Detailed information for compound 1442251

Basic information

Technical information
  • TDR Targets ID: 1442251
  • Name: 2-[(3,4-dichlorophenyl)methyl]-6-(2-phenyleth enyl)-4,5-dihydropyridazin-3-one
  • MW: 359.249 | Formula: C19H16Cl2N2O
  • H donors: 0 H acceptors: 1 LogP: 4.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC(=NN1Cc1ccc(c(c1)Cl)Cl)/C=C/c1ccccc1
  • InChi: 1S/C19H16Cl2N2O/c20-17-10-7-15(12-18(17)21)13-23-19(24)11-9-16(22-23)8-6-14-4-2-1-3-5-14/h1-8,10,12H,9,11,13H2/b8-6+
  • InChiKey: UGQLQYCGDGFRJZ-SOFGYWHQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(3,4-dichlorophenyl)methyl]-6-[(E)-2-phenylethenyl]-4,5-dihydropyridazin-3-one
  • 2-[(3,4-dichlorophenyl)methyl]-6-(2-phenylvinyl)-4,5-dihydropyridazin-3-one
  • 2-[(3,4-dichlorophenyl)methyl]-6-[(E)-2-phenylvinyl]-4,5-dihydropyridazin-3-one
  • 2-(3,4-dichlorobenzyl)-6-[(E)-2-phenylvinyl]-4,5-dihydropyridazin-3-one
  • 2-(3,4-dichlorobenzyl)-6-(2-phenylvinyl)-4,5-dihydropyridazin-3-one
  • 11K-381S
  • 2-(3,4-dichlorobenzyl)-6-styryl-4,5-dihydro-3(2H)-pyridazinone
  • ZINC01383004
  • Bionet1_002123
  • MLS000540310
  • SMR000125568
  • Oprea1_350759

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4326 0.4479 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0329 0.0308 0.0417
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0064 0.0031 0.0043
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0135 0.0105 0.3602
Echinococcus multilocularis discoidin domain receptor 0.005 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0038 0.0037
Echinococcus granulosus neuroendocrine convertase 2 0.4472 0.4631 0.6281
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.017 0.0142 0.0314
Schistosoma mansoni hypothetical protein 0.1391 0.1416 0.1921
Loa Loa (eye worm) hypothetical protein 0.0307 0.0285 0.0284
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0347 0.0327 0.0442
Echinococcus multilocularis discoidin domain containing receptor 2 0.005 0.0017 0.0022
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.0071 0.0155
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0066 0.0948
Loa Loa (eye worm) fatty acid synthase 0.0091 0.006 0.0059
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0095 0.0063 0.1726
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.017 0.0142 0.4908
Schistosoma mansoni chromatin regulatory protein sir2 0.0102 0.0071 0.0096
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0062 0.0029 0.0038
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0038 0.0544
Brugia malayi transcriptional regulator, Sir2 family protein 0.0689 0.0683 0.0682
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7099 0.7373 1
Brugia malayi protein kinase C II. 0.0091 0.0059 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Echinococcus granulosus serine:threonine protein kinase N2 0.0074 0.0042 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Brugia malayi transcriptional regulator, Sir2 family protein 0.0102 0.0071 0.007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0071 0.0039 0.053
Giardia lamblia Neurogenic locus Notch protein precursor 0.0212 0.0186 0.0438
Brugia malayi proprotein convertase 2 0.4472 0.4631 0.463
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0307 0.0285 0.0386
Echinococcus multilocularis protein jagged 2 0.0212 0.0186 0.0251
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.0061 0.0081
Echinococcus granulosus glutamate NMDA receptor subunit 0.0319 0.0298 0.0402
Echinococcus multilocularis adam 0.0515 0.0502 0.068
Loa Loa (eye worm) hypothetical protein 0.053 0.0518 0.0516
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0307 0.0285 0.0386
Leishmania major arginine N-methyltransferase-like protein 0.0062 0.0029 0.0414
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0029 0.0063
Giardia lamblia Tenascin-X 0.0212 0.0186 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0047 0.0013 0.043
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0097 0.0066 0.0948
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0071 0.0039 0.0802
Echinococcus multilocularis Furin 1 0.1698 0.1737 0.2355
Mycobacterium ulcerans polyketide synthase 0.0089 0.0057 0.1252
Echinococcus granulosus protein kinase c epsilon type 0.0091 0.0059 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0086 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0986 0.0994 0.0993
Echinococcus granulosus discoidin domain containing receptor 2 0.005 0.0017 0.0022
Echinococcus multilocularis discoidin domain containing receptor 2 0.005 0.0017 0.0022
Schistosoma mansoni hypothetical protein 0.005 0.0017 0.0023
