Detailed information for compound 144449

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 143.184 | Formula: C7H13NO2
  • H donors: 2 H acceptors: 2 LogP: -2.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/C(CC(=O)O)CN
  • InChi: 1S/C7H13NO2/c1-2-3-6(5-8)4-7(9)10/h2-3,6H,4-5,8H2,1H3,(H,9,10)/b3-2+
  • InChiKey: KNJPFVDARFWNET-NSCUHMNNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0771 0.0574
Echinococcus granulosus fmrfamide receptor 0.0125 0.398 0.6057
Trypanosoma brucei RNA helicase, putative 0.0273 1 1
Onchocerca volvulus 0.0125 0.398 0.7006
Brugia malayi Serotonin receptor 0.0125 0.398 0.4406
Schistosoma mansoni hypothetical protein 0.0125 0.398 0.3851
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.398 0.6057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0771 0.088
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.398 0.6057
Brugia malayi G-protein coupled receptor 0.0125 0.398 0.4406
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.2096 0.0309
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0125 0.398 0.3851
Onchocerca volvulus 0.0125 0.398 0.7006
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0073 0.1844 0.5
Echinococcus granulosus thymidylate synthase 0.0093 0.268 0.4078
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni hypothetical protein 0.0034 0.0246 0.0038
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0093 0.268 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0125 0.398 0.3851
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.398 0.6057
Trypanosoma brucei ingi protein (ORF1) 0.0079 0.2096 0.0309
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Onchocerca volvulus 0.0125 0.398 0.7006
Onchocerca volvulus 0.0125 0.398 0.7006
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Loa Loa (eye worm) TYRA-2 protein 0.0125 0.398 0.454
Echinococcus granulosus neuropeptide receptor A26 0.0125 0.398 0.6057
Trypanosoma brucei ingi protein (ORF1) 0.0079 0.2096 0.0309
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0125 0.398 0.454
Brugia malayi RNase H family protein 0.0073 0.1844 0.191
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Onchocerca volvulus 0.0125 0.398 0.7006
Brugia malayi G protein-coupled receptor F59B2.13 0.0125 0.398 0.4406
Brugia malayi larval opioid receptor 0.0125 0.398 0.4406
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Onchocerca volvulus 0.0125 0.398 0.7006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.398 0.3851
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.398 0.3851
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.398 0.3851
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Trypanosoma cruzi ribonuclease H1, putative 0.0073 0.1844 0.5806
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.398 0.6057
Brugia malayi Dopamine receptor protein 2 0.0125 0.398 0.4406
Loa Loa (eye worm) melatonin receptor type 1A 0.0125 0.398 0.454
Schistosoma mansoni opsin-like receptor 0.0125 0.398 0.3851
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.8768 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0125 0.398 0.454
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0125 0.398 0.3851
Brugia malayi hypothetical protein 0.0044 0.0686 0.0557
Echinococcus multilocularis g-protein coupled receptor 0.0125 0.398 0.6057
Brugia malayi neuropeptide F receptor 0.0125 0.398 0.4406
Mycobacterium ulcerans thymidylate synthase 0.0093 0.268 0.5
Schistosoma mansoni hypothetical protein 0.0125 0.398 0.3851
Schistosoma mansoni neuropeptide receptor 0.0125 0.398 0.3851
Schistosoma mansoni biogenic amine receptor 0.0125 0.398 0.3851
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni phosphoglucomutase 0.0073 0.1844 0.1669
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0246 0.0043
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis fmrfamide receptor 0.0125 0.398 0.6057
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0093 0.268 1
Echinococcus granulosus dro:myosuppressin receptor 0.0125 0.398 0.6057
Echinococcus granulosus alpha 1A adrenergic receptor 0.0125 0.398 0.6057
Brugia malayi putative neuropeptide receptor 0.0125 0.398 0.4406
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.398 0.6057
Schistosoma mansoni hypothetical protein 0.0034 0.0246 0.0038
Echinococcus granulosus G protein coupled receptor 139 0.0125 0.398 0.6057
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Loa Loa (eye worm) hypothetical protein 0.0106 0.3204 0.3654
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus granulosus peptide allatostatin:somatostatin 0.0125 0.398 0.6057
Echinococcus granulosus neuropeptide s receptor 0.0125 0.398 0.6057
Onchocerca volvulus 0.0125 0.398 0.7006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.398 0.3851
Schistosoma mansoni neuropeptide receptor 0.0125 0.398 0.3851
Echinococcus multilocularis g protein coupled receptor 0.0125 0.398 0.6057
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0093 0.268 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.398 0.6057
