Detailed information for compound 1444744

Basic information

Technical information
  • TDR Targets ID: 1444744
  • Name: N-[2-[(4-methyl-1,2,5-oxadiazol-3-yl)oxy]ethy l]-2,4-dinitroaniline
  • MW: 309.235 | Formula: C11H11N5O6
  • H donors: 1 H acceptors: 6 LogP: 2.34 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc(ccc1NCCOc1nonc1C)[N+](=O)[O-]
  • InChi: 1S/C11H11N5O6/c1-7-11(14-22-13-7)21-5-4-12-9-3-2-8(15(17)18)6-10(9)16(19)20/h2-3,6,12H,4-5H2,1H3
  • InChiKey: BNBXQUXYADJGKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[(4-methyl-1,2,5-oxadiazol-3-yl)oxy]ethyl]-2,4-dinitro-aniline
  • (2,4-dinitrophenyl)-[2-(4-methylfurazan-3-yl)oxyethyl]amine
  • (2,4-Dinitro-phenyl)-[2-(4-methyl-furazan-3-yloxy)-ethyl]-amine
  • ZINC06177691
  • A2292/0096563
  • MLS000568635
  • SMR000175003
  • AG-690/08668039
  • BAS 00434863

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Toxoplasma gondii GNS1/SUR4 family protein 0.0638 0.4117 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0013 0.0048 0.0116
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0048 0.0116
Trypanosoma cruzi fatty acid elongase, putative 0.0638 0.4117 1
Brugia malayi Smad1 0.0007 0.0007 0.0018
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0016 0.008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0016 0.0039
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0013 0.0048 0.0116
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0016 0.008
Echinococcus multilocularis geminin 0.0316 0.2016 0.201
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0459 0.1114
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0088 0.0214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0263 0.1303
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0088 0.0214
Trypanosoma cruzi fatty acid elongase, putative 0.0129 0.08 0.1943
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0459 0.2276
Loa Loa (eye worm) MH2 domain-containing protein 0.0106 0.065 0.1578
Giardia lamblia DINP protein human, muc B family 0.002 0.0088 1
Brugia malayi steroid hormone receptor 0.0009 0.0016 0.0039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0263 0.0638
Schistosoma mansoni fatty acid acyl transferase-related 0.0129 0.08 0.3968
Echinococcus multilocularis elongation of very long chain fatty acids 0.0129 0.08 0.0793
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.0638 0.4117 1
Trypanosoma cruzi fatty acid elongase, putative 0.0129 0.08 0.1943
Brugia malayi ecdysteroid receptor 0.0009 0.0016 0.0039
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0088 0.0436
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0088 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0088 0.0214
Trypanosoma cruzi fatty acid elongase, putative 0.0638 0.4117 1
Schistosoma mansoni hypothetical protein 0.0316 0.2016 1
Trypanosoma cruzi fatty acid elongase, putative 0.0129 0.08 0.1943
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.0048 0.0236
Brugia malayi GNS1/SUR4 family protein 0.0638 0.4117 1
Trypanosoma cruzi fatty acid elongase, putative 0.0129 0.08 0.1943
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0016 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0088 0.0214
Brugia malayi nuclear receptor NHR-88 0.0009 0.0016 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0088 0.0214
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0129 0.08 0.1943
Schistosoma mansoni smad1 5 8 and 0.0007 0.0007 0.0037
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Loa Loa (eye worm) Smad1 0.0007 0.0007 0.0018
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0088 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0088 0.0214
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0016 0.0044
Toxoplasma gondii fatty acid elongase 0.0129 0.08 0.1943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0016 0.0039
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0016 0.0044
Echinococcus granulosus dna polymerase eta 0.002 0.0088 0.0401
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0016 0.0009
Plasmodium vivax GNS1/SUR4 domain containing protein 0.0638 0.4117 1
Schistosoma mansoni coup transcription factor 0.0009 0.0016 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0016 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0048 0.0117
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0016 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0039
Loa Loa (eye worm) RNA binding protein 0.0076 0.0459 0.1114
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0129 0.08 0.1943
Trypanosoma cruzi fatty acid elongase, putative 0.0638 0.4117 1
Trypanosoma brucei Long chain fatty acyl elongase 0.0129 0.08 0.1943
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0088 1
Leishmania major fatty acid elongase, putative 0.0638 0.4117 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0016 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0039
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0088 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0048 0.0117
Leishmania major DNA polymerase kappa, putative 0.002 0.0088 0.0214
Trypanosoma cruzi fatty acid elongase, putative 0.0129 0.08 0.1943
Echinococcus granulosus elongation of very long chain fatty acids 0.0129 0.08 0.3946
Brugia malayi Isocitrate dehydrogenase 0.0013 0.0048 0.0116
Brugia malayi MH2 domain containing protein 0.0007 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0016 0.0039
Trypanosoma cruzi fatty acid elongase, putative 0.0129 0.08 0.1943
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.0638 0.4117 1
Schistosoma mansoni elongation of fatty acids protein 1 0.0129 0.08 0.3968
Brugia malayi fatty acid elongation protein 3 0.0129 0.08 0.1943
Trypanosoma cruzi fatty acid elongase, putative 0.0638 0.4117 1
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0016 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0088 0.0214
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0016 0.0009
Onchocerca volvulus 0.0129 0.08 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0263 0.1303
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0016 0.0044
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0016 0.008
Schistosoma mansoni elongation of fatty acids protein 1 0.0129 0.08 0.3968
Leishmania major DNA polymerase eta, putative 0.002 0.0088 0.0214
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0048 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0016 0.0039
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0013 0.0048 0.0116
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0039
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.0048 0.004
Plasmodium vivax long chain polyunsaturated fatty acid elongation enzyme, putative 0.0129 0.08 0.1943
Onchocerca volvulus Elongation of very long chain fatty acids protein 5 homolog 0.0129 0.08 1
Loa Loa (eye worm) fatty acid elongation protein 3 0.0638 0.4117 1
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0016 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0048 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0016 0.008
Loa Loa (eye worm) fatty acid elongation protein 3 0.0129 0.08 0.1943
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0016 0.008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0263 0.1271
Trypanosoma brucei Fatty acid elongase 0.0129 0.08 0.1943
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0016 0.008
Brugia malayi fatty acid elongation protein 3 0.0129 0.08 0.1943
Echinococcus granulosus elongation of very long chain fatty acids 0.0129 0.08 0.3946
