Detailed information for compound 1444293

Basic information

Technical information
  • TDR Targets ID: 1444293
  • Name: N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)- 2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]deca n-3-yl)acetamide
  • MW: 494.561 | Formula: C22H30N4O7S
  • H donors: 2 H acceptors: 5 LogP: 0.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)CN1C(=O)NC2(C1=O)CCCCC2C)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C22H30N4O7S/c1-15-5-3-4-8-22(15)20(28)26(21(29)24-22)14-19(27)23-17-13-16(6-7-18(17)32-2)34(30,31)25-9-11-33-12-10-25/h6-7,13,15H,3-5,8-12,14H2,1-2H3,(H,23,27)(H,24,29)
  • InChiKey: NGGGRCIZLYDFTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methoxy-5-morpholinosulfonyl-phenyl)-2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide
  • N-(2-methoxy-5-morpholinosulfonylphenyl)-2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide
  • 2-(2,4-diketo-6-methyl-1,3-diazaspiro[4.5]decan-3-yl)-N-(2-methoxy-5-morpholinosulfonyl-phenyl)acetamide
  • N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-2-(6-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)ethanamide
  • T0519-3017

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis protein disulfide isomerase, putative 0.0016 0.0143 0.0536
Loa Loa (eye worm) hypothetical protein 0.0072 0.1309 0.1311
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0334 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.2673 1
Leishmania major hypothetical protein, conserved 0.0016 0.0143 0.0044
Loa Loa (eye worm) phosphofructokinase 0.0122 0.2343 0.2368
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0667 0.463
Brugia malayi protein disulphide isomerase 0.0016 0.0144 0.0119
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0503 0.2091
Echinococcus granulosus protein disulfide isomerase 0.0016 0.0144 0.0154
Loa Loa (eye worm) hypothetical protein 0.0136 0.2633 0.2665
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1415 0.5293
Echinococcus granulosus dna polymerase eta 0.0049 0.0827 0.0888
Schistosoma mansoni regulator of G protein signaling 0.001 0.0028 0.0028
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.012 0.2299 0.2324
Trichomonas vaginalis protein disulfide isomerase, putative 0.0016 0.0144 0.0538
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0503 0.2091
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0046 0.0046
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1415 0.1419
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.2343 0.239
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0046 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0046 0.0019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0049 0.0827 0.0843
Loa Loa (eye worm) RNA binding protein 0.0068 0.1228 0.1228
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.012 0.2299 0.9802
Echinococcus multilocularis geminin 0.0354 0.7148 0.7679
Brugia malayi CXXC zinc finger family protein 0.0032 0.0488 0.0471
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0122 0.2343 0.2343
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0151 0.2956 0.3176
Echinococcus granulosus geminin 0.0354 0.7148 0.7679
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0046 0.005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0046 0.005
Echinococcus multilocularis protein disulfide isomerase A3 0.0016 0.0144 0.0154
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0049 0.0827 0.0888
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.2343 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1415 0.1415
Echinococcus multilocularis amyloid beta A4 protein 0.0077 0.1415 0.152
Echinococcus multilocularis ETS transcription factor Elf 1 0.0023 0.0299 0.0321
Loa Loa (eye worm) X11 protein 0.0077 0.1415 0.1419
Echinococcus multilocularis segment polarity protein dishevelled 0.0013 0.009 0.0097
Loa Loa (eye worm) DIX domain-containing protein 0.0013 0.009 0.0064
Echinococcus multilocularis cpg binding protein 0.0036 0.0566 0.0608
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0028 0.003
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1228 0.1253
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.2051 0.2203
Schistosoma mansoni gabp alpha 0.0159 0.3109 0.3172
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1415 0.152
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0046 0.0019
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0071 0.1285 0.1285
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0827 0.0827
Brugia malayi nuclear hormone receptor 0.0011 0.0046 0.0019
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0108 0.2051 0.2203
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0334 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0046 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1235 0.1259
Mycobacterium tuberculosis Conserved protein 0.0077 0.1415 0.1415
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0046 0.0019
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.012 0.2299 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1352 0.1355
