Detailed information for compound 1444043

Basic information

Technical information
  • TDR Targets ID: 1444043
  • Name: 1-(4-benzylpiperidin-1-yl)-3-(2,5-dimethylphe noxy)propan-2-ol hydrochloride
  • MW: 389.959 | Formula: C23H32ClNO2
  • H donors: 1 H acceptors: 1 LogP: 5.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CN1CCC(CC1)Cc1ccccc1)COc1cc(C)ccc1C.Cl
  • InChi: 1S/C23H31NO2.ClH/c1-18-8-9-19(2)23(14-18)26-17-22(25)16-24-12-10-21(11-13-24)15-20-6-4-3-5-7-20;/h3-9,14,21-22,25H,10-13,15-17H2,1-2H3;1H
  • InChiKey: UYPVMFFRUWQVFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-benzyl-1-piperidyl)-3-(2,5-dimethylphenoxy)propan-2-ol hydrochloride
  • 1-(4-benzyl-1-piperidinyl)-3-(2,5-dimethylphenoxy)propan-2-ol hydrochloride
  • 1-(2,5-dimethylphenoxy)-3-[4-(phenylmethyl)piperidin-1-yl]propan-2-ol hydrochloride
  • BIM-0034146.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0191 0.0191
Echinococcus granulosus Mastin 0.0044 0.0096 0.0096
Plasmodium falciparum subtilisin-like protease 1 0.0114 0.0396 1
Brugia malayi cell division control protein 2 homolog 0.0044 0.0094 0.0094
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.007 0.007
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0114 0.0396 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0683 0.2859 0.5207
Onchocerca volvulus 0.0066 0.0191 0.1489
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0066 0.0191 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.017 0.031
Entamoeba histolytica aldose reductase, putative 0.0061 0.017 0.7376
Loa Loa (eye worm) hypothetical protein 0.0114 0.0396 0.0396
Echinococcus multilocularis neuropeptide receptor A26 0.0066 0.0191 0.0217
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0191 0.0191
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Loa Loa (eye worm) hypothetical protein 0.0061 0.017 0.017
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0066 0.0191 0.0217
Brugia malayi Protein kinase domain containing protein 0.0089 0.0292 0.0292
Trypanosoma cruzi CYC2-like cyclin, putative 0.0075 0.0231 0.2082
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0083 0.0266 0.0266
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0066 0.0191 0.0191
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0044 0.0096 0.011
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Brugia malayi SPRY domain containing protein 0.0043 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0191 0.0191
Schistosoma mansoni neuropeptide receptor 0.0066 0.0191 0.0191
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0191 0.0191
Brugia malayi hypothetical protein 0.0044 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0066 0.0191 0.0191
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0121 0.0121
Plasmodium falciparum cyclin 0.0031 0.0041 0.1032
Schistosoma mansoni opsin-like receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis cyclins, putative 0.0051 0.0128 0.0233
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0118 0.0414 0.047
Loa Loa (eye worm) hypothetical protein 0.0044 0.0096 0.0096
Onchocerca volvulus 0.0066 0.0191 0.1489
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0061 0.017 0.017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Echinococcus granulosus glycoprotein Antigen 5 0.0044 0.0096 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0094 0.0094
Echinococcus granulosus cyclins 0.0031 0.0041 0.0041
Brugia malayi putative neuropeptide receptor 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Toxoplasma gondii SPRY domain-containing protein 0.004 0.0078 0.196
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0089 0.0292 0.2279
Loa Loa (eye worm) hypothetical protein 0.012 0.0426 0.0426
Echinococcus granulosus cyclins 0.0031 0.0041 0.0041
Brugia malayi gamma-secretase subunit aph-1 0.0714 0.2995 0.2995
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0061 0.017 0.017
Trypanosoma brucei aldo-keto reductase, putative 0.0061 0.017 0.1536
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0396 0.0722
Onchocerca volvulus 0.0066 0.0191 0.1489
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0191 0.0191
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0114 0.0396 0.0396
Onchocerca volvulus 0.0044 0.0096 0.0754
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0033 0.0048 0.0054
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Echinococcus granulosus allatostatin A receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0683 0.2859 0.5207
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0135 0.049 0.3827
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0094 0.4061
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0096 0.0096
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0683 0.2859 0.5207
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0117 0.0413 0.3726
Entamoeba histolytica cyclin, putative 0.0075 0.0231 1
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0114 0.0396 1
Trichomonas vaginalis cyclin D, putative 0.0031 0.0041 0.0074
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Schistosoma mansoni inhibitor of apoptosis protein 0.0135 0.049 0.049
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0191 0.0191
Echinococcus granulosus hypothetical protein 0.0066 0.0191 0.0191
Echinococcus multilocularis somatostatin receptor 0.0066 0.0191 0.0217
Brugia malayi Cyclin, N-terminal domain containing protein 0.0075 0.0231 0.0231
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0066 0.0191 0.0217
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0094 0.0846
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0066 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0066 0.0191 0.0191
