Detailed information for compound 1442990

Basic information

Technical information
  • TDR Targets ID: 1442990
  • Name: N-[(5-bromo-2-methoxyphenyl)methyl]-5-[(4-met hylphenyl)methyl]-4-oxo-7,8-dihydro-6H-pyrazo lo[5,1-c][1,4]diazepine-2-carboxamide
  • MW: 497.384 | Formula: C24H25BrN4O3
  • H donors: 1 H acceptors: 3 LogP: 3.72 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1CNC(=O)c1nn2c(c1)C(=O)N(CCC2)Cc1ccc(cc1)C)Br
  • InChi: 1S/C24H25BrN4O3/c1-16-4-6-17(7-5-16)15-28-10-3-11-29-21(24(28)31)13-20(27-29)23(30)26-14-18-12-19(25)8-9-22(18)32-2/h4-9,12-13H,3,10-11,14-15H2,1-2H3,(H,26,30)
  • InChiKey: GZFUWNDINQLKDW-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(5-bromo-2-methoxy-phenyl)methyl]-5-[(4-methylphenyl)methyl]-4-oxo-7,8-dihydro-6H-pyrazolo[5,1-c][1,4]diazepine-2-carboxamide
  • N-(5-bromo-2-methoxy-benzyl)-4-keto-5-(4-methylbenzyl)-7,8-dihydro-6H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide
  • G542-0620
  • NCGC00131558-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0329 0.0329
Brugia malayi Proteasome A-type and B-type family protein 0.0087 0.097 0.097
Echinococcus granulosus lamin 0.0033 0.021 0.0188
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0097 0.1109 0.0154
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0087 0.097 0.095
Brugia malayi intermediate filament protein 0.0033 0.021 0.021
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0087 0.097 0.097
Brugia malayi proteasome subunit beta type 3 0.0087 0.097 0.097
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0239 0.3082 0.2339
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0087 0.097 0.0533
Plasmodium falciparum proteasome subunit beta type-4 0.0087 0.097 0.0533
Echinococcus multilocularis proteasome subunit beta type 6 0.0087 0.097 0.095
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0087 0.097 0.097
Echinococcus multilocularis tumor protein p63 0.0408 0.5425 0.5415
Onchocerca volvulus Notchless protein homolog 0.0087 0.097 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.176 0.176
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0087 0.097 0.095
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.021 0.021
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0087 0.097 0.095
Echinococcus multilocularis lamin dm0 0.0033 0.021 0.0188
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0737 1 1
Plasmodium vivax proteasome subunit beta type-1, putative 0.0239 0.3082 0.2339
Loa Loa (eye worm) hypothetical protein 0.0097 0.1109 0.1109
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0594 0.0594
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0087 0.097 0.095
Brugia malayi proteasome subunit alpha type 4 0.0087 0.097 0.097
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0087 0.097 0.0533
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0594 0.0594
Echinococcus granulosus adhesion regulating molecule 1 0.0097 0.1109 0.109
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0162 0.2007 0.1989
Schistosoma mansoni lamin 0.0033 0.021 0.0188
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0087 0.097 0.0533
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0087 0.097 0.0533
Leishmania major proteasome beta 2 subunit, putative 0.0087 0.097 0.0533
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0737 1 1
Leishmania major proteasome alpha 7 subunit, putative 0.0087 0.097 0.0533
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0087 0.097 0.095
Trypanosoma brucei proteasome beta 6 subunit 0.0239 0.3082 0.2339
Echinococcus granulosus tumor protein p63 0.0408 0.5425 0.5415
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0087 0.097 0.0533
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0594 0.0594
Leishmania major proteasome alpha 3 subunit, putative 0.0087 0.097 0.0533
Echinococcus granulosus subfamily T1A non peptidase ue 0.0087 0.097 0.095
Schistosoma mansoni tar DNA-binding protein 0.0076 0.082 0.08
Schistosoma mansoni tar DNA-binding protein 0.0076 0.082 0.08
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0087 0.097 0.0533
Leishmania major proteasome alpha 1 subunit, putative 0.0087 0.097 0.0533
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0087 0.097 0.0533
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0062 0.0616 0.5338
Echinococcus granulosus lamin dm0 0.0033 0.021 0.0188
Toxoplasma gondii proteasome subunit beta type, putative 0.0737 1 1
Brugia malayi proteasome subunit alpha type 3 0.0087 0.097 0.097
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.176 0.176
Leishmania major proteasome beta 7 subunit, putative 0.0087 0.097 0.0533
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0737 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.082 0.08
Echinococcus multilocularis lamin 0.0033 0.021 0.0188
