TDR Targets

Basic information

Technical information

TDR Targets ID: 1443237
Name: 6-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-ox oethyl]-2-(4-methylphenyl)-[1,2,4]triazolo[1, 5-c]quinazolin-5-one
MW: 508.571 | Formula: C29H28N6O3
H donors: 0 H acceptors: 4 LogP: 4.31 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccccc1N1CCN(CC1)C(=O)Cn1c2ccccc2c2n(c1=O)nc(n2)c1ccc(cc1)C
InChi: 1S/C29H28N6O3/c1-20-11-13-21(14-12-20)27-30-28-22-7-3-4-8-23(22)34(29(37)35(28)31-27)19-26(36)33-17-15-32(16-18-33)24-9-5-6-10-25(24)38-2/h3-14H,15-19H2,1-2H3
InChiKey: CTQYHERSWRRZBC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxo-ethyl]-2-(4-methylphenyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-one
6-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-2-oxoethyl]-2-(4-methylphenyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-one
6-[2-keto-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2-(4-methylphenyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-one
G860-0072
NCGC00137412-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0028	0.0447	0.0447
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0028	0.0447	0.5
Schistosoma mansoni	laminin gamma-3 chain	0.0043	0.1071	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Onchocerca volvulus		0.0043	0.1071	0.0653
Echinococcus multilocularis	lamin dm0	0.0033	0.0639	0.0202
Entamoeba histolytica	aldose reductase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	oxidoreductase	0.0028	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0639	0.0639
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Schistosoma mansoni	peroxidasin	0.0254	1	1
Schistosoma mansoni	hypothetical protein	0.0043	0.1071	0.0653
Schistosoma mansoni	lamin	0.0033	0.0639	0.0202
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0043	0.1071	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	oxidoreductase	0.0028	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Brugia malayi	EGF-like domain containing protein	0.0043	0.1071	0.1071
Echinococcus multilocularis	musashi	0.0033	0.0639	0.0202
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	notch protein	0.0043	0.1071	0.1071
Echinococcus multilocularis	peroxidasin	0.0254	1	1
Brugia malayi	Animal haem peroxidase family protein	0.0254	1	1
Brugia malayi	Animal haem peroxidase family protein	0.0254	1	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0043	0.1071	0.0653
Onchocerca volvulus		0.0043	0.1071	0.0653
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Trichomonas vaginalis	aldo/keto reductase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0254	1	1
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0043	0.1071	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Schistosoma mansoni	cell polarity protein	0.0043	0.1071	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Echinococcus granulosus	protein jagged 1	0.0043	0.1071	0.0653
Trypanosoma brucei	aldo-keto reductase, putative	0.0028	0.0447	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0028	0.0447	0.5
Echinococcus granulosus	neurogenic locus protein delta	0.0043	0.1071	0.0653
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0028	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Schistosoma mansoni	notch	0.0043	0.1071	0.0653
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0447	0.5
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0028	0.0447	0.0447
Onchocerca volvulus		0.0254	1	1
Onchocerca volvulus		0.0254	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0028	0.0447	0.5
Echinococcus granulosus	lamin dm0	0.0033	0.0639	0.0202
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Schistosoma mansoni	slit	0.0043	0.1071	0.0653
Brugia malayi	Animal haem peroxidase family protein	0.0254	1	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0614	0.0614
Mycobacterium tuberculosis	Conserved protein	0.0028	0.0447	0.5
Echinococcus granulosus	neurogenic locus notch protein	0.0043	0.1071	0.0653
Onchocerca volvulus	Peroxidasin homolog	0.0254	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0028	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Loa Loa (eye worm)	oxidoreductase	0.0028	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Echinococcus granulosus	protein jagged 2	0.0043	0.1071	0.0653
