TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 273.31 | Formula: C13H11N3O2S
H donors: 2 H acceptors: 2 LogP: 1.99 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OCc1nn(c2ccccc2)c(=O)c2c1csc2N
InChi: 1S/C13H11N3O2S/c14-12-11-9(7-19-12)10(6-17)15-16(13(11)18)8-4-2-1-3-5-8/h1-5,7,17H,6,14H2
InChiKey: YQVLXBPSOKOCNY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	proprotein convertase 2	0.201	0.6276	0.6276
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0108	0.0235	0.5965
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Onchocerca volvulus		0.0068	0.0108	0.2964
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0051	0.0054	0.1382
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trypanosoma brucei	subtilisin peptidase	0.014	0.0336	0.8534
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0632	0.19	0.3131
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0772	0.2344	0.3863
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0148	0.0361	0.0361
Plasmodium falciparum	subtilisin-like protease 3	0.014	0.0336	1
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0051	0.0054	0.1382
Trichomonas vaginalis	conserved hypothetical protein	0.014	0.0336	0.0553
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.2539	0.2539
Onchocerca volvulus		0.014	0.0336	1
Schistosoma mansoni	site-1 peptidase (S08 family)	0.014	0.0336	0.0336
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.014	0.0336	1
Echinococcus granulosus	Furin 1	0.0772	0.2344	0.2344
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.006	0.0084	0.0084
Schistosoma mansoni	hypothetical protein	0.0052	0.0058	0.0058
Schistosoma mansoni	inhibitor of apoptosis protein	0.0052	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0192	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0129	0.03	0.03
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.006	0.0084	0.0084
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0772	0.2344	0.3863
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.014	0.0336	0.8534
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.014	0.0336	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.014	0.0336	0.0336
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0772	0.2344	0.3863
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0148	0.0361	0.0361
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0129	0.03	0.03
Schistosoma mansoni	site-1 peptidase (S08 family)	0.014	0.0336	0.0336
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.014	0.0336	1
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0038	0.0012	0.0014
Schistosoma mansoni	chromatin regulatory protein sir2	0.0108	0.0235	0.0235
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0052	0.0058	0.0073
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0189	0.0492	0.0492
Trypanosoma cruzi	oligopeptidase b	0.0051	0.0054	0.1382
Loa Loa (eye worm)	transcriptional regulator	0.0108	0.0235	0.0235
Echinococcus granulosus	furin	0.3182	1	1
Echinococcus granulosus	membrane bound transcription factor site 1	0.014	0.0336	0.0336
Leishmania major	subtilisin-like serine peptidase	0.014	0.0336	1
Brugia malayi	hypothetical protein	0.0068	0.0108	0.0108
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.006	0.0084	0.0138
Echinococcus multilocularis	neuroendocrine convertase 2	0.201	0.6276	0.7853
Toxoplasma gondii	subtilisin SUB5	0.014	0.0336	1
Brugia malayi	Subtilase family protein	0.014	0.0336	0.0336
Toxoplasma gondii	subtilisin SUB4	0.014	0.0336	1
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0047	0.0047
Echinococcus multilocularis		0.255	0.7992	1
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0051	0.0054	0.1382
Loa Loa (eye worm)	endoprotease bli-4	0.3182	1	1
Onchocerca volvulus		0.0051	0.0055	0.1349
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0051	0.0054	0.162
Echinococcus granulosus	protein arginine methyltransferase	0.006	0.0084	0.0084
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0108	0.0108
Toxoplasma gondii	subtilisin SUB7	0.014	0.0336	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Echinococcus granulosus	MAM	0.0068	0.0108	0.0108
Schistosoma mansoni	septate junction protein	0.0039	0.0016	0.0016
Schistosoma mansoni	sodium/solute symporter	0.0038	0.0012	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0058	0.0058
Echinococcus granulosus	prolyl endopeptidase	0.0129	0.03	0.03
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0108	0.0108
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0129	0.03	0.03
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.014	0.0336	0.0336
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.2539	0.2539
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.014	0.0336	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0052	0.0058	0.0058
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0108	0.0235	0.0235
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Schistosoma mansoni	protein arginine N-methyltransferase 1	0.006	0.0084	0.0084
