Detailed information for compound 1440792

Basic information

Technical information
  • TDR Targets ID: 1440792
  • Name: 2-(4-acetylphenyl)-1,1-dioxo-4H-benzo[e][1,2, 4]thiadiazin-3-one
  • MW: 316.332 | Formula: C15H12N2O4S
  • H donors: 1 H acceptors: 4 LogP: 1.56 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2ccccc2S(=O)(=O)N1c1ccc(cc1)C(=O)C
  • InChi: 1S/C15H12N2O4S/c1-10(18)11-6-8-12(9-7-11)17-15(19)16-13-4-2-3-5-14(13)22(17,20)21/h2-9H,1H3,(H,16,19)
  • InChiKey: VTAQVSRPAMRXMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-acetylphenyl)-1,1-diketo-4H-benzo[e][1,2,4]thiadiazin-3-one
  • 2-(4-ethanoylphenyl)-1,1-dioxo-4H-benzo[e][1,2,4]thiadiazin-3-one
  • ZINC04483817
  • K261-1730
  • NCGC00138375-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.0031 0.0026
Mycobacterium ulcerans polyketide synthase Pks13 0.0115 0.0102 0.1937
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0038 0.0031
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.0029 0.0491
Plasmodium falciparum LCCL domain-containing protein 0.0053 0.0031 0.0556
Mycobacterium ulcerans monoamine oxidase 0.0118 0.0106 0.2033
Loa Loa (eye worm) hypothetical protein 0.0101 0.0086 0.008
Schistosoma mansoni dock 0.0053 0.0031 0.0024
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0013 0.0013
Echinococcus granulosus protein will die slowly 0.0207 0.0206 0.02
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0053 0.0031 0.0032
Schistosoma mansoni discoidin domain receptor 0.0053 0.0031 0.0024
Echinococcus multilocularis expressed protein 0.0362 0.0382 0.0471
Toxoplasma gondii histone deacetylase SIR2 0.0105 0.0091 0.2052
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0118 0.0106 0.2266
Echinococcus multilocularis protein arginine methyltransferase 0.0195 0.0192 0.0233
Loa Loa (eye worm) hypothetical protein 0.0041 0.0018 0.0012
Loa Loa (eye worm) transcriptional regulator 0.0105 0.0091 0.0085
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0037 0.0013 0.0008
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0076 0.0058 0.0787
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0137
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0137
Loa Loa (eye worm) hypothetical protein 0.0118 0.0106 0.01
Plasmodium falciparum plasmepsin V 0.0414 0.0441 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0105 0.0091 0.0106
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.0029 0.0028
Echinococcus granulosus adam 0.0057 0.0036 0.003
Mycobacterium ulcerans thioesterase TesA 0.0066 0.0046 0.0482
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0714 0.0782 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0105 0.0091 0.192
Plasmodium falciparum plasmepsin IX 0.0037 0.0013 0.0126
Schistosoma mansoni amine oxidase 0.0118 0.0106 0.0098
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0714 0.0782 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Echinococcus multilocularis membrane bound transcription factor site 1 0.0389 0.0413 0.051
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0061 0.004 0.0333
Brugia malayi Nematode astacin protease protein 30 0.0035 0.0011 0.0011
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.011 0.0096 0.2174
Leishmania major hypothetical protein, conserved 0.0051 0.0029 0.0275
Echinococcus granulosus lysine specific histone demethylase 1A 0.0583 0.0634 0.0628
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0106 0.2266
Toxoplasma gondii subtilisin SUB9 0.0389 0.0413 1
Brugia malayi hypothetical protein 0.0037 0.0013 0.0013
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1761 0.1972 0.3223
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Schistosoma mansoni hypothetical protein 0.0101 0.0086 0.0079
Schistosoma mansoni apoptosis regulator bax 0.0053 0.0032 0.0024
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0007 0.0001
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0389 0.0413 0.5106
Loa Loa (eye worm) hypothetical protein 0.0053 0.0032 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0413 0.0666
Leishmania major arginine N-methyltransferase-like protein 0.0195 0.0192 0.2387
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Onchocerca volvulus 0.0037 0.0013 0.0033
Schistosoma mansoni discoidin domain receptor 0.0053 0.0031 0.0024
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0137
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0389 0.0413 0.0406
Toxoplasma gondii aspartyl protease 0.0037 0.0013 0.0135
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0304 0.0317 0.3825
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0005
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0081 0.0063 0.1376
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0035 0.0011 0.0004
Mycobacterium ulcerans thioesterase 0.0066 0.0046 0.0482
Leishmania major trypanothione synthetase, putative 0.0068 0.0048 0.0524
Trypanosoma brucei SIR2-like protein 4, putative 0.0105 0.0091 0.1076
Brugia malayi CUB domain containing protein 0.0035 0.0011 0.0011
Mycobacterium tuberculosis Probable thioesterase TesA 0.0066 0.0046 0.0948
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0413 0.0666
Toxoplasma gondii PA14 domain-containing protein 0.0053 0.0031 0.0595