Onchocerca volvulus 0.0125 0.398 0.7006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.398 0.6057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0771 0.1174
Echinococcus multilocularis fmrfamide receptor 0.0125 0.398 0.6057
Brugia malayi Melatonin receptor type 1A 0.0125 0.398 0.4406
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0189 0.6571 1
Echinococcus granulosus neuropeptide receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Brugia malayi putative neuropeptide receptor NPR1 0.0125 0.398 0.4406
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.398 0.6057
Brugia malayi hypothetical protein 0.0165 0.5592 0.6289
Schistosoma mansoni hypothetical protein 0.007 0.1752 0.1576
Loa Loa (eye worm) hypothetical protein 0.0073 0.1835 0.2093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.398 0.3851
Schistosoma mansoni growth hormone secretagogue receptor 0.0125 0.398 0.3851
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni biogenic amine receptor 0.0125 0.398 0.3851
Entamoeba histolytica hypothetical protein 0.0189 0.6571 0.5
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Brugia malayi ORL1-like opioid receptor 0.0125 0.398 0.4406
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni neuropeptide receptor 0.0125 0.398 0.3851
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.398 0.3851
Echinococcus multilocularis neuropeptide receptor 0.0125 0.398 0.6057
Onchocerca volvulus 0.0125 0.398 0.7006
Echinococcus multilocularis neuropeptide FF receptor 2 0.0125 0.398 0.6057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0246 0.0375
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0079 0.2096 0.0309
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0125 0.398 0.6057
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis neuropeptide s receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0125 0.398 0.6057
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.398 0.6057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0771 0.0574
Brugia malayi Tachykinin-like peptides receptor 99D 0.0125 0.398 0.4406
Onchocerca volvulus 0.0093 0.268 0.459
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0125 0.398 0.3851
Schistosoma mansoni amine GPCR 0.0125 0.398 0.3851
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0125 0.398 0.4406
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0125 0.398 0.3851
Brugia malayi thymidylate synthase 0.0093 0.268 0.2886
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0771 0.1174
Echinococcus granulosus hypothetical protein 0.0125 0.398 0.6057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0771 0.0657
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis allatostatin A receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.8768 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0125 0.398 0.3851
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0125 0.398 0.6057
Trypanosoma cruzi ribonuclease H1, putative 0.0073 0.1844 0.5806
Echinococcus granulosus orexin receptor type 2 0.0125 0.398 0.6057
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.398 0.3851
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.398 0.6057
Echinococcus granulosus neuropeptide Y receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.398 0.454
Echinococcus multilocularis neuropeptide receptor A26 0.0125 0.398 0.6057
Schistosoma mansoni adenoreceptor 0.0125 0.398 0.3851
Schistosoma mansoni amine GPCR 0.0125 0.398 0.3851
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0189 0.6571 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0125 0.398 0.454
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.398 0.6057
Brugia malayi GnHR receptor homolog 0.0125 0.398 0.4406
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0125 0.398 0.6057
Onchocerca volvulus Neuropeptide F receptor homolog 0.0125 0.398 0.7006
Echinococcus granulosus sex peptide receptor 0.0125 0.398 0.6057
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0246 0.0375
Onchocerca volvulus 0.0125 0.398 0.7006
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.398 0.3851
Brugia malayi Dopamine receptor 0.0125 0.398 0.4406
Brugia malayi Serotonin receptor 0.0125 0.398 0.4406
Echinococcus granulosus g protein coupled receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0239
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.3204 0.3499
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0246 0.0043
Schistosoma mansoni hypothetical protein 0.0125 0.398 0.3851
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.3204 0.3654
Echinococcus multilocularis sex peptide receptor 0.0125 0.398 0.6057
Schistosoma mansoni amine GPCR 0.0125 0.398 0.3851
Schistosoma mansoni biogenic amine receptor 0.0125 0.398 0.3851
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Loa Loa (eye worm) hypothetical protein 0.0165 0.5592 0.6378
Echinococcus multilocularis g protein coupled receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.398 0.6057
