Detailed information for compound 1443594

Basic information

Technical information
  • TDR Targets ID: 1443594
  • Name: ZINC01125886
  • MW: 353.372 | Formula: C19H19N3O4
  • H donors: 1 H acceptors: 4 LogP: 2.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)[N+](=O)[O-])N1CCC(CC1)C(=O)Nc1ccccc1
  • InChi: 1S/C19H19N3O4/c23-18(20-16-4-2-1-3-5-16)14-10-12-21(13-11-14)19(24)15-6-8-17(9-7-15)22(25)26/h1-9,14H,10-13H2,(H,20,23)
  • InChiKey: LAXRPCJXBMBOJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-nitrobenzoyl)-N-phenyl-4-piperidinecarboxamide
  • MLS000675873
  • SMR000292048

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Plasmodium falciparum thioredoxin reductase 0.0035 0.0063 0.0289
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0065 0.0065
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0025 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0799 0.201 0.5918
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0025 0.0098
Onchocerca volvulus 0.0186 0.0448 0.2229
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0465 0.1157 0.1157
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.01 0.0229 0.0673
Plasmodium falciparum thioredoxin reductase 0.002 0.0025 0.0098
Loa Loa (eye worm) hypothetical protein 0.0244 0.0596 0.1756
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0066 0.0196
Loa Loa (eye worm) hypothetical protein 0.0244 0.0596 0.1756
Brugia malayi Protein kinase domain containing protein 0.0017 0.0018 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0066 0.0066
Trypanosoma cruzi cruzipain precursor, putative 0.0799 0.201 0.5911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Echinococcus granulosus lamin 0.0033 0.0058 0.0169
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0465 0.1157 0.3397
Plasmodium vivax glutathione reductase, putative 0.0035 0.0063 0.0289
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0186 0.0448 0.0448
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0014 0.0042
Schistosoma mansoni hypothetical protein 0.0264 0.0647 0.0647
Treponema pallidum NADH oxidase 0.002 0.0025 0.5
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Giardia lamblia Cysteine protease 0.0186 0.0448 0.3267
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0186 0.0448 0.2207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Entamoeba histolytica cysteine protease, putative 0.0799 0.201 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0018 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Echinococcus granulosus carbonic anhydrase 0.0264 0.0647 0.1905
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Brugia malayi Muscleblind-like protein 0.018 0.0434 0.1278
Schistosoma mansoni carbonic anhydrase-related 0.0264 0.0647 0.0647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Schistosoma mansoni carbonic anhydrase 0.0264 0.0647 0.0647
Onchocerca volvulus 0.0799 0.201 1
Plasmodium vivax unspecified product 0.0186 0.0448 0.2207
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0019 0.0519
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Leishmania major hypothetical protein, conserved 0.0017 0.0018 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0053 0.011 0.0325
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.011 0.0523
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0065 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.011 0.0523
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Trypanosoma cruzi cysteine proteinase, putative 0.0455 0.1133 0.3324
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0244 0.0596 0.0596
Loa Loa (eye worm) cysteine protease 0.0799 0.201 0.5918
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0012 0.0006 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0186 0.0448 0.2207
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0012 0.0006 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0018 0.0036
Brugia malayi cathepsin B-like cysteine proteinase 0.1344 0.3396 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0101
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0544 0.136 0.6757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Brugia malayi Pre-SET motif family protein 0.0251 0.0615 0.1809
Echinococcus multilocularis growth factor receptor bound protein 2 0.0084 0.0189 0.0558
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Toxoplasma gondii thioredoxin reductase 0.0035 0.0063 0.0289
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0063 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0531 0.1325 0.3902
Onchocerca volvulus 0.0044 0.0086 0.0426
Loa Loa (eye worm) hypothetical protein 0.0264 0.0647 0.1905
Loa Loa (eye worm) hypothetical protein 0.0049 0.01 0.0294
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0134 0.0394
Brugia malayi cathepsin L precursor 0.0186 0.0448 0.1319
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0063 0.0171
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0025 0.0098
Trypanosoma cruzi cysteine peptidase, putative 0.0799 0.201 0.5911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.1133 0.5623
Brugia malayi hypothetical protein 0.0035 0.0065 0.0191
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0025 0.0098
Onchocerca volvulus 0.0033 0.0058 0.0286
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0448 0.3267
Schistosoma mansoni cathepsin F (C01 family) 0.0799 0.201 0.201
Loa Loa (eye worm) hypothetical protein 0.018 0.0434 0.1278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0066 0.0066
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Onchocerca volvulus 0.0799 0.201 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.0448 0.2207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0053 0.011 0.0325
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0053 0.011 0.0309
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0264 0.0647 0.1905
