Detailed information for compound 1444493

Basic information

Technical information
  • TDR Targets ID: 1444493
  • Name: 2-(5-methyltetrazol-1-yl)-N-(2-nitrophenyl)ac etamide
  • MW: 262.225 | Formula: C10H10N6O3
  • H donors: 1 H acceptors: 6 LogP: 1.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1nnnc1C)Nc1ccccc1[N+](=O)[O-]
  • InChi: 1S/C10H10N6O3/c1-7-12-13-14-15(7)6-10(17)11-8-4-2-3-5-9(8)16(18)19/h2-5H,6H2,1H3,(H,11,17)
  • InChiKey: KMSXCFBNTIZWDL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(5-methyl-1-tetrazolyl)-N-(2-nitrophenyl)acetamide
  • 2-(5-methyl-1,2,3,4-tetrazol-1-yl)-N-(2-nitrophenyl)ethanamide
  • Oprea1_041037
  • A2002/0084115
  • ZINC04524448
  • 2-(5-methyl-1H-tetrazol-1-yl)-N-(2-nitrophenyl)acetamide
  • MLS000677016
  • SMR000270839

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Grp94/Hsp90 0.0028 0.0043 0.0453
Brugia malayi hypothetical protein 0.1816 0.854 0.854
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0196 0.0842 0.0842
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0059 0.019 0.1456
Entamoeba histolytica hypothetical protein 0.0232 0.1012 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0105 0.0575
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.0292 0.2235
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0051 0.0393
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0032 0.0064 0.0064
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Echinococcus granulosus chromobox protein 1 0.0073 0.0257 0.0257
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0043 0.0188
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0222 0.1698
Schistosoma mansoni heat shock protein 0.002 0.0004 0.0004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0431 0.1959 1
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0105 0.0105
Loa Loa (eye worm) transcription factor SMAD2 0.0972 0.453 0.453
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0087 0.0467
Trypanosoma brucei unspecified product 0.0135 0.0553 0.4236
Brugia malayi MH1 domain containing protein 0.0066 0.0225 0.0225
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0059 0.019 0.1456
Leishmania major hypothetical protein, conserved 0.0162 0.0682 0.5229
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.011 0.0434 0.2043
Brugia malayi jmjC domain containing protein 0.0192 0.0823 0.0823
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0347 0.0347
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Brugia malayi A-kinase anchor protein 10, precursor 0.0032 0.0064 0.0064
Leishmania major phosphoglycerate kinase C, glycosomal 0.0179 0.0759 0.5813
Schistosoma mansoni chromosome transmission fidelity factor 0.0037 0.0087 0.0087
Schistosoma mansoni terminal deoxycytidyl transferase 0.0196 0.0842 0.0842
Plasmodium falciparum ataxin-2 like protein, putative 0.0162 0.0682 0.8994
Echinococcus multilocularis peregrin 0.0059 0.0189 0.0189
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0073 0.0256 0.0256
Plasmodium falciparum heat shock protein 90, putative 0.0113 0.0446 0.5873
Trypanosoma brucei DNA damage repair protein, putative 0.0061 0.0199 0.1527
Brugia malayi RNA recognition motif domain containing protein 0.0041 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0321
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.016 0.0671 0.0671
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0359 0.1615 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0005 0.0005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0059 0.019 0.0392
Echinococcus granulosus neuroligin 0.0359 0.1615 0.1615
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0059 0.019 0.1456
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0087 0.0467
Plasmodium vivax replication factor C subunit 1, putative 0.0037 0.0087 0.1153
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0065 0.0065
Trypanosoma brucei phosphoglycerate kinase, putative 0.0066 0.0222 0.1698
Loa Loa (eye worm) glutaminase 0.0287 0.1273 0.1273
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0051 0.047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0032 0.0064 0.0064
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0189 0.0189
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Leishmania major DNA damage repair protein, putative 0.0061 0.0199 0.1527
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.011 0.0434 0.0434
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0189 0.2488
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0247 0.0247
Loa Loa (eye worm) RNA binding protein 0.0041 0.0105 0.0105
Giardia lamblia Replication factor C, subunit 1 0.0037 0.0087 0.0989
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.0823 0.0823
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.0823 0.0823
Brugia malayi MH2 domain containing protein 0.0066 0.0225 0.0225
Loa Loa (eye worm) endoplasmin 0.003 0.0051 0.0051
Schistosoma mansoni DNA polymerase eta 0.0293 0.1305 0.1305
Schistosoma mansoni smad1 5 8 and 0.0066 0.0225 0.0225
Onchocerca volvulus 0.0032 0.0063 0.0069
Echinococcus multilocularis carboxylesterase 5A 0.2123 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0179 0.0759 0.5813
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0257 0.1528
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0189 0.0189
Leishmania major DNA polymerase eta, putative 0.0158 0.0662 0.5075
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.011 0.0434 0.5722
Loa Loa (eye worm) hypothetical protein 0.016 0.0671 0.0671
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0388 0.1753 0.8927
