Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2804 | 0.5155 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2804 | 0.2804 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2804 | 0.7321 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2804 | 0.5155 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.383 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.5439 | 0.5439 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2804 | 0.2804 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0503 | 0.0503 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0503 | 0.1313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2804 | 0.7321 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1708 | 0.1708 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2804 | 0.2804 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0503 | 0.0503 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0936 | 0.1721 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.5439 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2804 | 0.2804 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2804 | 0.2804 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2804 | 0.2804 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2804 | 0.7321 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0936 | 0.1721 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0503 | 0.0925 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0503 | 0.0925 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.2545 | 0.2545 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0503 | 0.1313 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.5439 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2804 | 0.7321 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2804 | 0.7321 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.