Loa Loa (eye worm)	TK/ALK protein kinase	0.0068	0.0108	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.014	0.0336	0.0553
Echinococcus multilocularis	Furin 1	0.0772	0.2344	0.2933
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0129	0.03	0.8947
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0108	0.0235	0.0294
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Schistosoma mansoni	tyrosine kinase	0.0189	0.0492	0.0492
Giardia lamblia	High cysteine membrane protein Group 2	0.1172	0.3616	1
Echinococcus granulosus	neuroendocrine convertase 2	0.201	0.6276	0.6276
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0158	0.0393	1
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.014	0.0336	0.042
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0094	0.0192	0.4875
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0772	0.2344	0.2344
Brugia malayi	prolyl oligopeptidase family protein	0.0129	0.03	0.03
Giardia lamblia	Furin precursor putative serine protease	0.0632	0.19	0.4925
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0772	0.2344	0.3863
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0058	0.0058
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trichomonas vaginalis	conserved hypothetical protein	0.014	0.0336	0.0553
Leishmania major	silent information regulator 2, putative	0.0108	0.0235	0.699
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0115	0.0258	0.7221
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0148	0.0361	0.0451
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0772	0.2344	0.3863
Trypanosoma brucei	Protein arginine N-methyltransferase 1 catalytic subunit	0.0094	0.0192	0.4875
Trypanosoma brucei	prolyl endopeptidase	0.0129	0.03	0.7635
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0068	0.0109	0.0109
Onchocerca volvulus	Deterin homolog	0.0052	0.0058	0.1435
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0108	0.0235	0.5965
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.014	0.0336	1
Schistosoma mansoni	hypothetical protein	0.0068	0.0108	0.0108
Echinococcus granulosus	inhibitor of apoptosis protein	0.0052	0.0058	0.0058
Toxoplasma gondii	subtilisin SUB10	0.014	0.0336	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0108	0.0108
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0108	0.0235	0.5965
Loa Loa (eye worm)	hypothetical protein	0.1238	0.3823	0.3823
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0012	0.0012
Toxoplasma gondii	subtilisin SUB12	0.014	0.0336	1
Plasmodium falciparum	subtilisin-like protease 2	0.014	0.0336	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Plasmodium falciparum	subtilisin-like protease 1	0.014	0.0336	1
Plasmodium vivax	subtilisin-like protease 1	0.014	0.0336	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.006	0.0084	0.0138
Echinococcus granulosus	chromatin regulatory protein sir2	0.0108	0.0235	0.0235
Echinococcus multilocularis	protein arginine N methyltransferase 8	0.006	0.0084	0.0105
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0108	0.0235	0.0294
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.0094	0.0192	0.8172
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.014	0.0336	0.0336
Echinococcus granulosus	solute carrier family 5	0.0148	0.0361	0.0361
Leishmania major	arginine N-methyltransferase-like protein	0.006	0.0084	0.2495
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0158	0.0393	1
Echinococcus granulosus	sodium:glucose cotransporter	0.0148	0.0361	0.0361
Onchocerca volvulus		0.0068	0.0108	0.2964
Toxoplasma gondii	subtilisin SUB2	0.014	0.0336	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0108	0.0235	0.0387
Toxoplasma gondii	subtilisin SUB9	0.014	0.0336	1
Echinococcus multilocularis	MAM	0.0068	0.0108	0.0135
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.2539	0.3177
Schistosoma mansoni	high-affinity choline transporter	0.0038	0.0012	0.0012
Echinococcus multilocularis	high affinity choline transporter 1	0.0038	0.0012	0.0014
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Schistosoma mansoni	furin-1 (S08 family)	0.1377	0.4267	0.4267
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.014	0.0336	1
Plasmodium vivax	subtilisin-like protease 2, putative	0.014	0.0336	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Echinococcus granulosus	high affinity choline transporter 1	0.0038	0.0012	0.0012
Echinococcus granulosus	protein arginine N methyltransferase 8	0.006	0.0084	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.014	0.0336	0.0553
Brugia malayi	neuroendocrine convertase 1 precursor	0.201	0.6276	0.6276
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Brugia malayi	Sodium:solute symporter family protein	0.0038	0.0012	0.0012
Entamoeba histolytica	hypothetical protein	0.0094	0.0192	0.8172
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0051	0.0054	0.1382
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Schistosoma mansoni	hypothetical protein	0.0068	0.0108	0.0108
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0129	0.03	0.8909