Trichomonas vaginalis beta-hexosaminidase B, putative 0.005 0.0017 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Loa Loa (eye worm) reprolysin 0.0231 0.0206 0.0205
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.0071 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Echinococcus multilocularis fibrillin 2 0.0212 0.0186 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Mycobacterium ulcerans Type I modular polyketide synthase 0.0089 0.0057 0.1252
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0089 0.0057 0.1912
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0095 0.0063 0.1481
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.0061 0.0081
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0089 0.0057 0.1912
Onchocerca volvulus 0.0103 0.0072 0.192
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.0071 0.0155
Loa Loa (eye worm) hypothetical protein 0.0212 0.0186 0.0185
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0046 0.0013 0.0016
Loa Loa (eye worm) subtilase 0.0307 0.0285 0.0284
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0035 0.0047
Brugia malayi hypothetical protein 0.0303 0.0281 0.028
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0062 0.0029 0.004
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0201 0.0175 0.0237
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0133 0.0104 0.0139
Schistosoma mansoni discoidin domain receptor 0.005 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0135 0.0106 0.0105
Brugia malayi EGF-like domain containing protein 0.0212 0.0186 0.0185
Echinococcus granulosus integrin beta 2 0.7098 0.7372 0.9998
Schistosoma mansoni septate junction protein 0.0059 0.0026 0.0035
Loa Loa (eye worm) transcriptional regulator 0.0102 0.0071 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1698 0.1737 0.3876
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0077 0.0045 0.1033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Brugia malayi metalloprotease 0.0064 0.0031 0.003
Leishmania major silent information regulator 2, putative 0.0689 0.0683 1
Loa Loa (eye worm) integrin beta-2 0.9617 1 1
Schistosoma mansoni hypothetical protein 0.0046 0.0013 0.0018
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0086 0.0055 0.181
Trichomonas vaginalis alpha-L-fucosidase, putative 0.005 0.0017 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Loa Loa (eye worm) hypothetical protein 0.0091 0.006 0.0059
Brugia malayi Integrin alpha pat-2 precursor 0.1954 0.2003 0.2002
Echinococcus granulosus protein arginine N methyltransferase 8 0.0062 0.0029 0.0038
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0201 0.0175 0.6112
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0102 0.0071 0.2381
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0319 0.0298 0.0403
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0102 0.0071 0.102
Giardia lamblia High cysteine protein 0.0212 0.0186 0.0438
Mycobacterium ulcerans Type I modular polyketide synthase 0.0089 0.0057 0.1252
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0089 0.0057 0.1503
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0689 0.0683 0.0925
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4326 0.4479 0.6075
Echinococcus multilocularis 0.5708 0.5921 0.8033
Echinococcus granulosus integrin alpha ps 0.0464 0.0449 0.0607
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0068 0.0036 0.0049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Schistosoma mansoni chromatin regulatory protein sir2 0.0689 0.0683 0.0927
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0102 0.0071 0.102
Echinococcus multilocularis membrane bound transcription factor site 1 0.0307 0.0285 0.0386
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0029 0.004
Brugia malayi hypothetical protein 0.1477 0.1506 0.1505
Toxoplasma gondii hypothetical protein 0.0212 0.0186 0.6508
Schistosoma mansoni hypothetical protein 0.0205 0.0178 0.0242
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0102 0.0071 0.102
Echinococcus multilocularis NMDA receptor 0.0046 0.0013 0.0016
Toxoplasma gondii subtilisin SUB7 0.0307 0.0285 1
Brugia malayi Disintegrin family protein 0.0096 0.0065 0.0064
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0089 0.0057 0.1503
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0307 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.149 0.1519 0.1518
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0337 0.0316 0.4623
Brugia malayi Glutamate receptor 2 precursor 0.0067 0.0035 0.0034
Loa Loa (eye worm) hypothetical protein 0.0091 0.006 0.0059
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0201 0.0175 0.2547
