Detailed information for compound 1445334

Basic information

Technical information
  • TDR Targets ID: 1445334
  • Name: 8-(2-methoxyethyl)-6-(2-phenylethyl)pteridin- 7-one
  • MW: 310.35 | Formula: C17H18N4O2
  • H donors: 0 H acceptors: 3 LogP: 1.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(=O)c(CCc2ccccc2)nc2c1ncnc2
  • InChi: 1S/C17H18N4O2/c1-23-10-9-21-16-15(11-18-12-19-16)20-14(17(21)22)8-7-13-5-3-2-4-6-13/h2-6,11-12H,7-10H2,1H3
  • InChiKey: NTUQADRZIWTNBY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-(2-methoxyethyl)-6-(2-phenylethyl)-7-pteridinone
  • NCGC00012496
  • PCOP-847310

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.069 0.069
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.069 0.069
Schistosoma mansoni coup transcription factor 0.0012 0.069 0.069
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0009 0 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.069 0.069
Schistosoma mansoni nuclear hormone receptor 0.0012 0.069 0.069
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.069 0.069
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.1997 0.1997
Loa Loa (eye worm) hypothetical protein 0.0012 0.069 0.069
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.069 0.069
Brugia malayi ecdysteroid receptor 0.0012 0.069 0.069
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0012 0.069 0.069
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.069 0.069
Brugia malayi steroid hormone receptor 0.0012 0.069 0.069
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0012 0.069 0.069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.069 0.069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.069 0.069
Mycobacterium leprae putative cytochrome p450 0.0009 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.069 0.069
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.069 0.069
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 1 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0009 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0009 0 0.5
Leishmania major cytochrome p450-like protein 0.0019 0.1997 0.1997
Loa Loa (eye worm) hypothetical protein 0.0012 0.069 0.069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.069 0.069
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0009 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.069 0.069
Schistosoma mansoni serine/threonine protein kinase 0.0062 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.069 0.069
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0009 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0009 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0009 0 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.069 0.069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.069 0.069
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0009 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.069 0.069
Trichomonas vaginalis CMGC family protein kinase 0.0062 1 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0012 0.069 0.069
Trypanosoma brucei protein kinase, putative 0.0062 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0009 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0009 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0384 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.069 0.069
Schistosoma mansoni thyroid hormone receptor 0.0012 0.069 0.069
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.069 0.069
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0009 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0009 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.069 0.069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.069 0.069
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0009 0 0.5
Brugia malayi nuclear receptor NHR-88 0.0012 0.069 0.069
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.069 0.069
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.069 0.069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.069 0.069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.069 0.069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0012 0.069 0.069
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 1 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.069 0.069
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0009 0 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.1997 0.1997
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.069 0.069
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.1997 0.1997
Trichomonas vaginalis CMGC family protein kinase 0.0062 1 0.5
Loa Loa (eye worm) CYP4Cod1 0.0019 0.1997 0.1997
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.1997 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.069 0.069
Schistosoma mansoni thyroid hormone receptor 0.0012 0.069 0.069
Onchocerca volvulus 0.0012 0.069 0.5
Brugia malayi nuclear hormone receptor 0.0012 0.069 0.069
Trichomonas vaginalis CMGC family protein kinase 0.0062 1 0.5
Giardia lamblia Kinase, CMGC MAPK 0.0062 1 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.069 0.069
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.069 0.069
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.069 0.069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.069 0.069
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.069 0.069
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0009 0 0.5
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0009 0 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.069 0.5
Trypanosoma brucei cytochrome P450, putative 0.0019 0.1997 0.1997
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0009 0 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.069 0.069
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.069 0.069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.069 0.069
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.069 0.069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.069 0.069
Brugia malayi Cytochrome P450 family protein 0.0019 0.1997 0.1997
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.069 0.069
Brugia malayi Cytochrome P450 family protein 0.0019 0.1997 0.1997
Echinococcus multilocularis mitogen activated protein kinase 0.0062 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.069 0.069
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 1 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.069 0.069
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.069 0.069
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 1 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0009 0 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.069 0.069
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.069 0.069
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.069 0.069
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 1 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.069 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.069 0.069
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0009 0 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.069 0.069
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.069 0.069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.069 0.069
Echinococcus granulosus mitogen activated protein kinase 0.0062 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 1 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.1997 0.1997
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0009 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.069 0.069
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.069 0.5
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0009 0 0.5

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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