0085 0.0867 0.0952
Giardia lamblia Proteasome subunit beta type 3 0.0085 0.0867 0.0946
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0378 0.0378
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0584 0.0604
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0085 0.0867 0.0952
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0085 0.0867 0.0952
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0085 0.0867 0.0952
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0378 0.0378
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0239 0.2747 0.3227
Brugia malayi Proteasome A-type and B-type family protein 0.0085 0.0867 0.096
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0085 0.0867 0.0867
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0085 0.0867 0.0952
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0085 0.0867 0.0952
Loa Loa (eye worm) PAS-3 protein 0.0085 0.0867 0.0952
Loa Loa (eye worm) pyruvate kinase 0.004 0.0325 0.0296
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0085 0.0867 0.0952
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0085 0.0867 0.0952
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0273 0.0273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0507 0.0507
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0698 0.8343 1
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0698 0.8343 1
Leishmania major hypothetical protein, conserved 0.003 0.0205 0.0151
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0239 0.2747 0.2747
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0325 0.0304
Loa Loa (eye worm) proteasome subunit beta type 3 0.0085 0.0867 0.0952
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0085 0.0867 0.0952
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0085 0.0867 0.0952
Echinococcus multilocularis pyruvate kinase 0.0032 0.0221 0.0221
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0085 0.0867 0.0952
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0085 0.0867 0.0867
Schistosoma mansoni hypothetical protein 0.0043 0.0363 0.0363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0378 0.0354
Echinococcus granulosus proteasome subunit alpha type 2 0.0085 0.0867 0.0867
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0085 0.0867 0.0952
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0085 0.0867 0.0952
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0584 0.061
Giardia lamblia Proteasome subunit beta type 2 0.016 0.179 0.2064
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0085 0.0867 0.0867
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0325 0.0296
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0363 0.0363
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0085 0.0867 0.0814
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0773 0.0839
Schistosoma mansoni pyruvate kinase 0.004 0.0325 0.0325
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0273 0.0273
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.008 0.008
Echinococcus granulosus Proteasome subunit alpha type 7 0.0085 0.0867 0.0867
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0085 0.0867 0.0952
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0273 0.0273
Brugia malayi hypothetical protein 0.003 0.0205 0.0159
Leishmania major proteasome alpha 1 subunit, putative 0.0085 0.0867 0.0952
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0584 0.061
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0085 0.0867 0.0952
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0085 0.0867 0.0952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Leishmania major proteasome alpha 7 subunit, putative 0.0085 0.0867 0.0952
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.008 0.008
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0085 0.0867 0.0952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0085 0.0867 0.0952
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0085 0.0867 0.0952
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0085 0.0867 0.0952
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0085 0.0867 0.0952
Entamoeba histolytica hypothetical protein 0.0043 0.0363 0.0343
Plasmodium vivax SET domain protein, putative 0.0036 0.0273 0.0234
Loa Loa (eye worm) pyruvate kinase 0.004 0.0325 0.0296
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0085 0.0867 0.0952
Leishmania major proteasome beta 2 subunit, putative 0.0085 0.0867 0.0952
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0085 0.0867 0.0814
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0053 0.0474 0.1215
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.016 0.179 0.2069
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0085 0.0867 0.0952
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0325 0.0755
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.008 0.008
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0239 0.2747 0.2747
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0085 0.0867 0.0867
Brugia malayi 20S proteasome alpha5 subunit 0.0085 0.0867 0.096
Echinococcus multilocularis proteasome subunit beta type 7 0.0085 0.0867 0.0867
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0085 0.0867 0.0952
Onchocerca volvulus 0.0286 0.3323 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0085 0.0867 0.0867
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0085 0.0867 0.0952
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0584 0.061
Plasmodium vivax proteasome subunit beta type-6, putative 0.0085 0.0867 0.0952
Echinococcus multilocularis pyruvate kinase 0.0021 0.0086 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0584 0.061