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Toxoplasma gondii subtilisin SUB10 0.0307 0.0285 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.005 0.0017 0.0036
Schistosoma mansoni tyrosine kinase 0.0315 0.0294 0.0399
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0689 0.0683 0.0926
Echinococcus multilocularis integrin alpha 3 0.145 0.1478 0.2003
Brugia malayi EGF-like domain containing protein 0.0212 0.0186 0.0185
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0201 0.0175 0.2547
Echinococcus granulosus integrin alpha ps 0.1034 0.1043 0.1414
Onchocerca volvulus 0.0307 0.0285 0.7962
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0071 0.1996
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0307 0.0285 0.0284
Loa Loa (eye worm) sirtuin 4 0.0102 0.0071 0.007
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0307 0.0285 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Brugia malayi EGF-like domain containing protein 0.0212 0.0186 0.0185
Onchocerca volvulus 0.0212 0.0186 0.5148
Toxoplasma gondii PA14 domain-containing protein 0.005 0.0017 0.0566
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0102 0.0071 0.102
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0307 0.0285 0.0387
Loa Loa (eye worm) TK/EGFR protein kinase 0.0315 0.0294 0.0293
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.0071 0.0155
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0689 0.0683 1
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0307 0.0285 1
Brugia malayi ADAM-TS Spacer 1 family protein 0.0135 0.0106 0.0105
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0337 0.0316 0.4623
Brugia malayi ADAMTS-like protease 0.0135 0.0106 0.0105
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0095 0.0063 0.2125
Echinococcus multilocularis neuroendocrine convertase 2 0.4472 0.4631 0.6282
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0689 0.0683 0.1524
Echinococcus multilocularis kelch ECH associated protein 1 0.0092 0.0061 0.0081
Loa Loa (eye worm) transcriptional regulator 0.0102 0.0071 0.007
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0689 0.0683 1
Giardia lamblia High cysteine membrane protein Group 2 0.2627 0.2707 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0689 0.0683 1
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Echinococcus multilocularis chromatin regulatory protein sir2 0.0689 0.0683 0.0926
Brugia malayi amine oxidase, flavin-containing family protein 0.01 0.0069 0.0068
Plasmodium vivax plasmepsin V, putative 0.0256 0.0232 0.8017
Loa Loa (eye worm) TK/ALK protein kinase 0.0091 0.006 0.0059
Toxoplasma gondii subtilisin SUB11 0.0307 0.0285 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0102 0.0071 0.0096
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0172 0.0144 0.0143
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0307 0.0285 1
Toxoplasma gondii subtilisin SUB5 0.0307 0.0285 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0038 0.0512
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Schistosoma mansoni chromatin regulatory protein sir2 0.0689 0.0683 0.0927
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0046 0.0013 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Schistosoma mansoni amine oxidase 0.007 0.0038 0.0052
Echinococcus multilocularis integrin alpha ps 0.1034 0.1043 0.1414
Trypanosoma cruzi subtilisin peptidase 0.0307 0.0285 0.4167
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.0285 0.0635
Brugia malayi Protein kinase domain containing protein 0.005 0.0017 0.0016
Schistosoma mansoni chromatin regulatory protein sir2 0.0102 0.0071 0.0096
Loa Loa (eye worm) hypothetical protein 0.008 0.0048 0.0047
Echinococcus multilocularis MAM 0.0091 0.006 0.008
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0307 0.0285 0.0284
Onchocerca volvulus 0.005 0.0017 0.0358
Mycobacterium ulcerans Type I modular polyketide synthase 0.0089 0.0057 0.1252
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0085 0.0053 0.0071
Giardia lamblia Tenascin-like 0.0212 0.0186 0.0438
Schistosoma mansoni ATP-binding cassette transporter 0.007 0.0038 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0059 0.0081
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.017 0.0142 0.4492
Echinococcus granulosus furin 0.7099 0.7373 1
Loa Loa (eye worm) transcriptional regulator 0.0689 0.0683 0.0682
Mycobacterium ulcerans protoporphyrinogen oxidase 0.007 0.0038 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0066 0.0034 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.005 0.0017 0.0016
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0061 0.0028 0.088
Brugia malayi neuroendocrine convertase 1 precursor 0.4472 0.4631 0.463
