Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7497 | 0.5903 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.9511 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.9511 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3891 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3891 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.2273 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.7497 | 0.7497 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2273 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.9511 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.2273 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2273 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.9511 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3891 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7497 | 0.5903 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7497 | 0.5903 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7497 | 0.5903 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.2273 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7497 | 0.5903 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.7497 | 0.6761 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.9511 | 0.92 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.9511 | 0.92 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.9511 | 0.92 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.9511 | 0.92 |
Brugia malayi | hypothetical protein | 0.0038 | 0.3891 | 0.3891 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7497 | 0.5903 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7497 | 0.5903 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3891 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.2273 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.2273 | 0.2273 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.9511 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.9511 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.