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0022 0.0022
Brugia malayi MH2 domain containing protein 0.0144 0.176 0.176
Echinococcus multilocularis proteasome subunit beta type 7 0.0087 0.097 0.095
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0087 0.097 0.095
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0737 1 1
Schistosoma mansoni hypothetical protein 0.0041 0.0329 0.0308
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0087 0.097 0.0533
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0087 0.097 0.095
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0087 0.097 0.095
Echinococcus granulosus intermediate filament protein 0.0033 0.021 0.0188
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0087 0.097 0.095
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0239 0.3082 0.2339
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0737 1 1
Giardia lamblia Proteasome subunit beta type 2 0.0162 0.2007 0.1148
Echinococcus multilocularis proteasome subunit alpha type 6 0.0087 0.097 0.095
Loa Loa (eye worm) proteasome subunit beta type 2 0.0162 0.2007 0.2007
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0162 0.2007 0.1989
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0239 0.3082 0.3067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0022
Echinococcus multilocularis musashi 0.0033 0.021 0.0188
Leishmania major proteasome alpha 1 subunit, putative 0.0087 0.097 0.0533
Echinococcus granulosus proteasome subunit alpha type 2 0.0087 0.097 0.095
Leishmania major proteasome alpha 7 subunit, putative 0.0087 0.097 0.0533
Echinococcus granulosus proteasome subunit beta type 6 0.0087 0.097 0.095
Echinococcus granulosus Proteasome subunit alpha type 7 0.0087 0.097 0.095
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0087 0.097 0.0533
Echinococcus granulosus proteasome prosome macropain 0.0737 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.082 0.082
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0087 0.097 0.095
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0737 1 1
Loa Loa (eye worm) proteasome subunit beta type 1 0.0239 0.3082 0.3082
Echinococcus multilocularis adhesion regulating molecule 1 0.0097 0.1109 0.109
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0087 0.097 0.0533
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0087 0.097 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.082 0.08
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0239 0.3082 0.3067
Echinococcus granulosus proteasome subunit beta t family 0.0087 0.097 0.095
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0737 1 1
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0087 0.097 0.095
Brugia malayi Proteasome A-type and B-type family protein 0.0087 0.097 0.097
Brugia malayi RNA binding protein 0.0076 0.082 0.082
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0087 0.097 0.095
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0087 0.097 0.095
Brugia malayi proteasome subunit alpha type 2 0.0087 0.097 0.097
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0239 0.3082 0.2339
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0087 0.097 0.097
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0097 0.1109 0.1109
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0087 0.097 0.095
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0087 0.097 0.0533
Loa Loa (eye worm) proteasome subunit beta type 3 0.0087 0.097 0.097
Loa Loa (eye worm) hypothetical protein 0.0032 0.0202 0.0202
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0087 0.097 0.097
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0087 0.097 0.095
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0087 0.097 0.095
Plasmodium falciparum proteasome subunit beta type-5 0.0737 1 1
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0239 0.3082 0.2339
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0737 1 1
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0087 0.097 0.0533
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0097 0.1109 0.109
Loa Loa (eye worm) TAR-binding protein 0.0076 0.082 0.082
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0087 0.097 0.095
Echinococcus granulosus Proteasome subunit alpha beta 0.0087 0.097 0.095
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0087 0.097 0.097
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0087 0.097 0.095
Echinococcus multilocularis proteasome (prosome, macropain) 0.0737 1 1
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0087 0.097 0.0533
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0162 0.2007 0.1148
Leishmania major proteasome beta 2 subunit, putative 0.0162 0.2007 0.162
Leishmania major proteasome beta-1 subunit, putative 0.0087 0.097 0.0533
Onchocerca volvulus 0.006 0.0587 0.4961
