Detailed information for compound 1441989

Basic information

Technical information
  • TDR Targets ID: 1441989
  • Name: N-[2-(4-methoxyphenyl)ethyl]-2-(2H-1,2,4-tria zol-3-ylsulfanyl)acetamide
  • MW: 292.357 | Formula: C13H16N4O2S
  • H donors: 2 H acceptors: 3 LogP: 2.1 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCNC(=O)CSc1n[nH]cn1
  • InChi: 1S/C13H16N4O2S/c1-19-11-4-2-10(3-5-11)6-7-14-12(18)8-20-13-15-9-16-17-13/h2-5,9H,6-8H2,1H3,(H,14,18)(H,15,16,17)
  • InChiKey: CRFRDLYRPHMWCU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[2-(4-methoxyphenyl)ethyl]-2-(2H-1,2,4-triazol-3-ylthio)acetamide
  • N-[2-(4-methoxyphenyl)ethyl]-2-(2H-1,2,4-triazol-3-ylsulfanyl)ethanamide
  • ZINC03225118
  • MLS000564984
  • SMR000152243
  • T0507-6755

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0115 0.0136
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0115 0.0115
Schistosoma mansoni biogenic amine receptor 0.0021 0.0115 0.0136
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni amine GPCR 0.0021 0.0115 0.0136
Echinococcus granulosus g protein coupled receptor 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi neuropeptide F receptor 0.0021 0.0115 0.0115
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.1385 0.1385
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1385 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 1 1
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0115 0.0115
Schistosoma mansoni adenoreceptor 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.1385 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Echinococcus granulosus somatostatin receptor 0.0021 0.0115 0.0115
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0115 0.0115
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.1385 0.1385
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2037 0.2037
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0115 0.0115
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1385 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0115 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Brugia malayi G-protein coupled receptor 0.0021 0.0115 0.0115
Brugia malayi GnHR receptor homolog 0.0021 0.0115 0.0115
Trypanosoma brucei glucosidase, putative 0.0044 0.1385 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0115 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2037 0.2037
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0115 0.0136
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0115 0.0136
Brugia malayi TAR-binding protein 0.0076 0.3233 0.3233
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi G-protein coupled receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis somatostatin receptor 0.0021 0.0115 0.0115
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1385 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0115 0.0115
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0115 0.0115
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0115 0.0115
Onchocerca volvulus 0.0114 0.5332 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2316 0.2316
Schistosoma mansoni neuropeptide receptor 0.0021 0.0115 0.0136
Schistosoma mansoni hypothetical protein 0.0041 0.1244 0.1471
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0115 0.0136
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0115 0.0115
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0115 0.0115
Schistosoma mansoni neuropeptide receptor 0.0021 0.0115 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3233 0.3822
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0115 0.0115
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0115 0.0115
Echinococcus granulosus g protein coupled receptor 0.0021 0.0115 0.0115
Brugia malayi AKH receptor 0.0021 0.0115 0.0115
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0021 0.0115 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3233 0.3822
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0115 0.0115
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2037 0.2037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3233 0.3822
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Brugia malayi neuropeptide F receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Schistosoma mansoni opsin-like receptor 0.0021 0.0115 0.0136
Schistosoma mansoni biogenic amine receptor 0.0021 0.0115 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0115 0.0136
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.1385 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0115 0.0115
Schistosoma mansoni amine GPCR 0.0021 0.0115 0.0136
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0115 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2037 0.2408
Schistosoma mansoni hypothetical protein 0.0021 0.0115 0.0136
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0115 0.0136
Brugia malayi larval opioid receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0115 0.0115
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0115 0.0136
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0115 0.0115
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0115 0.0115
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2037 0.2408
Echinococcus multilocularis sex peptide receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0115 0.0136
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0115 0.0115
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2037 0.2037
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.1385 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0115 0.0136
Brugia malayi Serotonin receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0115 0.0115
Brugia malayi Dopamine receptor 0.0021 0.0115 0.0115
Schistosoma mansoni opsin-like receptor 0.0021 0.0115 0.0136
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0115 0.0115
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0115 0.0136
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0115 0.0136
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0115 0.0115
Brugia malayi Serotonin receptor 0.0021 0.0115 0.0115
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0115 0.0136