Schistosoma mansoni	hypothetical protein	0.0043	0.1071	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Onchocerca volvulus		0.0043	0.1071	0.0653
Schistosoma mansoni	notch	0.0043	0.1071	0.0653
Loa Loa (eye worm)	Notch2	0.0043	0.1071	0.1071
Onchocerca volvulus		0.0043	0.1071	0.0653
Echinococcus multilocularis	lamin	0.0033	0.0639	0.0202
Echinococcus multilocularis	slit 2 protein	0.0043	0.1071	0.0653
Echinococcus granulosus	slit 2 protein	0.0043	0.1071	0.0653
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0028	0.0447	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Echinococcus multilocularis	fibropellin Ia	0.0043	0.1071	0.0653
Brugia malayi	NADH-dependent xylose reductase	0.0028	0.0447	0.0447
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0639	0.0639
Giardia lamblia	High cysteine protein	0.0043	0.1071	1
Echinococcus granulosus	neurogenic locus notch protein 4	0.0043	0.1071	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Schistosoma mansoni	septate junction protein	0.0043	0.1071	0.0653
Brugia malayi	Blistered cuticle protein 3	0.0254	1	1
Toxoplasma gondii	EGF family domain-containing protein	0.0043	0.1071	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0028	0.0447	0.5
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0043	0.1071	0.0653
Echinococcus multilocularis	protein jagged 2	0.0043	0.1071	0.0653
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0028	0.0447	0.0447
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Schistosoma mansoni	notch	0.0043	0.1071	0.0653
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Brugia malayi	EGF-like domain containing protein	0.0043	0.1071	0.1071
Schistosoma mansoni	lamin	0.0033	0.0639	0.0202
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0639	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Echinococcus granulosus	protein jagged 2	0.0043	0.1071	0.0653
Trypanosoma brucei	aldo/keto reductase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0639	0.0639
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0254	1	1
Schistosoma mansoni	hypothetical protein	0.0043	0.1071	0.0653
Schistosoma mansoni	notch	0.0043	0.1071	0.0653
Brugia malayi	EGF-like domain containing protein	0.0043	0.1071	0.1071
Trypanosoma cruzi	aldo/keto reductase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0254	1	1
Brugia malayi	intermediate filament protein	0.0033	0.0639	0.0639
Entamoeba histolytica	aldose reductase, putative	0.0028	0.0447	0.5
Echinococcus multilocularis	protein jagged 1	0.0043	0.1071	0.0653
Echinococcus multilocularis	neurogenic locus protein delta	0.0043	0.1071	0.0653
Brugia malayi	Peroxidasin	0.0254	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Echinococcus granulosus	intermediate filament protein	0.0033	0.0639	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0028	0.0447	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Brugia malayi	Animal haem peroxidase family protein	0.0254	1	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0028	0.0447	0.5
Onchocerca volvulus	Peroxidase homolog	0.0254	1	1
Plasmodium falciparum	aldehyde reductase, putative	0.0028	0.0447	0.5
Echinococcus granulosus	neurogenic locus notch protein	0.0043	0.1071	0.0653
Trypanosoma brucei	prostaglandin f synthase	0.0028	0.0447	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Onchocerca volvulus	Peroxidasin homolog	0.0254	1	1
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Schistosoma mansoni	hypothetical protein	0.0043	0.1071	0.0653
Echinococcus granulosus	protein jagged 1	0.0043	0.1071	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Onchocerca volvulus	Slit protein homolog	0.0043	0.1071	0.0653
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0028	0.0447	0.5
Mycobacterium ulcerans	oxidoreductase	0.0028	0.0447	0.5
Leishmania major	prostaglandin f synthase, putative	0.0028	0.0447	0.5
Onchocerca volvulus		0.0043	0.1071	0.0653
Schistosoma mansoni	peroxidasin	0.0254	1	1
Brugia malayi	EGF-like domain containing protein	0.0043	0.1071	0.1071