Brugia malayi Ets-domain containing protein 0.0023 0.0299 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0046 0.0019
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0503 0.1705
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0195 0.0199
Schistosoma mansoni 6-phosphofructokinase 0.0122 0.2343 0.239
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0028 0.0028
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0069 0.1247 0.1247
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.2673 1
Brugia malayi beta-lactamase 0.0077 0.1415 0.1419
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0503 0.2091
Loa Loa (eye worm) hypothetical protein 0.0013 0.009 0.0064
Toxoplasma gondii transporter, cation channel family protein 0.0023 0.0288 0.1147
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0108 0.2051 0.2092
Trichomonas vaginalis DNA polymerase eta, putative 0.0138 0.2673 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0046 0.0019
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0667 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1415 0.1415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0046 0.0019
Echinococcus multilocularis protein disulfide isomerase 0.0016 0.0144 0.0154
Schistosoma mansoni voltage-gated cation channel 0.0108 0.2051 0.2092
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.012 0.2299 0.247
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0046 0.0047
Schistosoma mansoni terminal deoxycytidyl transferase 0.0049 0.0827 0.0843
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0503 0.1881
Trypanosoma brucei unspecified product 0.0033 0.0515 0.1501
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.012 0.2299 0.2324
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0108 0.2051 0.2092
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0503 0.5
Echinococcus granulosus segment polarity protein dishevelled 0.0013 0.009 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.2673 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0122 0.2343 0.8765
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0046 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0046 0.0019
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0667 0.2494
Echinococcus multilocularis dnaJ subfamily B 0.0458 0.9308 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0667 0.0716
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0065 0.0038
Trypanosoma brucei unspecified product 0.0116 0.2215 0.8196
Echinococcus multilocularis ets variant gene 4 0.0023 0.0299 0.0321
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0015 0.0134 0.0466
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.018 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0046 0.0019
Echinococcus granulosus amyloid beta A4 protein 0.0077 0.1415 0.152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0138 0.2673 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0019
Brugia malayi DNA-binding protein D-ETS-3 0.0023 0.0299 0.0277
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0028 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0195 0.0199
Brugia malayi 6-phosphofructokinase 0.0122 0.2343 0.2368
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0046 0.0047
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0503 0.2146
Echinococcus granulosus dna polymerase kappa 0.0138 0.2673 0.2871
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1415 0.1443
Mycobacterium ulcerans DNA polymerase IV 0.0138 0.2673 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0667 0.2377
Brugia malayi polk-prov protein 0.0104 0.198 0.1997
Brugia malayi Bromodomain containing protein 0.0039 0.0627 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0046 0.0019
Loa Loa (eye worm) protein disulfide isomerase 0.0016 0.0144 0.0119
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.012 0.2299 0.8529
Loa Loa (eye worm) hypothetical protein 0.0023 0.0299 0.0277
Plasmodium vivax protein disulfide isomerase, putative 0.0016 0.0144 0.0047
Schistosoma mansoni amyloid beta A4 protein related 0.0077 0.1415 0.1443
Loa Loa (eye worm) voltage-dependent calcium channel 0.0023 0.0288 0.0267
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0488 0.0471
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.2343 0.87
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.012 0.2299 0.9803
Trypanosoma brucei ubiquitin-protein ligase, putative 0.012 0.2299 0.8529
Toxoplasma gondii protein disulfide isomerase 0.0016 0.0144 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.2673 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0023 0.0299 0.0277
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1415 0.1415
Mycobacterium ulcerans lipase LipD 0.0077 0.1415 0.5293
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0065 0.1178 0.4111
Echinococcus granulosus ETS transcription factor Elf 5 0.0023 0.0299 0.0321
Brugia malayi hypothetical protein 0.0074 0.1352 0.1355
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1228 0.1253
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0046 0.005
Brugia malayi TAR-binding protein 0.0068 0.1228 0.1228