Mycobacterium ulcerans hypothetical protein 0.0061 0.0199 0.0416
Schistosoma mansoni glutaminase 0.0287 0.1273 0.1273
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0359 0.1615 0.8206
Loa Loa (eye worm) hypothetical protein 0.003 0.0051 0.0051
Mycobacterium tuberculosis Probable reductase 0.0388 0.1753 0.8927
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0347 0.0347
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0347 0.0347
Brugia malayi PXA domain containing protein 0.0032 0.0064 0.0064
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0298 0.0298
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0051 0.0393
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0064
Onchocerca volvulus Serine\/threonine kinase homolog 0.008 0.0292 0.0337
Schistosoma mansoni DNA helicase recq5 0.002 0.0005 0.0005
Schistosoma mansoni regulator of G protein signaling 0.0032 0.0064 0.0064
Trypanosoma brucei heat shock protein, putative 0.003 0.0051 0.0393
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0292 0.1741
Plasmodium vivax DNA repair protein REV1, putative 0.0061 0.0199 0.2627
Schistosoma mansoni BC026374 protein (S09 family) 0.0359 0.1615 0.1615
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.019 0.1456
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.016 0.0671 0.0671
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0257 0.0257
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0032 0.0064 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0087 0.067
Brugia malayi Carboxylesterase family protein 0.2123 1 1
Brugia malayi MH2 domain containing protein 0.003 0.0051 0.0051
Plasmodium vivax thioredoxin reductase, putative 0.017 0.0718 0.9464
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0388 0.1753 0.8927
Echinococcus multilocularis muscleblind protein 1 0.018 0.0767 0.0767
Trypanosoma brucei DNA polymerase IV, putative 0.0196 0.0842 0.6452
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0087 0.0467
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0001 0.0015
Echinococcus multilocularis para nitrobenzyl esterase 0.0359 0.1615 0.1615
Echinococcus multilocularis transcription factor eb 0.0094 0.0358 0.0358
Echinococcus granulosus transcription factor eb 0.0094 0.0358 0.0358
Loa Loa (eye worm) TAR-binding protein 0.0041 0.0105 0.0105
Trypanosoma brucei phosphoglycerate kinase 0.0179 0.0759 0.5813
Schistosoma mansoni Smad4 0.0066 0.0225 0.0225
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0506 0.2316 0.2316
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0051 0.0051
Brugia malayi Thioredoxin reductase 0.017 0.0718 0.0718
Echinococcus multilocularis thioredoxin glutathione reductase 0.017 0.0718 0.0718
Trypanosoma brucei heat shock protein, putative 0.003 0.0051 0.0393
Trypanosoma cruzi DNA damage repair protein, putative 0.0061 0.0199 0.1527
Echinococcus granulosus axis inhibition protein axin 0.0032 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0232 0.1012 0.1012
Mycobacterium ulcerans hydrolase/amidase 0.082 0.3805 1
Trypanosoma cruzi trypanothione reductase, putative 0.017 0.0718 0.5502
Echinococcus granulosus bloom syndrome protein 0.0048 0.0139 0.0139
Entamoeba histolytica hypothetical protein 0.0032 0.0064 0.0596
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.016 0.0671 0.0671
Brugia malayi Carboxylesterase family protein 0.0359 0.1615 0.1615
Plasmodium vivax heat shock protein 90, putative 0.002 0.0004 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0199 0.1527
Schistosoma mansoni heat shock protein 0.003 0.0051 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Brugia malayi hypothetical protein 0.0232 0.1012 0.1012
Brugia malayi PHD-finger family protein 0.0059 0.0189 0.0189
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0051 0.0051
Echinococcus multilocularis neuroligin 0.0359 0.1615 0.1615
Schistosoma mansoni jumonji domain containing protein 0.0153 0.0635 0.0635
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0553 0.4236
Leishmania major DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0032 0.0064 0.0321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0064
Echinococcus granulosus muscleblind protein 0.018 0.0767 0.0767
Echinococcus multilocularis heat shock protein 0.003 0.0051 0.0051
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0066 0.0225 0.0225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0347 0.0347
Echinococcus multilocularis axis inhibition protein axin 0.0032 0.0064 0.0064
Schistosoma mansoni Smad4 0.003 0.0051 0.0051
Schistosoma mansoni DNA polymerase IV / kappa 0.0061 0.0199 0.0199
Trypanosoma brucei unspecified product 0.0135 0.0553 0.4236
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0059 0.019 0.019
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0066 0.0225 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0321
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0196 0.0842 0.0842
Trichomonas vaginalis chromobox protein, putative 0.0044 0.012 0.0667
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0001 0.0009
Echinococcus granulosus serine:threonine protein kinase PLK1 0.008 0.0292 0.0292
Trypanosoma brucei heat shock protein, putative 0.003 0.0051 0.0393
Mycobacterium ulcerans glutaminase 0.0287 0.1273 0.327
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0553 0.4236
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0247 0.0247
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0222 0.1698
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0087