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0347 0.0327 0.0443
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.0071 0.0155
Echinococcus multilocularis Kelch repeat type 1 0.0092 0.0061 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Schistosoma mansoni hypothetical protein 0.0062 0.0029 0.004
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0089 0.0057 0.0056
Schistosoma mansoni integrin alpha 0.1954 0.2003 0.2717
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0102 0.0071 0.102
Loa Loa (eye worm) hypothetical protein 0.2773 0.2859 0.2858
Schistosoma mansoni glutamate receptor NMDA 0.0319 0.0298 0.0404
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0774 0.0772 0.1047
Echinococcus granulosus lysine specific histone demethylase 1A 0.007 0.0038 0.005
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0095 0.0063 0.2125
Echinococcus granulosus kelch ECH associated protein 1 0.0092 0.0061 0.0081
Toxoplasma gondii histone deacetylase SIR2-like 0.0102 0.0071 0.2449
Mycobacterium ulcerans dehydrogenase 0.007 0.0038 0.0512
Trichomonas vaginalis hypothetical protein 0.005 0.0017 0.0036
Plasmodium vivax subtilisin-like protease 2, putative 0.0307 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0031 0.003
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.007 0.0038 0.0052
Echinococcus granulosus fibrillin 2 0.0212 0.0186 0.0251
Loa Loa (eye worm) endoprotease bli-4 0.7099 0.7373 0.7373
Loa Loa (eye worm) acyl carrier protein 0.0042 0.0009 0.0008
Brugia malayi endoprotease bli-4 precursor 0.7099 0.7373 0.7373
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0072 0.004 0.129
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0062 0.0029 0.0453
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1698 0.1737 0.3876
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.007 0.0038 0.1306
Schistosoma mansoni amine oxidase 0.007 0.0038 0.0052
Echinococcus multilocularis protein kinase c epsilon type 0.0091 0.0059 0.0079
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0066 0.0065
Brugia malayi Furin-like cysteine rich region family protein 0.0315 0.0294 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Echinococcus granulosus MAM 0.0091 0.006 0.0079
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1391 0.1416 0.316
Echinococcus granulosus Furin 1 0.1698 0.1737 0.2354
Echinococcus granulosus glutamate receptor 2 0.0038 0.0005 0.0005
Onchocerca volvulus Fatty acid synthase homolog 0.0166 0.0138 0.3789
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0038 0.1229
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0046 0.0013 0.0016
Echinococcus granulosus protein will die slowly 0.0066 0.0034 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Loa Loa (eye worm) hypothetical protein 0.0212 0.0186 0.0185
Brugia malayi hypothetical protein 0.0097 0.0066 0.0065
Echinococcus multilocularis protein arginine methyltransferase 0.0062 0.0029 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.0207 0.0281
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0307 0.0285 1
Schistosoma mansoni hypothetical protein 0.0091 0.006 0.0081
Echinococcus multilocularis fibrillin 1 0.0213 0.0187 0.0252
Schistosoma mansoni integrin alpha-ps 0.057 0.0559 0.0759
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0035 0.0047
Entamoeba histolytica PH domain containing protein kinase, putative 0.0074 0.0042 0.06
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4326 0.4479 1
Toxoplasma gondii F5/8 type C domain-containing protein 0.005 0.0017 0.0566
Onchocerca volvulus 0.005 0.0017 0.0358
Echinococcus granulosus fibrillin 1 0.0213 0.0187 0.0252
Loa Loa (eye worm) hypothetical protein 0.0062 0.0029 0.0028
Trypanosoma brucei SIR2-like protein 4, putative 0.0102 0.0071 0.102
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.0071 0.0155
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1698 0.1737 0.2356
Schistosoma mansoni chromatin regulatory protein sir2 0.0689 0.0683 0.0927
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0085 0.0053 0.0071
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0029 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.0285 0.0635
Echinococcus multilocularis epidermal growth factor receptor 0.0315 0.0294 0.0397
Giardia lamblia Furin precursor putative serine protease 0.1391 0.1416 0.5104
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1391 0.1416 0.316
Brugia malayi Subtilase family protein 0.0307 0.0285 0.0284
Brugia malayi hypothetical protein 0.0091 0.006 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.0285 0.0635
Toxoplasma gondii histone deacetylase SIR2 0.0102 0.0071 0.2449
