Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0299 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0299 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0299 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0299 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.5983 | 0.4584 |
Plasmodium falciparum | triosephosphate isomerase | 0.011 | 0.2582 | 0.2582 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0299 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.5983 | 0.4584 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0299 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0299 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0299 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0299 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0299 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0299 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | triosephosphate isomerase | 0.011 | 0.2582 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0299 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0299 | 1 | 1 |
Treponema pallidum | triosephosphate isomerase | 0.011 | 0.2582 | 0.5 |
Onchocerca volvulus | 0.0114 | 0.2719 | 0.5 | |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0299 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.4905 | 0.4905 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.5983 | 0.4584 |
Plasmodium vivax | triosephosphate isomerase, putative | 0.011 | 0.2582 | 0.2582 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0299 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.5983 | 0.4584 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.4905 | 0.4905 |
Chlamydia trachomatis | triosephosphate isomerase | 0.011 | 0.2582 | 0.5 |
Mycobacterium ulcerans | proteasome PrcB | 0.0299 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.5983 | 0.4584 |
Schistosoma mansoni | triosephosphate isomerase | 0.011 | 0.2582 | 0.2582 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | = 112.2018 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.