Echinococcus granulosus g-protein coupled receptor 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Trichomonas vaginalis cyclin B, putative 0.0075 0.0231 0.0421
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0061 0.017 0.4297
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.007 0.0079
Schistosoma mansoni adenoreceptor 0.0066 0.0191 0.0191
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0066 0.0191 0.0191
Schistosoma mansoni amine GPCR 0.0066 0.0191 0.0191
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0094 0.0094
Echinococcus multilocularis neuropeptide s receptor 0.0066 0.0191 0.0217
Brugia malayi sulfakinin receptor protein 0.0066 0.0191 0.0191
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0066 0.0191 0.1489
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trypanosoma cruzi cyclin, putative 0.0075 0.0231 0.2082
Onchocerca volvulus 0.0066 0.0191 0.1489
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0061 0.017 0.031
Schistosoma mansoni hypothetical protein 0.0066 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0066 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0089 0.0292 0.0292
Echinococcus multilocularis dro:myosuppressin receptor 0.0066 0.0191 0.0217
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0114 0.0396 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0055 0.0055
Trichomonas vaginalis retinoblastoma binding protein, putative 0.0075 0.0229 0.0417
Brugia malayi ORL1-like opioid receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis tissue type plasminogen activator 0.0089 0.0292 0.0332
Echinococcus multilocularis g-protein coupled receptor 0.0066 0.0191 0.0217
Loa Loa (eye worm) hypothetical protein 0.0135 0.049 0.049
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0121 0.0138
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0094 0.0094
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0033 0.0048 0.0054
Echinococcus multilocularis sex peptide receptor 0.0066 0.0191 0.0217
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0114 0.0396 1
Trichomonas vaginalis WD repeat domain, putative 0.007 0.0209 0.0381
Echinococcus multilocularis gamma secretase subunit aph 1 0.0714 0.2995 0.3404
Echinococcus granulosus cpg binding protein 0.0037 0.0064 0.0064
Echinococcus multilocularis NMDA receptor 0.0033 0.0048 0.0054
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0094 0.0094
Schistosoma mansoni amine GPCR 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0075 0.0231 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0061 0.017 0.4297
Brugia malayi larval opioid receptor 0.0066 0.0191 0.0191
Brugia malayi Furin-like cysteine rich region family protein 0.0289 0.1157 0.1157
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Plasmodium falciparum subtilisin-like protease 2 0.0114 0.0396 1
Echinococcus multilocularis cyclin b3 0.0031 0.0041 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Brugia malayi Dopamine receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0396 0.0722
Trypanosoma brucei aldo/keto reductase, putative 0.0061 0.017 0.1536
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0094 0.0094
Brugia malayi Dopamine receptor protein 1 0.0066 0.0191 0.0191
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0191 0.0191
Echinococcus granulosus G protein coupled receptor 139 0.0066 0.0191 0.0191
Loa Loa (eye worm) trypsin family protein 0.0044 0.0096 0.0096
Trypanosoma brucei mitotic cyclin 6 0.0075 0.0231 0.2082
Onchocerca volvulus 0.0044 0.0096 0.0754
Schistosoma mansoni alpha-1 adrenergic receptor 0.0066 0.0191 0.0191
Schistosoma mansoni tyrosine kinase 0.0289 0.1157 0.1157
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0121 0.0138
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0066 0.0191 0.1489
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0189 0.4777
Loa Loa (eye worm) hypothetical protein 0.0044 0.0096 0.0096
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Brugia malayi celfurPC protein 0.1819 0.7776 0.7776
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0114 0.0396 0.0396
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0191 0.0217
Mycobacterium ulcerans hypothetical protein 0.0061 0.017 0.2463
Schistosoma mansoni neuropeptide receptor 0.0066 0.0191 0.0191
Brugia malayi G-protein coupled receptor 0.0066 0.0191 0.0191
Schistosoma mansoni caspase-7 (C14 family) 0.0062 0.0172 0.0172
Echinococcus multilocularis cyclins 0.0031 0.0041 0.0046
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Loa Loa (eye worm) hypothetical protein 0.0044 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0066 0.0191 0.1489
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trypanosoma cruzi cyclin, putative 0.0075 0.0231 0.2082
Onchocerca volvulus 0.0061 0.017 0.1331
Echinococcus multilocularis cyclin B3 1 0.0031 0.0041 0.0046
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0114 0.0396 0.0451
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0191 0.0191
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0092
Brugia malayi neuropeptide F receptor 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.1097 0.4653 0.4653
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Onchocerca volvulus 0.007 0.0209 0.1634
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0094 0.2365
Echinococcus granulosus serotonin receptor 0.0066 0.0191 0.0191
Echinococcus granulosus glutamate receptor 4 0.0083 0.0266 0.0266
Onchocerca volvulus 0.0114 0.0396 0.3098
Schistosoma mansoni pol-related 0.0061 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0062 0.0172 0.0172
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0061 0.017 0.031
Echinococcus granulosus glutamate receptor subunit protein glur 0.0116 0.0409 0.0409
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0061 0.017 0.4297