Leishmania major	aldo-keto reductase-like protein	0.0028	0.0447	0.5
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Trypanosoma cruzi	aldo-keto reductase	0.0028	0.0447	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0028	0.0447	0.5
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0028	0.0447	0.5
Echinococcus multilocularis	neurogenic locus notch protein	0.0043	0.1071	0.0653
Brugia malayi	Cadherin domain containing protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Echinococcus multilocularis	neurogenic locus notch protein	0.0043	0.1071	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Echinococcus granulosus	fibropellin Ia	0.0043	0.1071	0.0653
Onchocerca volvulus		0.0033	0.0639	0.0202
Brugia malayi	GCC2 and GCC3 family protein	0.0043	0.1071	0.1071
Schistosoma mansoni	notch	0.0043	0.1071	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Onchocerca volvulus	Dual oxidase homolog	0.0254	1	1
Loa Loa (eye worm)	animal heme peroxidase	0.0254	1	1
Echinococcus granulosus	delta-like protein 1	0.0043	0.1071	0.0653
Echinococcus granulosus	neural cadherin	0.0043	0.1071	0.0653
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0028	0.0447	0.0447
Plasmodium vivax	aldehyde reductase, putative	0.0028	0.0447	0.5
Onchocerca volvulus	Peroxidase homolog	0.0254	1	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0254	1	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	oxidoreductase	0.0028	0.0447	0.0447
Echinococcus multilocularis	protein jagged 1	0.0043	0.1071	0.0653
Onchocerca volvulus		0.0033	0.0639	0.0202
Brugia malayi	Delta serrate ligand family protein	0.0043	0.1071	0.1071
Brugia malayi	Muscle positioning protein 4	0.0043	0.1071	0.1071
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Onchocerca volvulus	Neurogenic locus notch homolog	0.0043	0.1071	0.0653
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0043	0.1071	0.0653
Echinococcus multilocularis	notch	0.0043	0.1071	0.0653
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0043	0.1071	0.1071
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0028	0.0447	0.5
Brugia malayi	EGF-like domain containing protein	0.0043	0.1071	0.1071
Echinococcus granulosus	lamin	0.0033	0.0639	0.0202
Brugia malayi	Calcium binding EGF domain containing protein	0.0043	0.1071	0.1071
Onchocerca volvulus	Chorion peroxidase homolog	0.0254	1	1
Entamoeba histolytica	aldose reductase, putative	0.0028	0.0447	0.5
Echinococcus multilocularis	neural cadherin	0.0043	0.1071	0.0653
Onchocerca volvulus	Putative cubilin	0.0043	0.1071	0.0653
Schistosoma mansoni	hypothetical protein	0.0043	0.1071	0.0653
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Echinococcus granulosus	peroxidasin	0.0254	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Echinococcus granulosus	notch	0.0043	0.1071	0.0653
Brugia malayi	Cadherin domain containing protein	0.0043	0.1071	0.1071
Mycobacterium leprae	Possible oxidoreductase	0.0028	0.0447	0.5
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Onchocerca volvulus		0.0254	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1071	0.1071
Schistosoma mansoni	hypothetical protein	0.0043	0.1071	0.0653
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0028	0.0447	0.5
Schistosoma mansoni	notch	0.0043	0.1071	0.0653
Schistosoma mansoni	hypothetical protein	0.0043	0.1071	0.0653
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0639	0.0202
Brugia malayi	EGF-like domain containing protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	oxidoreductase	0.0028	0.0447	0.0447
Brugia malayi	notch-like transmembrane receptor	0.0043	0.1071	0.1071
Brugia malayi	EGF-like domain containing protein	0.0043	0.1071	0.1071
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0447	0.5
Brugia malayi	Calcium binding EGF domain containing protein	0.0043	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0028	0.0447	0.5
Brugia malayi	Animal haem peroxidase family protein	0.0254	1	1
Loa Loa (eye worm)	hypothetical protein	0.0254	1	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0028	0.0447	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1592992

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1443237