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0053 0.011 0.0523
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Onchocerca volvulus 0.0799 0.201 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0448 0.2207
Plasmodium falciparum cysteine proteinase falcipain 1 0.0455 0.1133 0.5623
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0615 0.1809
Brugia malayi Sex muscle abnormal protein 5 0.0084 0.0189 0.0558
Onchocerca volvulus Cathepsin L homolog 0.0799 0.201 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Giardia lamblia Cathepsin L-like protease 0.0186 0.0448 0.3267
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0042
Echinococcus granulosus cathepsin l1 0.0799 0.201 0.5918
Loa Loa (eye worm) hypothetical protein 0.0799 0.201 0.5918
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0053 0.011 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0186 0.0448 0.2207
Echinococcus multilocularis carbonic anhydrase 0.0264 0.0647 0.1905
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Plasmodium vivax thioredoxin reductase, putative 0.0035 0.0063 0.0289
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Plasmodium falciparum serine repeat antigen 4 0.0186 0.0448 0.2207
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0269 0.0659 0.1941
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0053 0.011 0.0448
Plasmodium falciparum serine repeat antigen 7 0.0186 0.0448 0.2207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Toxoplasma gondii cathepsin CPC2 0.0186 0.0448 0.2207
Echinococcus granulosus cathepsin L cysteine proteinase 0.0799 0.201 0.5918
Giardia lamblia Encystation-specific protease 0.0186 0.0448 0.3267
Plasmodium falciparum serine repeat antigen 8 0.0186 0.0448 0.2207
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0053 0.011 0.0523
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0448 0.2207
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0186 0.0448 0.2207
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0034 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 1
Plasmodium falciparum serine repeat antigen 6 0.0186 0.0448 0.2207
Echinococcus multilocularis cysteine protease 0.0799 0.201 0.5918
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0084 0.0189 0.0558
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.0448 0.2146
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.01 0.0229 0.1648
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0101
Plasmodium falciparum serine repeat antigen 1 0.0186 0.0448 0.2207
Toxoplasma gondii cathepsin B 0.0544 0.136 0.6757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0196
Onchocerca volvulus 0.0799 0.201 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0015 0.0043
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Brugia malayi Papain family cysteine protease containing protein 0.0455 0.1133 0.3335
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0012 0.0006 0.0016
Echinococcus multilocularis cathepsin b 0.1344 0.3396 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0799 0.201 1
Loa Loa (eye worm) PDE1B protein 0.0012 0.0006 0.0016
Brugia malayi fibroinase precursor 0.0186 0.0448 0.1319
Echinococcus granulosus cathepsin l1 0.0531 0.1325 0.3902
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0034 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0448 0.2207
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0042
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0086 0.0086
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0012 0.0006 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0066 0.0066
Brugia malayi Cathepsin L-like precursor 0.0531 0.1325 0.3902
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.1344 0.3396 1
Giardia lamblia Cathepsin B precursor 0.0544 0.136 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0025 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0465 0.1157 0.3408
Brugia malayi Thioredoxin reductase 0.0035 0.0063 0.0187
Onchocerca volvulus Cathepsin L homolog 0.0186 0.0448 0.2229
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0043
Trypanosoma cruzi cysteine peptidase, putative 0.0269 0.0659 0.1928
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0014 0.0042
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0244 0.0596 0.1756
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0025 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.1133 0.5623
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Schistosoma mansoni hypothetical protein 0.0035 0.0065 0.0065
Brugia malayi Serine protease Z688.6 precursor 0.0053 0.011 0.0325
Brugia malayi Papain family cysteine protease containing protein 0.0455 0.1133 0.3335
Plasmodium falciparum serine repeat antigen 2 0.0186 0.0448 0.2207
Onchocerca volvulus Cathepsin F homolog 0.0799 0.201 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Brugia malayi Serine protease Z688.6 precursor 0.0053 0.011 0.0325
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0012 0.0035
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Plasmodium falciparum serine repeat antigen 9 0.0186 0.0448 0.2207
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0088 0.0198 0.0582
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0186 0.0448 0.2207
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.0018 0.006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.018 0.0434 0.1278
Plasmodium falciparum histone acetyltransferase GCN5 0.0018 0.0021 0.0078
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0101
Trichomonas vaginalis bromodomain-containing protein, putative 0.002 0.0025 0.0099
Echinococcus granulosus growth factor receptor bound protein 2 0.0084 0.0189 0.0558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 0.0065
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0019 0.0056