Brugia malayi Lectin C-type domain containing protein 0.0035 0.0011 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0118 0.0106 0.2423
Echinococcus multilocularis thyroid hormone receptor alpha 0.017 0.0164 0.0198
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0031 0.0595
Toxoplasma gondii histone deacetylase SIR2-like 0.0105 0.0091 0.2052
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0035 0.0011 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0137
Brugia malayi hypothetical protein 0.0037 0.0013 0.0013
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0352 0.0371 0.4547
Echinococcus granulosus expressed protein 0.0362 0.0382 0.0376
Toxoplasma gondii kringle domain-containing protein 0.0051 0.0029 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Toxoplasma gondii subtilisin SUB1 0.0389 0.0413 1
Schistosoma mansoni hypothetical protein 0.011 0.0096 0.0088
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0057 0.0035 0.0694
Plasmodium falciparum plasmepsin III 0.0037 0.0013 0.0126
Schistosoma mansoni hypothetical protein 0.0101 0.0086 0.0079
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0226 0.0228 0.0228
Loa Loa (eye worm) TK/ALK protein kinase 0.0101 0.0086 0.008
Brugia malayi hypothetical protein 0.0037 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0007
Echinococcus granulosus protein arginine N methyltransferase 8 0.0195 0.0192 0.0186
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0048 0.0256
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0137
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0035 0.0011 0.0007
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0118 0.0106 0.2266
Brugia malayi hypothetical protein 0.0101 0.0086 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.0226 0.0219
Brugia malayi CUB domain containing protein 0.0035 0.0011 0.0011
Plasmodium falciparum plasmepsin II 0.0037 0.0013 0.0126
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0105 0.0091 0.0085
Schistosoma mansoni hypothetical protein 0.1761 0.1972 0.1967
Loa Loa (eye worm) hypothetical protein 0.0101 0.0086 0.008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.215 0.2415 0.3948
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0118 0.0106 0.2033
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0389 0.0413 1
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0035 0.0011 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Schistosoma mansoni thyroid hormone receptor 0.017 0.0164 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0413 0.0666
Schistosoma mansoni thyroid hormone receptor 0.017 0.0164 0.0157
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0005
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0013 0.0135
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0008
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0013 0.0005
Trypanosoma cruzi arginine N-methyltransferase, type I 0.011 0.0096 0.0889
Schistosoma mansoni hypothetical protein 0.0035 0.0011 0.0004
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0389 0.0413 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0053 0.0032 0.0026
Schistosoma mansoni hypothetical protein 0.0035 0.0011 0.0004
Brugia malayi neuroendocrine convertase 1 precursor 0.5578 0.631 0.631
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0389 0.0413 0.0408
Brugia malayi Protein kinase domain containing protein 0.0101 0.0086 0.0086
Brugia malayi protein kinase C II. 0.0093 0.0076 0.0076
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0031 0.0026
Onchocerca volvulus 0.0037 0.0013 0.0033
Echinococcus multilocularis adam 0.0057 0.0036 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0013 0.0005
Loa Loa (eye worm) hypothetical protein 0.013 0.0119 0.0113
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0105 0.0091 0.1076
Mycobacterium ulcerans polyketide synthase 0.0076 0.0058 0.0787
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0093 0.0076 0.007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0008
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.011 0.0096 0.114
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0011 0.0006
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.011 0.0096 0.0145
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0147 0.0138 0.0138
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0007 0.0001
Onchocerca volvulus 0.0632 0.069 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0081 0.0063 0.0932
Plasmodium falciparum LCCL domain-containing protein 0.0053 0.0031 0.0556
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0008
Schistosoma mansoni site-1 peptidase (S08 family) 0.0389 0.0413 0.0406
Schistosoma mansoni chromatin regulatory protein sir2 0.0714 0.0782 0.0775
Echinococcus granulosus protein arginine N methyltransferase 7 0.011 0.0096 0.009
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0389 0.0413 0.0413
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0389 0.0413 1
Echinococcus multilocularis c4b binding protein beta chain 0.0037 0.0013 0.001
Brugia malayi transcriptional regulator, Sir2 family protein 0.0105 0.0091 0.0091
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1323 0.1474 0.1468
