Detailed information for compound 1445094

Basic information

Technical information
  • TDR Targets ID: 1445094
  • Name: 5-chloro-N-[(4-dimethylaminophenyl)methyl]-N- (furan-2-ylmethyl)-3,6-dimethyl-1-benzofuran- 2-carboxamide
  • MW: 436.931 | Formula: C25H25ClN2O3
  • H donors: 0 H acceptors: 1 LogP: 5.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)CN(C(=O)c1oc2c(c1C)cc(c(c2)C)Cl)Cc1ccco1)C
  • InChi: 1S/C25H25ClN2O3/c1-16-12-23-21(13-22(16)26)17(2)24(31-23)25(29)28(15-20-6-5-11-30-20)14-18-7-9-19(10-8-18)27(3)4/h5-13H,14-15H2,1-4H3
  • InChiKey: PPUDNSIDHWHEDR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-chloro-N-[(4-dimethylaminophenyl)methyl]-N-(2-furylmethyl)-3,6-dimethyl-benzofuran-2-carboxamide
  • 5-chloro-N-[(4-dimethylaminophenyl)methyl]-N-(2-furylmethyl)-3,6-dimethyl-2-benzofurancarboxamide
  • 5-chloro-N-(4-dimethylaminobenzyl)-N-(2-furylmethyl)-3,6-dimethyl-benzofuran-2-carboxamide
  • NCGC00115619-01
  • D062-0354

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0188 0.0176
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0772 0.6806
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0301 0.0116
Mycobacterium tuberculosis Conserved protein 0.0043 0.1046 0.0793
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.2124 0.2407
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0741 0.0813
Trypanosoma brucei ISWI complex protein 0.0018 0.0123 0.0394
Echinococcus multilocularis muscleblind protein 0.0173 0.5815 0.871
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1046 0.0875
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2547 0.2404
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.1046 0.0793
Leishmania major hypothetical protein, conserved 0.0043 0.1046 0.427
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.128 0.1877
Plasmodium falciparum phd finger protein, putative 0.0035 0.0741 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.1099 0.1604
Mycobacterium tuberculosis Conserved protein 0.0043 0.1046 0.0793
Loa Loa (eye worm) beta-lactamase 0.0043 0.1046 0.1165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Loa Loa (eye worm) ctsf protein 0.002 0.0188 0.0176
Echinococcus multilocularis peregrin 0.0038 0.0846 0.1223
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0301 0.0402
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2038 0.8859
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1046 0.0875
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1314 0.1148
Brugia malayi beta-lactamase 0.0043 0.1046 0.12
Leishmania major DNA polymerase eta, putative 0.0023 0.0301 0.0825
Schistosoma mansoni chromobox protein 0.0084 0.2547 0.3785
Loa Loa (eye worm) hypothetical protein 0.0035 0.0741 0.0813
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0188 0.023
Onchocerca volvulus 0.005 0.128 0.1113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1532 0.2256
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1046 0.12
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1046 0.1524
Echinococcus multilocularis zinc finger protein 0.0024 0.0314 0.0421
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2285 1
Trypanosoma brucei unspecified product 0.0023 0.0301 0.1186
Giardia lamblia PHD finger protein 15 0.0035 0.0741 1
Echinococcus multilocularis muscleblind protein 1 0.0173 0.5815 0.871
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.1257 0.1408
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0361 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0188 0.0215
Schistosoma mansoni bromodomain containing protein 0.0076 0.2262 0.3356
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0301 0.0825
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0301 0.0825
Schistosoma mansoni hypothetical protein 0.0196 0.6672 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0741 0.6443
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0741 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0188 0.023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8718 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1182 0.1014
Brugia malayi Bromodomain containing protein 0.0046 0.1148 0.1317
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0674 0.0495
Loa Loa (eye worm) hypothetical protein 0.0047 0.1182 0.1321
Leishmania major cathepsin L-like protease 0.0077 0.2285 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0301 0.0402
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.2547 0.2893
Mycobacterium leprae Probable lipase LipE 0.0043 0.1046 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2285 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1182 0.1014
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0301 0.0346
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.2102 0.3115
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1046 0.0875
Mycobacterium tuberculosis Conserved protein 0.0043 0.1046 0.0793
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Echinococcus multilocularis geminin 0.0196 0.6672 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0188 0.0215
Echinococcus granulosus chromobox protein 1 0.0084 0.2547 0.3785
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.1046 0.0793