Echinococcus multilocularis glutamate receptor 4 0.0083 0.0266 0.0302
Echinococcus multilocularis glycoprotein Antigen 5 0.0044 0.0096 0.011
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0191 0.0217
Schistosoma mansoni hypothetical protein 0.0038 0.007 0.007
Echinococcus multilocularis membrane bound transcription factor site 1 0.0114 0.0396 0.0451
Toxoplasma gondii subtilisin SUB5 0.0114 0.0396 1
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Echinococcus granulosus voltage gated potassium channel subunit 0.0061 0.017 0.017
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0094 0.0107
Echinococcus multilocularis voltage gated potassium channel subunit 0.0061 0.017 0.0194
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0683 0.2859 0.5207
Echinococcus granulosus cyclin B3 1 0.0031 0.0041 0.0041
Schistosoma mansoni cyclin B3 0.0031 0.0041 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0426 0.0426
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0066 0.0191 0.0191
Plasmodium falciparum aldo-keto reductase, putative 0.0061 0.017 0.4297
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.0191 0.0191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0191 0.0217
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0061 0.017 0.017
Entamoeba histolytica cyclin, putative 0.0031 0.0041 0.1771
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0191 0.0217
Onchocerca volvulus 0.0061 0.017 0.1331
Echinococcus multilocularis serotonin receptor 0.0066 0.0191 0.0217
Trichomonas vaginalis cyclins, putative 0.0075 0.0231 0.0421
Schistosoma mansoni hypothetical protein 0.0033 0.0048 0.0048
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0191 0.0217
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0191 0.0217
Entamoeba histolytica aldose reductase, putative 0.0061 0.017 0.7376
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0133 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Echinococcus granulosus Furin 1 0.0683 0.2859 0.2859
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0066 0.0191 0.0191
Echinococcus granulosus wd40 repeat 0.0075 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Echinococcus granulosus alpha 1A adrenergic receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.007 0.0079
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0061 0.017 0.4297
Loa Loa (eye worm) proprotein convertase 2 0.0683 0.2859 0.2859
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0085 0.0271 0.5
Loa Loa (eye worm) hypothetical protein 0.2333 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0325 0.1313 0.1313
Echinococcus granulosus sex peptide receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0078 0.0141
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0061 0.017 0.031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0191 0.0191
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0318 0.128 0.128
Echinococcus granulosus cyclins 0.0031 0.0041 0.0041
Brugia malayi proprotein convertase 2 0.1725 0.7368 0.7368
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0066 0.0191 0.1489
Echinococcus granulosus orexin receptor type 2 0.0066 0.0191 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0191 0.0191
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0085 0.0271 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0426 0.0426
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0094 0.0094
Echinococcus granulosus peptide allatostatin:somatostatin 0.0066 0.0191 0.0191
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Onchocerca volvulus Neuropeptide F receptor homolog 0.0066 0.0191 0.1489
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.0191 0.0191
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Schistosoma mansoni amine GPCR 0.0066 0.0191 0.0191
Echinococcus granulosus epidermal growth factor receptor 0.0289 0.1157 0.1157
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0085 0.0271 0.4456
Loa Loa (eye worm) hypothetical protein 0.0089 0.0292 0.0292
Toxoplasma gondii aldose reductase, putative 0.0061 0.017 0.4297
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0094 0.0094
Echinococcus granulosus enteropeptidase 0.0044 0.0096 0.0096
Echinococcus granulosus dnaJ subfamily B 0.2055 0.8798 0.8798
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0094 0.4061
Loa Loa (eye worm) TYRA-2 protein 0.0066 0.0191 0.0191
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0066 0.0191 0.0191
Loa Loa (eye worm) oxidoreductase 0.0061 0.017 0.017
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0061 0.017 0.017
Trichomonas vaginalis cyclin A, putative 0.0075 0.0231 0.0421
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0061 0.017 0.017
Echinococcus multilocularis glutamate receptor 2 0.0133 0.0482 0.0548
Schistosoma mansoni glutamate receptor NMDA 0.0033 0.0048 0.0048
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Loa Loa (eye worm) oxidoreductase 0.0061 0.017 0.017
Toxoplasma gondii subtilisin SUB10 0.0114 0.0396 1
Echinococcus granulosus neuropeptide receptor 0.0066 0.0191 0.0191
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0094 0.0846
Plasmodium vivax aldehyde reductase, putative 0.0061 0.017 0.4297
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0061 0.017 0.017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Entamoeba histolytica alcohol dehydrogenase, putative 0.0061 0.017 0.7376
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0094 0.0846
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0033 0.0048 0.0048
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0066 0.0191 0.0191
Toxoplasma gondii kringle domain-containing protein 0.0089 0.0292 0.7357
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0044 0.0096 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0514 0.2129 0.3877