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0189 0.0189
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.011 0.0434 0.0434
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.2123 1 1
Leishmania major heat shock protein, putative 0.002 0.0004 0.003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0059 0.019 0.1456
Mycobacterium ulcerans carboxylesterase, LipT 0.0359 0.1615 0.4179
Echinococcus granulosus heat shock protein 90 0.0025 0.0031 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0347 0.0347
Brugia malayi polk-prov protein 0.0061 0.0199 0.0199
Brugia malayi hypothetical protein 0.0037 0.0087 0.0087
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0037 0.0087 0.0467
Schistosoma mansoni phosphoglycerate kinase 0.0179 0.0759 0.0759
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0321
Schistosoma mansoni smad1 5 8 and 0.0066 0.0225 0.0225
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0051 0.0393
Leishmania major DNA polymerase kappa, putative 0.0061 0.0199 0.1527
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0359 0.1615 0.1615
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0031 0.0031
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0051 0.0051
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0179 0.0759 0.3737
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0051 0.0393
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0059 0.019 0.019
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.011 0.0434 0.0434
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0032 0.0064 0.0064
Toxoplasma gondii ATPase, AAA family protein 0.0037 0.0087 0.1153
Onchocerca volvulus Alhambra homolog 0.0059 0.0189 0.0217
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0179 0.0759 0.4656
Brugia malayi Regulator of G protein signaling domain containing protein 0.0032 0.0064 0.0064
Giardia lamblia PHD finger protein 15 0.0059 0.0189 0.2198
Echinococcus multilocularis Regulator of G protein signaling 20 0.0032 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.138 0.6467 0.6467
Echinococcus multilocularis replication factor c subunit 1 0.0037 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0087
Entamoeba histolytica hypothetical protein 0.0032 0.0064 0.0596
Mycobacterium tuberculosis Carboxylesterase LipT 0.0359 0.1615 0.8206
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0037 0.0087 0.067
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0037 0.0087 0.0467
Echinococcus granulosus TGF beta signal transducer SmadC 0.0066 0.0225 0.0225
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0431 0.1959 1
Trypanosoma brucei DNA damage repair protein, putative 0.0061 0.0199 0.1527
Brugia malayi isocitrate dehydrogenase 0.011 0.0434 0.0434
Mycobacterium ulcerans DNA polymerase IV 0.0196 0.0842 0.2124
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0388 0.1753 0.8927
Trichomonas vaginalis replication factor C large subunit, putative 0.0037 0.0087 0.0467
Trichomonas vaginalis DNA helicase recq, putative 0.0048 0.0139 0.0791
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.011 0.0434 0.3326
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0222 0.1698
Loa Loa (eye worm) glutaminase 2 0.0287 0.1273 0.1273
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0033 0.0249
Brugia malayi MH1 domain containing protein 0.0037 0.0084 0.0084
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0059 0.019 0.2505
Schistosoma mansoni Smad4 0.003 0.0051 0.0051
Brugia malayi Pax transcription activation domain interacting protein 0.0037 0.0087 0.0087
Trichomonas vaginalis DNA polymerase eta, putative 0.0196 0.0842 0.5176
Giardia lamblia Phosphoglycerate kinase 0.0179 0.0759 0.9004
Echinococcus granulosus tar DNA binding protein 0.0041 0.0105 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0099 0.0539
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0179 0.0759 0.5813
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.011 0.0434 0.5722
Leishmania major phosphoglycerate kinase B, cytosolic 0.0179 0.0759 0.5813
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.019 0.1456
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0087
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0033 0.0249
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0033 0.0249
Brugia malayi RNA binding protein 0.0041 0.0105 0.0105
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0005 0.0062
Schistosoma mansoni gliotactin 0.0359 0.1615 0.1615
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0292 0.0292
Brugia malayi AF-10 protein 0.0019 0.0001 0.0001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0059 0.019 0.1456
Echinococcus multilocularis expressed protein 0.0631 0.2907 0.2907
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0037 0.0087 0.0087
Echinococcus granulosus heat shock protein 90 0.003 0.0051 0.0051
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0033 0.0125
Trypanosoma brucei Heat shock protein 83, putative 0.003 0.0051 0.0393
Brugia malayi MH1 domain containing protein 0.0037 0.0084 0.0084
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0033 0.0065 0.0065
Trypanosoma cruzi trypanothione reductase, putative 0.0059 0.019 0.1456
Echinococcus granulosus carboxylesterase 5A 0.2123 1 1
Brugia malayi Endoplasmin precursor 0.003 0.0051 0.0051
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0001 0.0015
Treponema pallidum phosphoglycerate kinase 0.0179 0.0759 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0179 0.0759 0.3737
Trypanosoma brucei trypanothione reductase 0.017 0.0718 0.5502