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0016 0.0039
Echinococcus granulosus geminin 0.0316 0.2016 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0016 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0016 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0048 0.004
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0638 0.4117 1
Trypanosoma brucei Fatty acid elongase 0.0129 0.08 0.1943
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0088 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0016 0.008
Schistosoma mansoni DNA polymerase eta 0.002 0.0088 0.0436
Brugia malayi MH2 domain containing protein 0.0007 0.0007 0.0018
Echinococcus granulosus tar DNA binding protein 0.0076 0.0459 0.2247
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0016 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0013 0.0048 0.0116
Onchocerca volvulus 0.0129 0.08 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0263 0.1271
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0016 0.0039
Brugia malayi fatty acid elongation protein 3 0.0129 0.08 0.1943
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0129 0.08 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0016 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0263 0.0256
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0016 0.008
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0048 0.0117
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0088 0.0214
Trypanosoma brucei unspecified product 0.0014 0.0048 0.0117
Schistosoma mansoni elongation of fatty acids protein 1 0.0129 0.08 0.3968
Schistosoma mansoni hypothetical protein 0.0316 0.2016 1
Trypanosoma brucei unspecified product 0.002 0.0088 0.0214
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0088 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0016 0.0039
Trypanosoma brucei Fatty acid elongase 0.0638 0.4117 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0016 0.0039
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0048 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0016 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0007 0.0037
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.0048 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0016 0.0009
Brugia malayi isocitrate dehydrogenase 0.0013 0.0048 0.0116
Brugia malayi MH2 domain containing protein 0.0106 0.065 0.1578
Loa Loa (eye worm) ELO-9 protein 0.0129 0.08 0.1943
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0088 0.0214
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0048 0.0116
Schistosoma mansoni smad1 5 8 and 0.0007 0.0007 0.0037
Schistosoma mansoni elongation of fatty acids protein 1 0.0129 0.08 0.3968
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0088 0.0436
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0016 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0129 0.08 0.1943
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0088 1
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0129 0.08 0.1943
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0048 0.004
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0016 0.0044
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.0638 0.4117 1
Leishmania major fatty acid elongase, putative 0.0129 0.08 0.1943
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0016 0.008
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0016 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0459 0.2276
Echinococcus multilocularis dna polymerase kappa 0.002 0.0088 0.0081
Trypanosoma brucei elongation of very long chain fatty acids protein, putative 0.0129 0.08 0.1943
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0088 1
Brugia malayi MH1 domain containing protein 0.0007 0.0007 0.0018
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0459 0.1114
Plasmodium falciparum long chain polyunsaturated fatty acid elongation enzyme, putative 0.0129 0.08 0.1943
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0039
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0459 0.1114
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0459 0.0452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0263 0.1303
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0129 0.08 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.0048 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0016 0.0039
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0016 0.0039
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0088 0.0081
Schistosoma mansoni smad 0.0007 0.0007 0.0037
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0088 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0088 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0016 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0016 0.008
Schistosoma mansoni smad1 5 8 and 0.0007 0.0007 0.0037
Loa Loa (eye worm) fatty acid elongation protein 3 0.0129 0.08 0.1943
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0459 0.2276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0016 0.0039
Echinococcus multilocularis elongation of very long chain fatty acids 0.0129 0.08 0.0793
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0459 0.2276
Echinococcus granulosus dna polymerase kappa 0.002 0.0088 0.0401
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.0048 0.0116
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0088 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0263 0.0638
Echinococcus multilocularis dna polymerase eta 0.002 0.0088 0.0081
Schistosoma mansoni Smad4 0.0007 0.0007 0.0037
Leishmania major fatty acid elongase, putative 0.0638 0.4117 1
Brugia malayi Fatty acid elongation protein 3 0.0638 0.4117 1
Loa Loa (eye worm) fatty acid elongation protein 3 0.0129 0.08 0.1943
Loa Loa (eye worm) transcription factor SMAD2 0.0106 0.065 0.1578
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0016 0.0039
Brugia malayi fatty acid elongation protein 3 0.0129 0.08 0.1943
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0007 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0016 0.008
Brugia malayi MH1 domain containing protein 0.0007 0.0007 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0016 0.0009
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0016 0.008
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0459 0.2276
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0039
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0007 0.0018
Leishmania major fatty acid elongase, putative 0.0638 0.4117 1
Plasmodium vivax elongation of very long chain fatty acids protein 3, putative 0.0129 0.08 0.1943
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0263 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0088 0.0214
Brugia malayi TAR-binding protein 0.0076 0.0459 0.1114
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0088 0.0214
Trypanosoma brucei unspecified product 0.0014 0.0048 0.0117
Brugia malayi GNS1/SUR4 family protein 0.0129 0.08 0.1943
Brugia malayi RNA binding protein 0.0076 0.0459 0.1114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0016 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0016 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0016 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0016 0.0039
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0013 0.0048 0.0116
Brugia malayi nuclear hormone receptor 0.0009 0.0016 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0016 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0016 0.0009

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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