Echinococcus granulosus g protein coupled receptor 0.0066 0.0191 0.0191
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0191 0.0191
Entamoeba histolytica cyclin family protein 0.0031 0.0041 0.1771
Giardia lamblia Aldose reductase 0.0061 0.017 0.0473
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0117 0.0413 0.3726
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0094 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0396 0.0722
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0044 0.0096 0.0096
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0066 0.0191 0.0191
Giardia lamblia Aldose reductase 0.0061 0.017 0.0473
Echinococcus granulosus membrane bound transcription factor site 1 0.0114 0.0396 0.0396
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0318 0.128 0.128
Schistosoma mansoni hypothetical protein 0.0044 0.0096 0.0096
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Echinococcus granulosus transmembrane protease serine 3 0.0044 0.0096 0.0096
Echinococcus granulosus 7tm_1 domain containing protein 0.0066 0.0191 0.0191
Trypanosoma cruzi aldo-keto reductase 0.0061 0.017 0.1536
Toxoplasma gondii hypothetical protein 0.0024 0.0008 0.0205
Toxoplasma gondii subtilisin SUB9 0.0114 0.0396 1
Echinococcus granulosus caspase 2 0.0062 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.007
Schistosoma mansoni cpg binding protein 0.0035 0.0055 0.0055
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0075 0.0231 0.0231
Echinococcus granulosus neuropeptide receptor 0.0066 0.0191 0.0191
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0191 0.0191
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0191 0.0191
Echinococcus granulosus set1:ash2 histone methyltransferase complex 0.0043 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0075 0.0229 0.0229
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Loa Loa (eye worm) TK/EGFR protein kinase 0.0289 0.1157 0.1157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1066 0.4517 0.5134
Onchocerca volvulus 0.0066 0.0191 0.1489
Toxoplasma gondii subtilisin SUB2 0.0114 0.0396 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.0191 0.0191
Brugia malayi Kringle domain containing protein 0.0089 0.0292 0.0292
Brugia malayi Serotonin receptor 0.0066 0.0191 0.0191
Trypanosoma cruzi cyclin 6, putative 0.0075 0.0231 0.2082
Loa Loa (eye worm) hypothetical protein 0.0082 0.0261 0.0261
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0044 0.0096 0.0096
Entamoeba histolytica alcohol dehydrogenase, putative 0.0061 0.017 0.7376
Trichomonas vaginalis cyclin B, putative 0.0075 0.0231 0.0421
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0191 0.0217
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0038 0.007 0.007
Echinococcus multilocularis cyclins 0.0031 0.0041 0.0046
Onchocerca volvulus 0.0044 0.0096 0.0754
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0033 0.0048 0.0048
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0191 0.0191
Brugia malayi AKH receptor 0.0066 0.0191 0.0191
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.0271 0.5821
Toxoplasma gondii subtilisin SUB1 0.0114 0.0396 1
Echinococcus multilocularis nmda type glutamate receptor 0.0118 0.0414 0.047
Trypanosoma cruzi aldo/keto reductase, putative 0.0061 0.017 0.1536
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis transmembrane protease serine 3 0.0044 0.0096 0.011
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.0191 0.0217
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Schistosoma mansoni hypothetical protein 0.0044 0.0096 0.0096
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0191 0.0217
Toxoplasma gondii subtilisin SUB4 0.0114 0.0396 1
Echinococcus granulosus tissue type plasminogen activator 0.0089 0.0292 0.0292
Brugia malayi RE15519p 0.0066 0.0191 0.0191
Echinococcus granulosus tm gpcr rhodopsin 0.1066 0.4517 0.4517
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0066 0.0191 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0066 0.0191 0.1489
Onchocerca volvulus 0.0066 0.0191 0.1489
Schistosoma mansoni opsin-like receptor 0.0066 0.0191 0.0191
Plasmodium falciparum cysteine repeat modular protein 1 0.0089 0.0292 0.7357
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Loa Loa (eye worm) oxidoreductase 0.0061 0.017 0.017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Brugia malayi Subtilase family protein 0.0114 0.0396 0.0396
Echinococcus granulosus cyclin B 0.0075 0.0231 0.0231
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Schistosoma mansoni hypothetical protein 0.0082 0.0261 0.0261
Trichomonas vaginalis aldo/keto reductase, putative 0.0061 0.017 0.031
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0061 0.017 0.4297
Loa Loa (eye worm) SPRY domain-containing protein 0.004 0.0078 0.0078
Echinococcus multilocularis aldo keto reductase 0.0061 0.017 0.0194
Schistosoma mansoni neuropeptide receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis glutamate receptor 2 0.0116 0.0409 0.0465
Echinococcus multilocularis caspase 2 0.0062 0.0172 0.0195
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Echinococcus multilocularis cpg binding protein 0.0037 0.0064 0.0072
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0085 0.0271 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0229 0.0417
Brugia malayi Trypsin family protein 0.0044 0.0096 0.0096
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0094 0.0107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Echinococcus multilocularis serotonin receptor 0.0066 0.0191 0.0217
Loa Loa (eye worm) WD40 repeat protein 0.007 0.0209 0.0209
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.0191 0.0217