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0087 0.097 0.097
Trypanosoma cruzi 20S proteasome subunit 0.0162 0.2007 0.1148
Giardia lamblia Proteasome subunit beta type 1 0.0239 0.3082 0.2339
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0087 0.097 0.0533
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0087 0.097 0.0533
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0162 0.2007 0.1989
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0087 0.097 0.097
Brugia malayi TAR-binding protein 0.0076 0.082 0.082
Loa Loa (eye worm) hypothetical protein 0.0041 0.0329 0.0329
Echinococcus granulosus tar DNA binding protein 0.0076 0.082 0.08
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0087 0.097 0.095
Brugia malayi Proteasome A-type and B-type family protein 0.0087 0.097 0.097
Brugia malayi proteasome subunit alpha type 6 0.0087 0.097 0.097
Brugia malayi proteasome subunit beta type 2 0.0162 0.2007 0.2007
Schistosoma mansoni lamin 0.0033 0.021 0.0188
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0087 0.097 0.097
Plasmodium vivax proteasome subunit beta type-5, putative 0.0737 1 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0737 1 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0587 0.0566
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0239 0.3082 0.2339
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0162 0.2007 0.162
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0087 0.097 0.0533
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0087 0.097 0.095
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0239 0.3082 0.2747
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0087 0.097 0.095
Plasmodium vivax proteasome subunit beta type-2, putative 0.0162 0.2007 0.1148
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0087 0.097 0.095
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0087 0.097 0.097
Echinococcus granulosus proteasome subunit alpha type 6 0.0087 0.097 0.095
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0239 0.3082 0.3067
Echinococcus granulosus proteasome subunit beta type 7 0.0087 0.097 0.095
Schistosoma mansoni intermediate filament proteins 0.0033 0.021 0.0188
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0162 0.2007 0.1148
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0162 0.2007 0.1989
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0737 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0587 0.0587
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0162 0.2007 0.1148
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.082 0.082
Mycobacterium ulcerans proteasome PrcB 0.0737 1 1
Brugia malayi proteasome subunit alpha type 1 0.0087 0.097 0.097
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0239 0.3082 0.2747
Loa Loa (eye worm) hypothetical protein 0.006 0.0594 0.0594
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0022 0.0022
Loa Loa (eye worm) PAS-3 protein 0.0087 0.097 0.097
Brugia malayi Proteasome subunit alpha type 1 0.0087 0.097 0.097
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0087 0.097 0.095
Leishmania major proteasome alpha 2 subunit, putative 0.0087 0.097 0.0533
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0162 0.2007 0.1148
Echinococcus multilocularis proteasome subunit alpha type 2 0.0087 0.097 0.095
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0087 0.097 0.095
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0087 0.097 0.095
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0087 0.097 0.095
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0087 0.097 0.095
Brugia malayi proteasome subunit beta type 1 0.0239 0.3082 0.3082
Leishmania major proteasome beta 3 subunit, putative 0.0087 0.097 0.0533
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0162 0.2007 0.1148
Loa Loa (eye worm) hypothetical protein 0.0033 0.021 0.021
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0087 0.097 0.0533
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0022 0.0022
Brugia malayi 20S proteasome alpha5 subunit 0.0087 0.097 0.097
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0087 0.097 0.0533
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0087 0.097 0.0533
Brugia malayi Proteasome subunit alpha type 7-1 0.0087 0.097 0.097
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0162 0.2007 0.1148
Loa Loa (eye worm) RNA binding protein 0.0076 0.082 0.082
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.021 0.021
Leishmania major proteasome beta 5 subunit, putative 0.0737 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.082 0.08
Loa Loa (eye worm) intermediate filament protein 0.0033 0.021 0.021
Echinococcus multilocularis tar DNA binding protein 0.0076 0.082 0.08

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.