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0179 0.0759 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0359 0.1615 0.1615
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0199 0.1527
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.0113 0.0113
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.002 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0105
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0347 0.0347
Schistosoma mansoni smad 0.0066 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0359 0.1615 0.1615
Brugia malayi MH2 domain containing protein 0.0066 0.0225 0.0225
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0232 0.1012 0.1012
Toxoplasma gondii Hsp90 domain-containing protein 0.0113 0.0446 0.5873
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0431 0.1959 1
Loa Loa (eye worm) hypothetical protein 0.0506 0.2316 0.2316
Echinococcus multilocularis dna polymerase kappa 0.0196 0.0842 0.0842
Trypanosoma brucei DNA polymerase IV, putative 0.0196 0.0842 0.6452
Entamoeba histolytica hypothetical protein 0.0032 0.0064 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0048 0.022
Echinococcus multilocularis mothers against decapentaplegic 5 0.0066 0.0225 0.0225
Echinococcus granulosus expressed protein 0.0631 0.2907 0.2907
Echinococcus multilocularis chromobox protein 1 0.0073 0.0257 0.0257
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0298 0.0298
Echinococcus multilocularis bloom syndrome protein 0.0048 0.0139 0.0139
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0292 0.1741
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Brugia malayi TAR-binding protein 0.0041 0.0105 0.0105
Echinococcus multilocularis Smad4 0.0066 0.0225 0.0225
Echinococcus multilocularis dna polymerase eta 0.0293 0.1305 0.1305
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0232 0.1012 0.1012
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0196 0.0842 0.5176
Loa Loa (eye worm) hypothetical protein 0.0101 0.0388 0.0388
Loa Loa (eye worm) pax transcription factor protein 2 0.064 0.2953 0.2953
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0051 0.0393
Plasmodium vivax glutathione reductase, putative 0.017 0.0718 0.9464
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0059 0.019 0.2505
Loa Loa (eye worm) latrophilin receptor protein 2 0.016 0.0671 0.0671
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0189 0.2488
Leishmania major trypanothione reductase 0.017 0.0718 0.5502
Schistosoma mansoni hypothetical protein 0.016 0.0671 0.0671
Mycobacterium ulcerans DNA polymerase IV 0.0196 0.0842 0.2124
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0059 0.019 0.019
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0247 0.0247
Toxoplasma gondii heat shock protein HSP90 0.003 0.0051 0.0677
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0247 0.0247
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0105 0.0118
Schistosoma mansoni topbp1 0.0037 0.0087 0.0087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0041 0.0105 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Entamoeba histolytica hypothetical protein 0.0232 0.1012 1
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0051 0.0051
Trypanosoma brucei heat shock protein 84, putative 0.002 0.0004 0.003
Echinococcus granulosus geminin 0.138 0.6467 0.6467
Giardia lamblia NADH oxidase lateral transfer candidate 0.0059 0.019 0.2213
Brugia malayi Regulator of G protein signaling domain containing protein 0.0032 0.0064 0.0064
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.011 0.0434 0.0434
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0031 0.0313
Brugia malayi heat shock protein 90 0.003 0.0051 0.0051
Brugia malayi glutathione reductase 0.017 0.0718 0.0718
Echinococcus multilocularis geminin 0.138 0.6467 0.6467
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0059 0.019 0.0392
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0099 0.0539
Schistosoma mansoni z-protein (S1r protein) 0.0043 0.0113 0.0113
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0051 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0189 0.2488
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0196 0.0842 0.4172
Brugia malayi hypothetical protein 0.0032 0.0064 0.0064
Echinococcus multilocularis regulator of G protein signaling 0.0032 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0037 0.0087 0.0626
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0292 0.1741
Echinococcus granulosus GPCR family 2 0.016 0.0671 0.0671
Plasmodium vivax phosphoglycerate kinase, putative 0.0179 0.0759 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0087
Brugia malayi Heterochromatin protein 1 0.0073 0.0257 0.0257
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0043 0.0116 0.0116
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0043 0.0113 0.0113
Echinococcus multilocularis isocitrate dehydrogenase 0.011 0.0434 0.0434
Echinococcus multilocularis heat shock protein 90 0.0025 0.0031 0.0031
Brugia malayi serine/threonine-protein kinase plk-2 0.008 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0359 0.1615 0.1615
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0087 0.067
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0033 0.0065 0.0858
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0005 0.0005
Entamoeba histolytica phosphoglycerate kinase, putative 0.0179 0.0759 0.7484
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0105 0.0105
Schistosoma mansoni chromobox protein 0.0073 0.0257 0.0257
Echinococcus granulosus nibrin 0.0037 0.0087 0.0087
