Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.1506 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1506 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1506 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1506 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1506 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1506 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1506 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1506 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1506 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1506 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1506 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1506 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | % inhibition of metastasis at 34 microM of the compound in mice | ChEMBL. | 9258369 |
Inhibition (functional) | = 1.4 % | % inhibition of metastasis at 34 microM of the compound in mice | ChEMBL. | 9258369 |
Inhibition (functional) | = 12.1 % | % inhibition of metastasis at 103 microM of the compound in mice | ChEMBL. | 9258369 |
Inhibition (functional) | = 26.6 % | % inhibition of metastasis at 103 microM of the compound in mice | ChEMBL. | 9258369 |
Inhibition (functional) | = 30.9 % | % inhibition of metastasis at 172 microM of the compound in mice | ChEMBL. | 9258369 |
Inhibition (functional) | = 44.3 % | % inhibition of metastasis at 172 microM of the compound in mice | ChEMBL. | 9258369 |
No. of cells (functional) | = 1.4 ml | Cell growth at 34 uM concentration of the compound in mice | ChEMBL. | 9258369 |
No. of cells (functional) | = 1.4 ml | Cell growth at 103 microM concentration of the compound in mice | ChEMBL. | 9258369 |
No. of cells (functional) | = 1.6 ml | Cell growth at 34 MicroM concentration of the compound in mice | ChEMBL. | 9258369 |
No. of cells (functional) | = 1.6 ml | Cell growth at 172 microM concentration of the compound in mice | ChEMBL. | 9258369 |
No. of cells (functional) | = 1.8 ml | Cell growth at 172 microM concentration of the compound in mice | ChEMBL. | 9258369 |
No. of cells (functional) | = 2.1 ml | Cell growth at 103 uM concentration of the compound in mice | ChEMBL. | 9258369 |
No. of lung metastasis (functional) | = 82 | Number of tumor nodules at 172 uM of compound in mice(Range 118-23) | ChEMBL. | 9258369 |
No. of lung metastasis (functional) | = 101.6 | Number of tumor nodules at 172 uM of compound in mice(Range 136-84 ) | ChEMBL. | 9258369 |
No. of lung metastasis (functional) | = 108.8 | Number of tumor nodules at 103 uM of compound in mice(Range 136-64 ) | ChEMBL. | 9258369 |
No. of lung metastasis (functional) | = 129.4 | Number of tumor nodules at 103 uM of compound in mice(Range 160-114 ) | ChEMBL. | 9258369 |
No. of lung metastasis (functional) | = 145.2 | Number of tumor nodules at 34 uM of compound in mice(Range 169-115 ) | ChEMBL. | 9258369 |
No. of lung metastasis (functional) | = 147.2 | Number of tumor nodules at 34 uM of compound in mice(Range 165-133 ) | ChEMBL. | 9258369 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.