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0062 0.0029 0.0453
Loa Loa (eye worm) hypothetical protein 0.0347 0.0327 0.0326
Plasmodium vivax subtilisin-like protease 1 0.0307 0.0285 1
Echinococcus multilocularis discoidin domain containing receptor 2 0.005 0.0017 0.0022
Plasmodium falciparum protoporphyrinogen oxidase 0.007 0.0038 0.0785
Loa Loa (eye worm) hypothetical protein 0.1383 0.1408 0.1407
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0003
Loa Loa (eye worm) apoptosis regulator protein 0.0062 0.0029 0.0028
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0029 0.004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.0071 0.0155
Echinococcus granulosus chromatin regulatory protein sir2 0.0689 0.0683 0.0925
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0233 0.0207 0.0206
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0097 0.0066 0.0948
Schistosoma mansoni btb and poz domain-containing protein 0.005 0.0017 0.0023
Toxoplasma gondii type I fatty acid synthase, putative 0.0095 0.0063 0.2194
Echinococcus multilocularis integrin beta 2 0.7098 0.7372 1
Mycobacterium ulcerans thioesterase TesA 0.0077 0.0045 0.0768
Schistosoma mansoni hypothetical protein 0.0464 0.0449 0.0609
Schistosoma mansoni discoidin domain receptor 0.005 0.0017 0.0023
Giardia lamblia Neurogenic locus notch-like protein 0.0212 0.0186 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Schistosoma mansoni dock 0.005 0.0017 0.0023
Brugia malayi NAD-dependent deacetylase SIRT1 0.0102 0.0071 0.007
Toxoplasma gondii subtilisin SUB8 0.0307 0.0285 1
Schistosoma mansoni apoptosis regulator bax 0.0062 0.0029 0.004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.006 0.0027 0.0916
Schistosoma mansoni integrin alpha-ps 0.0968 0.0974 0.1322
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.007 0.0038 0.0785
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0066 0.0065
Schistosoma mansoni integrin beta subunit 0.5621 0.5831 0.7908
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0089 0.0057 0.1252
Schistosoma mansoni hypothetical protein 0.0066 0.0034 0.0046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0395 0.0377 0.0376
Loa Loa (eye worm) hypothetical protein 0.0231 0.0206 0.0205
Schistosoma mansoni glutamate receptor kainate 0.0067 0.0035 0.0047
Loa Loa (eye worm) WD40 repeat protein 0.0066 0.0034 0.0033
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0085 0.0053 0.0071
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0096 0.0065 0.0086
Toxoplasma gondii type I fatty acid synthase, putative 0.0066 0.0033 0.1129
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.005 0.0017 0.0022
Plasmodium vivax hypothetical protein, conserved 0.007 0.0038 0.0785
Loa Loa (eye worm) hypothetical protein 0.0395 0.0377 0.0376
Loa Loa (eye worm) hypothetical protein 0.0048 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0066 0.0033 0.0032
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0062 0.0029 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0066 0.0034 0.0033
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0102 0.0071 0.0094
Brugia malayi EGF-like domain containing protein 0.0212 0.0186 0.0185
Echinococcus granulosus kelch ECH associated protein 1 like 0.0092 0.0061 0.0081
Echinococcus granulosus adam 0.0515 0.0502 0.068
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0085 0.0053 0.0071
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0102 0.0071 0.1996
Brugia malayi Kelch motif family protein 0.1506 0.1537 0.1536
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Brugia malayi angiogenesis inhibito 0.0135 0.0106 0.0105
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0102 0.0071 0.0094
Giardia lamblia High cysteine protein 0.0212 0.0186 0.0438
Loa Loa (eye worm) hypothetical protein 0.7099 0.7373 0.7373
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0231 0.0206 0.028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1698 0.1737 0.3876
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0102 0.0071 0.1996
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1383 0.1408 0.1407
Mycobacterium ulcerans polyketide synthase 0.0095 0.0063 0.1481
Echinococcus granulosus protein arginine methyltransferase 0.0062 0.0029 0.0038
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0052 0.0019 0.0561
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0337 0.0316 0.4623
Brugia malayi transcriptional regulator, Sir2 family protein 0.0102 0.0071 0.007
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0102 0.0071 0.0094
Plasmodium falciparum plasmepsin V 0.0256 0.0232 0.8017
Brugia malayi Reprolysin 0.0135 0.0106 0.0105