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0018 0.0052
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0799 0.201 0.5918
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.0448 0.1319
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.01 0.0229 0.0673
Toxoplasma gondii cathepsin CPC1 0.0186 0.0448 0.2207
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0012 0.0006 0.0016
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Entamoeba histolytica cysteine proteinase, putative 0.0799 0.201 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Echinococcus granulosus cathepsin L 0.0455 0.1133 0.3335
Loa Loa (eye worm) glutathione reductase 0.0035 0.0063 0.0187
Echinococcus multilocularis muscleblind protein 1 0.018 0.0434 0.1278
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.0448 0.1305
Plasmodium vivax vivapain-3 0.0455 0.1133 0.5623
Brugia malayi acetyltransferase, GNAT family protein 0.0068 0.0147 0.0434
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0025 0.0058
Loa Loa (eye worm) thioredoxin reductase 0.0035 0.0063 0.0187
Giardia lamblia Histone acetyltransferase GCN5 0.0018 0.0021 0.0116
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0012 0.0006 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0053 0.011 0.0523
Echinococcus granulosus thioredoxin glutathione reductase 0.0035 0.0063 0.0187
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0025 0.0074
Plasmodium vivax SET domain protein, putative 0.0036 0.0066 0.0304
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0058 0.0169
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Echinococcus multilocularis musashi 0.0033 0.0058 0.0169
Echinococcus granulosus cysteine protease 0.0455 0.1133 0.3335
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Echinococcus multilocularis lamin dm0 0.0033 0.0058 0.0169
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Entamoeba histolytica hypothetical protein 0.0035 0.0065 0.022
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0264 0.0647 0.1905
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0058 0.0169
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.002 0.0025 0.0099
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0186 0.0448 0.1319
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0014 0.0042
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0012 0.0006 0.0016
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0025 0.0098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 1
Echinococcus granulosus muscleblind protein 0.018 0.0434 0.1278
Schistosoma mansoni lamin 0.0033 0.0058 0.0058
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.002 0.0025 0.0099
Brugia malayi Trypsin family protein 0.0044 0.0086 0.0252
Brugia malayi Cathepsin L-like precursor 0.0531 0.1325 0.3902
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0189 0.0189
Mycobacterium ulcerans hypothetical protein 0.0023 0.0034 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0012 0.0006 0.0016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0025 0.4096
Loa Loa (eye worm) hypothetical protein 0.0264 0.0647 0.1905
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0455 0.1133 0.5623
Entamoeba histolytica hypothetical protein 0.0186 0.0448 0.2146
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0186 0.0448 0.2207
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.002 0.0025 0.1836
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0053 0.011 0.011
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1344 0.3396 0.3396
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0066 0.0196
Echinococcus multilocularis cathepsin b 0.1344 0.3396 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0448 0.3267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0448 0.2207
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0186 0.0448 0.3267
Trypanosoma brucei trypanothione reductase 0.0035 0.0063 0.0289
Giardia lamblia Thymus-specific serine protease precursor 0.0053 0.011 0.0774
Schistosoma mansoni cathepsin F (C01 family) 0.0531 0.1325 0.1325
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0455 0.1133 0.5623
Brugia malayi Serine carboxypeptidase S28 family protein 0.0244 0.0596 0.1756
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0025 0.0098
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0034 0.3735
Brugia malayi TAR-binding protein 0.0062 0.0134 0.0394
Leishmania major trypanothione reductase 0.0035 0.0063 0.0289
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Echinococcus granulosus cathepsin b 0.1344 0.3396 1
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Loa Loa (eye worm) hypothetical protein 0.0044 0.0086 0.0252
Entamoeba histolytica cysteine proteinase, putative 0.0799 0.201 1
Giardia lamblia Cathepsin B precursor 0.0544 0.136 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Plasmodium vivax unspecified product 0.0455 0.1133 0.5623
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0269 0.0659 0.1941
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Brugia malayi cathepsin L-like precursor 0.0531 0.1325 0.3902
Brugia malayi intermediate filament protein 0.0033 0.0058 0.0169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.01 0.0229 0.0673
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 0.0065
Brugia malayi Cathepsin L-like precursor 0.0269 0.0659 0.1941
Echinococcus multilocularis GPCR, family 2 0.0016 0.0014 0.0042
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0034 0.3735
Toxoplasma gondii preprocathepsin c precursor, putative 0.0186 0.0448 0.2207
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0012 0.0006 0.0016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0025 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.0448 0.2207
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0025 0.4096