Schistosoma mansoni dep domain containing protein 0.001 0.0028 0.0028
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0046 0.0046
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0046 0.005
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0108 0.2051 0.2069
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.2343 0.8765
Loa Loa (eye worm) TAR-binding protein 0.0068 0.1228 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.1285 0.4533
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0013 0.009 0.0064
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.018 0.0184
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1415 0.5046
Loa Loa (eye worm) fli-1 protein 0.0482 0.9803 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.1228 0.1228
Loa Loa (eye worm) hypothetical protein 0.0077 0.1415 0.1419
Schistosoma mansoni ap endonuclease 0.0041 0.0667 0.068
Brugia malayi hypothetical protein 0.0146 0.2844 0.2881
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0046 0.0019
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1415 0.5293
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.012 0.2299 0.2345
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0973 0.3305
Trypanosoma brucei DNA polymerase IV, putative 0.0138 0.2673 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0202 0.4009 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0046 0.005
Echinococcus multilocularis GA binding protein alpha chain 0.0159 0.3109 0.334
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0256 0.0233
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0065 0.1178 0.4111
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0046 0.0019
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.028 0.028
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.012 0.2299 0.8602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0667 0.2099
Schistosoma mansoni hypothetical protein 0.0458 0.9308 0.9495
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0973 0.3305
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1415 0.5046
Echinococcus multilocularis 6 phosphofructokinase 0.0122 0.2343 0.2517
Loa Loa (eye worm) hypothetical protein 0.0049 0.0827 0.0817
Loa Loa (eye worm) hypothetical protein 0.0108 0.2051 0.2069
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0108 0.2051 0.2203
Loa Loa (eye worm) hypothetical protein 0.0077 0.1415 0.1419
Loa Loa (eye worm) hypothetical protein 0.0018 0.0195 0.0171
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0046 0.0047
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0028 0.003
Brugia malayi transcription factor E74 isoform 0.0023 0.0299 0.0277
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0046 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0046 0.005
Mycobacterium tuberculosis Conserved protein 0.0077 0.1415 0.1415
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1415 0.5293
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0503 0.1705
Mycobacterium ulcerans beta-lactamase 0.0077 0.1415 0.5293
Loa Loa (eye worm) hypothetical protein 0.0104 0.198 0.1997
Onchocerca volvulus 0.0077 0.1415 0.3484
Echinococcus multilocularis dna polymerase kappa 0.0138 0.2673 0.2871
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0046 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0046 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0046 0.0019
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0046 0.0047
Schistosoma mansoni ets 0.0023 0.0299 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0973 0.3305
Echinococcus granulosus nuclear factor of activated T cells 5 0.0151 0.2956 0.3176
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0037 0.0592 0.2482
Loa Loa (eye worm) hypothetical protein 0.0045 0.0757 0.0745
Echinococcus multilocularis protein C ets 2 0.0023 0.0299 0.0321
Echinococcus granulosus protein disulfide isomerase A3 0.0016 0.0144 0.0154
Schistosoma mansoni zinc finger protein 0.0022 0.0271 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.198 0.7271
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.1228 0.1228
Leishmania major hypothetical protein, conserved 0.0077 0.1415 0.58
Echinococcus multilocularis ETS transcription factor Elf 2 0.0023 0.0299 0.0321
Loa Loa (eye worm) histone methyltransferase 0.001 0.0028 0.00000090482
Brugia malayi beta-lactamase family protein 0.0077 0.1415 0.1419
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0023 0.0299 0.0305
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0028 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0503 0.1881
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.018 0.0194
Echinococcus granulosus cpg binding protein 0.0036 0.0566 0.0608
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0503 0.1881
Schistosoma mansoni ets-related 0.0482 0.9803 1
Toxoplasma gondii ABC1 family protein 0.0077 0.1415 0.6106
Schistosoma mansoni DNA polymerase eta 0.0049 0.0827 0.0843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0046 0.0019
Schistosoma mansoni dishevelled 0.0013 0.009 0.0092
Brugia malayi Ets-domain containing protein 0.0159 0.3109 0.3152
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0195 0.0209