Loa Loa (eye worm) thioredoxin reductase 0.017 0.0718 0.0718
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0037 0.0087 0.1153
Loa Loa (eye worm) MH2 domain-containing protein 0.0972 0.453 0.453
Plasmodium falciparum endoplasmin, putative 0.0022 0.0013 0.0166
Loa Loa (eye worm) heat shock protein 75 0.002 0.0004 0.0004
Echinococcus granulosus dna polymerase kappa 0.0196 0.0842 0.0842
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.019 0.1456
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0073 0.0256 0.0256
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0359 0.1615 0.1615
Schistosoma mansoni regulator of G protein signaling 0.0032 0.0064 0.0064
Plasmodium falciparum thioredoxin reductase 0.0059 0.019 0.2505
Trypanosoma cruzi FHA domain containing protein, putative 0.0037 0.0087 0.067
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0199 0.1527
Echinococcus granulosus Regulator of G protein signaling 20 0.0032 0.0064 0.0064
Echinococcus multilocularis chromobox protein 1 0.0073 0.0257 0.0257
Echinococcus multilocularis heat shock protein 90 0.003 0.0051 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0065 0.0065
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0001 0.0015
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0031 0.0114
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0059 0.019 0.2505
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0059 0.019 0.2505
Trypanosoma cruzi DNA polymerase eta, putative 0.0158 0.0662 0.5075
Brugia malayi regulator of G-protein signaling rgs-7 0.0032 0.0064 0.0064
Schistosoma mansoni heat shock protein 0.003 0.0051 0.0051
Schistosoma mansoni neuroligin 3 (S09 family) 0.0359 0.1615 0.1615
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0059 0.019 0.2058
Echinococcus granulosus para nitrobenzyl esterase 0.0359 0.1615 0.1615
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0061 0.0199 0.2627
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Loa Loa (eye worm) hypothetical protein 0.0359 0.1615 0.1615
Loa Loa (eye worm) hypothetical protein 0.1565 0.7346 0.7346
Trypanosoma cruzi DNA damage repair protein, putative 0.0061 0.0199 0.1527
Toxoplasma gondii NADPH-glutathione reductase 0.0059 0.019 0.2505
Loa Loa (eye worm) RecQ helicase 0.0048 0.0139 0.0139
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0059 0.019 0.1456
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0033 0.0065 0.0065
Toxoplasma gondii heat shock protein 90, putative 0.003 0.0051 0.0677
Schistosoma mansoni kinase 0.0041 0.0104 0.0104
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.0199 0.1527
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0033 0.0065 0.0065
Trypanosoma cruzi PAB1-binding protein , putative 0.0162 0.0682 0.5229
Loa Loa (eye worm) hypothetical protein 0.0293 0.1305 0.1305
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.2123 1 1
Loa Loa (eye worm) carboxylesterase 0.0359 0.1615 0.1615
Brugia malayi hypothetical protein 0.0037 0.0087 0.0087
Trypanosoma brucei polo-like protein kinase 0.008 0.0292 0.2235
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.0113 0.0113
Echinococcus granulosus replication factor c subunit 1 0.0037 0.0087 0.0087
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0196 0.0842 0.0842
Loa Loa (eye worm) hypothetical protein 0.0179 0.0759 0.0759
Schistosoma mansoni endoplasmin 0.003 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0359 0.1615 0.1615
Brugia malayi Latrophilin receptor protein 2 0.016 0.0671 0.0671
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0064
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.016 0.0671 0.0671
Loa Loa (eye worm) hypothetical protein 0.0243 0.1064 0.1064
Schistosoma mansoni axis inhibition protein axin 0.0032 0.0064 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Brugia malayi latrophilin 2 splice variant baaae 0.0346 0.1555 0.1555
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0031 0.0237
Schistosoma mansoni hypothetical protein 0.0059 0.0189 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0292 0.1741
Brugia malayi Hsp90 protein 0.002 0.0004 0.0004
Brugia malayi N-terminal motif family protein 0.021 0.0908 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0105 0.0575
Plasmodium falciparum ataxin-2 like protein, putative 0.0162 0.0682 0.8994
Trichomonas vaginalis heat shock protein, putative 0.003 0.0051 0.0242
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.008 0.0292 0.2235
Plasmodium falciparum glutathione reductase 0.017 0.0718 0.9464
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.008 0.0292 0.0292
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0001 0.0015
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0043 0.0327
Echinococcus multilocularis regulator of G protein signaling 7 0.0043 0.0113 0.0113
Plasmodium falciparum glutathione reductase 0.0059 0.019 0.2505
Loa Loa (eye worm) hypothetical protein 0.0359 0.1615 0.1615
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.0199 0.1527
Schistosoma mansoni regulator of G protein signaling 0.0032 0.0064 0.0064
Loa Loa (eye worm) carboxylesterase 0.2123 1 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0032 0.0064 0.0064
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0059 0.019 0.0769
Brugia malayi hypothetical protein 0.1565 0.7346 0.7346
Chlamydia trachomatis phosphoglycerate kinase 0.0179 0.0759 1
Trypanosoma brucei heat shock protein, putative 0.003 0.0051 0.0393
Mycobacterium tuberculosis Probable dehydrogenase 0.0388 0.1753 0.8927
