TDR Targets

Basic information

Technical information

TDR Targets ID: 1441637
Name: 5-chloro-N-(3-chloro-4-methoxyphenyl)-1-[(2-c hlorophenyl)methyl]-3-methylpyrazole-4-carbox amide
MW: 424.708 | Formula: C19H16Cl3N3O2
H donors: 1 H acceptors: 2 LogP: 5.25 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1Cl)NC(=O)c1c(C)nn(c1Cl)Cc1ccccc1Cl
InChi: 1S/C19H16Cl3N3O2/c1-11-17(19(26)23-13-7-8-16(27-2)15(21)9-13)18(22)25(24-11)10-12-5-3-4-6-14(12)20/h3-9H,10H2,1-2H3,(H,23,26)
InChiKey: DFCOAABPZDSRBY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-chloro-N-(3-chloro-4-methoxy-phenyl)-1-[(2-chlorophenyl)methyl]-3-methyl-pyrazole-4-carboxamide
5-chloro-N-(3-chloro-4-methoxyphenyl)-1-[(2-chlorophenyl)methyl]-3-methyl-4-pyrazolecarboxamide
5-chloro-1-(2-chlorobenzyl)-N-(3-chloro-4-methoxy-phenyl)-3-methyl-pyrazole-4-carboxamide
MLS000335956
SMR000253710
T5252388