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0577 0.062
Echinococcus granulosus zinc finger protein 0.0022 0.0271 0.0292
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0667 0.2461
Trypanosoma brucei unspecified product 0.0033 0.0515 0.1501
Brugia malayi RasGEF domain containing protein 0.001 0.0031 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1228 0.1253
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0503 0.1881
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1228 0.1253
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0046 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0138 0.2673 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1415 0.5293
Mycobacterium ulcerans DNA polymerase IV 0.0138 0.2673 1
Echinococcus granulosus tar DNA binding protein 0.0068 0.1228 0.132
Brugia malayi Bromodomain containing protein 0.0078 0.1437 0.1441
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0046 0.0019
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0503 0.1881
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0046 0.005
Schistosoma mansoni coup transcription factor 0.0011 0.0046 0.0047
Giardia lamblia DINP protein human, muc B family 0.0071 0.1285 1
Schistosoma mansoni elf1 0.0023 0.0299 0.0305
Mycobacterium tuberculosis Conserved protein 0.0077 0.1415 0.1415
Echinococcus granulosus ETS transcription factor Elf 1 0.0023 0.0299 0.0321
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.2343 0.8765
Schistosoma mansoni dishevelled 0.0013 0.009 0.0092
Brugia malayi steroid hormone receptor 0.0011 0.0046 0.0019
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.012 0.2299 1
Trichomonas vaginalis protein disulfide isomerase, putative 0.0016 0.0144 0.0538
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0046 0.0019
Trypanosoma brucei protein disulfide isomerase 0.0016 0.0144 0.004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0667 0.2461
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0046 0.0019
Loa Loa (eye worm) hypothetical protein 0.0146 0.2844 0.2881
Brugia malayi PHD-finger family protein 0.0027 0.0384 0.0364
Mycobacterium leprae Probable lipase LipE 0.0077 0.1415 0.6039
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0503 0.1705
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0019
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0667 0.0667
Loa Loa (eye worm) transglutaminase 0.0016 0.0144 0.0119
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0046 0.0046
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0046 0.0767 0.0824
Schistosoma mansoni ets-related 0.0023 0.0299 0.0305
Onchocerca volvulus 0.0146 0.2844 0.7075
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0028 0.003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1415 0.1443
Echinococcus granulosus ETS transcription factor Elf 2 0.0023 0.0299 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0104 0.198 0.7271
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0049 0.0827 0.0817
Brugia malayi N-terminal motif family protein 0.0202 0.4009 0.4072
Onchocerca volvulus 0.0077 0.1415 0.3484
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0046 0.005
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0028 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0138 0.2673 1
Leishmania major ATP-dependent phosphofructokinase 0.0122 0.2343 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0193 0.0169
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0046 0.0047
Echinococcus granulosus protein C ets 2 0.0023 0.0299 0.0321
Echinococcus granulosus voltage dependent calcium channel 0.0023 0.0288 0.031
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0013 0.009 0.0157
Loa Loa (eye worm) RasGEF domain-containing protein 0.001 0.0031 0.0003
Onchocerca volvulus 0.0011 0.0046 0.0046
Brugia malayi DIX domain containing protein 0.0013 0.009 0.0064
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0046 0.0047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0046 0.005
Brugia malayi Fli-1 protein 0.0482 0.9803 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0667 0.2845
Brugia malayi phosphofructokinase 0.0122 0.2343 0.2368
Leishmania major DNA polymerase eta, putative 0.0049 0.0827 0.3137
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0108 0.2051 0.2203
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.2343 0.2368
Brugia malayi ecdysteroid receptor 0.0011 0.0046 0.0019
Echinococcus granulosus segment polarity protein dishevelled 0.0013 0.009 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.2343 0.8765
Schistosoma mansoni bromodomain containing protein 0.0066 0.119 0.1214
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1415 0.1415
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0049 0.0827 0.0888
Loa Loa (eye worm) hypothetical protein 0.0039 0.0629 0.0615
Echinococcus multilocularis segment polarity protein dishevelled 0.0013 0.009 0.0097
Brugia malayi Ets-domain containing protein 0.0159 0.3109 0.3152
Echinococcus multilocularis ewsr:fli fusion protein type 0.0023 0.0299 0.0321
Trypanosoma brucei ISWI complex protein 0.0016 0.0143 0.0039
