Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Get druggable targets OG5_133042 | All targets in OG5_133042 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled | 388 aa | 314 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0217 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0217 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0217 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0217 | 0.5 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0217 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0217 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0217 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0217 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0217 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0217 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0217 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | Binding affinity towards cloned human 5-hydroxytryptamine 4E receptor expressed in C6 glial cells using [3H]-GR-113,808 as radioligand; Not determined | ChEMBL. | 12801225 | |
Ki (binding) | = 180 nM | Binding affinity towards cloned human 5-hydroxytryptamine 4E receptor expressed in C6 glial cells using [3H]-GR-113,808 as radioligand | ChEMBL. | 12801225 |
Ki (binding) | = 180 nM | Binding affinity towards cloned human 5-hydroxytryptamine 4E receptor expressed in C6 glial cells using [3H]-GR-113,808 as radioligand | ChEMBL. | 12801225 |
ND (binding) | 0 | Binding affinity towards cloned human 5-hydroxytryptamine 4E receptor expressed in C6 glial cells using [3H]-GR-113,808 as radioligand; Not determined | ChEMBL. | 12801225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.