Mycobacterium ulcerans monoamine oxidase 0.007 0.0038 0.0512
Loa Loa (eye worm) hypothetical protein 0.057 0.0559 0.0558
Echinococcus granulosus discoidin domain containing receptor 2 0.005 0.0017 0.0022
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0096 0.0065 0.0086
Echinococcus granulosus integrin alpha 3 0.145 0.1478 0.2003
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0029 0.0063
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0102 0.0071 0.0094
Schistosoma mansoni site-1 peptidase (S08 family) 0.0307 0.0285 0.0387
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0307 0.0285 1
Echinococcus granulosus discoidin domain receptor 0.005 0.0017 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0086 0.0055 0.0054
Toxoplasma gondii subtilisin SUB4 0.0307 0.0285 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0307 0.0285 1
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0212 0.0186 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Toxoplasma gondii F5/8 type C domain-containing protein 0.005 0.0017 0.0566
Giardia lamblia Tenascin precursor 0.0212 0.0186 0.0438
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0085 0.0053 0.0071
Onchocerca volvulus 0.0161 0.0132 0.362
Echinococcus granulosus membrane bound transcription factor site 1 0.0307 0.0285 0.0386
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0058 0.0025 0.0287
Echinococcus granulosus lysine specific histone demethylase 1A 0.0347 0.0327 0.0442
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0233 0.0207 0.028
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.017 0.0142 0.5
Plasmodium falciparum subtilisin-like protease 2 0.0307 0.0285 1
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0062 0.0029 0.0993
Schistosoma mansoni hypothetical protein 0.0205 0.0178 0.0242
Echinococcus granulosus discoidin domain containing receptor 2 0.005 0.0017 0.0022
Toxoplasma gondii subtilisin SUB9 0.0307 0.0285 1
Brugia malayi SWIRM domain containing protein 0.0376 0.0357 0.0356
Brugia malayi Stress-activated protein kinase jnk-1 0.0233 0.0207 0.0206
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0038 0.0544
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0062 0.0029 0.0038
Onchocerca volvulus 0.0086 0.0055 0.1419
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0089 0.0058 0.193
Loa Loa (eye worm) hypothetical protein 0.0097 0.0066 0.0065
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0307 0.0285 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0077 0.0045 0.1465
Onchocerca volvulus 0.0091 0.006 0.1564
Schistosoma mansoni hypothetical protein 0.0091 0.006 0.0081
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0035 0.0046
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0029 0.004
Schistosoma mansoni furin-1 (S08 family) 0.3081 0.318 0.4313
Toxoplasma gondii subtilisin SUB1 0.0307 0.0285 1
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.005 0.0017 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Onchocerca volvulus 0.0066 0.0034 0.0835
Loa Loa (eye worm) metalloprotease 0.0064 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0212 0.0186 0.0185
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0062 0.0029 0.0028
Echinococcus multilocularis serine:threonine protein kinase N2 0.0083 0.0051 0.0068
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0201 0.0175 0.0174
Leishmania major subtilisin-like serine peptidase 0.0307 0.0285 0.4167
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0689 0.0683 0.1524
Trichomonas vaginalis WD repeat domain, putative 0.0066 0.0034 0.0073
Plasmodium vivax protoporphyrinogen oxidase, putative 0.007 0.0038 0.0785
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Schistosoma mansoni hypothetical protein 0.0066 0.0034 0.0046
Loa Loa (eye worm) integrin alpha pat-2 0.2806 0.2893 0.2893
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.0285 0.0635
Loa Loa (eye worm) hypothetical protein 0.0091 0.006 0.0059
Echinococcus multilocularis integrin alpha ps 0.0464 0.0449 0.0607
Giardia lamblia hypothetical protein 0.0212 0.0186 0.0438
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0201 0.0175 0.0174
Schistosoma mansoni dihydroceramide desaturase 0.0096 0.0065 0.0088
Echinococcus multilocularis geminin 0.0205 0.0178 0.024
Schistosoma mansoni hypothetical protein 0.0062 0.0029 0.004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.0071 0.0155
Schistosoma mansoni protein arginine n-methyltransferase 0.0035 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0091 0.006 0.0059
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0071 0.0039 0.053