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.012 0.2299 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1415 0.1419
Echinococcus multilocularis sodium channel protein 0.0046 0.0767 0.0824
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0046 0.005
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.2051 0.2203
Onchocerca volvulus 0.0077 0.1415 0.3484
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0195 0.0209
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0667 0.0653
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.2051 0.2203
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1415 0.5293
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0503 0.3207
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0046 0.0047
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0046 0.005
Loa Loa (eye worm) D-ets-2 protein 0.0023 0.0299 0.0277
Brugia malayi ubiquitin conjugating enzyme protein 13 0.012 0.2299 0.2324
Schistosoma mansoni Probable protein disulfide-isomerase ER-60 precursor (ERP60) 0.0016 0.0144 0.0147
Loa Loa (eye worm) hypothetical protein 0.0077 0.1415 0.1419
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0046 0.005
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.012 0.2299 0.247
Loa Loa (eye worm) ets-domain-containing protein 0.0023 0.0299 0.0277
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0019
Echinococcus granulosus 6 phosphofructokinase 0.0122 0.2343 0.2517
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.2343 1
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0046 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1228 0.1253
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.2051 0.2203
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.012 0.2299 0.2324
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0667 0.2412
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.2673 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0122 0.2343 0.87
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0015 0.0134 0.0466
Loa Loa (eye worm) hypothetical protein 0.0014 0.0106 0.008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0577 0.062
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0667 0.0653
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0019
Brugia malayi nuclear receptor NHR-88 0.0011 0.0046 0.0019
Schistosoma mansoni cpg binding protein 0.0032 0.0488 0.0498
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0334 0.034
Schistosoma mansoni hypothetical protein 0.0354 0.7148 0.7291
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.2673 1
Loa Loa (eye worm) calcium channel 0.0108 0.2051 0.2069
Schistosoma mansoni hypothetical protein 0.0354 0.7148 0.7291
Schistosoma mansoni hypothetical protein 0.0016 0.0143 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1415 0.5293
Mycobacterium leprae conserved hypothetical protein 0.0077 0.1415 0.6039
Loa Loa (eye worm) Pdia4 protein 0.0016 0.0144 0.0119
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0827 0.2729
Schistosoma mansoni hypothetical protein 0.0021 0.0256 0.0261
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0028 0.003
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0023 0.0299 0.0321
Echinococcus multilocularis tar DNA binding protein 0.0068 0.1228 0.132
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0046 0.0047
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0046 0.0047
Echinococcus granulosus ETS domain containing protein Elk 1 0.0023 0.0299 0.0321
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1415 0.1415
Echinococcus multilocularis ETS transcription factor Elf 5 0.0023 0.0299 0.0321
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1133 0.4868
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0159 0.3109 0.3152
Echinococcus granulosus dnaJ subfamily B 0.0458 0.9308 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1415 0.1415
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0138 0.2673 1
Loa Loa (eye worm) hypothetical protein 0.0202 0.4009 0.4072
Echinococcus multilocularis dna polymerase eta 0.0049 0.0827 0.0888
Entamoeba histolytica deoxycytidyl transferase, putative 0.0049 0.0827 0.3105
Schistosoma mansoni hypothetical protein 0.0023 0.0299 0.0305
Trichomonas vaginalis protein disulfide isomerase, putative 0.0016 0.0144 0.0538
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0046 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0678 0.0666
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0122 0.2343 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0503 0.1633
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0019
Mycobacterium ulcerans hypothetical protein 0.0077 0.1415 0.5293
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1415 0.5046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.2673 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0288 0.0267
Echinococcus granulosus GA binding protein alpha chain 0.0159 0.3109 0.334
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0071 0.1285 0.521
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0023 0.0299 0.0277