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Loa Loa (eye worm) hypothetical protein 0.0062 0.0172 0.0172
Echinococcus multilocularis cyclins 0.0031 0.0041 0.0046
Echinococcus multilocularis fmrfamide receptor 0.0066 0.0191 0.0217
Brugia malayi Glutamate receptor 2 precursor 0.0116 0.0409 0.0409
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0121 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0292 0.263
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0121 0.0138
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Brugia malayi G protein-coupled receptor 0.0066 0.0191 0.0191
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0066 0.0191 0.0191
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0569 0.2368 0.4312
Loa Loa (eye worm) SPRY domain-containing protein 0.0043 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0061 0.017 0.1331
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0096 0.011
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0135 0.049 0.049
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0066 0.0191 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0396 0.0722
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis Mastin 0.0044 0.0096 0.011
Trichomonas vaginalis cyclin B, putative 0.0075 0.0231 0.0421
Schistosoma mansoni biogenic amine receptor 0.0066 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0038 0.007 0.007
Schistosoma mansoni growth hormone secretagogue receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis aldo/keto reductase, putative 0.0061 0.017 0.031
Onchocerca volvulus 0.0066 0.0191 0.1489
Brugia malayi putative neuropeptide receptor NPR1 0.0066 0.0191 0.0191
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0135 0.049 0.0557
Brugia malayi neuroendocrine convertase 1 precursor 0.2074 0.8877 0.8877
Echinococcus multilocularis G protein coupled receptor 139 0.0066 0.0191 0.0217
Echinococcus granulosus dro:myosuppressin receptor 0.0066 0.0191 0.0191
Brugia malayi hypothetical protein 0.0062 0.0172 0.0172
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0094 0.0171
Schistosoma mansoni cpg binding protein 0.0037 0.0064 0.0064
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0044 0.0096 0.0096
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0031 0.0041 0.0041
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Plasmodium falciparum aldehyde reductase, putative 0.0061 0.017 0.4297
Echinococcus multilocularis set1:ash2 histone methyltransferase complex 0.0043 0.0093 0.0105
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis cyclins 0.0031 0.0041 0.0046
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0094 0.0107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Echinococcus granulosus neuroendocrine convertase 2 0.1725 0.7368 0.7368
Echinococcus granulosus neuropeptide s receptor 0.0066 0.0191 0.0191
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0114 0.0396 0.0396
Loa Loa (eye worm) oxidoreductase 0.0061 0.017 0.017
Echinococcus granulosus aldo keto reductase 0.0061 0.017 0.017
Onchocerca volvulus 0.0318 0.128 1
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0114 0.0396 0.3575
Loa Loa (eye worm) subtilase 0.0114 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Onchocerca volvulus Cell death protein 3 homolog 0.0062 0.0172 0.1344
Schistosoma mansoni neuropeptide f receptor 76f 0.0066 0.0191 0.0191
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Plasmodium falciparum protein kinase 5 0.0044 0.0094 0.2365
Echinococcus granulosus aldo keto reductase 0.0061 0.017 0.017
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0062 0.0172 0.1344
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0114 0.0396 1
Echinococcus multilocularis neuroendocrine convertase 2 0.1725 0.7368 0.8374
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0191 0.0217
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0048 0.0048
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0169 0.0635 0.1157
Onchocerca volvulus 0.0273 0.1088 0.8504
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0191 0.0217
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0135 0.049 0.049
Echinococcus multilocularis neuropeptide FF receptor 2 0.0764 0.3211 0.3649
Brugia malayi Latrophilin receptor protein 2 0.0038 0.007 0.007
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0569 0.2368 0.4312
Echinococcus multilocularis inhibitor of apoptosis protein 0.0135 0.049 0.0557
Schistosoma mansoni hypothetical protein 0.0038 0.007 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Onchocerca volvulus 0.0066 0.0191 0.1489
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0089 0.0292 0.7357
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0066 0.0191 0.0191
Schistosoma mansoni site-1 peptidase (S08 family) 0.0114 0.0396 0.0396
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0048 0.0048
Echinococcus granulosus protein will die slowly 0.007 0.0209 0.0209
Echinococcus granulosus somatostatin receptor 0.0066 0.0191 0.0191
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0096 0.0096
Mycobacterium leprae Possible secreted protease 0.0114 0.0396 1
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0135 0.049 0.049
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Trypanosoma brucei subtilisin peptidase 0.0114 0.0396 0.3575
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0093 0.0169
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0061 0.017 0.017
Echinococcus multilocularis glutamate receptor 2 0.01 0.0339 0.0386
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0114 0.0396 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0066 0.0191 0.0217
Echinococcus granulosus glutamate receptor 2 0.01 0.0339 0.0339
Echinococcus multilocularis cyclin B 0.0075 0.0231 0.0262