Loa Loa (eye worm) hypothetical protein 0.0152 0.0123 0.0122
Brugia malayi Will die slowly protein 0.0066 0.0034 0.0033
Echinococcus multilocularis glutamate receptor 2 0.0085 0.0053 0.0071
Echinococcus multilocularis protoporphyrinogen oxidase 0.007 0.0038 0.005
Mycobacterium tuberculosis Possible oxidoreductase 0.007 0.0038 0.1229
Mycobacterium leprae Probable polyketide synthase Pks1 0.0095 0.0063 0.1726
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0201 0.0175 0.0236
Schistosoma mansoni glutamate receptor AMPA 0.0067 0.0035 0.0047
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Loa Loa (eye worm) hypothetical protein 0.007 0.0038 0.0037
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0201 0.0175 0.2547
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0066 0.0948
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0307 0.0285 1
Echinococcus granulosus c-Jun N-terminal kinases 0.0233 0.0207 0.028
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0085 0.0053 0.0071
Toxoplasma gondii subtilisin SUB2 0.0307 0.0285 1
Trichomonas vaginalis hypothetical protein 0.1391 0.1416 0.316
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1698 0.1737 0.3876
Echinococcus multilocularis protein will die slowly 0.0066 0.0034 0.0045
Echinococcus multilocularis nmda type glutamate receptor 0.0133 0.0104 0.0139
Giardia lamblia Hypothetical protein 0.0689 0.0683 0.2324
Trichomonas vaginalis hypothetical protein 0.0212 0.0186 0.0413
Echinococcus granulosus epidermal growth factor receptor 0.0315 0.0294 0.0397
Loa Loa (eye worm) hypothetical protein 0.0347 0.0327 0.0326
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1506 0.1537 0.1536
Brugia malayi Calcium binding EGF domain containing protein 0.0038 0.0005 0.0003
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0307 0.0285 0.0387
Echinococcus granulosus geminin 0.0205 0.0178 0.024
Leishmania major sir2-family protein-like protein 0.0102 0.0071 0.102
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.0071 0.0155
Mycobacterium ulcerans Sir2-like regulatory protein 0.0102 0.0071 0.1759
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0689 0.0683 1
Loa Loa (eye worm) angiogenesis inhibito 0.0064 0.0031 0.003
Echinococcus granulosus glutamate receptor 2 0.0085 0.0053 0.0071
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0087 0.0055 0.125
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Loa Loa (eye worm) hypothetical protein 0.01 0.0069 0.0068
Loa Loa (eye worm) glutamate receptor 2 0.0067 0.0035 0.0034
Echinococcus granulosus glutamate receptor subunit protein glur 0.0046 0.0013 0.0016
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0201 0.0175 0.0236
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0091 0.0059 0.0058
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0087 0.0055 0.1168
Loa Loa (eye worm) hypothetical protein 0.0102 0.0071 0.007
Chlamydia trachomatis glutamine binding protein 0.0087 0.0055 0.125
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0087 0.0055 0.1835
Loa Loa (eye worm) hypothetical protein 0.0376 0.0357 0.0356
Brugia malayi hypothetical protein 0.007 0.0038 0.0037
Echinococcus multilocularis 0.007 0.0038 0.005
Echinococcus granulosus adam 17 protease 0.0096 0.0065 0.0086
Mycobacterium ulcerans thioesterase 0.0077 0.0045 0.0768
Mycobacterium leprae Possible secreted protease 0.0307 0.0285 1
Onchocerca volvulus 0.0376 0.0357 1
Toxoplasma gondii aspartyl protease ASP5 0.0234 0.0208 0.7293
Loa Loa (eye worm) proprotein convertase 2 0.1698 0.1737 0.1736
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0102 0.0071 0.102
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Toxoplasma gondii F5/8 type C domain-containing protein 0.005 0.0017 0.0566
Leishmania major UDP-galactopyranose mutase 0.007 0.0038 0.0544
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0034 0.0033
Mycobacterium ulcerans oxidoreductase 0.007 0.0038 0.0512
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1698 0.1737 0.3876
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0046 0.0013 0.0016
Echinococcus multilocularis disintegrin and metalloproteinase 0.0096 0.0065 0.0086
Toxoplasma gondii subtilisin SUB6 0.0307 0.0285 1
Plasmodium vivax subtilisin-like serine protease, putative 0.0307 0.0285 1
Schistosoma mansoni glutamate receptor NMDA 0.0085 0.0053 0.0072
Mycobacterium ulcerans polyketide synthase Pks13 0.0135 0.0105 0.3079
Echinococcus granulosus disintegrin and metalloproteinase 0.0096 0.0065 0.0086
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0303 0.0281 0.0381
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0201 0.0175 0.5879