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni alpha-glucosidase 0.0169 0.8458 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi putative neuropeptide receptor 0.0021 0.0115 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.1385 0.5
Brugia malayi RNA binding protein 0.0076 0.3233 0.3233
Schistosoma mansoni biogenic amine receptor 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3233 0.3822
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2037 0.2408
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0115 0.0115
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2316 0.2316
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0115 0.0115
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0115 0.0115
Echinococcus granulosus sex peptide receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0115 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis serotonin receptor 0.0021 0.0115 0.0115
Echinococcus granulosus hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0115 0.0115
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0115 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0115 0.0115
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.1385 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0115 0.0136
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1244 0.1244
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0115 0.0115
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0115 0.0115
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1385 0.5
Echinococcus multilocularis tar DNA binding protein 0.0076 0.3233 0.3233
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0115 0.0136
Schistosoma mansoni amine GPCR 0.0021 0.0115 0.0136
Echinococcus granulosus allatostatin A receptor 0.0021 0.0115 0.0115
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.1385 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0115 0.0136
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0115 0.0136
Schistosoma mansoni histamine h1 receptor 0.0021 0.0115 0.0136
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus tar DNA binding protein 0.0076 0.3233 0.3233
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0115 0.0115
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0115 0.0136
Echinococcus multilocularis serotonin receptor 0.0021 0.0115 0.0115
Echinococcus granulosus neuropeptide receptor 0.0021 0.0115 0.0115
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.006 0.2316 0.2316
Schistosoma mansoni alpha glucosidase 0.0044 0.1385 0.1637
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi RE15519p 0.0021 0.0115 0.0115
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.3233 0.3233
Schistosoma mansoni amine GPCR 0.0021 0.0115 0.0136
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0115 0.0115
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2316 0.2316
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 1 1
Brugia malayi Dopamine receptor protein 2 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0115 0.0115
Echinococcus granulosus serotonin receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.3233 0.3233
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.1385 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0115 0.0136
Schistosoma mansoni opsin-like receptor 0.0021 0.0115 0.0136
Brugia malayi sulfakinin receptor protein 0.0021 0.0115 0.0115
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.1385 0.5
Schistosoma mansoni neuropeptide receptor 0.0021 0.0115 0.0136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.1385 0.1385
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0115 0.0115
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0115 0.0115
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.1385 0.5
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0115 0.0115
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0115 0.0115
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0021 0.0115 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Brugia malayi ORL1-like opioid receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0115 0.0115
Echinococcus granulosus fmrfamide receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0115 0.0115
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0115 0.0115
Brugia malayi hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0115 0.0115
Echinococcus granulosus orexin receptor type 2 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0115 0.0136
Brugia malayi Dopamine receptor protein 1 0.0021 0.0115 0.0115
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0115 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0076 0.3233 0.3233
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1385 0.5
Schistosoma mansoni alpha-glucosidase 0.0169 0.8458 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3233 0.3822
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0115 0.0115
Echinococcus granulosus g protein coupled receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0041 0.1244 0.1244
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0115 0.0115
Echinococcus granulosus neuropeptide receptor 0.0021 0.0115 0.0115
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0115 0.0136
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0115 0.0136
Loa Loa (eye worm) RNA binding protein 0.0076 0.3233 0.3233
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.1385 0.1385
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0115
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0115 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.1385 0.5
Brugia malayi G protein-coupled receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0115 0.0115
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0115 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2037 0.2037
Brugia malayi Melatonin receptor type 1A 0.0021 0.0115 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2037 0.2037
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0115 0.0136
Schistosoma mansoni myosin xvIII 0.0021 0.0115 0.0136
Schistosoma mansoni neuropeptide receptor 0.0021 0.0115 0.0136
Schistosoma mansoni amine GPCR 0.0021 0.0115 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0115 0.0115
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0115 0.0115

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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