Onchocerca volvulus 0.0044 0.0096 0.0754
Brugia malayi Cyclin, N-terminal domain containing protein 0.0075 0.0231 0.0231
Onchocerca volvulus 0.0061 0.017 0.1331
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0396 0.0722
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0094 0.0094
Echinococcus multilocularis cyclins 0.0031 0.0041 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Loa Loa (eye worm) hypothetical protein 0.0044 0.0095 0.0095
Schistosoma mansoni cpg binding protein 0.0037 0.0064 0.0064
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Toxoplasma gondii subtilisin SUB11 0.0114 0.0396 1
Echinococcus granulosus GPCR family 2 0.0038 0.007 0.007
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0135 0.049 0.049
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0094 0.0846
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0116 0.0409 0.0465
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0191 0.0217
Schistosoma mansoni potassium channel beta 0.0061 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0044 0.0096 0.0096
Trichomonas vaginalis cyclin D, putative 0.0031 0.0041 0.0074
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0094 0.0107
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1291 0.5491 0.6241
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0191 0.0191
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0048 0.0048
Brugia malayi Cell death protein 3 precursor 0.0062 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0083 0.0266 0.0266
Onchocerca volvulus 0.0061 0.017 0.1331
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0061 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0191 0.0217
Trypanosoma cruzi Aph-1 protein, putative 0.0278 0.1109 1
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0094 0.0846
Echinococcus granulosus gamma secretase subunit aph 1 0.0714 0.2995 0.2995
Toxoplasma gondii aldo-keto reductase 0.0061 0.017 0.4297
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Onchocerca volvulus 0.0055 0.0144 0.1126
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0061 0.017 0.017
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0066 0.0191 0.0191
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0191 0.0191
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.007 0.007
Echinococcus granulosus glutamate NMDA receptor subunit 0.0033 0.0048 0.0048
Schistosoma mansoni ATP-binding cassette transporter 0.0033 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0514 0.2129 0.2129
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis orexin receptor type 2 0.0066 0.0191 0.0217
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0714 0.2995 0.2995
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0066 0.0191 0.0217
Brugia malayi Trypsin family protein 0.0044 0.0096 0.0096
Trypanosoma cruzi aldo/keto reductase, putative 0.0061 0.017 0.1536
Brugia malayi Melatonin receptor type 1A 0.0066 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0144 0.0262
Brugia malayi CXXC zinc finger family protein 0.0035 0.0055 0.0055
Brugia malayi Trypsin-like protease protein 5 0.0044 0.0096 0.0096
Schistosoma mansoni aldo-keto reductase 0.0061 0.017 0.017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Schistosoma mansoni retinoblastoma binding protein 0.0075 0.0229 0.0229
Entamoeba histolytica cyclin family protein 0.0031 0.0041 0.1771
Leishmania major hypothetical protein, conserved 0.0089 0.0292 0.7357
Echinococcus granulosus 7TM GPCR rhodopsin 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0083 0.0266 0.0266
Plasmodium vivax subtilisin-like protease 1 0.0114 0.0396 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0191 0.0191
Brugia malayi G protein-coupled receptor F59B2.13 0.0066 0.0191 0.0191
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0135 0.049 0.049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0094 0.0846
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.2333 1 1
Trichomonas vaginalis cyclins, putative 0.0075 0.0231 0.0421
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0191 0.0191
Echinococcus multilocularis dnaJ subfamily B 0.2055 0.8798 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0061 0.017 0.031
Plasmodium vivax protein kinase Crk2 0.0044 0.0094 0.2365
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0066 0.0191 0.0191
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0096 0.0096
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0683 0.2859 0.5207
Onchocerca volvulus 0.0066 0.0191 0.1489
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0094 0.0171
Schistosoma mansoni histamine h1 receptor 0.0066 0.0191 0.0191
Schistosoma mansoni aldo-keto reductase 0.0061 0.017 0.017
Onchocerca volvulus 0.0035 0.0055 0.0431
Brugia malayi G-protein coupled receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Trichomonas vaginalis hypothetical protein 0.0514 0.2129 0.3877
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0066 0.0191 0.1489
Echinococcus granulosus neuropeptide receptor A26 0.0066 0.0191 0.0191
Echinococcus granulosus nmda type glutamate receptor 0.0118 0.0414 0.0414
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0404 0.1653 0.1653
Schistosoma mansoni opsin-like receptor 0.0066 0.0191 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0191 0.0191
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0094 0.0193
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Toxoplasma gondii subtilisin SUB6 0.0114 0.0396 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0764 0.3211 0.3211
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Echinococcus multilocularis epidermal growth factor receptor 0.0289 0.1157 0.1315
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0114 0.0396 0.0396