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0186 0.0448 0.2207
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.01 0.0294
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0012 0.0006 0.0016
Onchocerca volvulus 0.0799 0.201 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.002 0.0025 0.0099
Loa Loa (eye worm) hypothetical protein 0.0531 0.1325 0.3902
Onchocerca volvulus 0.0799 0.201 1
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0264 0.0647 0.1905
Trypanosoma cruzi cysteine proteinase, putative 0.0455 0.1133 0.3324
Plasmodium falciparum serine repeat antigen 3 0.0186 0.0448 0.2207
Echinococcus multilocularis cathepsin L 0.0455 0.1133 0.3335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0848 0.2133 0.6279
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.1133 0.5588
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0531 0.1325 0.3892
Entamoeba histolytica hypothetical protein 0.0035 0.0065 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Loa Loa (eye worm) fibroinase 0.0799 0.201 0.5918
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0012 0.0006 0.0016
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Onchocerca volvulus 0.0036 0.0066 0.033
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0019 0.0068
Schistosoma mansoni intermediate filament proteins 0.0033 0.0058 0.0058
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0012 0.0006 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.1133 0.5588
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.0018 0.006
Loa Loa (eye worm) hypothetical protein 0.0531 0.1325 0.3902
Brugia malayi Pre-SET motif family protein 0.0036 0.0066 0.0196
Echinococcus multilocularis thioredoxin glutathione reductase 0.0035 0.0063 0.0187
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0025 0.4096
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0544 0.136 0.6757
Plasmodium vivax vivapain-2 0.0799 0.201 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0034 1
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0025 0.0098
Echinococcus granulosus GPCR family 2 0.0016 0.0014 0.0042
Giardia lamblia Cysteine protease 0.0186 0.0448 0.3267
Trypanosoma brucei carbonic anhydrase-like protein 0.0465 0.1157 0.5747
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0066 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.1133 0.5588
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.0448 0.2207
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0186 0.0448 0.0448
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0042
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0034 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0025 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0134 0.0394
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0012 0.0006 0.0016
Echinococcus multilocularis lamin 0.0033 0.0058 0.0169
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0053 0.011 0.0448
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0143
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0053 0.011 0.0448
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0134 0.0394
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Schistosoma mansoni lamin 0.0033 0.0058 0.0058
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0264 0.0647 0.1905
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.0448 0.1319
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Plasmodium falciparum carbonic anhydrase 0.0264 0.0647 0.3201
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Schistosoma mansoni carbonic anhydrase-related 0.0264 0.0647 0.0647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Giardia lamblia Cathepsin L precursor 0.0186 0.0448 0.3267
Giardia lamblia Hypothetical protein 0.0186 0.0448 0.3267
Brugia malayi cathepsin F-like cysteine proteinase 0.0269 0.0659 0.1941
Loa Loa (eye worm) hypothetical protein 0.0269 0.0659 0.1941
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0012 0.0006 0.0006
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0455 0.1133 0.1133
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0035 0.0063 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0229 0.0673
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1344 0.3396 0.3396
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0455 0.1133 0.1133
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0025 0.0098
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0025 0.0098
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0012 0.0006 0.0016
Leishmania major cysteine peptidase A (CPA) 0.0799 0.201 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0703 0.3479
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0799 0.201 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.01 0.0229 0.0229
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0455 0.1133 0.1133
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0186 0.0448 0.2207
Echinococcus granulosus histone acetyltransferase KAT2B 0.0066 0.0143 0.042
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0012 0.0006 0.0016
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0186 0.0448 0.2207
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Trypanosoma cruzi cysteine peptidase, putative 0.0455 0.1133 0.3324
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0025 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0448 0.2207
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.0448 0.1319
Echinococcus multilocularis cathepsin L cysteine protease 0.0799 0.201 0.5918
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0012 0.0035
Brugia malayi cathepsin L-like cysteine proteinase 0.0186 0.0448 0.1319
Loa Loa (eye worm) hypothetical protein 0.0269 0.0659 0.1941
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Onchocerca volvulus 0.0017 0.0018 0.0088
Schistosoma mansoni hypothetical protein 0.0017 0.0018 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.1133 0.5588