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	thyroid hormone receptor, beta	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma mansoni	thyroid hormone receptor	Get druggable targets OG5_134830	All targets in OG5_134830
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Thyroid hormone receptor alpha, putative	Get druggable targets OG5_134830	All targets in OG5_134830
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	thyroid hormone receptor alpha	Get druggable targets OG5_134830	All targets in OG5_134830
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Brugia malayi	photoreceptor-specific nuclear receptor	thyroid hormone receptor, beta	461 aa	414 aa	24.6 %
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	sex peptide receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0122	0.0122
Echinococcus multilocularis	sex peptide receptor	0.0022	0.0608	0.0608
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.1788	0.2593
Echinococcus granulosus	dro:myosuppressin receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0122	0.0122
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	thyroid hormone receptor	0.0164	0.7926	0.7926
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0122	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0022	0.0608	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0122	0.0122
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	hypothetical protein	0.0022	0.0608	0.0608
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0608	0.0881
Onchocerca volvulus		0.0022	0.0608	1
Brugia malayi	ecdysteroid receptor	0.0012	0.0122	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Brugia malayi	sulfakinin receptor protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	allatostatin A receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	orexin receptor type 2	0.0022	0.0608	0.0608
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0022	0.0608	0.0608
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881
Onchocerca volvulus		0.0022	0.0608	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Brugia malayi	G-protein coupled receptor	0.0022	0.0608	0.0881
Schistosoma mansoni	growth hormone secretagogue receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	neuropeptide receptor A26	0.0022	0.0608	0.0608
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.1788	0.1788
Onchocerca volvulus		0.0022	0.0608	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0122	0.0122
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0022	0.0608	0.0881
Onchocerca volvulus		0.0022	0.0608	1
Loa Loa (eye worm)	TYRA-2 protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	adenoreceptor	0.0022	0.0608	0.0608
Schistosoma mansoni	amine GPCR	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.1788	0.5
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.73	0.73
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0608	0.0881
Brugia malayi	RE15519p	0.0022	0.0608	0.0881
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0608	0.0608
Echinococcus granulosus	allatostatin A receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.73	0.73
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0122	0.0177
Schistosoma mansoni	histamine h1 receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0022	0.0608	0.0608
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	g-protein coupled receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0608	0.0608
Brugia malayi	G protein-coupled receptor F59B2.13	0.0022	0.0608	0.0881
Brugia malayi	steroid hormone receptor	0.0012	0.0122	0.0177
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.1788	0.1788
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0608	0.0608
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0122	0.0177
Echinococcus multilocularis	dro:myosuppressin receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0122	0.0122
Loa Loa (eye worm)	melatonin receptor type 1A	0.0022	0.0608	0.0881
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	amine GPCR	0.0022	0.0608	0.0608
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0122	0.0122
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0022	0.0608	0.0608
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0122	0.0177
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0022	0.0608	0.0881
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0608	0.0608
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0608	0.0608
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.1788	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0608	0.0608
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0122	0.0177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0608	0.0608
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Schistosoma mansoni	hypothetical protein	0.0205	1	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.1788	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0177
Echinococcus granulosus	fmrfamide receptor	0.0022	0.0608	0.0608
Onchocerca volvulus		0.0022	0.0608	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0177
Schistosoma mansoni	amine GPCR	0.0022	0.0608	0.0608
Echinococcus multilocularis	serotonin receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0122	0.0122
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0022	0.0608	0.0881
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0122	0.0177
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0608	0.0608
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0122	0.0177
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.1788	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0122	0.0122
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.1788	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	serotonin receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	serotonin receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Onchocerca volvulus		0.0022	0.0608	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0022	0.0608	0.0608
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0122	0.0122
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0122	0.0177
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.1788	0.1788
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0177
Schistosoma mansoni	thyroid hormone receptor	0.0164	0.7926	0.7926
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1788	0.2593
Onchocerca volvulus		0.0022	0.0608	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0022	0.0608	0.0608
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0608	0.0608
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.1788	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.6896	1
Onchocerca volvulus		0.0022	0.0608	1
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0122	0.0122
Schistosoma mansoni	hypothetical protein	0.0022	0.0608	0.0608
Schistosoma mansoni	hypothetical protein	0.0205	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	myosin xvIII	0.0022	0.0608	0.0608
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0608	0.0608
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0122	0.0122
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0608	0.0608
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	opsin-like receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0022	0.0608	0.0881
Echinococcus granulosus	G protein coupled receptor 139	0.0022	0.0608	0.0608
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0122	0.0177
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.1788	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0122	0.0122
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0022	0.0608	0.0608
Echinococcus multilocularis	orexin receptor type 2	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Brugia malayi	ORL1-like opioid receptor	0.0022	0.0608	0.0881
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0608	0.0608
Brugia malayi	neuropeptide F receptor	0.0022	0.0608	0.0881
Echinococcus granulosus	somatostatin receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0122	0.0122
Schistosoma mansoni	hypothetical protein	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0177
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0122	0.0122
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0608	0.0608
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0122	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0608	0.0608
Echinococcus granulosus	7TM GPCR rhodopsin	0.0022	0.0608	0.0608
Onchocerca volvulus		0.0022	0.0608	1
Schistosoma mansoni	hypothetical protein	0.0152	0.73	0.73
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0122	0.0122
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0022	0.0608	0.0881
Echinococcus multilocularis	somatostatin receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0122	0.0122
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0122	0.0177
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	opsin-like receptor	0.0022	0.0608	0.0608
Brugia malayi	MH2 domain containing protein	0.0144	0.6896	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0608	0.0608
Brugia malayi	putative neuropeptide receptor NPR1	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Schistosoma mansoni	hypothetical protein	0.0022	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	amine GPCR	0.0022	0.0608	0.0608
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0608	0.0608
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	neuropeptide s receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0608	0.0608
Brugia malayi	neuropeptide F receptor	0.0022	0.0608	0.0881
Echinococcus multilocularis	neuropeptide s receptor	0.0022	0.0608	0.0608
Onchocerca volvulus		0.0022	0.0608	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0122	0.0177
Onchocerca volvulus		0.0022	0.0608	1
Brugia malayi	G-protein coupled receptor	0.0022	0.0608	0.0881
Brugia malayi	larval opioid receptor	0.0022	0.0608	0.0881
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.1788	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0122	0.0122
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0122	0.0122
Echinococcus granulosus	neuropeptide FF receptor 2	0.0022	0.0608	0.0608
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0022	0.0608	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	neuropeptide f receptor 76f	0.0022	0.0608	0.0608
Onchocerca volvulus		0.0022	0.0608	1
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0608	0.0608
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0022	0.0608	0.0881
Echinococcus multilocularis	geminin	0.0205	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Brugia malayi	Serotonin receptor	0.0022	0.0608	0.0881
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0122	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0122	0.0177
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.1788	0.1788
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0608	0.0608
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0122	0.0177
Echinococcus multilocularis	G protein coupled receptor 139	0.0022	0.0608	0.0608
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.1788	0.1788
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0022	0.0608	0.0608
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0122	0.0122
Brugia malayi	AKH receptor	0.0022	0.0608	0.0881
Brugia malayi	putative neuropeptide receptor	0.0022	0.0608	0.0881
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0122	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0122	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0177
Brugia malayi	GnHR receptor homolog	0.0022	0.0608	0.0881
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.1788	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	7tm_1 domain containing protein	0.0022	0.0608	0.0608
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0608	0.0608
Brugia malayi	follicle stimulating hormone receptor	0.0022	0.0608	0.0881
Onchocerca volvulus		0.0022	0.0608	1
Schistosoma mansoni	coup transcription factor	0.0012	0.0122	0.0122
Brugia malayi	Dopamine receptor	0.0022	0.0608	0.0881
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0122	0.0177
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0122	0.0122
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0122	0.0177
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0122	0.0122
Echinococcus granulosus	hypothetical protein	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0022	0.0608	0.0608
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0022	0.0608	0.0881
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0122	0.0177
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0022	0.0608	0.0608
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0122	0.0177
Brugia malayi	Dopamine receptor protein 1	0.0022	0.0608	0.0881
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0122	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Brugia malayi	G protein-coupled receptor	0.0022	0.0608	0.0881
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0022	0.0608	0.0608
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0122	0.0122
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0122	0.0177
Brugia malayi	Melatonin receptor type 1A	0.0022	0.0608	0.0881
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0122	0.0122
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0608	0.0608
Onchocerca volvulus		0.0022	0.0608	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0608	0.0608
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0608	0.0608
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0122	0.0122
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0608	0.0608
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Brugia malayi	nuclear hormone receptor	0.0012	0.0122	0.0177
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0022	0.0608	0.0881
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.1788	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0022	0.0608	0.0608
Onchocerca volvulus		0.0022	0.0608	1
Brugia malayi	Dopamine receptor protein 2	0.0022	0.0608	0.0881
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0122	0.0122
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0608	0.0608
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0608	0.0608
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0122	0.0177
Echinococcus granulosus	neuropeptide receptor A26	0.0022	0.0608	0.0608
Onchocerca volvulus		0.0022	0.0608	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.1788	0.1788
Schistosoma mansoni	amine GPCR	0.0022	0.0608	0.0608
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0608	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Schistosoma mansoni	opsin-like receptor	0.0022	0.0608	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0608	0.0881
Echinococcus multilocularis	g-protein coupled receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0164	0.7926	0.7926
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.1788	0.5
Onchocerca volvulus		0.0022	0.0608	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.6896	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0022	0.0608	0.0608
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0608	0.0608
Brugia malayi	Serotonin receptor	0.0022	0.0608	0.0881
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0122	0.0177
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0122	0.0177
Brugia malayi	hypothetical protein	0.0022	0.0608	0.0881

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)]	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	21.1923 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1606587

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1441637