Brugia malayi chromobox protein homolog 3 0.0047 0.1182 0.1356
Loa Loa (eye worm) hypothetical protein 0.0023 0.0301 0.0307
Leishmania major cathepsin L-like protease 0.002 0.0188 0.0298
Brugia malayi Heterochromatin protein 1 0.0084 0.2547 0.2921
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1314 0.1148
Mycobacterium ulcerans hypothetical protein 0.0043 0.1046 1
Schistosoma mansoni chromobox protein 0.0084 0.2547 0.3785
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0772 0.1111
Echinococcus multilocularis dna polymerase eta 0.0023 0.0301 0.0402
Loa Loa (eye worm) hypothetical protein 0.0043 0.1046 0.1165
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1676 0.7185
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0301 0.0825
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.1099 0.1604
Brugia malayi Bromodomain containing protein 0.0091 0.2784 0.3194
Onchocerca volvulus 0.0043 0.1046 0.0875
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0188 0.023
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.3697 0.5519
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.1014 0.1476
Schistosoma mansoni hypothetical protein 0.0025 0.0361 0.0492
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.2285 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0723 0.1037
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Toxoplasma gondii ABC1 family protein 0.0043 0.1046 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1043 0.1519
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1046 0.0875
Brugia malayi Pre-SET motif family protein 0.0036 0.0772 0.0885
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1046 0.1524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Loa Loa (eye worm) hypothetical protein 0.0043 0.1046 0.1165
Leishmania major cysteine peptidase A (CPA) 0.002 0.0188 0.0298
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0188 0.023
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0301 0.0346
Echinococcus granulosus zinc finger protein 0.0024 0.0314 0.0421
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.1046 0.0793
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Schistosoma mansoni zinc finger protein 0.0018 0.0123 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0201 0.0251
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0772 0.1111
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0188 0.023
Leishmania major cathepsin L-like protease 0.002 0.0188 0.0298
Schistosoma mansoni hypothetical protein 0.0196 0.6672 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0674 0.0495
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1046 0.1524
Schistosoma mansoni hypothetical protein 0.0018 0.0123 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.1532 0.2256
Brugia malayi Cathepsin L-like precursor 0.002 0.0188 0.0215
Loa Loa (eye worm) hypothetical protein 0.0037 0.0806 0.0888
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.1099 0.1226
Schistosoma mansoni zinc finger protein 0.0024 0.0314 0.0421
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0741 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0301 0.1186
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0188 0.0215
Schistosoma mansoni hypothetical protein 0.0035 0.0741 0.1064
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2285 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1046 0.1165
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.1046 0.0793
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0301 0.0307
Brugia malayi Cathepsin L-like precursor 0.002 0.0188 0.0215
Echinococcus granulosus dna polymerase eta 0.0023 0.0301 0.0402
Brugia malayi Cathepsin L-like precursor 0.002 0.0188 0.0215
Echinococcus granulosus geminin 0.0196 0.6672 1
Schistosoma mansoni DNA polymerase eta 0.0023 0.0301 0.0402
Leishmania major cathepsin L-like protease 0.0077 0.2285 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0188 0.0215
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1046 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1046 0.427
Loa Loa (eye worm) cysteine protease 0.002 0.0188 0.0176
Brugia malayi Muscleblind-like protein 0.0173 0.5815 0.667
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1046 0.1165
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0188 0.023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.2102 0.3115
Echinococcus granulosus jumonji domain containing protein 0.0049 0.125 0.1831
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0301 0.0825
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.1046 0.0793
Brugia malayi PHD-finger family protein 0.003 0.0552 0.0633
Leishmania major cathepsin L-like protease 0.0077 0.2285 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1046 0.0875
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.1046 0.0793
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.125 0.1831
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0301 0.1186
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0201 0.0251
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.1182 0.1014
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.3697 0.5519
