Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Histone deacetylase family protein | 0.0124 | 0.733 | 1 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0064 | 0.3383 | 0.4615 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0124 | 0.733 | 0.733 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0112 | 0.6571 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0112 | 0.6571 | 0.8077 |
Echinococcus granulosus | histone deacetylase 3 | 0.0112 | 0.6571 | 0.7148 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0064 | 0.3383 | 0.3383 |
Loa Loa (eye worm) | histone deacetylase | 0.0124 | 0.733 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0112 | 0.6571 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.013 | 0.7762 | 0.7762 |
Schistosoma mansoni | histone deacetylase hda2 | 0.013 | 0.7762 | 0.7762 |
Echinococcus granulosus | histone deacetylase 6 | 0.013 | 0.7762 | 0.8443 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.9193 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0124 | 0.733 | 0.733 |
Trypanosoma brucei | histone deacetylase 1 | 0.0112 | 0.6571 | 0.8077 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0064 | 0.3383 | 0.3383 |
Brugia malayi | Histone deacetylase family protein | 0.0124 | 0.733 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0124 | 0.733 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3521 | 0.4803 |
Echinococcus multilocularis | histone deacetylase | 0.0124 | 0.733 | 0.733 |
Echinococcus granulosus | histone deacetylase 6 | 0.0124 | 0.733 | 0.7973 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0064 | 0.3383 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0124 | 0.733 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0112 | 0.6571 | 0.6571 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3088 | 0.4213 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.6571 | 0.8964 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0124 | 0.733 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0112 | 0.6571 | 0.6571 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0112 | 0.6571 | 0.5 |
Brugia malayi | histone deacetylase 11 | 0.0064 | 0.3383 | 0.4615 |
Echinococcus granulosus | histone deacetylase | 0.0124 | 0.733 | 0.7973 |
Plasmodium vivax | histone deacetylase, putative | 0.0124 | 0.733 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.0124 | 0.733 | 0.7973 |
Leishmania major | histone deacetylase, putative | 0.0124 | 0.733 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0124 | 0.733 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0124 | 0.733 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.9193 | 0.9193 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0112 | 0.6571 | 0.8964 |
Giardia lamblia | Histone deacetylase | 0.0112 | 0.6571 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0112 | 0.6571 | 0.8964 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0124 | 0.733 | 0.733 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.3383 | 0.4615 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.9193 | 0.9193 |
Brugia malayi | Histone deacetylase 1 | 0.0112 | 0.6571 | 0.8964 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0112 | 0.6571 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0112 | 0.6571 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0112 | 0.6571 | 0.8077 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0112 | 0.6571 | 0.8964 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0112 | 0.6571 | 0.6571 |
Entamoeba histolytica | histone deacetylase, putative | 0.0112 | 0.6571 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0112 | 0.6571 | 0.8077 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0112 | 0.6571 | 0.5 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0124 | 0.733 | 0.733 |
Plasmodium falciparum | histone deacetylase, putative | 0.0124 | 0.733 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0124 | 0.733 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0112 | 0.6571 | 0.8077 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0124 | 0.733 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0112 | 0.6571 | 0.6571 |
Trypanosoma brucei | histone deacetylase 4 | 0.0124 | 0.733 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0124 | 0.733 | 0.7973 |
Leishmania major | histone deacetylase, putative | 0.0124 | 0.733 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0112 | 0.6571 | 0.8077 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0112 | 0.6571 | 0.8964 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0112 | 0.6571 | 0.5 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0064 | 0.3383 | 0.3383 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0124 | 0.733 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.0064 | 0.3383 | 0.368 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0124 | 0.733 | 0.733 |
Echinococcus granulosus | histone deacetylase 1 | 0.0112 | 0.6571 | 0.7148 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0112 | 0.6571 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0124 | 0.733 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0112 | 0.6571 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.