Echinococcus multilocularis discoidin domain receptor 0.0053 0.0031 0.0032
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0061 0.004 0.0333
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0007 0.0002
Schistosoma mansoni hypothetical protein 0.0053 0.0032 0.0024
Echinococcus multilocularis Furin 1 0.215 0.2415 0.3014
Brugia malayi Protein arginine N-methyltransferase 0.011 0.0096 0.0096
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0118 0.0106 0.0098
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0053 0.0031 0.004
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0013 0.0135
Plasmodium falciparum subtilisin-like protease 1 0.0389 0.0413 0.9353
Trichomonas vaginalis hypothetical protein 0.0053 0.0031 0.004
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0668 0.073 0.0906
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0583 0.0634 0.0785
Brugia malayi Kelch motif family protein 0.0035 0.0011 0.0011
Brugia malayi Calcium binding EGF domain containing protein 0.0045 0.0022 0.0022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Toxoplasma gondii histone lysine-specific demethylase 0.0118 0.0106 0.2422
Trypanosoma brucei subtilisin peptidase 0.0389 0.0413 0.5241
Plasmodium vivax aspartyl protease, putative 0.0037 0.0013 0.0126
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0053 0.0031 0.004
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0714 0.0782 1
Loa Loa (eye worm) hypothetical protein 0.0304 0.0317 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0027 0.0032
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0013 0.0007
Echinococcus granulosus CUB 0.0035 0.0011 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Loa Loa (eye worm) WD40 repeat protein 0.0207 0.0206 0.02
Brugia malayi transcriptional regulator, Sir2 family protein 0.0714 0.0782 0.0782
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0714 0.0782 0.0776
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0076 0.0058 0.0787
Plasmodium falciparum subtilisin-like protease 3 0.0389 0.0413 0.9353
Loa Loa (eye worm) DPY-31 protein 0.0035 0.0011 0.0005
Entamoeba histolytica SWIRM domain protein 0.0049 0.0027 0.0255
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0105 0.0091 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Onchocerca volvulus 0.0037 0.0013 0.0023
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0105 0.0091 0.1076
Echinococcus multilocularis protein kinase c epsilon type 0.0093 0.0076 0.0088
Brugia malayi proprotein convertase 2 0.5578 0.631 0.631
Brugia malayi Protein kinase domain containing protein 0.0053 0.0031 0.0031
Onchocerca volvulus 0.0037 0.0013 0.0033
Onchocerca volvulus 0.0037 0.0013 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Trypanosoma cruzi UDP-galactopyranose mutase 0.0118 0.0106 0.1023
Plasmodium falciparum plasmepsin IV 0.0037 0.0013 0.0126
Brugia malayi Nematode astacin protease protein 30 0.0035 0.0011 0.0011
Echinococcus granulosus cubilin 0.0035 0.0011 0.0005
Loa Loa (eye worm) sirtuin 4 0.0105 0.0091 0.0085
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0258 0.0264 0.0258
Loa Loa (eye worm) transcriptional regulator 0.0105 0.0091 0.0085
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0044 0.0021 0.0018
Brugia malayi SWIRM domain containing protein 0.0632 0.069 0.069
Echinococcus granulosus protein arginine methyltransferase 0.0195 0.0192 0.0186
Schistosoma mansoni hypothetical protein 0.0207 0.0206 0.0199
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0035 0.0011 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0195 0.0192 0.4554
Toxoplasma gondii subtilisin SUB7 0.0389 0.0413 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0091 0.0083
Plasmodium vivax LCCL domain-containing protein 0.0053 0.0031 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Echinococcus granulosus discoidin domain receptor 0.0053 0.0031 0.0026
Schistosoma mansoni hypothetical protein 0.0053 0.0032 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Brugia malayi GCC2 and GCC3 family protein 0.0047 0.0024 0.0024
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0035 0.0011 0.0005
Brugia malayi CUB domain containing protein 0.0039 0.0016 0.0016
Brugia malayi Angiotensin-converting enzyme family protein 0.0673 0.0736 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0091 0.192
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5398 0.6105 1
Loa Loa (eye worm) transcriptional regulator 0.0714 0.0782 0.0776
Loa Loa (eye worm) protein arginine N-methyltransferase 0.011 0.0096 0.009
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.011 0.0096 0.0889
Mycobacterium ulcerans NAD-dependent deacetylase 0.0105 0.0091 0.1644
Mycobacterium ulcerans dehydrogenase 0.0118 0.0106 0.2033
Trichomonas vaginalis hypothetical protein 0.1761 0.1972 0.3223
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0195 0.0192 0.426
Loa Loa (eye worm) endoprotease bli-4 0.8825 1 1
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.011 0.0096 0.2174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0005
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0714 0.0782 1