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0189 0.0189
Schistosoma mansoni regulator of G protein signaling 0.0032 0.0064 0.0064
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0359 0.1615 0.1615
Loa Loa (eye worm) hypothetical protein 0.018 0.0767 0.0767
Toxoplasma gondii isocitrate dehydrogenase 0.011 0.0434 0.5722
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0051 0.0393
Schistosoma mansoni transcription factor LCR-F1 0.0232 0.1012 0.1012
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0059 0.019 0.1456
Plasmodium vivax heat shock protein 86, putative 0.003 0.0051 0.0677
Brugia malayi topoisomerase 0.0037 0.0087 0.0087
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0043 0.0188
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.012 0.0135
Schistosoma mansoni smad1 5 8 and 0.0066 0.0225 0.0225
Trypanosoma cruzi PAB1-binding protein , putative 0.0162 0.0682 0.5229
Schistosoma mansoni hypothetical protein 0.138 0.6467 0.6467
Loa Loa (eye worm) RGS-3 protein 0.0032 0.0064 0.0064
Echinococcus granulosus acetylcholinesterase 0.2123 1 1
Echinococcus granulosus heat shock protein 0.003 0.0051 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Echinococcus granulosus regulator of G protein signaling 7 0.0043 0.0113 0.0113
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0094 0.0358 0.0358
Echinococcus granulosus regulator of G protein signaling 3 0.0032 0.0064 0.0064
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0005 0.0005
Brugia malayi Isocitrate dehydrogenase 0.011 0.0434 0.0434
Echinococcus multilocularis beta adrenergic receptor kinase 0.0033 0.0065 0.0065
Schistosoma mansoni axis inhibition protein axin 0.0032 0.0064 0.0064
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0061 0.0199 0.2627
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0031 0.0237
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0485 0.0485
Echinococcus granulosus smad 0.0066 0.0225 0.0225
Schistosoma mansoni endoplasmin 0.003 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0346 0.1555 0.1555
Loa Loa (eye worm) hypothetical protein 0.0059 0.0189 0.0189
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.011 0.0434 0.3326
Trypanosoma brucei heat shock protein, putative 0.003 0.0051 0.0393
Schistosoma mansoni chromobox protein 0.0073 0.0257 0.0257
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.002 0.0004 0.0004
Trypanosoma brucei chrX additional, unordered contigs 0.0061 0.0199 0.1527
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0059 0.019 0.2058
Brugia malayi MH1 domain containing protein 0.0066 0.0225 0.0225
Entamoeba histolytica deoxycytidyl transferase, putative 0.0196 0.0842 0.8311
Echinococcus granulosus axis inhibition protein axin 0.0032 0.0064 0.0064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Probable oxidoreductase 0.0431 0.1959 1
Echinococcus multilocularis smad 0.0066 0.0225 0.0225
Loa Loa (eye worm) nuclear factor I 0.0037 0.0084 0.0084
Giardia lamblia DNA damage repair protein 0.0061 0.0199 0.2324
Echinococcus granulosus chromobox protein 1 0.0073 0.0257 0.0257
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0388 0.1753 0.8927
Trypanosoma brucei phosphoglycerate kinase 0.0179 0.0759 0.5813
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0158 0.0662 0.873
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0321
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0087 0.0467
Onchocerca volvulus 0.0037 0.0087 0.0098
Brugia malayi jmjC domain containing protein 0.0071 0.0247 0.0247
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.021 0.0908 0.106
Giardia lamblia DINP protein human, muc B family 0.0196 0.0842 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.017 0.0718 0.3525
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0037 0.0087 0.0467
Loa Loa (eye worm) PXA domain-containing protein 0.0032 0.0064 0.0064
Brugia malayi Carboxylesterase family protein 0.0359 0.1615 0.1615
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0063 0.0834
Trypanosoma brucei PAB1-binding protein , putative 0.0162 0.0682 0.5229
Echinococcus multilocularis endoplasmin 0.0028 0.0043 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0105 0.0105
Treponema pallidum NADH oxidase 0.0059 0.019 0.2058
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.011 0.0434 0.0434
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0037 0.0087 0.0829
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0037 0.0087 0.0234
Loa Loa (eye worm) carboxylesterase 0.0359 0.1615 0.1615
Loa Loa (eye worm) hypothetical protein 0.0346 0.1555 0.1555
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0222 0.1698
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0105 0.0105
Plasmodium falciparum DNA repair protein REV1, putative 0.0061 0.0199 0.2627
Trypanosoma cruzi heat shock protein, putative 0.002 0.0004 0.003
Schistosoma mansoni hypothetical protein 0.0073 0.0256 0.0256
Brugia malayi PXA domain containing protein 0.0032 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.018 0.0767 0.0767
Brugia malayi Phosphoglycerate kinase 0.0066 0.0222 0.0222
Trypanosoma brucei heat shock protein, putative 0.003 0.0051 0.0393
Loa Loa (eye worm) hypothetical protein 0.0359 0.1615 0.1615
Echinococcus granulosus beta-adrenergic receptor kinase 0.0033 0.0065 0.0065
Brugia malayi hypothetical protein 0.0359 0.1615 0.1615
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0179 0.0759 1
Echinococcus multilocularis axis inhibition protein axin 0.0032 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0162 0.0682 0.0682