Loa Loa (eye worm) hypothetical protein 0.0173 0.5815 0.6657
Leishmania major cathepsin L-like protease 0.002 0.0188 0.0298
Leishmania major cathepsin L-like protease 0.002 0.0188 0.0298
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0188 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Loa Loa (eye worm) hypothetical protein 0.0057 0.1532 0.1724
Loa Loa (eye worm) hypothetical protein 0.0046 0.1152 0.1286
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0446 0.062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0301 0.0825
Schistosoma mansoni jumonji domain containing protein 0.0092 0.2823 0.4201
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0741 0.1064
Brugia malayi Bromodomain containing protein 0.0038 0.0846 0.0971
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1046 0.427
Brugia malayi jmjC domain containing protein 0.0045 0.1099 0.1261
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.1099 0.1604
Onchocerca volvulus 0.0043 0.1046 0.0875
Echinococcus granulosus chromobox protein 1 0.0084 0.2547 0.3785
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0301 0.0402
Brugia malayi beta-lactamase family protein 0.0043 0.1046 0.12
Onchocerca volvulus Alhambra homolog 0.0035 0.0741 0.0564
Brugia malayi CHD4 protein 0.0016 0.0035 0.004
Loa Loa (eye worm) hypothetical protein 0.0052 0.1342 0.1506
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.9695 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1046 0.1165
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0301 0.1186
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.1046 0.4495
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0446 0.062
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0188 0.023
Loa Loa (eye worm) hypothetical protein 0.0043 0.1046 0.1165
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Onchocerca volvulus 0.0043 0.1046 0.0875
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0201 0.0251
Plasmodium vivax SET domain protein, putative 0.0036 0.0772 0.6806
Loa Loa (eye worm) fibroinase 0.002 0.0188 0.0176
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0229 0.0223
Echinococcus granulosus peregrin 0.0038 0.0846 0.1223
Echinococcus multilocularis chromobox protein 1 0.0084 0.2547 0.3785
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0201 0.0251
Echinococcus multilocularis cysteine protease 0.002 0.0188 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Leishmania major cathepsin L-like protease 0.002 0.0188 0.0298
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0301 0.0402
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.1532 0.2256
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0188 0.0176
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0741 0.6443
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2547 0.2404
Echinococcus multilocularis chromobox protein 1 0.0084 0.2547 0.3785
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0301 0.1186
Mycobacterium ulcerans beta-lactamase 0.0043 0.1046 1
Echinococcus granulosus muscleblind protein 0.0173 0.5815 0.871
Brugia malayi PHD-finger family protein 0.0035 0.0741 0.085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.0301 0.0825
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0446 0.062
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.1314 0.1148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1046 0.1524
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.1046 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0188 0.023
Echinococcus granulosus dna polymerase kappa 0.0023 0.0301 0.0402
Brugia malayi jmjC domain containing protein 0.0115 0.3697 0.4241
Loa Loa (eye worm) hypothetical protein 0.0173 0.5815 0.6657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2285 1
Trichomonas vaginalis esterase, putative 0.0043 0.1046 0.0875
Loa Loa (eye worm) hypothetical protein 0.0085 0.2594 0.2947
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.1046 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.1532 0.2256
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0741 0.6443
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0188 0.0176
Brugia malayi beta-lactamase family protein 0.0043 0.1046 0.12
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0301 0.0116
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0301 0.0402
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0301 0.0825
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.1046 0.0793
Echinococcus multilocularis cysteine protease 0.002 0.0188 0.023
Loa Loa (eye worm) hypothetical protein 0.0043 0.1046 0.1165
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0301 0.1186
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1043 0.1519
Brugia malayi Pre-SET motif family protein 0.0251 0.8718 1
Mycobacterium ulcerans lipase LipD 0.0043 0.1046 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1669 0.1882
Onchocerca volvulus 0.0037 0.0806 0.063
Mycobacterium leprae conserved hypothetical protein 0.0043 0.1046 0.5
Echinococcus granulosus cathepsin l1 0.002 0.0188 0.023

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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