Echinococcus granulosus C type lectin domian containing protein 0.0037 0.0013 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0031 0.0032
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0013 0.0005
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0044 0.0021 0.0015
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0053 0.0032 0.0032
Toxoplasma gondii rhoptry neck protein RON9 0.0037 0.0013 0.0152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0029 0.0023
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0105 0.0091 0.0085
Echinococcus multilocularis serine:threonine protein kinase N2 0.0085 0.0067 0.0077
Echinococcus multilocularis growth factor receptor bound protein 2 0.0137 0.0126 0.0151
Brugia malayi Subtilase family protein 0.0389 0.0413 0.0413
Toxoplasma gondii type I fatty acid synthase, putative 0.0056 0.0035 0.0679
Loa Loa (eye worm) CUB domain-containing protein 0.0035 0.0011 0.0005
Echinococcus granulosus methyltransferase protein 5 0.011 0.0096 0.009
Schistosoma mansoni hypothetical protein 0.0053 0.0031 0.0024
Echinococcus multilocularis MAM 0.0101 0.0086 0.0101
Onchocerca volvulus 0.0037 0.0013 0.0023
Toxoplasma gondii subtilisin SUB2 0.0389 0.0413 1
Entamoeba histolytica protein kinase, putative 0.0033 0.0009 0.002
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1761 0.1972 0.3223
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0021 0.0013
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0105 0.0091 0.0175
Onchocerca volvulus 0.0389 0.0413 0.5925
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0049 0.0027 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0076 0.0069
Echinococcus multilocularis C type lectin domian containing protein 0.0037 0.0013 0.001
Echinococcus multilocularis CUB 0.0035 0.0011 0.0007
Trypanosoma cruzi arginine N-methyltransferase, type I 0.011 0.0096 0.0889
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0389 0.0413 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0195 0.0192 0.0303
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0105 0.0091 0.2053
Echinococcus multilocularis cubilin 0.0035 0.0011 0.0007
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0035 0.0011 0.0011
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0013 0.0005
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0115 0.0102 0.2332
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0195 0.0192 0.0303
Schistosoma mansoni hypothetical protein 0.0035 0.0011 0.0004
Brugia malayi Cam kinase protein 1 0.0032 0.0007 0.0007
Mycobacterium leprae Possible secreted protease 0.0389 0.0413 1
Schistosoma mansoni SWI/SNF complex-related 0.0049 0.0027 0.002
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0118 0.0106 0.2266
Echinococcus multilocularis 0.0118 0.0106 0.0125
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0062 0.0041 0.0836
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0195 0.0192 0.426
Echinococcus granulosus membrane bound transcription factor site 1 0.0389 0.0413 0.0408
Onchocerca volvulus 0.0037 0.0013 0.0033
Schistosoma mansoni site-1 peptidase (S08 family) 0.0389 0.0413 0.0406
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0389 0.0413 0.0413
Echinococcus granulosus growth factor receptor bound protein 2 0.0137 0.0126 0.012
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0013 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0714 0.0782 0.127
Brugia malayi hypothetical protein 0.0037 0.0013 0.0013
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0013 0.0126
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0144 0.0138
Brugia malayi hypothetical protein 0.0057 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0035 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0001
Brugia malayi NAD-dependent deacetylase SIRT1 0.0105 0.0091 0.0091
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0013 0.0013
Trichomonas vaginalis WD repeat domain, putative 0.0207 0.0206 0.0326
Brugia malayi Stress-activated protein kinase jnk-1 0.0224 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0053 0.0031 0.0026
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0058 0.0787
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0076 0.0058 0.0058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.215 0.2415 0.3948
Loa Loa (eye worm) reprolysin 0.0044 0.0021 0.0015
Onchocerca volvulus 0.0053 0.0031 0.0298
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0007 0.0001
Plasmodium falciparum plasmepsin VII 0.0037 0.0013 0.0126
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0195 0.0192 0.0185
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0021 0.0013
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0031 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0241 0.0244 0.0237
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0007 0.0007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0063 0.0042 0.0035
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0048 0.0256
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0118 0.0106 0.2033
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0389 0.0413 1
Loa Loa (eye worm) hypothetical protein 0.0632 0.069 0.0684
Brugia malayi Kringle domain containing protein 0.0051 0.0029 0.0029
