Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | arachidonate 15-lipoxygenase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Onchocerca volvulus | Huntingtin homolog | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132837 | All targets in OG5_132837 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | arachidonate 15-lipoxygenase | 662 aa | 590 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0655 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0067 | 0.3851 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0609 | 0.0609 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.3449 | 0.3025 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0655 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3449 | 0.8761 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0655 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.3449 | 0.8761 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.3449 | 0.3025 |
Schistosoma mansoni | lipoxygenase | 0.0067 | 0.3851 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.7556 | 0.7397 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0067 | 0.3851 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.7556 | 0.7556 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.7556 | 0.7397 |
Brugia malayi | RNA binding protein | 0.0061 | 0.3449 | 0.3449 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3449 | 0.8761 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0609 | 0.0609 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0655 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.3449 | 0.8761 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0655 | 0.0049 |
Brugia malayi | Doublecortin family protein | 0.0024 | 0.0609 | 0.0609 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3449 | 0.8761 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0655 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0655 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.3449 | 0.3449 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.3449 | 0.3025 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3449 | 0.8761 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0655 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.3449 | 0.3449 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0655 | 0.0655 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3449 | 0.8761 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0655 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3981 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.