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.2051 0.2203
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0046 0.0047
Mycobacterium ulcerans hypothetical protein 0.0015 0.0134 0.05
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0122 0.2343 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.1415 0.1419
Schistosoma mansoni cpg binding protein 0.0036 0.0566 0.0577
Echinococcus granulosus ETS transcription factor Elf 2 0.0023 0.0299 0.0321
Loa Loa (eye worm) 6-phosphofructokinase 0.0122 0.2343 0.2368
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0827 0.2729
Trypanosoma cruzi DNA polymerase kappa, putative 0.0138 0.2673 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0019
Schistosoma mansoni ap endonuclease 0.0041 0.0667 0.068
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.2051 0.2203
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.018 0.0184
Trypanosoma cruzi bloodstream- specific protein 2 precursor 0.0016 0.0144 0.004
Schistosoma mansoni protein disulfide-isomerase er-60 precursor (erp60) 0.0016 0.0144 0.0147
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1415 0.1415
Echinococcus multilocularis ETS transcription factor Elf 2 0.0023 0.0299 0.0321
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0503 0.1881
Trypanosoma cruzi ISWI complex protein 0.0016 0.0143 0.0039
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0046 0.0019
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.012 0.2299 0.8529
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0667 0.2494
Entamoeba histolytica phosphofructokinase, putative 0.0122 0.2343 1
Giardia lamblia Protein disulfide isomerase PDI2 0.0016 0.0144 0.0088
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0503 0.1881
Leishmania major DNA polymerase kappa, putative 0.0071 0.1285 0.521
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0028 0.0028
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0503 0.5
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0503 0.1705
Trypanosoma cruzi ISWI complex protein 0.0016 0.0143 0.0039
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.1115 0.1198
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.1115 0.1198
Trypanosoma cruzi DNA polymerase kappa, putative 0.0138 0.2673 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0667 0.2099
Loa Loa (eye worm) hypothetical protein 0.002 0.0232 0.0209
Brugia malayi beta-lactamase family protein 0.0077 0.1415 0.1419
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.2673 1
Brugia malayi RNA binding protein 0.0068 0.1228 0.1228
Loa Loa (eye worm) hypothetical protein 0.002 0.0232 0.0209
Onchocerca volvulus 0.0032 0.0488 0.1156
Brugia malayi 6-phosphofructokinase 0.0122 0.2343 0.2368
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0667 0.2494
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1415 0.5916
Plasmodium falciparum protein disulfide isomerase 0.0016 0.0144 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0046 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0046 0.005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1415 0.5293
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1415 0.152
Schistosoma mansoni hypothetical protein 0.0023 0.0299 0.0305
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0667 0.0716
Schistosoma mansoni DNA polymerase IV / kappa 0.0015 0.0134 0.0136
Brugia malayi probable protein disulfide-isomerase 0.0016 0.0144 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.2673 1
Schistosoma mansoni protein disulfide-isomerase 0.0016 0.0144 0.0147
Echinococcus multilocularis zinc finger protein 0.0022 0.0271 0.0292
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.012 0.2299 0.8602
Trypanosoma brucei DNA polymerase IV, putative 0.0116 0.2215 0.8196
Echinococcus granulosus voltage dependent calcium channel 0.0108 0.2051 0.2203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0667 0.2099
Loa Loa (eye worm) hypothetical protein 0.0023 0.0299 0.0277
Echinococcus granulosus ewsr:fli fusion protein type 0.0023 0.0299 0.0321
Brugia malayi transglutaminase 0.0016 0.0144 0.0119
Leishmania major protein disulfide isomerase 0.0016 0.0144 0.0046
Toxoplasma gondii hypothetical protein 0.002 0.0232 0.09
Schistosoma mansoni zinc finger protein 0.0016 0.0143 0.0146
Toxoplasma gondii exonuclease III APE 0.0041 0.0667 0.2812
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0046 0.0019
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0827 0.0817
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1415 0.1419
Trichomonas vaginalis esterase, putative 0.0077 0.1415 0.5293
Loa Loa (eye worm) beta-lactamase 0.0077 0.1415 0.1419
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0077 0.1415 0.1419
Schistosoma mansoni cpg binding protein 0.0036 0.0566 0.0577
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0046 0.005
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0028 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0827 0.0817
Trichomonas vaginalis phosphofructokinase, putative 0.0122 0.2343 0.8765

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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