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0053 0.0031 0.0111
Echinococcus multilocularis protein will die slowly 0.0207 0.0206 0.025
Schistosoma mansoni protein kinase 0.0258 0.0264 0.0257
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0051 0.0029 0.0539
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.0063 0.1376
Echinococcus granulosus Furin 1 0.215 0.2415 0.241
Plasmodium vivax subtilisin-like protease 2, putative 0.0389 0.0413 0.9353
Echinococcus granulosus Tolloid protein 1 0.0035 0.0011 0.0005
Mycobacterium ulcerans oxidoreductase 0.0118 0.0106 0.2033
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0144 0.0173
Leishmania major sir2-family protein-like protein 0.0105 0.0091 0.1076
Schistosoma mansoni amine oxidase 0.0118 0.0106 0.0098
Schistosoma mansoni protein kinase 0.0258 0.0264 0.0257
Plasmodium falciparum plasmepsin X 0.0037 0.0013 0.0126
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0013 0.0013
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.0029 0.0491
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0118 0.0106 0.2422
Entamoeba histolytica hypothetical protein 0.0049 0.0027 0.0255
Onchocerca volvulus 0.0052 0.0031 0.0285
Brugia malayi hypothetical protein 0.0037 0.0013 0.0013
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0053 0.0032 0.0032
Onchocerca volvulus 0.0037 0.0013 0.0033
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0389 0.0413 0.0406
Giardia lamblia Sirtuin type 2 0.0105 0.0091 0.0175
Brugia malayi CUB domain containing protein 0.0035 0.0011 0.0011
Toxoplasma gondii subtilisin SUB10 0.0389 0.0413 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0091 0.0083
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0304 0.0317 0.3825
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0425 0.0453 0.5641
Brugia malayi Pepsin A precursor 0.0037 0.0013 0.0013
Plasmodium vivax subtilisin-like protease 1 0.0389 0.0413 0.9353
Echinococcus multilocularis Tolloid protein 1 0.0035 0.0011 0.0007
Trypanosoma brucei protein arginine n-methyltransferase 7 0.011 0.0096 0.114
Giardia lamblia Transcriptional regulator, Sir2 family 0.0105 0.0091 0.0175
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0224 0.0226 0.0275
Brugia malayi Will die slowly protein 0.0207 0.0206 0.0206
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0013 0.0005
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0389 0.0413 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0118 0.0106 0.0125
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0106 0.2266
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0005
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0425 0.0453 0.5761
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0195 0.0192 0.0185
Loa Loa (eye worm) fatty acid synthase 0.0078 0.006 0.0054
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0091 0.0083
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Entamoeba histolytica hypothetical protein, conserved 0.0105 0.0091 0.1076
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Loa Loa (eye worm) hypothetical protein 0.0118 0.0106 0.01
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0258 0.0264 0.0323
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0053 0.0031 0.0596
Loa Loa (eye worm) subtilase 0.0389 0.0413 0.0408
Plasmodium vivax plasmepsin V, putative 0.0414 0.0441 1
Onchocerca volvulus 0.0101 0.0086 0.1106
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5398 0.6105 0.7631
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.011 0.0096 0.114
Loa Loa (eye worm) TK/EGFR protein kinase 0.0618 0.0673 0.0667
Echinococcus granulosus protein kinase c epsilon type 0.0093 0.0076 0.0071
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0137
Echinococcus multilocularis epidermal growth factor receptor 0.0618 0.0673 0.0835
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0425 0.0453 0.5641
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.215 0.2415 0.3948
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0413 0.0666
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0013 0.0005
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0105 0.0091 0.192
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0031 0.0595
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0079 0.006 0.0053
Schistosoma mansoni memapsin-2 (A01 family) 0.0037 0.0013 0.0005
Onchocerca volvulus 0.0074 0.0055 0.0642
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0304 0.0317 0.3995
Plasmodium vivax apical sushi protein, putative 0.0037 0.0013 0.0142
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0007
Plasmodium vivax LCCL domain-containing protein 0.0053 0.0031 0.0556
Brugia malayi hypothetical protein 0.0037 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0304 0.0317 0.3995
Echinococcus granulosus chromatin regulatory protein sir2 0.0714 0.0782 0.0776
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Echinococcus multilocularis chromatin regulatory protein sir2 0.0714 0.0782 0.0971
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0013 0.0126
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0013 0.0007
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.004 0.0016 0.0222