Echinococcus granulosus carbonic anhydrase 0.0264 0.0647 0.1905
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0716 0.1797 0.1797
Plasmodium falciparum glutathione reductase 0.002 0.0025 0.0098
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0025 0.0146
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0018 0.0052
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0025 0.0074
Loa Loa (eye worm) acetyltransferase 0.0068 0.0147 0.0434
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1344 0.3396 0.3396
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0465 0.1157 0.1157
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0034 0.0065
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.0448 0.2146
Onchocerca volvulus 0.0531 0.1325 0.6594
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.0448 0.2207
Onchocerca volvulus 0.0038 0.007 0.035
Entamoeba histolytica cysteine proteinase, putative 0.0531 0.1325 0.6557
Plasmodium falciparum cysteine proteinase falcipain 3 0.0799 0.201 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0025 0.0098
Echinococcus granulosus carbonic anhydrase 0.0264 0.0647 0.1905
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1344 0.3396 0.3396
Echinococcus multilocularis carbonic anhydrase 0.0264 0.0647 0.1905
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0134 0.0394
Entamoeba histolytica hypothetical protein 0.0035 0.0065 0.022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0053 0.011 0.0309
Entamoeba histolytica cysteine protease, putative 0.0186 0.0448 0.2146
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.0448 0.1319
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0088 0.0198 0.0582
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0186 0.0448 0.2207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0053 0.011 0.0309
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0012 0.0006 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0186 0.0448 0.2207
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0448 0.2207
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1344 0.3396 1
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0025 0.0058
Echinococcus granulosus lamin dm0 0.0033 0.0058 0.0169
Schistosoma mansoni cathepsin B (C01 family) 0.0186 0.0448 0.0448
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.01 0.0294
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0019 0.0068
Echinococcus multilocularis cysteine protease 0.0799 0.201 0.5918
Echinococcus multilocularis cathepsin L cysteine protease 0.0799 0.201 0.5918
Giardia lamblia Cysteine protease 0.0186 0.0448 0.3267
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0544 0.136 0.136
Loa Loa (eye worm) ctsf protein 0.0799 0.201 0.5918
Echinococcus granulosus cathepsin l cysteine peptidase 0.0799 0.201 0.5918
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.002 0.0025 0.1836
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0025 0.0098
Brugia malayi Papain family cysteine protease containing protein 0.0799 0.201 0.5918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Plasmodium vivax vivapain-2 0.0799 0.201 1
Giardia lamblia Cysteine protease 0.0186 0.0448 0.3267
Giardia lamblia Serine peptidase, putative 0.0053 0.011 0.0774
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0244 0.0596 0.1756
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0189 0.0189
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0264 0.0647 0.1905
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0799 0.201 0.5918
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0039
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0016
Echinococcus granulosus carbonic anhydrase II 0.0465 0.1157 0.3408
Loa Loa (eye worm) cathepsin B 0.0544 0.136 0.4004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0034 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0058 0.0169
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.002 0.0025 0.0099
Echinococcus multilocularis muscleblind protein 0.018 0.0434 0.1278
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0025 0.0098
Plasmodium falciparum serine repeat antigen 5 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0044 0.0086 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0799 0.201 1
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0448 0.2207
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0068 0.0147 0.0147
Entamoeba histolytica cysteine proteinase 1, putative 0.0455 0.1133 0.5588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.1325 0.6584
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.01 0.0229 0.1113
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0034 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0025 0.1836
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0799 0.201 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0531 0.1325 0.6584
Trypanosoma brucei cysteine peptidase C (CPC) 0.0544 0.136 0.6757
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.01 0.0294
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0264 0.0647 0.1905
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.0448 0.1305
Echinococcus multilocularis carbonic anhydrase 0.0264 0.0647 0.1905
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.0448 0.2207
Entamoeba histolytica hypothetical protein 0.0035 0.0065 0.022
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0012 0.0006 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.0799 0.201 0.5911
Leishmania major cathepsin L-like protease 0.0799 0.201 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0098
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.01 0.0229 0.0673
Echinococcus granulosus intermediate filament protein 0.0033 0.0058 0.0169
Giardia lamblia Cathepsin L-like protease 0.0186 0.0448 0.3267