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.016 0.179 0.179
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0085 0.0867 0.0952
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0325 0.0755
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0085 0.0867 0.0952
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0257 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0584 0.061
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0325 0.0755
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0085 0.0867 0.0952
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0273 0.0273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0085 0.0867 0.0952
Loa Loa (eye worm) hypothetical protein 0.0028 0.0176 0.0116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0378 0.0361
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0085 0.0874 0.0961
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0363 0.0363
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0584 0.061
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0239 0.2747 0.3227
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0085 0.0867 0.0952
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0205 0.0151
Echinococcus multilocularis pyruvate kinase 0.004 0.0325 0.0325
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0584 0.061
Brugia malayi Cathepsin L-like precursor 0.002 0.008 0.0008
Leishmania major pyruvate kinase 0.004 0.0325 0.0296
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.016 0.179 0.2069
Trypanosoma brucei pyruvate kinase 1 0.004 0.0325 0.0148
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0584 0.0584
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0085 0.0867 0.0952
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0584 0.061
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0085 0.0867 0.0867
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0085 0.0867 0.0952
Entamoeba histolytica hypothetical protein 0.0043 0.0363 0.0343
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0378 0.0361
Toxoplasma gondii peptidase, T1 family protein 0.0085 0.0867 0.0952
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0085 0.0867 0.0676
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0085 0.0867 0.0952
Plasmodium falciparum proteasome subunit beta type-2, putative 0.016 0.179 0.2069
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0325 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0378 0.0361
Trypanosoma brucei proteasome alpha 7 subunit 0.0085 0.0867 0.0814
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0378 0.0361
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0239 0.2747 0.3227
Leishmania major hypothetical protein, conserved 0.0043 0.0359 0.0338
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.29 0.3412
Brugia malayi hypothetical protein 0.0043 0.0363 0.0351
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0507 0.0507
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.008 0.008
Trypanosoma brucei protein kinase, putative 0.0062 0.0584 0.0466
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0085 0.0867 0.0952
Echinococcus multilocularis proteasome subunit alpha type 6 0.0085 0.0867 0.0867
Brugia malayi Cytochrome P450 family protein 0.0059 0.0552 0.0579
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0325 0.0296
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0378 0.0378
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0085 0.0867 0.0952
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0085 0.0867 0.0952
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0085 0.0867 0.0952
Leishmania major proteasome beta 5 subunit, putative 0.0698 0.8343 1
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0085 0.0867 0.0814
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0085 0.0867 0.0952
Mycobacterium ulcerans proteasome PrcB 0.0698 0.8343 1
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0085 0.0867 0.0676
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0083 0.0843 0.0843
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0085 0.0867 0.0952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Brugia malayi Cathepsin L-like precursor 0.002 0.008 0.0008
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0378 0.0378
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0698 0.8343 0.8343
Entamoeba histolytica hypothetical protein 0.0043 0.0363 0.0343
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0085 0.0867 0.0952
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0085 0.0867 0.0952
Echinococcus multilocularis proteasome subunit beta type 6 0.0085 0.0867 0.0867
Giardia lamblia 20S proteasome alpha subunit 1 0.0085 0.0867 0.0946
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0378 0.0378
Brugia malayi Pre-SET motif family protein 0.0036 0.0273 0.0242
Leishmania major cathepsin L-like protease 0.0077 0.0773 0.0839
Echinococcus granulosus pyruvate kinase 0.0021 0.0086 0.0086
Echinococcus granulosus pyruvate kinase 0.0021 0.0086 0.0086
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0584 0.0466
Giardia lamblia 20S proteasome alpha subunit 2 0.0085 0.0867 0.0946
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0085 0.0867 0.0867
Brugia malayi Proteasome A-type and B-type family protein 0.0698 0.8343 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3323 0.3925
Echinococcus granulosus proteasome prosome macropain 0.0698 0.8343 0.8343
Echinococcus granulosus proteasome subunit beta t family 0.0085 0.0867 0.0867
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0378 0.0361
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0085 0.0867 0.0946
Echinococcus granulosus Proteasome subunit alpha beta 0.0085 0.0867 0.0867