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5398 0.6105 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0389 0.0413 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0008 0.0003
Plasmodium falciparum protoporphyrinogen oxidase 0.0118 0.0106 0.2266
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0007 0.0002
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0061 0.004 0.0333
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0031 0.0032
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0058 0.0787
Brugia malayi pregnancy-associated plasma protein-A 0.0037 0.0013 0.0013
Mycobacterium leprae Polyketide synthase Pks13 0.0115 0.0102 0.1937
Loa Loa (eye worm) hypothetical protein 0.0583 0.0634 0.0628
Schistosoma mansoni hypothetical protein 0.0053 0.0032 0.0024
Echinococcus multilocularis 0.7064 0.7999 1
Brugia malayi Protein kinase domain containing protein 0.0051 0.0029 0.0029
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0013 0.0135
Onchocerca volvulus 0.0101 0.0086 0.1106
Brugia malayi CUB domain containing protein 0.0035 0.0011 0.0011
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.0063 0.0932
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0008
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0137
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0013 0.0126
Schistosoma mansoni btb and poz domain-containing protein 0.0053 0.0031 0.0024
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Onchocerca volvulus Putative cubilin 0.0045 0.0022 0.0162
Schistosoma mansoni chromatin regulatory protein sir2 0.0714 0.0782 0.0775
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0081 0.0063 0.1376
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0058 0.0787
Schistosoma mansoni protein kinase 0.0258 0.0264 0.0257
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.215 0.2415 0.3948
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0013 0.0007
Toxoplasma gondii bicoid-interacting protein BIN3 0.011 0.0096 0.2174
Toxoplasma gondii subtilisin SUB8 0.0389 0.0413 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.215 0.2415 0.3948
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0031 0.0032
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0668 0.073 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0045 0.0022 0.0363
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0007 0.0001
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0053 0.0031 0.004
Giardia lamblia Furin precursor putative serine protease 0.1761 0.1972 0.5353
Echinococcus multilocularis cubilin 0.0035 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0005
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0053 0.0031 0.0026
Toxoplasma gondii subtilisin SUB6 0.0389 0.0413 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0105 0.0091 0.0823
Mycobacterium leprae Probable polyketide synthase Pks1 0.0081 0.0063 0.0932
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0714 0.0782 1
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0389 0.0413 0.051
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.0029 0.0023
Echinococcus granulosus furin 0.8825 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0137 0.0126 0.0119
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0053 0.0032 0.0024
Brugia malayi celfurPC protein 0.7064 0.7999 0.7999
Brugia malayi hypothetical protein 0.0037 0.0013 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Brugia malayi astacin protease protein 30 0.0035 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.013 0.0119 0.0113
Toxoplasma gondii SWIRM domain-containing protein 0.0049 0.0027 0.0486
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0195 0.0192 0.0233
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0105 0.0091 0.1076
Loa Loa (eye worm) hypothetical protein 0.0168 0.0162 0.0156
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0058 0.0787
Toxoplasma gondii aspartyl protease ASP5 0.0377 0.0399 0.9661
Loa Loa (eye worm) hypothetical protein 0.0389 0.0413 0.0408
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0053 0.0031 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0076 0.0058 0.1239
Schistosoma mansoni chromatin regulatory protein sir2 0.0714 0.0782 0.0775
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0007
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0115 0.0102 0.2332
Brugia malayi hypothetical protein 0.0037 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.0029 0.0023
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0035 0.0011 0.0004
Echinococcus multilocularis protein arginine N methyltransferase 7 0.011 0.0096 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0005
Trypanosoma cruzi arginine N-methyltransferase, type III 0.011 0.0096 0.0889
Loa Loa (eye worm) proprotein convertase 2 0.215 0.2415 0.241
Schistosoma mansoni tyrosine kinase 0.0618 0.0673 0.0666
Loa Loa (eye worm) hypothetical protein 0.0044 0.0021 0.0015
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0057 0.0036 0.0029
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0035 0.0011 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Loa Loa (eye worm) CUB domain-containing protein 0.0035 0.0011 0.0005