Echinococcus granulosus serotonin receptor 0.0125 0.398 0.6057
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0125 0.398 0.6057
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0125 0.398 0.6057
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0093 0.268 0.2523
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0125 0.398 0.3851
Loa Loa (eye worm) hypothetical protein 0.0034 0.0246 0.0281
Schistosoma mansoni neuropeptide f receptor 76f 0.0125 0.398 0.3851
Entamoeba histolytica hypothetical protein 0.0189 0.6571 0.5
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus granulosus g-protein coupled receptor 0.0125 0.398 0.6057
Echinococcus granulosus biogenic amine 5HT receptor 0.0125 0.398 0.6057
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0125 0.398 0.4406
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0125 0.398 0.6057
Schistosoma mansoni phosphoglucomutase 0.0073 0.1844 0.1669
Echinococcus multilocularis GPCR, family 2 0.0034 0.0246 0.0375
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0125 0.398 0.7006
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Onchocerca volvulus 0.0125 0.398 0.7006
Onchocerca volvulus 0.007 0.1752 0.2867
Brugia malayi RE15519p 0.0125 0.398 0.4406
Brugia malayi Thrombospondin type 1 domain containing protein 0.007 0.1752 0.1803
Brugia malayi G-protein coupled receptor 0.0125 0.398 0.4406
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0125 0.398 0.6057
Schistosoma mansoni hypothetical protein 0.0125 0.398 0.3851
Echinococcus granulosus allatostatin A receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus granulosus tachykinin peptides receptor 99D 0.0125 0.398 0.6057
Loa Loa (eye worm) G-protein coupled receptor 0.0125 0.398 0.454
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.398 0.3851
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0125 0.398 0.6057
Onchocerca volvulus 0.0125 0.398 0.7006
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.007 0.1752 0.1999
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0125 0.398 0.4406
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Brugia malayi RNase H family protein 0.0073 0.1844 0.191
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Schistosoma mansoni hypothetical protein 0.0034 0.0246 0.0038
Echinococcus granulosus g protein coupled receptor 0.0125 0.398 0.6057
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0125 0.398 0.6057
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0093 0.268 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0246 0.0281
Echinococcus multilocularis orexin receptor type 2 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni phosphoglucomutase 0.0073 0.1844 0.1669
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0125 0.398 0.6057
Onchocerca volvulus Ribonuclease H1 homolog 0.0073 0.1844 0.3036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.398 0.6057
Onchocerca volvulus 0.0125 0.398 0.7006
Echinococcus multilocularis thymidylate synthase 0.0093 0.268 0.4078
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0093 0.268 0.1025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.398 0.3851
Onchocerca volvulus 0.0165 0.5592 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis g protein coupled receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.398 0.454
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Echinococcus granulosus somatostatin receptor 0.0125 0.398 0.6057
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Echinococcus multilocularis ribonuclease H1 0.0073 0.1844 0.2806
Schistosoma mansoni neuropeptide receptor 0.0125 0.398 0.3851
Schistosoma mansoni hypothetical protein 0.0189 0.6571 0.6498
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.398 0.3851
Brugia malayi sulfakinin receptor protein 0.0125 0.398 0.4406
Brugia malayi hypothetical protein 0.0189 0.6571 0.7433
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0125 0.398 0.3851
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Brugia malayi AKH receptor 0.0125 0.398 0.4406
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Schistosoma mansoni neuropeptide F-like receptor 0.0125 0.398 0.3851
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Schistosoma mansoni amine GPCR 0.0125 0.398 0.3851
Schistosoma mansoni histamine h1 receptor 0.0125 0.398 0.3851
Schistosoma mansoni hypothetical protein 0.0034 0.0246 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0125 0.398 0.3851
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.398 0.6057
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.398 0.6057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.398 0.3851
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Echinococcus multilocularis neuropeptides capa receptor 0.0125 0.398 0.6057
Trichomonas vaginalis ribonuclease H1, putative 0.0073 0.1844 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0771 0.1174
Onchocerca volvulus 0.0125 0.398 0.7006
