Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 0.1627 | 0.1616 |
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 0.1627 | 0.1616 |
Echinococcus granulosus | neuroligin | 0.1154 | 0.1627 | 0.1627 |
Echinococcus multilocularis | neuroligin | 0.1154 | 0.1627 | 0.1471 |
Loa Loa (eye worm) | hypothetical protein | 0.6828 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.6828 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.1154 | 0.1627 | 0.1471 |
Brugia malayi | Carboxylesterase family protein | 0.6828 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1154 | 0.1627 | 0.1616 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.0526 | 0.0526 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.1154 | 0.1627 | 0.1616 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.1154 | 0.1627 | 0.1616 |
Echinococcus granulosus | acetylcholinesterase | 0.6828 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.1154 | 0.1627 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.6828 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1154 | 0.1627 | 0.1471 |
Brugia malayi | Carboxylesterase family protein | 0.1154 | 0.1627 | 0.1471 |
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 0.1627 | 0.1616 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.1154 | 0.1627 | 0.1627 |
Echinococcus granulosus | carboxylesterase 5A | 0.6828 | 1 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.0182 | 0.017 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.6828 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.1154 | 0.1627 | 0.1471 |
Echinococcus multilocularis | acetylcholinesterase | 0.6828 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.6828 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.6828 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1154 | 0.1627 | 0.1616 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.0182 | 0.017 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.0526 | 0.035 |
Echinococcus granulosus | acetylcholinesterase | 0.6828 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1154 | 0.1627 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1154 | 0.1627 | 0.5 |
Schistosoma mansoni | gliotactin | 0.1154 | 0.1627 | 0.1616 |
Onchocerca volvulus | 0.1154 | 0.1627 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 0.1627 | 0.1616 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.1154 | 0.1627 | 0.5 |
Onchocerca volvulus | 0.1154 | 0.1627 | 1 | |
Onchocerca volvulus | 0.1154 | 0.1627 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.1154 | 0.1627 | 0.1627 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1154 | 0.1627 | 0.1616 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.0175 | 0.0175 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.1154 | 0.1627 | 0.1616 |
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 0.1627 | 0.1616 |
Onchocerca volvulus | 0.1154 | 0.1627 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 0.1627 | 0.1616 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.1154 | 0.1627 | 0.1471 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.1154 | 0.1627 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1154 | 0.1627 | 0.1616 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.1154 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | hypothetical protein | 0.6828 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1154 | 0.1627 | 0.1616 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.1154 | 0.1627 | 0.1471 |
Brugia malayi | Carboxylesterase family protein | 0.1154 | 0.1627 | 0.1471 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1154 | 0.1627 | 0.1616 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.1154 | 0.1627 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1154 | 0.1627 | 0.1471 |
Onchocerca volvulus | 0.1154 | 0.1627 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 0.8913 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.