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0085 0.0867 0.0952
Loa Loa (eye worm) pyruvate kinase 0.004 0.0325 0.0296
Brugia malayi Papain family cysteine protease containing protein 0.002 0.008 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0507 0.0525
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0083 0.0843 0.0931
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0507 0.0507
Trypanosoma cruzi 20S proteasome subunit 0.016 0.179 0.2069
Leishmania major proteasome beta-1 subunit, putative 0.0085 0.0867 0.0952
Plasmodium falciparum proteasome subunit beta type-4 0.0085 0.0867 0.0952
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0085 0.0867 0.0952
Brugia malayi proteasome subunit alpha type 4 0.0085 0.0867 0.096
Loa Loa (eye worm) proteasome subunit beta type 2 0.016 0.179 0.2069
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0692 0.074
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0085 0.0867 0.0952
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0085 0.0867 0.0867
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0085 0.0867 0.0867
Leishmania major proteasome alpha 7 subunit, putative 0.0085 0.0867 0.0952
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0085 0.0867 0.0814
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0085 0.0867 0.0952
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0085 0.0867 0.0867
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0378 0.0361
Brugia malayi MAP kinase sur-1 0.0062 0.0584 0.0618
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0325 0.0148
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0773 0.0839
Plasmodium vivax proteasome subunit beta type-3, putative 0.0085 0.0867 0.0952
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0085 0.0867 0.0952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Echinococcus multilocularis pyruvate kinase 0.0021 0.0086 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0584 0.0584
Toxoplasma gondii heat shock protein hslv, putative 0.0085 0.0867 0.0952
Plasmodium vivax proteasome subunit beta type-1, putative 0.0239 0.2747 0.3227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0507 0.0507
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0085 0.0867 0.0952
Chlamydia trachomatis pyruvate kinase 0.004 0.0325 0.5
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0325 0.0296
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0085 0.0867 0.0952
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0043 0.0359 0.0338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.008 0.008
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0085 0.0867 0.0952
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0085 0.0867 0.0814
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0205 0.0151
Plasmodium falciparum proteasome subunit beta type-5 0.0698 0.8343 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0085 0.0867 0.0952
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0239 0.2747 0.3227
Echinococcus multilocularis adhesion regulating molecule 1 0.0083 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.0045 0.0378 0.0361
Brugia malayi Proteasome A-type and B-type family protein 0.0085 0.0867 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0698 0.8343 1
Brugia malayi Cathepsin L-like precursor 0.002 0.008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0507 0.0507
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0584 0.0584
Loa Loa (eye worm) proteasome subunit beta type 1 0.0239 0.2747 0.3227
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0085 0.0867 0.0952
Echinococcus granulosus cathepsin l1 0.002 0.008 0.008
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0378 0.0378
Leishmania major proteasome alpha 3 subunit, putative 0.0085 0.0867 0.0952
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.016 0.179 0.2069
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0085 0.0867 0.0867
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0378 0.0361
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0085 0.0867 0.0952
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0085 0.0867 0.0952
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0378 0.0369
Brugia malayi Cathepsin L-like precursor 0.002 0.008 0.0008
Giardia lamblia Proteasome subunit beta type 1 0.0239 0.2747 0.3223
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0085 0.0867 0.0814
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0085 0.0867 0.0952
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0552 0.0571
Schistosoma mansoni pyruvate kinase 0.0021 0.0086 0.0086
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0085 0.0867 0.0867
Mycobacterium ulcerans proteasome PrcA 0.0085 0.0867 0.0676
Echinococcus multilocularis proteasome subunit alpha type 2 0.0085 0.0867 0.0867
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0176 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0773 0.0699
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.008 0.008
Echinococcus multilocularis pyruvate kinase 0.0021 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0325 0.0296
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0085 0.0867 0.0867
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.016 0.179 0.2069
Giardia lamblia 20S proteasome alpha subunit 6 0.0085 0.0867 0.0946
Echinococcus granulosus proteasome subunit alpha type 6 0.0085 0.0867 0.0867

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.412537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (functional) > 100 uM PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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