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0231 0.0206 0.0278
Loa Loa (eye worm) hypothetical protein 0.0071 0.0039 0.0038
Entamoeba histolytica hypothetical protein 0.0097 0.0066 0.0948
Mycobacterium ulcerans NAD-dependent deacetylase 0.0102 0.0071 0.1759
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4326 0.4479 0.6074
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0201 0.0175 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0231 0.0206 0.028
Brugia malayi Glutamate receptor 1 precursor 0.0067 0.0035 0.0034
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0231 0.0206 0.0278
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0329 0.0308 0.0417
Echinococcus multilocularis glutamate receptor 2 0.0038 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0017 0.0036
Schistosoma mansoni chromatin regulatory protein sir2 0.0102 0.0071 0.0096
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0089 0.0058 0.193
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0095 0.0063 0.1726
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.017 0.0142 0.465
Toxoplasma gondii subtilisin SUB12 0.0307 0.0285 1
Plasmodium falciparum subtilisin-like protease 3 0.0307 0.0285 1
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.005 0.0017 0.0022
Plasmodium vivax NAD-dependent deacetylase, putative 0.0102 0.0071 0.1996
Loa Loa (eye worm) hypothetical protein 0.1477 0.1506 0.1505
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0095 0.0063 0.2125
Loa Loa (eye worm) hypothetical protein 0.0096 0.0065 0.0064
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0095 0.0063 0.1481
Schistosoma mansoni site-1 peptidase (S08 family) 0.0307 0.0285 0.0387
Brugia malayi celfurPC protein 0.5708 0.5921 0.5921
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.007 0.0038 0.0785
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0085 0.0053 0.0071
Loa Loa (eye worm) hypothetical protein 0.005 0.0017 0.0016
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.007 0.0038 0.0785
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0052 0.0019 0.0263
Giardia lamblia Tenascin-37 0.0212 0.0186 0.0438
Schistosoma mansoni hypothetical protein 0.0092 0.0061 0.0083
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0089 0.0057 0.1912
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0102 0.0071 0.0094
Schistosoma mansoni hypothetical protein 0.0035 0.0001 0.0001
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0046 0.0013 0.0016
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0102 0.0071 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Toxoplasma gondii histone lysine-specific demethylase 0.007 0.0038 0.1306
Trichomonas vaginalis conserved hypothetical protein 0.1391 0.1416 0.316
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0307 0.0285 0.0635
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0135 0.0105 0.3602
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0307 0.0285 0.4167
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.005 0.0017 0.0482
Schistosoma mansoni glutamate receptor AMPA 0.0067 0.0035 0.0047
Entamoeba histolytica hypothetical protein, conserved 0.0102 0.0071 0.102
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1391 0.1416 0.316
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0085 0.0053 0.0071
Loa Loa (eye worm) glutamate receptor 1 0.0067 0.0035 0.0034
Mycobacterium leprae Polyketide synthase Pks13 0.0135 0.0105 0.3278
Loa Loa (eye worm) hypothetical protein 0.0135 0.0106 0.0105
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0774 0.0772 0.1046
Onchocerca volvulus 0.0091 0.006 0.1564
Loa Loa (eye worm) hypothetical protein 0.0212 0.0186 0.0185
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0038 0.0785
Trichomonas vaginalis conserved hypothetical protein 0.0307 0.0285 0.0635
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0689 0.0683 1
Schistosoma mansoni hypothetical protein 0.0062 0.0029 0.004
Plasmodium falciparum subtilisin-like protease 1 0.0307 0.0285 1
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0201 0.0175 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1698 0.1737 0.3876
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0201 0.0175 0.5879
Echinococcus granulosus nmda type glutamate receptor 0.0133 0.0104 0.0139
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0046 0.0013 0.0016
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0038 0.0512
Trypanosoma brucei subtilisin peptidase 0.0307 0.0285 0.4167
Echinococcus multilocularis integrin alpha ps 0.0968 0.0974 0.1321
Plasmodium vivax hypothetical protein, conserved 0.007 0.0038 0.0785

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.