Echinococcus granulosus tar DNA binding protein 0.0062 0.0134 0.0394
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0019 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0799 0.201 0.5918
Schistosoma mansoni cathepsin F (C01 family) 0.0799 0.201 0.201
Giardia lamblia Cathepsin B precursor 0.0544 0.136 1
Trypanosoma cruzi cruzipain precursor, putative 0.0269 0.0659 0.1928
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0465 0.1157 0.3408
Onchocerca volvulus 0.0799 0.201 1
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0053 0.011 0.0325
Trypanosoma cruzi cysteine peptidase, putative 0.0799 0.201 0.5911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0012 0.0006 0.0016
Onchocerca volvulus 0.0023 0.0034 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0799 0.201 1
Giardia lamblia Cathepsin B precursor 0.0186 0.0448 0.3267
Schistosoma mansoni carbonic anhydrase-related 0.0264 0.0647 0.0647
Onchocerca volvulus Cathepsin L homolog 0.0799 0.201 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.0448 0.3267
Schistosoma mansoni cathepsin S (C01 family) 0.0186 0.0448 0.0448
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0088 0.0198 0.0582
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0465 0.1157 0.3408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Echinococcus multilocularis carbonic anhydrase II 0.0465 0.1157 0.3408
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0053 0.011 0.0523
Toxoplasma gondii cathepsin CPL 0.0799 0.201 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0244 0.0596 0.1756
Echinococcus granulosus cathepsin L cysteine protease 0.0455 0.1133 0.3335
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0065 0.0191
Onchocerca volvulus 0.0286 0.0703 0.3497
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0088 0.0198 0.0582
Onchocerca volvulus 0.0033 0.0058 0.0286
Schistosoma mansoni cathepsin s 0.0269 0.0659 0.0659
Plasmodium vivax unspecified product 0.0269 0.0659 0.3261
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0012 0.0006 0.0016
Plasmodium falciparum glutathione reductase 0.0035 0.0063 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.0448 0.2207
Toxoplasma gondii hypothetical protein 0.0264 0.0647 0.3201
Loa Loa (eye worm) hypothetical protein 0.0032 0.0056 0.0165
Loa Loa (eye worm) hypothetical protein 0.0186 0.0448 0.1319
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.0448 0.0448
Brugia malayi Cathepsin L-like precursor 0.0799 0.201 0.5918
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0101
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0101
Mycobacterium tuberculosis Probable oxidoreductase 0.002 0.0025 0.1836
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0068 0.0147 0.0434
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.006 0.0177
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0012 0.0006 0.0016
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.0448 0.0448
Echinococcus granulosus cathepsin L 0.0186 0.0448 0.1319
Schistosoma mansoni cathepsin C 0.0186 0.0448 0.0448
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0455 0.1133 0.3324
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0066 0.0196
Giardia lamblia Hypothetical protein 0.0186 0.0448 0.3267
Echinococcus multilocularis cathepsin L 0.0186 0.0448 0.1319
Loa Loa (eye worm) hypothetical protein 0.0531 0.1325 0.3902
Onchocerca volvulus 0.0053 0.011 0.0549
Brugia malayi Kringle domain containing protein 0.0017 0.0018 0.0052
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.0058 0.0169
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0056
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0012 0.0006 0.0006
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0098
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Trypanosoma cruzi cysteine peptidase, putative 0.0799 0.201 0.5911
Echinococcus granulosus cathepsin b 0.1344 0.3396 1
Trypanosoma cruzi cysteine protease, putative 0.0455 0.1133 0.3324
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0018 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.0448 0.2207
Loa Loa (eye worm) carbonic anhydrase 3 0.0465 0.1157 0.3408
Leishmania major carbonic anhydrase-like protein 0.0465 0.1157 0.5747
Schistosoma mansoni hypothetical protein 0.0034 0.006 0.006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0025 0.0025
Plasmodium vivax vivapain-1 0.0455 0.1133 0.5623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Entamoeba histolytica cysteine protease, putative 0.0455 0.1133 0.5588
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0025 0.0098
Loa Loa (eye worm) hypothetical protein 0.0269 0.0659 0.1941
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0134
Echinococcus granulosus histone acetyltransferase KAT2B 0.002 0.0025 0.0075
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0042
Loa Loa (eye worm) RNA binding protein 0.0062 0.0134 0.0394
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0186 0.0448 0.1319
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0186 0.0448 0.2207
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0799 0.201 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0186 0.0448 0.2207
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0544 0.136 0.3994
Entamoeba histolytica cysteine proteinase 2 0.0455 0.1133 0.5588
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0066 0.0304
Brugia malayi RNA binding protein 0.0062 0.0134 0.0394
Brugia malayi glutathione reductase 0.0035 0.0063 0.0187
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0465 0.1157 0.3397
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0015 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0799 0.201 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0025 0.0058

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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