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Echinococcus granulosus peregrin 0.0059 0.0189 0.0189
Echinococcus granulosus endoplasmin 0.0028 0.0043 0.0043
Toxoplasma gondii heat shock protein 75, putative 0.002 0.0004 0.0052
Onchocerca volvulus 0.064 0.2953 0.3454
Schistosoma mansoni DNA helicase recq1 0.002 0.0005 0.0005
Brugia malayi Smad1 0.0066 0.0225 0.0225
Brugia malayi hypothetical protein 0.0162 0.0682 0.0682
Echinococcus multilocularis tar DNA binding protein 0.0041 0.0105 0.0105
Brugia malayi hypothetical protein 0.0105 0.0409 0.0409
Trichomonas vaginalis spcc417.12 protein, putative 0.0359 0.1615 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0196 0.0842 0.0842
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0064
Echinococcus multilocularis GPCR, family 2 0.016 0.0671 0.0671
Schistosoma mansoni smad 0.003 0.0051 0.0051
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0051 0.047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Trichomonas vaginalis glutaminase, putative 0.0287 0.1273 0.7866
Onchocerca volvulus 0.1816 0.854 1
Brugia malayi chromobox protein homolog 3 0.0041 0.0105 0.0105
Schistosoma mansoni DNA ligase IV 0.0037 0.0087 0.0087
Trichomonas vaginalis glutathione reductase, putative 0.0059 0.019 0.1107
Echinococcus granulosus dna polymerase eta 0.0293 0.1305 0.1305
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0059 0.019 0.2505
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0043 0.0116 0.0116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0347 0.0347
Plasmodium vivax ataxin-2 like protein, putative 0.0162 0.0682 0.8994
Brugia malayi Bloom's syndrome protein homolog 0.0048 0.0139 0.0139
Loa Loa (eye worm) acetylcholinesterase 1 0.2123 1 1
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0347 0.0347
Echinococcus granulosus phosphoglycerate kinase 1 0.0179 0.0759 0.0759
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0292 0.1741
Brugia malayi Carboxylesterase family protein 0.0359 0.1615 0.1615
Mycobacterium tuberculosis Conserved hypothetical protein 0.0196 0.0842 0.4172
Toxoplasma gondii LsmAD domain-containing protein 0.0162 0.0682 0.8994
Loa Loa (eye worm) heat shock protein 90 0.003 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0037 0.0087 0.0829
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.016 0.0671 0.0671
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0059 0.019 0.1456
Loa Loa (eye worm) hypothetical protein 0.0037 0.0084 0.0084
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.0292 0.2235
Leishmania major DNA polymerase eta, putative 0.0293 0.1305 1
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Loa Loa (eye worm) glutathione reductase 0.017 0.0718 0.0718
Onchocerca volvulus 0.0359 0.1615 0.1887
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0196 0.0842 0.6452
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0359 0.1615 0.8206
Brugia malayi Bromodomain containing protein 0.0059 0.0189 0.0189
Echinococcus multilocularis regulator of G protein signaling 3 0.0032 0.0064 0.0064
Entamoeba histolytica recQ family helicase, putative 0.0026 0.0033 0.0284
Treponema pallidum DNA ligase (lig) 0.0037 0.0087 0.0626
Trypanosoma brucei phosphoglycerate kinase 0.0066 0.0222 0.1698
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0359 0.1615 0.1615
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0292 0.1741
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0222 0.1698
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0059 0.019 0.0392
Brugia malayi ImpB/MucB/SamB family protein 0.0196 0.0842 0.0842
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Trypanosoma cruzi Heat shock protein 83, putative 0.003 0.0051 0.0393
Loa Loa (eye worm) Smad1 0.0066 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0061 0.0199 0.0199
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0113 0.0113
Trypanosoma brucei isocitrate dehydrogenase, putative 0.011 0.0434 0.3326
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0321
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0037 0.0087 0.0467
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.019 0.1456
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0388 0.1753 0.8927
Echinococcus granulosus BC026374 protein S09 family 0.0359 0.1615 0.1615
Trypanosoma cruzi DNA polymerase eta, putative 0.0293 0.1305 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0094 0.0356 0.0356
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0005 0.0062
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.011 0.0434 0.3326
Onchocerca volvulus 0.0359 0.1615 0.1887
Plasmodium falciparum heat shock protein 90 0.003 0.0051 0.0677
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0553 0.4236
Brugia malayi ImpB/MucB/SamB family protein 0.0293 0.1305 0.1305
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0257 0.1528
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.016 0.0671 0.0671
Trichomonas vaginalis mercuric reductase, putative 0.0059 0.019 0.1107
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0059 0.019 0.1456
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0059 0.019 0.019
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0179 0.0759 1
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0292 0.1741
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0065 0.0065
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0066 0.0222 0.1698
Schistosoma mansoni topbp1 0.0037 0.0087 0.0087
Mycobacterium ulcerans phosphoglycerate kinase 0.0179 0.0759 0.1903