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0037 0.0013 0.0009
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.3428 0.3866 0.3863
Onchocerca volvulus 0.0037 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0045 0.0022 0.0016
Onchocerca volvulus 0.0169 0.0163 0.2237
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0013 0.0009
Toxoplasma gondii subtilisin SUB5 0.0389 0.0413 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Plasmodium falciparum plasmepsin VI 0.0037 0.0013 0.0126
Schistosoma mansoni chromatin regulatory protein sir2 0.0105 0.0091 0.0083
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0005
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0105 0.0091 0.1076
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0077 0.0058 0.1249
Loa Loa (eye worm) hypothetical protein 0.0101 0.0086 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.215 0.2415 0.2409
Onchocerca volvulus 0.0051 0.0029 0.0256
Echinococcus granulosus histone arginine methyltransferase CARMER 0.011 0.0096 0.009
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0031 0.0026
Toxoplasma gondii rhoptry neck protein RON1 0.0037 0.0013 0.0152
Schistosoma mansoni furin-1 (S08 family) 0.3817 0.4308 0.4304
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0714 0.0782 0.127
Chlamydia trachomatis protoporphyrinogen oxidase 0.0118 0.0106 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0007 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Plasmodium vivax aspartyl protease, putative 0.0037 0.0013 0.0126
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0105 0.0091 0.0137
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0031 0.0595
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5398 0.6105 0.6103
Echinococcus granulosus lysine specific histone demethylase 1A 0.0118 0.0106 0.01
Schistosoma mansoni growth factor receptor-bound protein 0.0137 0.0126 0.0119
Mycobacterium ulcerans polyketide synthase 0.0081 0.0063 0.0932
Echinococcus granulosus c-Jun N-terminal kinases 0.0224 0.0226 0.022
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0118 0.0106 0.2266
Schistosoma mansoni protein arginine n-methyltransferase 0.011 0.0096 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Brugia malayi SWIRM domain containing protein 0.0049 0.0027 0.0027
Echinococcus granulosus epidermal growth factor receptor 0.0618 0.0673 0.0667
Echinococcus granulosus cubilin 0.0035 0.0011 0.0005
Loa Loa (eye worm) hypothetical protein 0.8825 1 1
Brugia malayi Probable ATP-dependent helicase DHX35 0.0033 0.0008 0.0008
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0077 0.0058 0.1249
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0714 0.0782 1
Schistosoma mansoni hypothetical protein 0.0035 0.0011 0.0004
Trypanosoma brucei trypanothione synthetase 0.0068 0.0048 0.0524
Echinococcus granulosus serine:threonine protein kinase N2 0.0076 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0011 0.0005
Brugia malayi Sushi domain 0.0037 0.0013 0.0013
Loa Loa (eye worm) acyl carrier protein 0.0036 0.0012 0.0006
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0066 0.0046 0.0482
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0673 0.0736 0.073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Toxoplasma gondii subtilisin SUB4 0.0389 0.0413 1
Toxoplasma gondii subtilisin SUB12 0.0389 0.0413 1
Leishmania major subtilisin-like serine peptidase 0.0389 0.0413 0.5241
Entamoeba histolytica SWIRM domain protein 0.0049 0.0027 0.0255
Brugia malayi Sex muscle abnormal protein 5 0.0137 0.0126 0.0126
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0035 0.0011 0.0011
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0049 0.0027 0.0021
Plasmodium vivax NAD-dependent deacetylase, putative 0.0105 0.0091 0.192
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Schistosoma mansoni c4b-binding protein beta chain 0.0037 0.0013 0.0006
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1761 0.1972 0.3223
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0076 0.0058 0.1239
Trypanosoma brucei trypanothione synthetase, putative 0.0068 0.0048 0.0524
Plasmodium falciparum plasmepsin I 0.0037 0.0013 0.0126
Echinococcus granulosus MAM 0.0101 0.0086 0.008
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0081 0.0063 0.0932
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0031 0.0007 0.0007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0074 0.0055 0.0049
Leishmania major arginine N-methyltransferase, type I 0.011 0.0096 0.114
Brugia malayi Carm1-pending protein 0.011 0.0096 0.0096
Plasmodium falciparum apical sushi protein 0.0037 0.0013 0.0142
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0013 0.0135
Onchocerca volvulus 0.0037 0.0013 0.0033
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0013 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0013 0.0005
Brugia malayi Muscle positioning protein 4 0.0031 0.0006 0.0006
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0195 0.0192 0.0303
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0008
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.011 0.0096 0.0145