Echinococcus granulosus tm gpcr rhodopsin 0.0125 0.398 0.6057
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni opsin-like receptor 0.0125 0.398 0.3851
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0125 0.398 0.6057
Schistosoma mansoni alpha-1 adrenergic receptor 0.0125 0.398 0.3851
Echinococcus granulosus neuropeptide receptor 0.0125 0.398 0.6057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.398 0.6057
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0125 0.398 0.454
Loa Loa (eye worm) thymidylate synthase 0.0093 0.268 0.3056
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0093 0.268 1
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.398 0.6057
Onchocerca volvulus 0.0125 0.398 0.7006
Brugia malayi follicle stimulating hormone receptor 0.0125 0.398 0.4406
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis neuropeptide receptor 0.0125 0.398 0.6057
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0125 0.398 0.4406
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0771 0.1174
Echinococcus multilocularis serotonin receptor 0.0125 0.398 0.6057
Onchocerca volvulus 0.0125 0.398 0.7006
Brugia malayi Dopamine receptor protein 1 0.0125 0.398 0.4406
Schistosoma mansoni myosin xvIII 0.0125 0.398 0.3851
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0093 0.268 1
Echinococcus multilocularis G protein coupled receptor 139 0.0125 0.398 0.6057
Echinococcus granulosus ribonuclease H1 0.0073 0.1844 0.2806
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.398 0.3851
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0093 0.268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0125 0.398 0.3851
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.1835 0.1899
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0239
Entamoeba histolytica hypothetical protein 0.0189 0.6571 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.398 0.6057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0246 0.0375
Echinococcus multilocularis dro:myosuppressin receptor 0.0125 0.398 0.6057
Echinococcus multilocularis somatostatin receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0125 0.398 0.454
Entamoeba histolytica hypothetical protein 0.0189 0.6571 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0125 0.398 0.6057
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.3204 0.3499
Brugia malayi hypothetical protein 0.0125 0.398 0.4406
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0125 0.398 0.4406
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0125 0.398 0.6057
Echinococcus granulosus 7TM GPCR rhodopsin 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni hypothetical protein 0.0073 0.1835 0.166
Brugia malayi RNase H family protein 0.0073 0.1844 0.191
Loa Loa (eye worm) neuropeptide F receptor 0.0125 0.398 0.454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0771 0.0574
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Schistosoma mansoni amine GPCR 0.0125 0.398 0.3851
Schistosoma mansoni transcription factor LCR-F1 0.0189 0.6571 0.6498
Echinococcus multilocularis G-protein coupled receptor, putative 0.0125 0.398 0.6057
Trypanosoma brucei unspecified product 0.0079 0.2096 0.0309
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Onchocerca volvulus 0.0125 0.398 0.7006
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0125 0.398 0.3851
Giardia lamblia Ribonuclease H 0.0073 0.1844 0.5
Echinococcus granulosus g protein coupled receptor 0.0125 0.398 0.6057
Echinococcus granulosus GPCR family 2 0.0034 0.0246 0.0375
Echinococcus multilocularis neuropeptide Y receptor 0.0125 0.398 0.6057
Schistosoma mansoni opsin-like receptor 0.0125 0.398 0.3851
Brugia malayi neuropeptide F receptor 0.0125 0.398 0.4406
Echinococcus granulosus 7tm_1 domain containing protein 0.0125 0.398 0.6057
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.0209 0.0319
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0246 0.0375
Treponema pallidum ribonuclease H (rnhA) 0.0073 0.1844 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0239
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.398 0.6057
Loa Loa (eye worm) hypothetical protein 0.0125 0.398 0.454
Echinococcus multilocularis rhodopsin orphan GPCR 0.0125 0.398 0.6057
Brugia malayi G protein-coupled receptor 0.0125 0.398 0.4406
Schistosoma mansoni biogenic amine (5HT) receptor 0.0125 0.398 0.3851
Echinococcus multilocularis serotonin receptor 0.0125 0.398 0.6057
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0125 0.398 0.6057
Brugia malayi MH2 domain containing protein 0.0243 0.8768 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0125 0.398 0.6057
Echinococcus granulosus neuropeptide FF receptor 2 0.0125 0.398 0.6057

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) NA 0 Compound was evaluated for the inhibitory activity against glutamate decarboxylase at 2.5 mM dose; No significant activation ChEMBL. 9873588

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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