Echinococcus granulosus neuropeptide FF receptor 2 0.0764 0.3211 0.3211
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.0191 0.0191
Loa Loa (eye worm) melatonin receptor type 1A 0.0066 0.0191 0.0191
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.0191 0.0191
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0061 0.017 0.017
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0061 0.017 0.4297
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0048 0.0048
Echinococcus granulosus aldo keto reductase 0.0061 0.017 0.017
Brugia malayi Serotonin receptor 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Plasmodium falciparum SPRY domain, putative 0.0043 0.0093 0.2336
Loa Loa (eye worm) hypothetical protein 0.0062 0.0172 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0093 0.0169
Onchocerca volvulus 0.0061 0.017 0.1331
Trypanosoma brucei prostaglandin f synthase 0.0061 0.017 0.1536
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Loa Loa (eye worm) oxidoreductase 0.0061 0.017 0.017
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0061 0.017 0.017
Chlamydia trachomatis glutamine binding protein 0.0085 0.0271 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0061 0.017 0.017
Brugia malayi NADH-dependent xylose reductase 0.0061 0.017 0.017
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0061 0.017 0.017
Trichomonas vaginalis cyclins, putative 0.0075 0.0231 0.0421
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0191 0.0217
Schistosoma mansoni neuropeptide receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0033 0.0048 0.0048
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0191 0.0217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0191 0.0217
Echinococcus multilocularis G-protein coupled receptor, putative 0.0066 0.0191 0.0217
Echinococcus multilocularis neuropeptide receptor 0.0066 0.0191 0.0217
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.0094 0.2365
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0041 0.0074
Onchocerca volvulus Deterin homolog 0.0135 0.049 0.3827
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0133 0.0482 0.0548
Leishmania major subtilisin-like serine peptidase 0.0114 0.0396 1
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0114 0.0396 1
Echinococcus granulosus hypothetical protein 0.0061 0.017 0.017
Leishmania major cyclin 0.0075 0.0231 0.5825
Echinococcus granulosus g protein coupled receptor 0.0066 0.0191 0.0191
Echinococcus granulosus tachykinin peptides receptor 99D 0.0066 0.0191 0.0191
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0683 0.2859 0.2859
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Giardia lamblia Furin precursor putative serine protease 0.0569 0.2368 0.8508
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0061 0.017 0.017
Schistosoma mansoni amine GPCR 0.0066 0.0191 0.0191
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0094 0.0193
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis aldo-keto reductase, putative 0.0061 0.017 0.031
Echinococcus multilocularis cyclins 0.0031 0.0041 0.0046
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Echinococcus multilocularis cyclins 0.0031 0.0041 0.0046
Echinococcus multilocularis apoptotic protease activating factor 1 0.0062 0.0172 0.0195
Brugia malayi Trypsin family protein 0.0318 0.128 0.128
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis protein will die slowly 0.007 0.0209 0.0238
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0066 0.0191 0.0191
Trypanosoma brucei Aph-1 protein, putative 0.0278 0.1109 1
Echinococcus multilocularis aldo keto reductase 0.0061 0.017 0.0194
Onchocerca volvulus 0.0066 0.0191 0.1489
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0066 0.0191 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Onchocerca volvulus 0.0044 0.0096 0.0754
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0191 0.0191
Echinococcus granulosus furin 0.2333 1 1
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0048 0.0048
Brugia malayi follicle stimulating hormone receptor 0.0066 0.0191 0.0191
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Echinococcus multilocularis aldo keto reductase 0.0061 0.017 0.0194
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0096 0.0096
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0066 0.0191 0.0217
Toxoplasma gondii subtilisin SUB8 0.0114 0.0396 1
Giardia lamblia G2/mitotic-specific cyclin B 0.0075 0.0231 0.0695
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1291 0.5491 1
Brugia malayi Hypothetical WD-repeat protein F21H12.1 in chromosome II 0.0075 0.0229 0.0229
Schistosoma mansoni cyclins 0.0031 0.0041 0.0041
Loa Loa (eye worm) glutamate receptor 1 0.0116 0.0409 0.0409
Schistosoma mansoni furin-1 (S08 family) 0.1156 0.4906 0.4906
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.0191 0.0191
Echinococcus granulosus apoptotic protease activating factor 1 0.0062 0.0172 0.0172
Brugia malayi Dopamine receptor protein 2 0.0066 0.0191 0.0191
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1291 0.5491 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.007 0.007
Brugia malayi Trypsin family protein 0.0044 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.007 0.0209 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Plasmodium vivax subtilisin-like serine protease, putative 0.0114 0.0396 1
Leishmania major aldo-keto reductase-like protein 0.0061 0.017 0.4297
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0117 0.0413 0.3726
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Entamoeba histolytica aldose reductase, putative 0.0061 0.017 0.7376
Loa Loa (eye worm) hypothetical protein 0.0044 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Schistosoma mansoni myosin xvIII 0.0066 0.0191 0.0191