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0013 0.0005
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0137 0.0126 0.012
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0013 0.0126
Echinococcus granulosus c4b binding protein beta chain 0.0037 0.0013 0.0008
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.011 0.0096 0.0112
Onchocerca volvulus 0.0137 0.0127 0.1709
Echinococcus multilocularis neuroendocrine convertase 2 0.5578 0.631 0.7887
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.001
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0105 0.0091 0.0823
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0035 0.0011 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Brugia malayi hypothetical protein 0.0035 0.0011 0.0011
Onchocerca volvulus 0.0037 0.0013 0.0033
Onchocerca volvulus Fatty acid synthase homolog 0.0142 0.0133 0.1791
Trypanosoma cruzi subtilisin peptidase 0.0389 0.0413 0.5106
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0195 0.0192 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0027 0.0032
Leishmania major UDP-galactopyranose mutase 0.0118 0.0106 0.1269
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.011 0.0096 0.0145
Loa Loa (eye worm) hypothetical protein 0.0049 0.0027 0.0021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.215 0.2415 0.3948
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.0413 0.0666
Loa Loa (eye worm) Carm1-pending protein 0.011 0.0096 0.009
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0118 0.0106 0.2033
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0105 0.0091 0.0085
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0058 0.1239
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0118 0.0106 0.2033
Entamoeba histolytica PH domain containing protein kinase, putative 0.0076 0.0057 0.0643
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Onchocerca volvulus 0.0207 0.0206 0.2871
Loa Loa (eye worm) apoptosis regulator protein 0.0053 0.0032 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0001
Schistosoma mansoni hypothetical protein 0.0051 0.0029 0.0021
Loa Loa (eye worm) hypothetical protein 0.0583 0.0634 0.0628
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0013 0.0005
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8825 1 1
Schistosoma mansoni septate junction protein 0.0063 0.0042 0.0035
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0035 0.0011 0.0005
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0013 0.0005
Leishmania major silent information regulator 2, putative 0.0714 0.0782 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.0063 0.0932
Loa Loa (eye worm) hypothetical protein 0.0047 0.0024 0.0019
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0105 0.0091 0.0106
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0224 0.0226 0.022
Loa Loa (eye worm) hypothetical protein 0.0105 0.0091 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Mycobacterium tuberculosis Possible oxidoreductase 0.0118 0.0106 0.2423
Schistosoma mansoni hypothetical protein 0.0152 0.0144 0.0137
Onchocerca volvulus 0.0037 0.0013 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666
Brugia malayi transcriptional regulator, Sir2 family protein 0.0105 0.0091 0.0091
Plasmodium falciparum subtilisin-like protease 2 0.0389 0.0413 0.9353
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0074 0.0055 0.1171
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0389 0.0413 1
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Giardia lamblia High cysteine membrane protein Group 2 0.3247 0.3661 1
Echinococcus granulosus neuroendocrine convertase 2 0.5578 0.631 0.6308
Toxoplasma gondii subtilisin SUB11 0.0389 0.0413 1
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.0008 0.0003
Plasmodium vivax subtilisin-like serine protease, putative 0.0389 0.0413 0.9353
Onchocerca volvulus 0.0053 0.0031 0.0298
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0304 0.0317 0.3995
Brugia malayi hypothetical protein 0.0037 0.0013 0.0013
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0583 0.0634 0.0627
Brugia malayi Furin-like cysteine rich region family protein 0.0618 0.0673 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.1761 0.1972 0.3223
Brugia malayi hypothetical protein 0.0118 0.0106 0.0106
Brugia malayi amine oxidase, flavin-containing family protein 0.0168 0.0162 0.0162
Giardia lamblia Hypothetical protein 0.0714 0.0782 0.2077
Mycobacterium ulcerans Sir2-like regulatory protein 0.0105 0.0091 0.1644
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0389 0.0413 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0031 0.004
Toxoplasma gondii type I fatty acid synthase, putative 0.0081 0.0063 0.1375
Trypanosoma cruzi UDP-galactopyranose mutase 0.0118 0.0106 0.1023
Brugia malayi hypothetical protein 0.0304 0.0317 0.0317
Plasmodium vivax aspartyl protease, putative 0.0037 0.0013 0.0126
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0226 0.0228 0.0222
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0389 0.0413 0.0666

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0355 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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