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2123 1 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0037 0.0087 0.067
Echinococcus multilocularis phosphoglycerate kinase 1 0.0179 0.0759 0.0759
Plasmodium falciparum replication factor C subunit 1, putative 0.0037 0.0087 0.1153
Trypanosoma brucei DNA polymerase eta, putative 0.0293 0.1305 1
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0059 0.019 0.1528
Plasmodium vivax endoplasmin, putative 0.003 0.0051 0.0677
Schistosoma mansoni hypothetical protein 0.016 0.0671 0.0671
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.019 0.1456
Brugia malayi hypothetical protein 0.0032 0.0064 0.0064
Echinococcus multilocularis BC026374 protein (S09 family) 0.0359 0.1615 0.1615
Onchocerca volvulus 0.0359 0.1615 0.1887
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0347 0.0347
Onchocerca volvulus 0.0359 0.1615 0.1887
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0005 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0196 0.0842 0.6452
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0001 0.0009
Trichomonas vaginalis DNA helicase recq1, putative 0.0048 0.0139 0.0791
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0051 0.0051
Brugia malayi glutaminase DH11.1 0.0287 0.1273 0.1273
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0043 0.0113 0.0113
Plasmodium falciparum phosphoglycerate kinase 0.0179 0.0759 1
Echinococcus multilocularis acetylcholinesterase 0.2123 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0005 0.0062
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0042 0.0111 0.147
Brugia malayi Muscleblind-like protein 0.018 0.0767 0.0767
Onchocerca volvulus 0.0359 0.1615 0.1887
Echinococcus multilocularis nibrin 0.0037 0.0087 0.0087
Brugia malayi DKFZp564C0469 protein 0.0037 0.0087 0.0087
Brugia malayi MH2 domain containing protein 0.0972 0.453 0.453
Echinococcus multilocularis muscleblind protein 0.018 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0359 0.1615 0.1615
Echinococcus granulosus acetylcholinesterase 0.2123 1 1
Schistosoma mansoni acetylcholinesterase 0.0359 0.1615 0.1615
Plasmodium falciparum thioredoxin reductase 0.017 0.0718 0.9464
Toxoplasma gondii thioredoxin reductase 0.017 0.0718 0.9464
Loa Loa (eye worm) hypothetical protein 0.1816 0.854 0.854
Giardia lamblia Kinase, PLK 0.008 0.0292 0.3427
Loa Loa (eye worm) isocitrate dehydrogenase 0.011 0.0434 0.0434
Brugia malayi PHD-finger family protein 0.0019 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.008 0.0292 0.0292
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0247 0.0247
Schistosoma mansoni phosphoglycerate kinase 0.0179 0.0759 0.0759
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.011 0.0434 0.0434
Echinococcus granulosus mothers against decapentaplegic 5 0.0066 0.0225 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0064 0.0321
Plasmodium falciparum phd finger protein, putative 0.0059 0.0189 0.2488
Toxoplasma gondii isocitrate dehydrogenase 0.011 0.0434 0.5722
Echinococcus granulosus regulator of G protein signaling 3 0.0032 0.0064 0.0064
Echinococcus granulosus Smad4 0.0066 0.0225 0.0225
Echinococcus multilocularis acetylcholinesterase 0.2123 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.017 0.0718 0.0718
Trypanosoma brucei unspecified product 0.0196 0.0842 0.6452
Trypanosoma brucei heat shock protein, putative 0.003 0.0051 0.0393
Entamoeba histolytica serine/threonine protein kinase, putative 0.008 0.0292 0.2853
Brugia malayi Calcitonin receptor-like protein seb-1 0.0506 0.2316 0.2316
Schistosoma mansoni blooms syndrome DNA helicase 0.0038 0.0091 0.0091
Trichomonas vaginalis chromobox protein, putative 0.0044 0.012 0.0667
Trypanosoma brucei DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0051 0.0557
Entamoeba histolytica hypothetical protein 0.0232 0.1012 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0066 0.0225 0.0225
Plasmodium vivax heat shock protein, putative 0.0113 0.0446 0.5873
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0051 0.0051
Brugia malayi regulator of G-protein signaling egl-10 0.0043 0.0113 0.0113
Leishmania major heat shock protein 83-1 0.003 0.0051 0.0393
Entamoeba histolytica hypothetical protein 0.0232 0.1012 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0059 0.019 0.1456
Brugia malayi Carboxylesterase family protein 0.0359 0.1615 0.1615
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0199 0.1527
Trypanosoma cruzi DNA polymerase kappa, putative 0.0196 0.0842 0.6452
Trypanosoma brucei heat shock protein, putative 0.003 0.0051 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0087 0.0467
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0037 0.0087 0.0119
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.011 0.0434 0.3326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0059 0.019 0.1456
Brugia malayi Pax transcription factor protein 2 0.064 0.2953 0.2953
Brugia malayi Phosphoglycerate kinase 0.0179 0.0759 0.0759
Schistosoma mansoni hypothetical protein 0.016 0.0671 0.0671
Loa Loa (eye worm) hypothetical protein 0.0094 0.0356 0.0356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0506 0.2316 0.2316
Schistosoma mansoni tar DNA-binding protein 0.0041 0.0105 0.0105
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0179 0.0759 0.4656
Loa Loa (eye worm) hypothetical protein 0.021 0.0908 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0048 0.022
Echinococcus multilocularis regulator of G protein signaling 3 0.0032 0.0064 0.0064

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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