Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0126 | 0.0484 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0053 | 0.0204 |
Onchocerca volvulus | 0.0048 | 0.0053 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0053 | 0.0204 |
Echinococcus granulosus | carboxylesterase 5A | 0.0287 | 0.2598 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0053 | 0.0204 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0.0053 | 0.0211 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0048 | 0.0053 | 0.0053 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0126 | 0.0126 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0048 | 0.0053 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0048 | 0.0053 | 0.0204 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0179 | 0.0688 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0048 | 0.0053 | 0.0204 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0126 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0053 | 0.0204 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0048 | 0.0053 | 0.0204 |
Onchocerca volvulus | 0.0048 | 0.0053 | 1 | |
Schistosoma mansoni | gliotactin | 0.0048 | 0.0053 | 0.0204 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0126 | 0.0484 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0053 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0053 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0053 | 0.0204 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0048 | 0.0053 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0048 | 0.0053 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0287 | 0.2598 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0053 | 0.0204 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.2598 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0126 | 0.0484 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.2504 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0053 | 0.0204 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0179 | 0.0688 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0287 | 0.2598 | 1 |
Onchocerca volvulus | 0.0048 | 0.0053 | 1 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0048 | 0.0053 | 0.0204 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0.0053 | 0.0211 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0048 | 0.0053 | 0.0053 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0053 | 0.0204 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0053 | 0.0204 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0053 | 0.0204 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.2598 | 0.2598 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0053 | 0.0204 |
Onchocerca volvulus | 0.0048 | 0.0053 | 1 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0126 | 0.0484 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0048 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0053 | 0.0204 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0126 | 0.0484 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0048 | 0.0053 | 0.0211 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 0.2598 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0048 | 0.0053 | 0.0204 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0179 | 0.0688 |
Schistosoma mansoni | acetylcholinesterase | 0.0048 | 0.0053 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0179 | 0.0688 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0126 | 0.0484 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0053 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.2598 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0048 | 0.0053 | 0.0204 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0053 | 0.0204 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.0053 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0053 | 0.0204 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0287 | 0.2598 | 0.2598 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.2598 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 0.2598 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0287 | 0.2598 | 1 |
Echinococcus multilocularis | neuroligin | 0.0048 | 0.0053 | 0.0053 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0126 | 0.0484 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7305 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.