Onchocerca volvulus 0.0066 0.0191 0.1489
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0191 0.0217
Plasmodium falciparum subtilisin-like protease 3 0.0114 0.0396 1
Schistosoma mansoni cyclin B 0.0075 0.0231 0.0231
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0114 0.0396 1
Mycobacterium ulcerans oxidoreductase 0.0061 0.017 0.2463
Toxoplasma gondii subtilisin SUB7 0.0114 0.0396 1
Echinococcus granulosus cyclin b3 0.0031 0.0041 0.0041
Trypanosoma cruzi Aph-1 protein, putative 0.0278 0.1109 1
Giardia lamblia High cysteine membrane protein Group 2 0.0663 0.2776 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0318 0.128 0.128
Loa Loa (eye worm) glutamate receptor 2 0.0033 0.0048 0.0048
Trichomonas vaginalis cyclin B, putative 0.0031 0.0041 0.0074
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0223 0.0223
Echinococcus granulosus glutamate receptor 1 0.0083 0.0266 0.0266
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.0191 0.0217
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0114 0.0396 1
Echinococcus granulosus glutamate receptor 2 0.0133 0.0482 0.0482
Echinococcus multilocularis enteropeptidase 0.0044 0.0096 0.011
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1291 0.5491 0.5491
Echinococcus multilocularis 0.1819 0.7776 0.8838
Schistosoma mansoni hypothetical protein 0.0135 0.049 0.049
Brugia malayi hypothetical protein 0.0066 0.0191 0.0191
Toxoplasma gondii subtilisin SUB12 0.0114 0.0396 1
Echinococcus granulosus inhibitor of apoptosis protein 0.0135 0.049 0.049
Trichomonas vaginalis aldo/keto reductase, putative 0.0061 0.017 0.031
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0683 0.2859 0.5207
Trichomonas vaginalis cyclins, putative 0.0075 0.0231 0.0421
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0261 0.0261
Trypanosoma brucei RNA helicase, putative 0.01 0.0339 0.3056
Echinococcus multilocularis allatostatin A receptor 0.0066 0.0191 0.0217
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0066 0.0191 0.0191
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0031 0.0041 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Echinococcus multilocularis aldo keto reductase 0.0061 0.017 0.0194
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Brugia malayi Glutamate receptor 1 precursor 0.0116 0.0409 0.0409
Echinococcus multilocularis Furin 1 0.0683 0.2859 0.3249
Schistosoma mansoni site-1 peptidase (S08 family) 0.0114 0.0396 0.0396
Schistosoma mansoni biogenic amine receptor 0.0066 0.0191 0.0191
Trichomonas vaginalis cyclins, putative 0.0031 0.0041 0.0074
Echinococcus granulosus fmrfamide receptor 0.0066 0.0191 0.0191
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0169 0.0635 0.0635
Schistosoma mansoni hypothetical protein 0.01 0.0339 0.0339
Brugia malayi neuropeptide F receptor 0.0066 0.0191 0.0191
Brugia malayi Protein kinase domain containing protein 0.0044 0.0094 0.0094
Echinococcus multilocularis GPCR, family 2 0.0038 0.007 0.0079
Schistosoma mansoni biogenic amine receptor 0.0066 0.0191 0.0191
Leishmania major prostaglandin f synthase, putative 0.0061 0.017 0.4297
Loa Loa (eye worm) endoprotease bli-4 0.2333 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0061 0.017 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0514 0.2129 0.3877
Onchocerca volvulus 0.0066 0.0191 0.1489
Onchocerca volvulus 0.0061 0.017 0.1331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.0191 0.0217
Loa Loa (eye worm) hypothetical protein 0.0764 0.3211 0.3211
Plasmodium vivax subtilisin-like protease 2, putative 0.0114 0.0396 1
Echinococcus granulosus cyclins 0.0031 0.0041 0.0041
Echinococcus granulosus g protein coupled receptor 0.0066 0.0191 0.0191
Brugia malayi Will die slowly protein 0.007 0.0209 0.0209
Trichomonas vaginalis cyclin B3, putative 0.0031 0.0041 0.0074
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.0191 0.0191
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0114 0.0396 0.0722
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.0191 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0093 0.2336
Echinococcus multilocularis wd40 repeat 0.0075 0.0229 0.026
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0061 0.017 0.017
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0075 0.0231 0.5825
Brugia malayi GnHR receptor homolog 0.0066 0.0191 0.0191
Schistosoma mansoni cercarial elastase (S01 family) 0.0044 0.0096 0.0096
Trypanosoma cruzi subtilisin peptidase 0.0114 0.0396 0.3575
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.0191 0.0217
Loa Loa (eye worm) TK/ROR protein kinase 0.0089 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0191
Schistosoma mansoni trithorax protein ash2 0.0043 0.0093 0.0093
Onchocerca volvulus 0.0075 0.0231 0.1805
Echinococcus multilocularis g protein coupled receptor 0.0066 0.0191 0.0217
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0061 0.017 0.017
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.0094 0.2365
Schistosoma mansoni hypothetical protein 0.2055 0.8798 0.8798
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0041 0.0041
Trichomonas vaginalis cyclin B, putative 0.0075 0.0231 0.0421
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0033 0.0048 0.0054
Schistosoma mansoni amine GPCR 0.0066 0.0191 0.0191
Schistosoma mansoni gamma-secretase subunit aph-1 0.0714 0.2995 0.2995
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0048 0.0113 0.0113
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0121 0.0121
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0066 0.0191 0.0191
Echinococcus granulosus cyclins 0.0031 0.0041 0.0041

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 75.193 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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