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1944	0.6069	1
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0094	0.0192	0.4875
Brugia malayi	GH02984p	0.0038	0.0012	0.0012
Plasmodium vivax	subtilisin-like serine protease, putative	0.014	0.0336	1
Echinococcus granulosus	epidermal growth factor receptor	0.0189	0.0492	0.0492
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Echinococcus multilocularis	membrane bound transcription factor site 1	0.014	0.0336	0.042
Mycobacterium leprae	Possible secreted protease	0.014	0.0336	1
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.1944	0.6069	0.7594
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0158	0.0393	1
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Toxoplasma gondii	subtilisin SUB8	0.014	0.0336	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0189	0.0492	0.0616
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.014	0.0336	1
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.3182	1	1
Toxoplasma gondii	subtilisin SUB1	0.014	0.0336	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0772	0.2344	0.3863
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.014	0.0336	0.0336
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0632	0.19	0.3131
Loa Loa (eye worm)	subtilase	0.014	0.0336	0.0336
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0052	0.0058	0.0058
Echinococcus multilocularis	protein arginine methyltransferase	0.006	0.0084	0.0105
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0038	0.0012	0.0345
Toxoplasma gondii	subtilisin SUB11	0.014	0.0336	1
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0052	0.0058	0.0073
Toxoplasma gondii	histone arginine methyltransferase PRMT1	0.006	0.0084	0.2495
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trypanosoma cruzi	subtilisin peptidase	0.014	0.0336	0.8534
Schistosoma mansoni	chromatin regulatory protein sir2	0.0108	0.0235	0.0235
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0148	0.0361	0.0451
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0108	0.0235	0.0235
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0108	0.0235	0.0387
Brugia malayi	hypothetical protein	0.0094	0.0192	0.0192
Loa Loa (eye worm)	proprotein convertase 2	0.0772	0.2344	0.2344
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0108	0.0235	1
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.014	0.0336	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trypanosoma cruzi	prolyl endopeptidase	0.0129	0.03	0.7635
Toxoplasma gondii	subtilisin SUB6	0.014	0.0336	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Trichomonas vaginalis	hypothetical protein	0.0632	0.19	0.3131
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1944	0.6069	1
Schistosoma mansoni	inositol transporter	0.0148	0.0361	0.0361
Echinococcus multilocularis	prolyl endopeptidase	0.0129	0.03	0.0376
Schistosoma mansoni	hypothetical protein	0.0632	0.19	0.19
Trypanosoma cruzi	oligopeptidase b	0.0051	0.0054	0.1382
Loa Loa (eye worm)	hypothetical protein	0.014	0.0336	0.0336
Echinococcus multilocularis	solute carrier family 5	0.0148	0.0361	0.0451
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0038	0.0012	0.0012
Onchocerca volvulus		0.0052	0.0058	0.1435
Brugia malayi	Furin-like cysteine rich region family protein	0.0189	0.0492	0.0492
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Schistosoma mansoni	inositol transporter	0.0148	0.0361	0.0361
Toxoplasma gondii	prolyl endopeptidase	0.0129	0.03	0.8947
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.1944	0.6069	0.6069
Trichomonas vaginalis	conserved hypothetical protein	0.0632	0.19	0.3131
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0052	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.3182	1	1
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0632	0.19	0.3131
Trichomonas vaginalis	conserved hypothetical protein	0.014	0.0336	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0012	0.0012
Schistosoma mansoni	chromatin regulatory protein sir2	0.0108	0.0235	0.0235
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0108	0.0235	1
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.006	0.0084	0.0138
Trypanosoma brucei	oligopeptidase b	0.0051	0.0054	0.1382
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.014	0.0336	0.0553
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.014	0.0336	1
Leishmania major	oligopeptidase b	0.0051	0.0054	0.162
Brugia malayi	celfurPC protein	0.255	0.7992	0.7992
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0052	0.0058	0.0058
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.014	0.0336	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0108	0.0108

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	= 3.9811 um	PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 1460 ]	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 1468 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1592419

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1443755